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At least 127 records · Page 7Linked to original sources
PubMed1976

The effect of delta 9-tetrahydrocannabinol and LSD on the acquisition of an active avoidance response in the rat.

The course of active avoidance learning of rats in a symmetrical Y-maze under the influence of 1, 3, and 9 mg/kg of delta 9-THC i.p., and 5, 20, and mug/kg of LSD was investigated. Delta-THC in a dosage of 1 mg/kg had no effect on avoidance learning. Three to a lesser extent 9 mg/kg produced more rapid learning with a significantly better performance. Learning under delta 9-THC proved to be state-dependent. The withdrawal of delta 9-THC caused a decrease in the avoidance rate, which was dependent on the dosage. Upon renewal of the THC doses, the animals reattained their earlier preformance. In the course of the experiment there was rapid tolerance development, especially of the sedative properties of THC. LSD retarded the rate of acquisition of the active avoidance response. Whereas the control animals displayed over 80% successful active avoidance from the 14th session onwards, this was achieved by the LSD groups only after the 20th session. However, in contrast to the control group the LSD animals were able to increase their avoidance rate to over 90%, and this was maintained to the end of the experiment (a total of 24 sessions with LSD). The sudden withdrawal of LSD produced a fall in avoidance rate, which was dependent on the pervious training dosage; as with delta 9-THC state-dependent learning can also be assumed for LSD.

Animals↗
PubMedDate not supplied

Extending the Rescorla-Wagner theory to account for transswitching.

This article is a brief response to commentaries made by Bond and Siddle (1988) and Lovibond (1988) to our article (Kimmel & Lachnit, 1988) outlining some of the difficulties encountered by the Rescorla-Wagner theory in predicting the outcome of transswitching experiments. We show that Bond and Siddle's assertion that increasing the value of beta would "bring the model into line with the empirical data" (p. 186) is incorrect. Increasing beta in simulated transswitching experiments causes the theory to predict a more rapid increase in associative values, to higher levels, but does not change the degree of predicted phasic switching. We agree with Lovibond's observation that the Rescorla-Wagner theory can predict phasic switching more effectively if it is assumed that an unobserved additional stimulus is present whenever the phasic stimulus occurs in positive tonic segments and a different unobserved additional stimulus is present whenever the phasic stimulus occurs in negative tonic segments. But this kind of usage of the "unique cue hypothesis" does little more then immunize a theory against problematic empirical findings. When the salience of the unique cue is increased relative to that of the stimuli that are actually physically present, simulated transswitching experiments show greater and greater phasic switching. But, unless there is a good a priori reason to postulate such unique cues, or unless the unique cue hypothesis leads to empirically testable new hypotheses, it does not provide a scientifically useful solution to the theory's problem with transswitching.

Association Learning↗
PubMed1994

The enigma of olfactory learning revisited.

If, as indicated in olfactory conditioning studies, rats are able to demonstrate primate-like behavior by their acquisition of response strategies, rodent olfactory learning may provide a particularly useful model for neurobiological analyses of learning and memory. Reid and Morris [Proc. R. Soc. Lond., Ser. B 247, 137-143 (1992); Trends Neurosci. 16, 17-20 (1993)] have recently challenged these views. They suggested that the evidence for acquisition of an olfactory learning set in rodents is insufficient and that rat olfactory learning may provide no special advantage for the neurobiologist. This essay reviews the relevant studies and concludes that there are serious shortcomings in the Reid and Morris argument, that the available data base provides clear evidence for the claim that rats acquire abstract rules for responding and that olfactory learning may be qualitatively different from other forms of instrumental learning in rodents.

Animals↗
PubMed2005

Hippocampal theta activity related to elicitation and inhibition of approach locomotion.

This study determined if the hippocampal theta rhythm showed phase relationships or changes in amplitude and frequency with the onset of stimuli and locomotion in a task in which auditory cues initiated and suppressed approach locomotion. Rats with electrodes in the dorsal hippocampus lapped at a milk dipper and were presented a tone which predicted the delivery of a food pellet. In some trials the pellet cue tone was negated by 60-Hz clicks beginning 0.3 s after onset, and no pellet was delivered. A video capture system (20-ms sampling) synchronized to the hippocampal recording system (10-ms sampling) was used to determine the onset of locomotor approach to the pellet area. The findings failed to support proposals that phase-related mechanisms play a role in encoding and retrieval of movement-related information. Neither the pellet cue nor the negating cue reset the theta rhythm, and they did not produce differential evoked potentials. During milk lapping, theta amplitude increased in the 1/2s prior to all pellet cues regardless of their locomotor effect. Frequency also rose but only when a non-negated pellet elicited short-latency locomotion. During locomotor execution, theta peak amplitude peaked earlier than theta frequency by approximately one period. In general during performance of this task, increasing theta amplitude reflected a general preparation to process the cue and increasing theta frequency reflected the readiness to respond to the cue with locomotion.

