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At least 127 records · Page 7Linked to original sources
PubMed1999

Does the National Institutes of Health Stroke Scale favor left hemisphere strokes? NINDS t-PA Stroke Study Group.

BACKGROUND AND PURPOSE: The National Institutes of Health Stroke Scale (NIHSS) is a valid, reproducible scale that measures neurological deficit. Of 42 possible points, 7 points are directly related to measurement of language compared with only 2 points related to neglect. METHODS: We examined the placebo arm of the NINDS t-PA stroke trial to test the hypothesis that the total volume of cerebral infarction in patients with right hemisphere strokes would be greater than the volume of cerebral infarction in patients with left hemisphere strokes who have similar NIHSS scores. The volume of stroke was determined by computerized image analysis of CT films and CT images stored on computer tape and optical disks. Cube-root transformation of lesion volume was performed for each CT. Transformed lesion volume was analyzed in a logistic regression model to predict volume of stroke by NIHSS score for each hemisphere. Spearman rank correlation was used to determine the relation between the NIHSS score and lesion volume. RESULTS: The volume for right hemisphere stroke was statistically greater than the volume for left hemisphere strokes, adjusting for the baseline NIHSS (P<0. 001). For each 5-point category of the NIHSS score <20, the median volume of right hemisphere strokes was approximately double the median volume of left hemisphere strokes. For example, for patients with a left hemisphere stroke and a 24-hour NIHSS score of 16 to 20, the median volume of cerebral infarction was 48 mL (interquartile range 14 to 111 mL) as compared with 133 mL (interquartile range 81 to 208 mL) for patients with a right hemisphere stroke (P<0.001). The median volume of a right hemisphere stroke was roughly equal to the median volume of a left hemisphere stroke in the next highest 5-point category of the NIHSS. The Spearman rank correlation between the 24-hour NIHSS score and 3-month lesion volume was 0.72 for patients with left hemisphere stroke and 0.71 for patients with right hemisphere stroke. CONCLUSIONS: For a given NIHSS score, the median volume of right hemisphere strokes is consistently larger than the median volume of left hemisphere strokes. The clinical implications of our finding need further exploration.

Brain↗
PubMed1998

Cine film replacement: digital archival requirements and remaining obstacles.

The acceptance of the Digital Imaging and Communication in Medicine (DICOM) standard and the Compact Disk-Recordable (CD-R) as the interchange medium have been critical developments for laboratories that need to move forward on the cine replacement front, while at the same time retain a means to communicate with other centers. One remaining essential component which has not been satisfactorily addressed is the issue of how digital image data should be archived within an institution. Every laboratory must consider the diverse issues which affect the choice of a digital archiving system. These factors include technical and economic issues, along with the clinical routines prevailing in their laboratory. A complete understanding of the issues will lead to the formulation of multiple options which may prove acceptable and will help to overcome the last obstacle which remains for the complete replacement of cine film in the cardiac catheterization laboratory.

Archives↗
PubMed2000

Procedural costs of digital vs. analog archiving of diagnostic cardiac catheterizations.

The use of digital technology in the cardiac catheterization laboratory is expanding at a rapid pace. The cost-effectiveness of this new technology is yet to be proven. The aims of this study were to determine the direct cost differences of digital versus analog media (CDs) for the storage of diagnostic cardiac catheterizations and to explore the factors influencing these differences. Procedural costs of all diagnostic angiograms (n = 109), from three physicians, performed in an analog catheterization laboratory (room A) and a digital catheterization laboratory (room C) were compared during a 9-month period. The mean procedural cost was higher in room A than in room C ($1,102 vs. $1,087, P < 0.001). This cost difference was eliminated when recording media costs were excluded from analysis ($1,079 vs. $1,080, P = 0.931). Therefore, we conclude there is a procedural cost savings in a cardiac catheterization room that uses digital CDs versus cineangiogram film as the archival media. Cathet. Cardiovasc. Intervent. 49:246-250, 2000.

Cardiac Catheterization↗
PubMed1992

The electronic information revolution and how to exploit it.

