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At least 127 records · Page 7Linked to original sources

Numerical simulation of steady turbulent flow through trileaflet aortic heart valves--I. Computational scheme and methodology.

A numerical simulation model and technique are described to simulate steady turbulent blood flow through trileaflet tissue valves of varying degrees of stenosis. The aortic trileaflet tissue valve design was chosen as the subject of this study, since it is the only popular valve in current clinical use which is approximately axisymmetric. An axisymmetric geometry is computationally more convenient since it involves only two dimensional equations. The geometry and dimensions of the aorta were designed from angiographic studies and measurements made from cadavers. The valve dimensions were obtained from tissue leaflet photography studies conducted on tissue bioprostheses of varying degrees of stenosis. The non-rectangular nature of this valve necessitated the use of a body conforming grid. Thompson's method coupled with a Chimera grid system was chosen for this purpose. The Chimera grid was used to avoid a grid with highly skewed cells. Turbulence was simulated by using the kappa-epsilon model with the wall function method. This decision was made after comparing the kappa-epsilon model's performance with that of lower order models, and after considering the increased computer time requirements and decreased stability of more complex models, such as the Reynolds stress model. The results of the study which are very encouraging and compare favorably with in vitro experimental data, are described in Part II of the paper.

Aortic Valve↗

A methodology for near-optimal computational superimposition of two-dimensional digital facial photographs and three-dimensional cranial surface meshes.

The authors present a methodology for human identification based on digital superimposition techniques. This methodology computes a fast, near optimal fit between a three-dimensional skull surface mesh and a two-dimensional digitized facial photograph. Since this is done digitally, (1) the photograph can be enhanced to reduce or eliminate motion blur, overexposure or underexposure, and out-of-focus distortions; (2) previous problems with skull/photograph scaling and alignment are minimized or eliminated; and (3) the photograph and skull can be numerically correlated. Two of several test cases produced from an implementation of this methodology are also presented.

Forensic Medicine↗

Historical and methodological aspects of computer-assisted medical history-taking.

The purpose is to draw, in a historical perspective, the main outlines of a theoretical and methodological approach of computer-assisted anamnesis (CAA). At the University of Liège (Belgium), studies on CAA were started in 1966, as an extension of previous works in the field of computer-assisted instruction (CAI). A short retrospect of the SIAM-DOCEO Project is given. Various factors contribute to reducing the place physicians effectively assign to history-taking, in spite of its essential role. Non-interactive self-administered questionnaires cope only very partially with that situation. For about 20 years, a number of CAA projects have been set up in many countries. Four basic questions dealing with the diffusion of CAA techniques are examined. (a) It is crucial not to put man-machine interaction and human dialogue on the same footing. A computer is quite unable to understand anything, but it can help health professionals in gathering medical history data. (b) As a rule, a CAA program should intervene in a limited and well defined pathological field, i.e. not too far from the diagnostic stage. (c) Acceptance by patients is very encouraging. (d) In contrast, reactions are mixed among physicians, essentially because of subjective factors. Accuracy and reliability, completeness and relevancy are, as a whole, undeniable qualities of CAA data, but the computer is--hopefully only for a short time--still often perceived more as a competitor than as a tool. The bibliography comprises 84 references.

Diagnosis, Computer-Assisted↗

Will the digital computer transform classical mathematics?

Mathematics and machines have influenced each other for millennia. The advent of the digital computer introduced a powerfully new element that promises to transform the relation between them. This paper outlines the thesis that the effect of the digital computer on mathematics, already widespread, is likely to be radical and far-reaching. To articulate this claim, an abstract model of doing mathematics is introduced based on a triad of actors of which one, the 'agent', corresponds to the function performed by the computer. The model is used to frame two sorts of transformation. The first is pragmatic and involves the alterations and progressive colonization of the content and methods of enquiry of various mathematical fields brought about by digital methods. The second is conceptual and concerns a fundamental antagonism between the infinity enshrined in classical mathematics and physics (continuity, real numbers, asymptotic definitions) and the inherently real and material limit of processes associated with digital computation. An example which lies in the intersection of classical mathematics and computer science, the P=NP problem, is analysed in the light of this latter issue.

