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PubMed2004

Changes in functional capacity in older adults living alone: a three-year longitudinal study in a rural area of Japan.

OBJECTIVE: The purposes of this research were to clarify three-year changes in functional capacity and to investigate related physical health, psychological/mental health, and social health factors in older adults living alone in a rural area of Japan. METHODS: Home visit interviews were conducted in 2000 (the baseline survey: n = 128) and in 2003 (the follow-up survey: n = 101) with older adults living alone in a town in Ishikawa prefecture. Seventy nine subjects were analyzed using logistic regression analysis at the follow-up survey. RESULTS: Of these 79 subjects, 40 persons had scores for functional capacity decreased by one or more points, the "Lowered" group (50.6%), while 27 persons were "Unchanged" (34.2%), and 12 persons were "Improved" (15.2%). Factors at the baseline survey were compared between the "Lowered" group and the "Unchanged/Improved" group. Significant factors that caused a decreased functional capacity were age (75 years old and over), no participation in social activities, and contact with friends/neighbors over the phone less than once a week. CONCLUSION: This research has shown that participation in social activities and contact with friends/neighbors maintain a higher functional capacity in older adults living alone.

Activities of Daily Living↗

PubMed1992

[Functional capacity of patients over 65 according to the Katz index. Reliability of the method].

OBJECTIVE: To find functional capacity of elderly patients by using the Katz Index, which measures the "Basic Activities of Daily Life". To examine how reliable the Katz Index is in the Primary Care field. DESIGN: Descriptive crossover study. Assessment of the measuring instrument's internal consistency and reliability, using a test-retest method. SITE. Otero Health Area, in Oviedo. PATIENTS OR OTHERS PARTICIPANTS: This was a random sample, ordered by age and gender, of people over 65 who used the Otero Health centre. MAIN MEASUREMENTS AND RESULTS: The elderly population made up 12.86% of our base Health Area. The Katz Index showed that 81.6% of the elderly in the sample were independent in all their functions. A significant age difference was found. Internal consistency was measured by Cronbach's Alpha and was 0.8612 for nurses and 0.8362 for doctors. The correlation coefficient within Sperman's estimated observer was r = 0.936074. Kappa was 0.8436 (p < 0.0000) for the different observers, i.e. nurses or doctors. CONCLUSIONS: Most of the elderly patients in our base Health area possess full functional capacity, at the level of the routine activities of their daily life. The Katz Index is a reliable method of evaluating elderly peoples' functional capacity, at the Primary Care level. It can be used by any professional in the health team.

Activities of Daily Living↗

PubMed2005

Factors influencing results of functional capacity evaluations in workers' compensation claimants with low back pain.

BACKGROUND AND PURPOSE: Physical and psychosocial factors are hypothesized to influence performance-based assessment. The purpose of this study was to evaluate the association between performance on the Isernhagen Work System Functional Capacity Evaluation (IWS-FCE) and various clinical and psychosocial factors. SUBJECTS: The sample consisted of 170 workers' compensation claimants who were undergoing functional capacity evaluations (FCEs) for low back injuries. METHODS: In this cross-sectional study, claimants completed a battery of work-related measures, including the IWS-FCE, the Pain Disability Index (PDI), a workplace organizational policies and practices scale, and a recovery expectations questionnaire. Functional capacity evaluation performance indicators were the number of tasks in which subjects did not meet work demands and weight lifted on the floor-to-waist lift. Analysis included multivariable regression. RESULTS: Only the PDI, pain intensity, age, and sex independently contributed to floor-to-waist lift performance. The PDI, pain intensity, and duration of injury contributed to the number of failed tasks. DISCUSSION AND CONCLUSION: The results indicate that performance on FCEs is influenced by physical factors, perceptions of disability, and pain intensity. However, perceptions of workplace organizational policies and procedures were not associated with FCE results for workers' compensation claimants with chronic back pain disability. Functional capacity evaluations should be considered behavioral tests influenced by multiple factors, including physical ability, beliefs, and perceptions.

Adult↗

PubMed1989

A brief self-administered questionnaire to determine functional capacity (the Duke Activity Status Index).