Medical information is increasingly stored in electronic format, enabling faster and more flexible access to the literature. Online, compact disc and floppy disc databases are widely available. The origins and development of these different database media are described. The strengths and weaknesses of each, and the ways in which they complement each other, are examined. Ease of access to medical information can result in data management problems; the role of bibliographic software in ensuring full exploitation of the electronic information revolution is therefore emphasized.

CD-ROM↗
PubMed2002

Imaging technique implemented in CellTracks system.

BACKGROUND: We developed the CellTracks cell analysis system that, similar to flow cytometry, yields multiparameter information by which the cells can be differentiated. We describe the implementation of a laser scanning imaging method in the system. Image analysis of the cells improves the specificity of cell classification, especially in cases where the particular cells are found relatively infrequently and one has to discriminate between artifacts and real events. METHODS: Fluorescent images of immunomagnetically labeled and aligned cells are obtained by passing the cells through a laser focus. The laser focus is smaller than the objects and subsequent frames captured by a regular surveillance CCD camera with a frame grabber board represent different parts of the cells. Complete images of the cells are constructed by shifting each image with respect to each other and adding individual pixel values. RESULTS: The power of combining a fluorescent image with multiparametric data is demonstrated by imaging fluorescent and magnetically labeled beads and cells. The image gives additional information about the dye distribution across the objects. Changes in dye distribution as a function of time were observed in leukocytes labeled with the red fluorescent label, Oxazine750, which are imaged at different time intervals. CONCLUSIONS: An imaging technique implemented in the CellTracks system provides high-resolution fluorescent images of events previously identified by the system. The images of the fluorescent cells enhance the ability to classify rare events.

Blood Cells↗
PubMed2001

Amperometric determination of dipyrone in pharmaceutical formulations with a flow cell containing gold electrodes from recordable compact discs.

A simple, rapid, and precise amperometric method for quantification of dipyrone in pharmaceutical formulations is presented. The proposed method permits determinations in the 10(-7) mol L(-1) of the analyte and enables 90 determinations h(-1), employing only 100 microL of sample per determination. This method is based on the direct quantification of dipyrone in many pharmaceutical products, avoiding cumbersome processes such as previous separations, solvent extraction, or sample filtration. This new procedure was applied to commercial pharmaceutical tablets, and the results obtained were in excellent agreement with the ones obtained by the classical iodometric method.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1997

Influence of Relative Humidity of Storage Air on the Adhesion and Autoadhesion of Micronized Particles to Particulate and Compacted Powder Surfaces

The influence of the relative humidity of storage air on the median adhesion force at the interface of lactose monohydrate and salmeterol xinafoate has been investigated by the centrifuge technique using particle-on-particle and particle-on-surface experiments. The relative humidity of storage air can strongly affect the median adhesion force. Condensed moisture was found to result in strong irreversible solid bridge bonds or in weak solid bridge bonds that are of comparable strength to Lifshitz-van der Waals forces obtained under conditions of low relative humidity up to 35%. The effect was dependent on the structure of the substrate surface, the solubility of the particles adhered, and the solubility of the surface material. The use of different substrate surfaces such as particles and compacted powder disks of identical materials led to different results. Hence, if the influence of relative humidity of storage air on the adhesion between particles in, for example, an interactive mixture is to be predicted, the adhesion measurements have to be performed using particle-on-particle adhesion force measurements. Relative humidity of the air greater than 75% results in irreversible, strong forces acting at the interface of the particles. Below this humidity level, capillary forces can be removed by storing the mixtures at a very low relative humidity of about 5% for at least 72 h.

Journal Article↗
PubMed1995

Replacing cinefilm: motion or commotion?

Digital techniques are well established in the world of cardiac imaging. The catheterization laboratory has become a compilation of independent digitized systems. There is a broad choice of alternatives for cinefilm, but a lot of questions remain unanswered. The last two years, some breakthroughs have been realized: the acceptance of DICOM and CD-R has opened new perspectives. Considering the different user requirements, however, it remains very difficult to actually find an ideal solution. Therefore, the best investments for the coming two to three years remains a hybrid solution: digital modalities for acquisition and reviewing, and 35 mm cinefilm for archiving and communication.

Cardiac Catheterization↗
PubMed1995

Requirements for cardiac interchange media and the role of recordable CD.