Artificial Intelligence↗

Artificial chemistries--a review.

This article reviews the growing body of scientific work in artificial chemistry. First, common motivations and fundamental concepts are introduced. Second, current research activities are discussed along three application dimensions: modeling, information processing, and optimization. Finally, common phenomena among the different systems are summarized. It is argued here that artificial chemistries are "the right stuff" for the study of prebiotic and biochemical evolution, and they provide a productive framework for questions regarding the origin and evolution of organizations in general. Furthermore, artificial chemistries have a broad application range of practical problems, as shown in this review.

Chemistry↗

Usefulness of 3-dimensional computed tomography for caudate lobectomy by transhepatic anterior approach.

BACKGROUND/AIMS: Improvement of precision and safety of resection of caudate lobe by the transhepatic anterior approach using preoperative 3-dimensional computed tomography. METHODOLOGY: The 3D-computed tomography images of 32 patients who underwent hepatectomy for hepatocellular carcinoma and metastatic tumors were reviewed. The usefulness of 3D-computed tomography was assessed on the basis of its depiction of the portal branch distribution of the caudate lobe and of the position of the parenchymal division plane in the transhepatic anterior approach. RESULTS: 1) Number of portal vein branches in the caudate lobe: 1 to 5 (average, 2.75) portal vein branches were detected in the caudate lobe at the optimal angle (left-posterior 135 degrees) by 3D-computed tomography: P1l-sup in 84.3%, P1r-sup in 71.9%, P1r-inf in 71.9%, P1l-med in 15.6% and P1-trunk in 3.1%. 2). We classified the structure of the caudate lobe into four types, one type having two subtypes, based on the 3D-computed tomography findings of its portal branch distribution: Type 1: presence of 1rs, 1ri, 1ls; Type 2a: absence of 1ri; Type 2b: absence of 1rs; Type 3: absence of 1ls; Type 4: presence of 1t alone. Type 1 was observed in 16 of the 32 patients (50.0%), type 2a in 4 (12.5%), type 2b in 8 (25.0%), type 3 in 3 (9.4%) and type 4 in 1 (3.1%). 3) When the tributary of the right hepatic vein draining segment 5 (RV5) can be detected (type 1: 81.3%), the right surface of the middle hepatic vein should be exposed; whereas its left surface should be exposed when RV5 cannot be detected (types 2 and 3: 18.7%). CONCLUSIONS: Preoperative 3D-computed tomography images enable more accurate diagnosis of intrahepatic tumor location and facilitate detection of the portal veins of the caudate lobe, thus simplifying both caudate lobectomy and the selection of which side of the division plane and of the middle hepatic vein to divide the liver parenchyma in the transhepatic anterior approach, and allowing complete preservation of the circulation of the remnant liver.

Aged↗

Computer-automated structure evaluation of gastric antiulcer compounds: study of cytoprotective and antisecretory imidazo[1,2-a]pyridines and -pyrazines.

A quantitative structure-activity relationship study of a set of antiulcer compounds has been performed using the computer-automated structure evaluation methodology. Computer-automated structure evaluation identified cyanomethyl and hydroxymethyl functionalities, substituted in the 3-position of imidazo[1,2-a]pyridine and -Pyrazine, as descriptors relevant to antisecretory activity. The phenoxy group at the 8-position and the methyl group at the 2-position were shown to be sterically involved in the activity. A parabolic relationship was observed between the antisecretory activity and the logarithm of the partition coefficient of the compounds. Thus, hydrophobicity is found to be a necessary criterion for the inhibition of acid secretion. An attempt has been made to provide a rationale for designing a more potent antiulcer agent in this series of congeneric compounds.

Animals↗

A methodology for generating computer-based explanations of decision-theoretic advice.