To develop a brief, self-administered questionnaire that accurately measures functional capacity and assesses aspects of quality of life, 50 subjects undergoing exercise testing with measurement of peak oxygen uptake were studied. All subjects were questioned about their ability to perform a variety of common activities by an interviewer blinded to exercise test findings. A 12-item scale (the Duke Activity Status Index) was then developed that correlated well with peak oxygen uptake (Spearman correlation coefficient 0.80). To test this new index, an independent group of 50 subjects completed a self-administered questionnaire to determine functional capacity and underwent exercise testing with measurement of peak oxygen uptake. The Duke Activity Status Index correlated significantly (p less than 0.0001) with peak oxygen uptake (Spearman correlation coefficient 0.58) in this independent sample. The Duke Activity Status Index is a valid measure of functional capacity that can be obtained by self-administered questionnaire.

Activities of Daily Living↗

PubMed2004

The prognostic value of functional capacity evaluation in patients with chronic low back pain: part 1: timely return to work.

STUDY DESIGN: Historical cohort study. OBJECTIVES: We examined the validity of the Isernhagen Work Systems' Evaluation in predicting timely return to work. SUMMARY OF BACKGROUND DATA: Functional Capacity Evaluations are used commonly to determine readiness for return to work, yet little is known of their validity. METHODS: Workers' compensation claimants undergoing Functional Capacity Evaluations following work-related low back injury were studied. Two cohorts were formed, one on which exploratory analyses were conducted and a second for confirmation. Evaluation indicators were the number of tasks in the protocol rated as failed and performance during the floor-to-waist lift task. The primary outcome investigated was time receiving total temporary disability benefits (as a surrogate of return to work) and a secondary outcome was time until claim closure in the year following Evaluation. Cox proportional-hazards regression was used to determine the prognostic effect of Evaluation crudely and after controlling for potential confounders. RESULTS: Few patients (4%) were found to pass all Evaluation tasks, yet most experienced total temporary disability suspension and claim closure within 1 year following Functional Capacity Evaluations. Better Evaluation performance was related to faster time to suspension of total temporary disability benefits and claim closure after controlling confounding factors, but explained little of the variation in these outcomes (approximately 10%). Performance on the floor-to-waist lift was as predictive as the number of failed tasks in the entire Functional Capacity Evaluations protocol. CONCLUSIONS: Better performance on Evaluation was weakly associated with faster recovery; however, the amount of variation explained was small. One task in the Evaluation was as predictive as the entire protocol.

Adult↗

PubMedDate not supplied

[Perceived health and functional capacity of a non-institutionalized elderly population in Barcelona].

In order to explore the perceived health and functional capacity in the elderly, a cross-sectional study was undertaken in a representative sample of the non-institutionalized population aged 65 and over, resident in Barcelona (N = 1,288), and included in the 2nd Health Interview Survey. Sociodemographic information was collected, as well as perceived morbidity, sensorial problems and functional capacity (measured by the activities of daily living [ADL]). Some 60.3% of the elderly reported having "good" or "very good" health, and 56% reported being able to do all ADL without difficulties. Women in general reported a worse perceived health and a higher chronic limitation in each age group (p = 0.001). Age was not significantly associated with perceived health, but was...associated with disability (ADL) (p = 0.001). Variables with a stronger association with "poor", "bad" o "very bad" perceived health were: comorbidity (OR = 3.69 IC 95% = 2.60-5.25), restricted activity (OR = 3.25 IC 95% = 1.86-5.66) and incapacity in any of the basic ADL (OR = 2.15 IC 95% = 1.38-3.36). The elderly who were dependent in any of the basic ADL were more frequently female, 75 or more years old, and in 10.5% of the cases did not receive any personal help. The present study gives a general description of the health status and functional capacity of the elderly and identifies a group of old people with unmet basic care needs.

Activities of Daily Living↗

PubMed1990

Predictors of high functional capacity and mortality in elderly Finnish men.

Factors predicting high functional capacity in old age and 25-year mortality were studied in 1711 men aged 40 to 59 years. The study population was that of the East-West Study, i.e. the Finnish part of the Seven Countries Study. After the 25-year follow-up (in 1984) 766 men were still alive. Nonsmoking and good pulmonary function in earlier middle-age and the absence of coronary heart disease, cerebrovascular disease or emphysema in later middle-age predicted high functional capacity in old age. High systolic blood pressure, low forced vital capacity, smoking, and the presence of coronary heart disease predicted mortality in the next 10 to 25 years. Although mortality rates were higher in eastern Finland, the predictors were similar in both the eastern and the southwestern parts of the country.

