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At least 127 records · Page 7Linked to original sources
PubMed2005

Correlation of results of pulmonary computed tomography and pathologic findings in mice with Pasteurella-induced pneumonia.

OBJECTIVE: To determine correlation between results of computed tomography (CT) versus pathologic examination for determining the volume percentage of affected lung in mice experimentally infected with Pasteurella pneumotropica. ANIMALS: 30 adult mice. PROCEDURE: After helical CT scans on day 0, mice were inoculated intranasally with P. pneumotropica. Repeat CT scans were performed on days 1, 2, 3, 4, 6, 8, 10, and 13. Regions of interest (affected areas) were manually drawn on the CT images, and percentage volume of normal lung was calculated by use of 3 methods: first-day volume, largest volume, and last-day volume. Three mice were euthanatized for pathologic evaluation after each scan day. The lungs were examined with a dissection microscope, and lesion scores were assigned on the basis of percentage volume of pneumonia. Correlation coefficients comparing results of the 3 CT methods with results of gross examination were calculated. RESULTS: Lung abnormalities were detected via dissection microscopy by postinfection day 2 and via CT by days 2 or 3. Correlation coefficients for the 3 CT methods of analysis, compared with pathologic findings, were 0.7 via first-day lung volume, 0.8 via largest lung volume, and 0.8 via last-day lung volume. CONCLUSIONS AND CLINICAL RELEVANCE: Results of CT correlated well with results of dissection microscopy for estimating percentage volume of lung affected by pneumonia in mice experimentally infected with P. pneumotropica. This method may be useful for longitudinal studies of pneumonia in mice.

Animals↗
PubMedDate not supplied

[The use of a local computer network in a pathology bureau].

The activities of a large bureau of pathology using local computer network are analyzed. Every pathologist has at his working place a personal computer switched in the local computer network. The latter and relevant program is employed for all cases of surgical and biopsy material. The advantages of such work are described.

Computer Communication Networks↗
PubMed1984

[X-ray computed tomography in pleuropulmonary asbestos pathology].

Results of computed tomography and conventional radiology were compared during investigation of 17 patients with pleuropulmonary lesions from confirmed asbestosis. Computed tomography images appeared to provide improved data for detection and analysis of pleural plaques, particularly in the costovertebral grooves; false pleural images (associated shadows, fatty tissue) can be eliminated. The CT scan should occupy a place of choice for surveillance of subjects in contact with asbestos and presenting pleural anomalies.

Asbestosis↗
PubMed1995

Solitary tracheal plasmacytoma: computed tomography and pathological findings.

Extramedullary plasmacytomas most frequently occur in the head and the neck, although intrathoracic cases have occasionally been described. Solitary tracheal plasmacytomas are exceedingly rare. The authors describe the computed tomography and pathological appearance of a solitary tracheal plasmacytoma and briefly discuss the treatment and implications of such a lesion.

Humans↗
PubMed1999

Computed tomography and pathologic findings in fulminant forms of idiopathic interstitial pneumonia.

This study describes the computed tomography features of various fulminant forms of idiopathic interstitial pneumonia and to clarify the usefulness of computed tomography in such patients. Computed tomography scans in 19 patients with fulminant forms of idiopathic interstitial pneumonia were reviewed. This study included patients with acute interstitial pneumonia (n = 7), an accelerated form of idiopathic pulmonary fibrosis (n = 2), and an acute exacerbation of idiopathic pulmonary fibrosis (n = 10). Pathologic confirmation of the diagnosis was obtained in all patients. Follow-up computed tomography scans were available for eight patients, and postmortem computed tomography scans were available for three patients. All patients had progressive ground-glass attenuation, consolidation, or both. In patients with an acute exacerbation of idiopathic pulmonary fibrosis, subpleural honeycombing was also seen. Follow-up computed tomography showed a change from ground-glass attenuation to consolidation with distortion. Architectural distortion, traction bronchiectasis, and ground-glass opacity were the prominent features in the initial computed tomography scans obtained more than 7 days after the onset of symptoms, and cystic lesions were seen in follow-up computed tomography obtained more than 1 month after the onset. High-resolution computed tomography was more sensitive than the plain radiographs in the early detection of these entities. Computed tomography examination at the onset of the acute symptoms is useful in classifying these fulminant forms of idiopathic interstitial pneumonia.

Acute Disease↗
PubMedDate not supplied

[An attempt to adopt computer technology in the pathology bureau].

The experience of computer facilities introduction in Taganrog regional pathology bureau (TRPB) is presented. A special program "Autopsy" for pathologists developed by TRPB specialists is described. The hardware and the structure of TRPB local computer network is described. Application of the program in the activities of the bureau is detailed. The results of the program trial in 1995 and prospects of the program introduction in the activities of pathology service of the Rostov region are outlined.