Decision analysis is an appealing methodology with which to provide decision support to the practicing physician. However, its use in the clinical setting is impeded because computer-based explanations of decision-theoretic advice are difficult to generate without resorting to mathematical arguments. Nevertheless, human decision analysts generate useful and intuitive explanations based on decision trees. To facilitate the use of decision theory in a computer-based decision support system, the authors developed a computer program that uses symbolic reasoning techniques to generate nonquantitative explanations of the results of decision analyses. A combined approach has been implemented to explain the differences in expected utility among branches of a decision tree. First, the mathematical relationships inherent in the structure of the tree are used to find any asymmetries in tree structure or inequalities among analogous decision variables that are responsible for a difference in expected utility. Next, an explanation technique is selected and applied to the most significant variables, creating a symbolic expression that justifies the decision. Finally, the symbolic expression is converted to English-language text, thereby generating an explanation that justifies the desirability of the choice with the greater expected utility. The explanation does not refer to mathematical formulas, nor does it include probability or utility values. The results suggest that explanations produced by a combination of decision analysis and symbolic processing techniques may be more persuasive and acceptable to clinicians than those produced by either technique alone.

Artificial Intelligence↗

Computational issues in mapping variation affecting susceptibility to complex disorders: the chicken and the egg.

Linkage mapping strategies for complex disorders have evolved under a variety of constraints. Some of these constraints reflect the nature of complex disorders and are manifest in limitations on the kinds of data that can be collected, while others were (at least historically) strictly computational. This paper focuses on how computational issues have impacted the design of studies on complex disorders and, conversely, how our study designs have influenced the computational issues that have been addressed. We now have unprecedented computational resources, but also face unprecedented computational and methodological challenges as we move from the linkage mapping of genes influencing susceptibility to complex disorders toward the identification of the actual variation affecting susceptibility to these disorders. The near-term computational and methodological issues we must address will be profoundly influenced by the study designs of the recent past. But future study designs, as well as our investments in computational and methodological research, ought to be developed considering the computational and informatics resources we now have at hand.

Algorithms↗

From computing with numbers to computing with words. From manipulation of measurements to manipulation of perceptions.

Interest in issues relating to consciousness has grown markedly during the last several years. And yet, nobody can claim that consciousness is a well-understood concept that lends itself to precise analysis. It may be argued that, as a concept, consciousness is much too complex to fit into the conceptual structure of existing theories based on Aristotelian logic and probability theory. An approach suggested in this paper links consciousness to perceptions and perceptions to their descriptors in a natural language. In this way, those aspects of consciousness which relate to reasoning and concept formation are linked to what is referred to as the methodology of computing with words (CW). Computing, in its usual sense, is centered on manipulation of numbers and symbols. In contrast, computing with words, or CW for short, is a methodology in which the objects of computation are words and propositions drawn from a natural language (e.g., small, large, far, heavy, not very likely, the price of gas is low and declining, Berkeley is near San Francisco, it is very unlikely that there will be a significant increase in the price of oil in the near future, etc.). Computing with words is inspired by the remarkable human capability to perform a wide variety of physical and mental tasks without any measurements and any computations. Familiar examples of such tasks are parking a car, driving in heavy traffic, playing golf, riding a bicycle, understanding speech, and summarizing a story. Underlying this remarkable capability is the brain's crucial ability to manipulate perceptions--perceptions of distance, size, weight, color, speed, time, direction, force, number, truth, likelihood, and other characteristics of physical and mental objects. Manipulation of perceptions plays a key role in human recognition, decision and execution processes. As a methodology, computing with words provides a foundation for a computational theory of perceptions: a theory which may have an important bearing on how humans make--and machines might make--perception-based rational decisions in an environment of imprecision, uncertainty, and partial truth. A basic difference between perceptions and measurements is that, in general, measurements are crisp, whereas perceptions are fuzzy. One of the fundamental aims of science has been and continues to be that of progressing from perceptions to measurements. Pursuit of this aim has led to brilliant successes. We have sent men to the moon; we can build computers that are capable of performing billions of computations per second; we have constructed telescopes that can explore the far reaches of the universe; and we can date the age of rocks that are millions of years old. But alongside the brilliant successes stand conspicuous underachievements and outright failures. We cannot build robots that can move with the agility of animals or humans; we cannot automate driving in heavy traffic; we cannot translate from one language to another at the level of a human interpreter; we cannot create programs that can summarize non-trivial stories; our ability to model the behavior of economic systems leaves much to be desired; and we cannot build machines that can compete with children in the performance of a wide variety of physical and cognitive tasks. It may be argued that underlying the underachievements and failures is the unavailability of a methodology for reasoning and computing with perceptions rather than measurements. An outline of such a methodology--referred to as a computational theory of perceptions--is presented in this paper. The computational theory of perceptions (CTP) is based on the methodology of CW. In CTP, words play the role of labels of perceptions, and, more generally, perceptions are expressed as propositions in a natural language. CW-based techniques are employed to translate propositions expressed in a natural language into what is called the Generalized Constraint Language (GCL). In this language, the meaning of a proposition is expressed as a generalized constraint, X isr R, where X is the constrained variable, R is the constraining relation, and isr is a variable copula in which r is an indexing variable whose value defines the way in which R constrains X. Among the basic types of constraints are possibilistic, veristic, probabilistic, random set, Pawlak set, fuzzy graph, and usuality. The wide variety of constraints in GCL makes GCL a much more expressive language than the language of predicate logic. In CW, the initial and terminal data sets, IDS and TDS, are assumed to consist of propositions expressed in a natural language. These propositions are translated, respectively, into antecedent and consequent constraints. Consequent constraints are derived from antecedent constraints through the use of rules of constraint propagation. The principal constraint propagation rule is the generalized extension principle. (ABSTRACT TRUNCATED)