Aged↗

PubMed2005

Elderly patients on haemodialysis have 50% less functional capacity than gender- and age-matched healthy subjects.

OBJECTIVE: Patients on haemodialysis (HD) are by necessity inactive for 3-6 h three times a week. The aim of this prospective controlled study was to investigate the level of functional capacity of elderly HD patients using simple measures. MATERIAL AND METHODS: A total of 11 consecutive HD patients aged > 60 years (median age 75 years) were included in the study. They were compared with 22 gender- and age-matched healthy subjects using a prospective 1:2 case:healthy subject study design. As tests of functional capacity and maximal exercise capacity we used a "sit-to-stand" test (number of cycles within 10 s) and a staircase test (the number of cycles completed per second was used as the effect variable), respectively. RESULTS: The patients managed significantly fewer cycles than the healthy subjects in the staircase test (median 2 vs 10; p<0.003) and performed approximately 50% fewer cycles in the sit-to-stand test (p<0.014). The work performed in a given time in the staircase test was 54% less for the patients (p<0.017). CONCLUSIONS: The HD patients in the study had a considerably lower functional capacity than the healthy subjects, which may have interfered with their daily living activities. The tests used are easy to apply and need no specialized equipment. The importance of investigating functional capacity and instituting rehabilitation programmes is emphasized.

Activities of Daily Living↗

PubMed2003

[Factors related to discrepancy in evaluation on functional capacity between reports by community-dwelling older people with cognitive decline and their family members].

Overestimation or underestimation of functional capacity in community-dwelling older people with cognitive impairment was evaluated between the responses of subjects and family members (proxies) by cognitive function level. Out of all the residents aged 65 years and over living in Yoita town, Niigata Prefecture in 2000 (n = 1,673), 1,544 voluntarily participated in the interview survey held at community halls or at home (92.3% response). They underwent the Mini-Mental State Examination (MMSE) for assessment of cognitive function and answered questionnaires comprising socio-demographic, psychological, physical and medical, and social activity items (2000/11). According to the age of the subject and MMSE score, we defined cognitive decline (MMSE scores < 1 SD below age-specific means, n = 371). 158 pairs among 371 subjects with cognitive decline and their proxies participated in a follow-up survey (2001/11). The subjects themselves underwent MMSE again. 136 subject-proxy pairs reported any complaints of memory-related problem and evaluated higher-level functional capacity (TMIG-IC, Tokyo Metropolitan Institute of Gerontology Index of Competence). We established criteria at follow-up survey as follows: control (n = 29), MMSE scores > 1 SD below age-specific means and CDR (Clinical Dementia Rating) = 0: mild cognitive decline (MCD) (n = 54), 21 < or = MMSE scores < 1 SD below age-specific means or CDR = 0.5); and severe cognitive decline (SCD) (n = 53), MMSE scores 20 < or = CDR > 0.5. SCD subjects significantly overestimated total and Instrumental Self-Maintenance scores in TMIG-IC more than control or SCD subjects. Multiple logistic regression analyses indicated that complaints of memory by the proxy, response by spouse, and higher levels of education were extracted as significantly independent variables affecting overestimation for functional capacity. On the other hand, aging affected underestimation.

Activities of Daily Living↗

PubMed2006

Correlations of functional capacity and neuropsychological performance in older patients with schizophrenia: evidence for specificity of relationships?

BACKGROUND: Neuropsychological (NP) performance is a consistent correlate of everyday functioning in schizophrenia, but it is unclear whether relationships between individual NP ability areas and domains of everyday functioning are general or specific. Assessments of real-world everyday functioning may be influenced by environmental and social factors (e.g., social security, disability status, opportunities and restrictions in living situations). This study examined the specificity of the relationships between different NP abilities and performance-based measures of social and living skills. METHODS: 181 ambulatory older (age>50) patients with schizophrenia were examined with NP tests measuring episodic and working memory, executive functioning, verbal fluency, and processing speed. All subjects performed tasks examining social (Social Skills Performance Assessment: SSPA) and everyday living (UCSD Performance Based Skills Assessment: UPSA) skills. RESULTS: Using canonical analysis, the NP variables were used to predict the functional capacity measures. The analysis found that 37% of the variance in the functional capacity and NP measures was shared, X(2) (54)=106.29, p<.001. Two canonical roots described the cognitive variables and the roots were differentially associated with everyday living and social skills. The root loading on processing speed, episodic memory, and executive functions were associated with UPSA scores, while the root loading on working and episodic memory and verbal fluency were associated most strongly with social competence. IMPLICATIONS: Social and everyday living skills deficits in patients with schizophrenia may reflect generally independent domains of functional outcome, linked through cognitive performance. The data suggest that somewhat different cognitive processes are associated with these two domains of functional capacity, although there appears to be some overlap, which may be due to the nature of the NP tests employed.