Local Area Networks↗
PubMed1978

Computed tomography of the paranasal sinuses and face: part II. Pathological anatomy.

Computed tomography (CT) has added an important new dimension to the radiological evaluation of diseases of the paranasal sinuses and face. Using transverse and coronal scans, accurate assessment of the character and extent of mass lesions in this region can be achieved. Erosion of thin bony lamine and involvement of soft tissue structures of the face can be seen. Most important, CT is capable of precisely defining the extension of lesions into the pterygopalatine fossa, orbit, and cranial cavity, information that is essential for therapeutic planning.

Adult↗
PubMed1993

Whole lung sections for computed tomographic-pathologic correlations. Modified Gough-Wentworth technique.

RATIONALE AND OBJECTIVES: High-resolution computed tomography of the lung has been advocated in the evaluation of interstitial lung diseases and emphysema. To provide material for correlations with gross pathology and macroscopic quantitation of emphysema, the authors have shortened and simplified the Gough-Wentworth technique. METHODS: The method permits more precise correlation of cross-sectional images and pathologic specimens and is less time-consuming. RESULTS AND CONCLUSIONS: This modified method can be routinely performed in a clinical laboratory of pathology and provides paper-mounted whole lung sections within four days. The sections are protected by a transparency film.

Histological Techniques↗
PubMedDate not supplied

Aspergillus infection of the airways: computed tomography and pathologic findings.

Aspergillosis is a serious pathologic condition caused by Aspergillus organisms and is frequently seen in immunocompromised patients. In recent years, it has been shown that Aspergillus infection can result in a broad range of airway complications. In this article, we illustrate and review the characteristic computed tomography and pathologic findings of the different manifestations of Aspergillus infection involving the airways.

Adult↗
PubMedDate not supplied

[Corpus callosum pathological lesions in computed tomography and magnetic resonance imaging].

The spectrum of congenital anomalies and other pathologic changes of the corpus callosum is presented. Callosal agenesis and hypoplasia, lesions in cases of congenital neurometabolic disorders, traumatic, vascular, inflammatory and neoplastic conditions as well as callosal atrophy are discussed. CT and MR images from the authors' own experience illustrate the material.

Adolescent↗
PubMedDate not supplied

Congenital apnea with medullary and olivary hypoplasia: a pathologic study with computer reconstructions.

We report a three-month-old infant with congenital central apnea who was ventilator-dependent throughout his brief life. At autopsy the most significant findings were localized to the medulla and included severe tegmental necrosis involving respiratory-related sites and olivary hypoplasia. Golgi impregnations of the cerebellum demonstrated several Purkinje cells with changes consistent with experimental olivary ablation. The majority of Purkinje cells, however, were normal; this observation suggests that in an early and subtotal olivary lesion, the incomplete complement of olivary neurons maintains sufficient collateral axonal branches to compensate for decreased cell number. Computer graphics enabled us to dissect the components of the complex medullary pathology and examine them individually and in selected combinations in three dimensions. Computer reconstruction aided the identification and dating of a malformative lesion (first trimester) from a later (second/third trimester), superimposed destructive lesion. This report suggests that the synthesis of complex morphologic data in human neuropathology into meaningful three-dimensional visual displays by computer reconstruction facilitates their comprehension. Computer reconstruction is especially valuable in the elucidation of 3-D topographic relationships in functionally and architecturally complex regions such as the brain stem.

Apnea↗
PubMed1993

Computed tomography-pathologic assessment of laser-induced necrosis in rat liver.

RATIONALE AND OBJECTIVES: Interstitial laser photocoagulation (ILP) causes localized tissue necrosis. This study was performed to determine 1) whether the changes seen on computed tomography (CT) correspond to the necrosis pathologically, and 2) which CT technique best shows the necrosis. METHODS: Eighteen Wistar rats had ILP to their liver using a neodymium yttrium aluminum garnet [Nd:YAG] laser. Radio-opaque markers attached to the liver defined an imaging plane. Precontrast "dynamic" and delayed CT scans were performed. The size of necrosis was measured on CT, and macroscopically after resecting the liver. Computed tomography density numbers were measured from the necrotic area and normal liver for each CT technique. RESULTS: There was a good correlation between the necrosis size on CT and pathologically (P < .001). Maximum lesion-to-liver contrast was obtained on "dynamic" CT scans. CONCLUSIONS: The extent of tissue density changes on CT in rat liver after ILP match the extent of necrosis seen pathologically. The best CT technique use assessed for evaluating laser-induced liver necrosis is dynamic contrast-enhanced scanning.

Animals↗