Consciousness↗

[Methodological bases for using computer technologies in the activities of the medical service of the Armed Forces].

Authors state methodological bases of construction of automated control system (ACS) of the medical service of the Armed Forces and the Navy. A basis of the methodological rules is made by the analysis of conformity of the purpose (preservation and strengthening of the servicemen' health and management composed process: the tax, processing, storage and distribution of data and preparation of the decision, i.e. the information-and-target approach. The automation of processes of profile activity of forces and means of the medical service provides the constant control by functioning of medical units and institutions. The main targets of the ACS' functioning are processing of the information about quality of rendering of the medical care to the servicemen, its timeliness and profitability, productivity of their labour, conformity of work results to the medical standards and others. The quality and the efficiency of ACS'application is defined by a level of information maintenance. ACS of the medical service should be subsystem of the automated control system of the troops.

Computer Systems↗

Mathematical analysis of transport and consumption of molecules in heterogeneous brain tissue (methodology).

A computer model of metabolite transport and consumption in heterogeneous brain tissue, using a combination of probabilistic and deterministic techniques is being developed. The metabolites are put into two separate classes: (I) those that have reached a membrane for the first time during a small time step, delta t, and (II) those that have not yet reached a cell membrane for the first time during that time step. The time dependent spatial distribution of class (I) molecules is determined using random walk theory, which takes into account the actual paths of the molecules. The variation of the spatial distribution of class (II) molecules with time is determined using the time dependent diffusion equation with a boundary condition of zero concentration on the enclosing membrane boundaries.

Biological Transport, Active↗

Horizontal plane morphometry of normal and scoliotic vertebrae. A methodological study.

Computed tomography (CT) scans are widely used for quantification of the morphology of the vertebral body and of the changes of the thoracic cage in the horizontal plane in scoliosis. So far, however, no method exists for precise quantification of the parameters of the posterior elements. We present a method for quantification on the basis of CT scans of different parameters of the morphology of both the vertebral body and posterior elements in the horizontal plane. The precision and accuracy of the method were estimated in a model study by CT scanning of a normal and a scoliotic vertebra in different, controlled, tilted positions. Moreover, in a clinical study CT scans of 19 thoracic vertebrae from non-scoliotic subjects and the apex vertebra from 40 scoliotic subjects were selected to test the applicability of the method to clinical studies. The intra- and interobserver variation of the measurements was analysed. The angle between the longitudinal axis of the vertebral body and that of the whole vertebra was used to evaluate the asymmetry of the vertebral body. The right to left pedicle width index, the right to left hemi-canal width index and the index of transverse process angles related to the axis of the vertebra were used to quantify the asymmetry of the posterior elements. The results indicate that, except for the pedicle width index, the variables under study were not significantly influenced by a 5 degrees or 10 degrees tilt ventrally, dorsally, or laterally of either the normal or the scoliotic vertebra. Hence, the method can be satisfactorily applied to longitudinal group comparisons.(ABSTRACT TRUNCATED AT 250 WORDS)

Anthropometry↗