Activities of Daily Living↗

PubMed1981

Compensation mechanisms for experimental reduction of the functional capacity in the guinea pig placenta. I. Changes in the maternal and fetal placenta vascularization.

After experimental reduction of its functional capacity, the placenta of the guinea pig has been studied microscopically for changes in the maternal and fetal vascularization pattern which could be interpreted as a compensation for this reduction. The functional capacity has been reduced in four ways. In the experimental groups the volume compared with untreated controls. The volume density of fetal capillaries in the labyrinthine part of the placenta was increased significantly compared with untreated controls. The surface density of these vessels, however, remained the same as in the control placentas. The volume density and surface density of the maternal lacunae did not change significantly. The conclusion is that after experimental reduction of its functional capacity the only structural modification in the guinea pig placenta involving the maternal and fetal vascularization, which can be interpreted as a compensation mechanism, is a widening of the fetal capillaries in the labyrinth.

Animals↗

PubMed1994

Sustained improvement in functional capacity after removal of body fluid with isolated ultrafiltration in chronic cardiac insufficiency: failure of furosemide to provide the same result.

OBJECTIVES: This study was designed to investigate whether a subclinical accumulation of fluid in the lung interstitium associated with moderate congestive heart failure interferes with the patient's functional capacity, and whether furosemide treatment can promote reabsorption of the excessive fluid. BACKGROUND: In patients with moderate congestive heart failure, pulmonary overhydration may be detected by chest roentgenography even if therapy is optimized to keep the urinary output normal and to prevent weight gain and dependent edema formation. Removal of the overhydration may help define its significance. METHODS: Patients, whose regimens of digoxin, oral furosemide, and angiotensin-converting enzyme (ACE) inhibitor therapy were kept constant, were randomly allocated to receive ultrafiltration (8 cases) or an intravenous bolus of supplemental furosemide (mean dose: 248 mg; 8 cases). The amount of body fluid removed with each method approximated 1600 mL. Functional performance was assessed with cardiopulmonary exercise tests. RESULTS: Soon after fluid withdrawal by either method, the filling pressures of the two ventricles and body weight were reduced and plasma renin activity, norepinephrine, and aldosterone were augmented. After furosemide administration, hormone levels remained elevated for the next 4 days, and during this period, patients had positive water metabolism, recovery of the elevated ventricular filling pressures, and re-occurrence of lung congestion with no improvement in functional capacity. After ultrafiltration, levels of renin, norepinephrine, and aldosterone fell to below control values within the first 48 hours and water metabolism was equilibrated at a new set point (less fluid intake and diuresis without weight gain). The favorable circulatory and ventilatory adjustments consequent to the reabsorption of lung water improved the functional capacity of these patients. That may also have restored the lung's ability to clear norepinephrine, thus restraining its facilitation of renin release. The improvement continued 3 months after the procedure. CONCLUSIONS: In patients with congestive heart failure the set point of fluid balance is altered in spite of oral furosemide therapy; supplemental intravenous furosemide does not shift the set point, at least not when combined with ACE inhibition. Excessive, although asymptomatic, lung water limits the functional capacity of the patient.

Aged↗

PubMed1998

Intracellular magnesium predicts functional capacity in patients with coronary artery disease.

To determine whether increased intracellular levels of magnesium ([Mg]i) are associated with enhanced functional capacity, we performed symptom-limited exercise treadmill testing on 42 stable coronary artery disease (CAD) patients (37 men, 5 women, mean age 68 +/- 9 years). [Mg]i was found to be an independent and significant predictor of exercise duration (R = 0.31, p = 0.02) in a multivariate stepwise regression model. Patients with > normal [Mg]i of 1.23 microg/mg protein (n = 13) had a significantly greater mean functional capacity, measured in higher achieved metabolic equivalents (10.6 +/- 2.5 vs. 8.9 +/- 2.3, p < 0.05) and exercise duration (9.4 +/- 2.3 vs. 7.9 +/- 2.2 min, p < 0.05) compared to patients with [Mg]i </= the normal (n = 29). Thus, functional capacity is greater in stable CAD patients with higher [Mg]i, suggesting that magnesium may play a role in CAD pathophysiology, possibly via ventricular unloading.