Acoustic Stimulation↗
PubMed2005

A rodent model of sleep disturbances in posttraumatic stress disorder: the role of context after fear conditioning.

BACKGROUND: A prominent sleep disturbance, likely including a disruption of rapid eye movement sleep (REMS) continuity, characterizes posttraumatic stress disorder (PTSD). We set out to develop a fear conditioning paradigm in rats that displays alterations in sleep architecture analogous to those in PTSD. METHODS: Baseline polysomnographic recordings of rats were performed in a neutral context to which the rats had been habituated for several days. Rats were then shock- or mock-trained in a distinctly different context, and their sleep was studied the following day in that context. A separate group of rats was shock-trained and studied in the neutral context on the following 2 days. RESULTS: Rats that slept in the neutral context exhibited a REMS-selective increase in sleep 24 hours after training and increases in REMS and non-REMS 48 hours after training. In contrast, rats that slept in the presence of situational reminders of the training context exhibited a REMS-selective decrease in sleep 24 hours later. Animals that were mock-trained showed no changes in sleep. CONCLUSIONS: Shock training induced days-long changes in sleep architecture that were disrupted when the animal was exposed to situational reminders of the training context.

Analysis of Variance↗
PubMed2004

The challenges of understanding mammalian cognition and memory-based behaviours: an interactive learning and memory systems approach.

Various research problems are presented to illustrate the utility of using the interactive multiple learning and memory systems view to better understand normal and abnormal manifestations of mammalian behaviour. Evidence for incidental learning and memory processes is presented and various implications of this work are discussed. Empirical and theoretical work directed at understanding the cognitive and non-cognitive processes associated with place learning in the water task and context conditioning during aversive events is also presented.

Amnesia, Retrograde↗
PubMed2005

MEG responses correlated with the visual perception of velocity change.

Magnetoencephalography (MEG) was used to find neural activities, in the human brain, involved in perception of velocity changes in visual motion. We recorded MEG responses evoked by the stimuli whose velocity increased by 40% or 80% of baseline velocities of 1.0, 2.0, 3.0, and 4.0 deg/s. The velocity increment threshold and the manual reaction time (RT) were also measured under similar stimulus conditions. To manipulate observer's sensitivity to velocity increments, the MEG responses and the psychophysical performances were measured after adaptation to motion in one direction (adapted condition) or alternating directions (control condition). MEG responses evoked by velocity increments peaked at 200-290 ms (M1), and the M1 amplitudes, especially those obtained for 40% increments, were correlated with the sensitivities, which are the reciprocal of velocity increment thresholds. Furthermore, motion adaptation enhanced sensitivity to velocity increments and increased the M1 amplitudes. These results suggest a close correlation between the perceptual velocity increment and the evoked MEG response. In other words, the results suggest that velocity increments are detectable when there is a constant increment in magnetic neural response. As for latencies, nearly constant value of M1 latency did not quantitatively match a large decrease in manual RT with the increase in the baseline velocity. Motion adaptation reduced neither the peak MEG latency nor the manual RT.

Adaptation, Psychological↗
PubMed2006

Motivational control of blocking.

Hungry and thirsty rats lever pressed for food pellets in 1 visual stimulus (V1) and for a saline solution in another stimulus (V2). In a 2nd phase, the rats were made either hungry or thirsty and pressed for a starch solution in 2 stimulus compounds, each containing 1 of the visual cues and an auditory cue, that is, V1A1 and V2A2. On test, rats responded less to A1 than to A2 when hungry but less to A2 than to A1 when thirsty. Two further experiments replicated this selective blocking effect when the rats were both hungry and thirsty during Phase 2 and demonstrated that the magnitude of blocking was comparable to that observed when the reinforcer identity was held constant across the 2 phases.

Animals↗
PubMed2004

Neural bases of talker normalization.

To recognize phonemes across variation in talkers, listeners can use information about vocal characteristics, a process referred to as "talker normalization." The present study investigates the cortical mechanisms underlying talker normalization using fMRI. Listeners recognized target words presented in either a spoken list produced by a single talker or a mix of different talkers. It was found that both conditions activate an extensive cortical network. However, recognizing words in the mixed-talker condition, relative to the blocked-talker condition, activated middle/superior temporal and superior parietal regions to a greater degree. This temporal-parietal network is possibly associated with selectively attending and processing spectral and spatial acoustic cues required in recognizing speech in a mixed-talker condition.

Acoustic Stimulation↗