Over the past two years, representatives of the American College of Cardiology (ACC) have collaborated with the x-ray equipment industry through the National Electrical Manufacturers Association (NEMA) to develop a digital standard for the exchange of x-ray angiographic images. These efforts have resulted in an extension of the Digital Imaging and Communications in Medicine (DICOM) Standard and the selection of recordable CD as the medium for interchange. This report, which is based on an INCIS '94 presentation in Mainz, Germany, is focused on the results of the medium selection. Included is a discussion of the distinction between archiving and interchange of digital image data, an outline of the medium selection criteria, a mapping of recordable CD against these criteria, and a discussion of the future of this medium. Finally, this report contains information about the ongoing ACC-NEMA activities.

Cardiac Catheterization↗
PubMed1995

Information management in the cardiology department. An analysis of current options for replacing cinefilm.

A major cost component in cardiac angiography is the use of cinefilm for archiving. In addition, cinefilm is difficult to reproduce. There is only one unique archival copy, and if it becomes torn, or lost, it cannot be replaced. Consequently, physicians and administrators looking to save time, increase efficiency and cut costs are also looking for ways to eliminate cinefilm use. Major driving forces that must lead to a replacement of cinefilm are: Cost reduction and Efficiency improvement. The challenge in cardiology is to find a digital cardiac archiving solution that meets the three basic requirements: 1. Cost effectiveness, 2. Ability to perform the basic clinical functions: Review, Exchange and Archive, and 3. Standard format for exchange. A single medium solution, based on CD technology, can fulfill all requirements for review, exchange and archiving. This CD solution, based on CD-Recordable must conform to the DICOM standard for exchange as defined by the ACC/NEMA committee. As advanced technology becomes available, further efficiency improvement can be achieved as extensions to the digital cine replacement based on CD technology. Such networked, multi media solutions are based on a hierarchical storage management concept, incorporate short term archives for on-line availability, and long term archives based on CD for immediate retrieval and exchange.

Cardiac Catheterization↗
PubMed1997

CD-based image archival and management on a hybrid radiology intranet.

This article describes the design and implementation of a low-cost image archival and management solution on a radiology network consisting of UNIX, IBM personal computer-compatible (IBM, Purchase, NY) and Macintosh (Apple Computer, Cupertino, CA) workstations. The picture archiving and communications system (PACS) is modular, scaleable and conforms to the Digital Imaging and Communications in Medicine (DICOM) 3.0 standard for image transfer, storage and retrieval. Image data is made available on soft-copy reporting workstations by a work-flow management scheme and on desktop computers through a World Wide Web (WWW) interface. Data archival is based on recordable compact disc (CD) technology and is automated. The project has allowed the radiology department to eliminate the use of film in magnetic resonance (MR) imaging, computed tomography (CT) and ultrasonography.

Compact Disks↗
PubMed2004

Integrating RIS/PACS: the web-based solution at University Hospital of Ribeirão Preto, Brazil.

Integration of a Radiology Information System (RIS) and a Picture Archiving and Communication System (PACS) reduces the risk of inconsistent data by reducing interfaces among databases that contain largely redundant information. Furthermore, RIS/PACS integration is the basis for a filmless radiology facility. Web technology is based on international standards and supplies the main features for the RIS/PACS integration task based on a client/server model. This article presents a web-based system developed to manage and distribute images and diagnostic information within the University Hospital of Ribeirão Preto (HCRP) at the University of Sao Paulo.

Brazil↗
PubMed1994

Application of high-performance membrane chromatography for separation of annexins from the plasma membranes of liver and isolation of monospecific polyclonal antibodies.

The separation of annexins, calcium-binding plasma membrane-associated proteins from rat liver and Morris hepatoma 7777 by high-performance membrane chromatography (HPMC) is described. The annexins with low molecular masses, CBP 33 and CBP 35, and the annexin with a high molecular mass, CBP 65/67, can be separated within 10 min from one another by anion-exchange HPMC under non-denaturing conditions. The separation devices used consist of compact, porous disks (QuickDisk) on the one hand and of bundled membranes made of cellulose fibers (MemSep) on the other. Both have been found to be equally well suited for this separation. The annexins obtained in this way are subsequently bound to epoxy-activated porons disks and used for the separation of monospecific polyclonal antibodies against the annexin CBP 65/67.

Animals↗