Adult↗

PubMed2005

[Functional capacity in patients after myocardial infarction dependent on treatment strategy in acute phase of disease].

BACKGROUND AND AIM: Recently published studies suggest that percutaneous coronary inetrvention (PCI) is superior to fibrinolysis in terms of early and late mortality in patients with acute myocardial infarction (MI) with ST-elevation. The aim of this study was to evaluate the influence of treatment strategy in the acute phase of MI on postinfarction functional capacity. PATIENTS AND METHODS: This prospective study included 128 consecutive patients with MI, with ST-elevation over 12 weeks from the disease onset. There were 92 (72%) male and 36 (28%) female patients, mean age 59 +/- 10 years. Inclusion criteria were age under 70, first MI with ST-elevation, and sinus rhythm. Exclusion criteria were previous MI, non ST-elevation MI, acute heart failure, atrial fibrillation, unstable angina pectoris, re-IM or necessity for coronarography and PCI during rehabilitation, and other acute disease. Patients were divided into three groups according to treatment modality: group 1, 38 (30%) patients treated with primary PCI; group 2, 46 (36%) patients treated with fibrinolysis; and group 3, 44 (34%) conservatively treated patients. There were no significant between-group differences according to age, sex, risk factors for coronary artery disease, infarct site, and frequency of complications in the acute phase of MI. The functional capacity of patients was evaluated by symptom-limited exercise test. Echocardiographic examinations were also done in each patient. Statistical analysis was performed by using the commercial software package, Microsoft SPSS for Windows, Version 8.0. Results were expressed as a mean standard deviation. Differences between the groups were tested by analysis of variance (ANOVA) and post hoc Tuckey test. The value of p < 0.05 was considered statistically significant. RESULTS: At the end of rehabilitation, the mean values of exercise capacity in groups 1, 2 and 3 were 6.1 +/- 1.3, 5.5 +/- 1.2, and 4.8 +/- 1.3 METs, respectively (group 1 vs. 2, p = 0.03; group 1 vs. 3, p < 0.001; group 2 vs. 3, p = 0.01). The mean values of ejection fraction in groups 1, 2 and 3 were 56 +/- 10, 53 +/- 9 and 47 +/- 11, respectively (group 1 vs. 2, p = 0.03; group 1 vs. 3, p < 0.001: group 2 vs. 3, p = 0.009). Four (3%) patients were excluded from the study because of complications during rehabilitation treatment. CONCLUSION: Postinfarction functional capacity in patients with MI depends on treatment strategy in the acute phase of disease. Patients who underwent PCI in the acute phase of MI had a higher functional capacity and better preserved systolic function of the left ventricle in comparison with patients who received fibrinolysis or those who were treated conservatively.

Angioplasty, Balloon, Coronary↗

PubMed1990

Functional capacity and living arrangements of unmarried elderly persons.

This analysis employed the 1986 Longitudinal Study of Aging (LSOA) to examine the impact of functional capacity, gender, race and ethnicity, and various socioeconomic characteristics on changes in living arrangements among unmarried elderly persons over a two-year period. The results reveal that a decline in functional capacity greatly increases the likelihood that an elderly person will move in with others or become institutionalized. Nonetheless, even when they experience significant declines in health, most single elderly persons who were living alone at the initial interview continued to live alone two years later. Multivariate analyses show that women who suffer declines in functional capacity are somewhat less likely than men who experience declines to live alone at Time two. In contrast, Blacks who suffer declines are more likely than Whites who experience declines to continue living alone at follow-up.

Activities of Daily Living↗

PubMed1992

Opinions of patients with rheumatoid arthritis about their own functional capacity: how valid is it?

