Interaction of fluoride, calcium, phosphorus, and thyroidectomy on porcine bone.
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Three groups of weanling female rats were fed different, commercially available, 'natural ingredient' diets containing 12, 28 or 45 parts/10(6) F, mainly as bone meal, for six weeks. Two other groups were fed a low-fluoride (0.76 parts/10(6)) semipurified diet. They received fluoride doses, either in the drinking water or by daily intraperitoneal injection, which were approximately equal to the average dose of the other three groups. Rats on the 'natural ingredient' diets ingested more food and water and excreted more faeces and urine, effects which were attributed to the higher amounts of dietary fibre, Na, K and Cl. Thus, at any given concentration of fluoride in the food or water, the level of fluoride ingestion and the ensuing effects would be influenced by the type of diet used. The values for fractional fluoride absorption (45-49%) and retention (38-47%) were similar among the groups given 'natural ingredient' diets. In the groups given semipurified diet, the corresponding values were about twice as high with the exception that fractional absorption was negative (-41%) in the injected group, which indicated net intestinal secretion of fluoride. Fluoride balances and tissue concentrations were highest in the groups fed the semipurified diet, even though the level of intake was not always higher. The fractional values for calcium and phosphorus absorption (41-51%) and retention (33-43%) were also similar among the groups given 'natural ingredient' diets. The corresponding values were about twice as high in the groups fed the semipurified diet. In terms of supporting maximum bone calcification, phosphorus absorption was marginal in two of the groups on the 'natural ingredient' diets.(ABSTRACT TRUNCATED AT 250 WORDS)
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OBJECTIVES: The objective of this study was to investigate the effects of CO(2) laser on fluoride uptake in the loosely- and firmly-bound forms in enamel. METHODS: Five human molars were cut into halves before being treated with 2.0% NaF topical gel. Each half had three windows on the enamel surface, including one control and two experimental windows irradiated by two laser therapies. One half of each tooth was treated with 1 M KOH solution to remove the loosely-bound fluoride (calcium fluoride). A tooth section was obtained from each window and the relative fluorine concentration was analyzed with Secondary Ion Mass Spectrometry (SIMS). The morphology of the enamel surfaces in the windows was examined using an Environmental Scanning Electron Microscope (ESEM). RESULTS: Significant laser-induced increases in the uptake of fluoride were revealed in both loosely-bound and firmly-bound apatitic fluoride, with both laser treatments (all p<0.001). Calcium fluoride-like deposits on the enamel surfaces receiving the combined laser-fluoride treatment were revealed by ESEM. CONCLUSIONS: The finding of this study substantiated the laser effect in increasing the fluoride uptake into enamel.
Fluoride 27 mg was given perorally to 14 subjects. It was found that the serum fluoride concentration increased followed by a decrease to normal levels during 24 h. Serum concentrations of calcium and phosphate decreased initially whereas those of serum immunoreactive parathyroid hormone increased. After 24 h the measured quantities were within normal limits. The results are discussed with reference to mineralization of hard tissues and to fluoride treatment of osteoporotic patients.