Self assessment health status questionnaires are increasingly used to measure health status or the effect of treatment in patients with rheumatoid arthritis (RA). Most of these questionnaires measure functional (physical) disabilities. The question arises, however, as to how well self assessment questionnaires reflect the true functional status of patients or whether they only reflect their imaginary functional capacities. How valid is the opinion of patients with RA about their own functional capacity? To answer this question an investigation was performed in 80 patients with RA. Forty Dutch and 40 Belgian patients with RA completed the functional items of the DUTCH-AIMS, the Dutch version of the Arthritis Impact Measurement Scales (AIMS), a self assessment questionnaire specific to arthritis. Their scores on the functional scales were compared with the scores on the same scales completed by two experienced physiotherapists after evaluation of the functional ability of these patients. This was achieved by observing the patients perform the tasks given in the questionnaire. Correlation coefficients between the scores of the patients and the physiotherapists were highly significant for all the scales. No significant differences were found between the patients' and physiotherapists' mean scale scores except for the mobility scale in the Dutch patients. The strength of agreement (Cohen's kappa) of most scale scores of the patients and physiotherapists was substantial. The estimates of the overall functional capacity (the mean of the five scale scores) of the Belgian and Dutch patients show high correlations between the patients and the physiotherapists. It is concluded that patients' opinion about their functional ability is valid in that it is in agreement with their real functional abilities. This study provides further evidence for the validity of the DUTCH-AIMS as a measure of functional disability and health status in Dutch and Belgian patients with RA.

Activities of Daily Living↗

PubMed2005

Obesity is an independent contributor to functional capacity and inflammation in systemic lupus erythematosus.

OBJECTIVE: Obesity induces a proinflammatory state and is a major cause of morbidity in the general population. However, little is known about the effects of obesity in patients with chronic inflammatory illnesses such as systemic lupus erythematosus (SLE). METHODS: One hundred consecutive patients with SLE were studied to determine the relationship between body mass index (BMI) and functional capacity, measures of fatigue, quality of life, and the inflammation markers C-reactive protein (CRP), the erythrocyte sedimentation rate, and interleukin-6 (IL-6). The association between BMI and patient characteristics was determined, and multiple logistic regression models were used to adjust for age, sex, disease activity, and disease-related damage. RESULTS: Thirty-three patients had a normal BMI (< 25 kg/m(2)), 28 were overweight (25-29.9 kg/m(2)), and 39 were obese (> or =30 kg/m(2)). Obese patients had worse functional capacity, more fatigue, and higher concentrations of inflammation markers. The mean +/- SD modified Health Assessment Questionnaire (M-HAQ) score was 0.6 +/- 0.4 in obese patients compared with 0.3 +/- 0.4 and 0.2 +/- 0.3 in overweight patients and those with a normal BMI, respectively (P = 0.001). The mean +/- SD concentrations of CRP in obese patients (10.0 +/- 8.6 mg/liter) were higher than those in patients who were overweight (4.7 +/- 5.4 mg/liter) or had a normal BMI (6.2 +/- 9.9 mg/liter) (P < 0.001). Similarly, concentrations of IL-6 were higher in obese patients (P = 0.003). After adjusting for age, sex, disease activity, and damage indices, the associations between BMI and CRP (P < 0.001), M-HAQ scores (P = 0.005), and IL-6 concentrations (P = 0.01) remained significant. CONCLUSION: Obesity is independently associated with impaired functional capacity and inflammation markers in patients with lupus. Thus, weight loss may improve functional capacity and decrease cardiovascular risk factors.

Activities of Daily Living↗

PubMed1999

Functional capacity of the cirrhotic liver after partial hepatectomy in the rat.

BACKGROUND: Posthepatectomy liver insufficiency is one of the most serious problems associated with a major hepatic resection, especially in the cirrhotic liver, which has less functional reserve than the normal liver. Evaluation of morphologic liver regeneration is important in cirrhotic rats, as well as in the normal liver, and assessment of functional capacity in cirrhosis is clinically important for preventing hepatic insufficiency of the remnant liver after hepatectomy. METHODS: We evaluated the functional capacity of the cirrhotic liver induced by carbon tetrachloride in rats and studied the correlation between morphologic and functional restoration of the liver after partial hepatectomy in comparison with healthy rats. Morphologic restoration of the liver after hepatectomy was evaluated on the basis of remnant liver weight, proliferating cell nuclear antigen labeling index, and the DNA content of the regenerating liver. Functional restoration was evaluated by the indocyanine green disappearance rate and serum aminopyrine clearance. RESULTS: Morphologic restoration in cirrhotic rats was delayed in comparison with healthy rats. Although functional capacity in the cirrhotic rats was diminished, functional restoration was advanced after a two-thirds hepatectomy, in comparison with morphologic restoration. CONCLUSIONS: Functional restoration in cirrhotic rats after partial hepatectomy is advanced in comparison with morphologic restoration.

Animals↗