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At least 127 records · Page 7Linked to original sources
PubMed1978

Lymphosarcoma with lymphoblastic leukemia in a New Zealand white rabbit.

An 8 to 10-week-old female New Zealand white rabbit, Oryctolagus cuniculus, which exhibited clinical signs of anorexia, depression, and torticollis was found to have lymphosarcoma with lymphoblastic leukemia. The multiple visceral involvement with neoplastic lymphoid cells observed in this animal was similar to previously reprted cases of lymphosarcoma in the rabbit. An unusual finding was the occurrence of lymphoblastic leukemia since lymphosarcoma in the rabbit has previously been reported as aleukemic.

Animals↗
PubMed1978

Selection and biologic properties of malignant variants of a murine lymphosarcoma.

A syngeneic tumor model system with the RAW117 lymphosarcoma cell line was developed for use in investigations of host and tumor cell properties associated with an enhanced state of malignancy. This BALB/c mouse model was found to be similar to human lymphosarcoma in that liver and spleen were the major organs involved. Sequential in vivo selections were performed by iv tumor cell inoculation, removal of resulting solid liver tumor nodules for growth in vitro, and reinjection of the cultured cells iv. After ten such sequential selections for implantation, invasion, survival, and growth in liver, a lymphosarcoma cell line was obtained (RAW 117-H10) that formed approximately 200-fold more gross liver tumor nodules than did the parental tumor cell line in comparative biologic assays and displayed enhanced malignant properties when monitored by time of host death. Very few lung nodules or tumors were present at other sites with either the parental or any of the selected RAW117 lines, which confirms previous reports in which in vivo sequential selection yielded stable cell lines with preferential tumor colonization at specific sites.

Animals↗
PubMed1985

Antigenic heterogeneity of metastasizing and nonmetastasizing forms of hamster lymphosarcoma: comparison of primary tumor and spontaneous liver metastases.

Antisera were raised in rabbits against nonmetastasizing (NML) and metastasizing (ML) forms of hamster lymphosarcoma and were purified against normal hamster tissues. Immunoglobulins from the purified antisera were precipitated with 1.6 M ammonium sulfate, radioiodinated and IgG separated by Sephadex G-200 gel filtration. 125I-IgG preparations were analyzed by a direct cell binding assay and by a complement-dependent cytotoxicity test, employing single cell suspensions from primary lymphosarcoma. In some experiments, 125I-IgG was also tested against ML cells obtained from primary tumor (1 degree) and its liver metastasis (2 degrees). NML induced greater anti-tumor antibody production than ML, suggesting greater antigenicity of the non-metastasizing tumor. The two lymphosarcomas appeared to share some common tumor-associated antigens since antibody to one tumor type was either completely or partially absorbed by tumor cells of the other type. Anti-ML 125I-IgG proved up to 2-5 times more cytotoxic for ML 1 degree than 2 degrees cells. Although both tumors were highly tumorigenic in hamsters, only ML gave rise to distant metastases, predominantly in the liver.

Animals↗
PubMed1987

[Morphofunctional characteristics of blasts in lymphoblastic leukemia and lymphoblastic lymphosarcoma].

The authors investigated morphocytochemical and immunological indices of blast cells of 81 patients with acute leukemia and 70 patients with lymphosarcoma at the stage of leukemization. Blast cells in acute leukemia were shown to have the phenotype of early hemopoietic precursors whereas in lymphosarcoma blasts were more differentiated. Morphologically in leukemia blasts were characterized by homogeneity, and in lymphosarcoma by considerable polymorphism and a higher mitotic activity.

Adult↗
PubMed1986

Thymic lymphosarcoma in three heifers.

Three heifers with the thymic form of lymphosarcoma were examined. In each of the 3 cases, fever, bloat, and jugular venous distention had developed. Detectable antibody to bovine leukosis virus was not found on agar gel immunodiffusion testing in any of the cases. Thymic lymphosarcoma was confirmed by necropsy and histologic examination. Thymic lymphosarcoma must be considered in the differential diagnosis in heifers with fever, bloat, and jugular venous distention.

Animals↗
PubMed1985

[Results of the treatment of lymphosarcoma of the large intestine].

Comparative study of the efficacy of the different therapeutic measures for colonic lymphosarcoma indicates that in locally disseminated colonic lymphosarcoma (primary injury) radical surgery appears to be the most efficacious. Application of the drug therapy is helpful for disseminated primary colonic lymphosarcoma and metastatic injuries. The performance of the palliative surgery noticeably deteriorates the disease prognosis.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1985

Two cases of lymphosarcoma in channel catfish exposed to N-methyl-N'-nitro-N-nitrosoguanidine.

Of 158 channel catfish (Ictalurus punctatus) exposed to N-methyl-N'-nitro-N-nitrosoguanidine [(MNNG) CAS:70-25-7] in water for 28 days, 2 developed disseminated lymphosarcoma. One fish was necropsied at 12 months and another at 18 months following exposure. Both fish had a massive neoplastic infiltration of the bilateral pairs of head and trunk kidneys from which the neoplastic cells appeared to originate. The neoplastic infiltration was also observed in the following: thymus, gills, oral mucosa, liver, skin, skeletal muscle of head-neck region, and to a lesser extent spleen and bone marrow. This is probably the first report of lymphosarcoma in channel catfish. Although the occurrence of lymphosarcoma in these 2 catfish appeared to be related to exposure to MNNG, the exact role MNNG played in the tumor formation was not determined.

Animals↗
PubMed1966

The relation between lymphosarcoma and leukemia.

Of 283 cases of lymphocytic disease, 81% fell within three distinct categories: lymphocytic and lymphoblastic lymphosarcoma and lymphocytic leukemia. The remaining 19% showed transitions from more mature to less mature cell types or from local to general anatomic distribution. The clinical course was related to the cell type and the extent of disease rather than to the presence of blood stream invasion. Survival of patients with lymphocytic leukemia and of those with lymphocytic lymphosarcoma was the same, while that of patients with lymphoblastic lymphosarcoma was much shorter. Survival curves are simple exponentials and do not suggest two populations, one with disease less malignant than the other.

Adolescent↗
PubMed1981

Induction of lymphosarcoma in sheep by bovine leukemia virus.

Newborn sheep inoculated with phytohemagglutinin (PHA)-treated short-term, cultures of lymphocytes from cattle infected with bovine leukemia virus (BLV) or with a BLV- infected long-term culture of bovine leukemic lymphocytes became persistently infected with BLV. Fifty percent or more of the sheep died with histologically confirmed lymphosarcomas. Cytogenetic studies of representative cases demonstrated that the tumors did not result from the progressive growth of neoplastic lymphocytes in the inoculum but rather from the neoplastic transformation of the recipients lymphoid cells. Neither BLV infection nor lymphosarcoma was observed in control uninoculated sheep or in sheep given injections of PHA-treated cultures of lymphocytes from BLV-free cows. The virus recovered from the tumorous sheep was indistinguishable from BLV morphologically, antigenically, and biologically, and its reverse transcriptase had the same cation preference and immunologic properties as the BLV enzyme. Persistent BLV infection and lymphosarcoma were also observed in a group of sheep inoculated neonatally with BLV-containing cell-free culture supernatants. These results extend previous observations on the high susceptibility of sheep to BLV infection and provide definitive evidence that BLV is a tumor-inducing virus.

Animals↗
PubMed1984

Anti-tumor effects of allogeneic bone marrow transplantation in (NZB X NZW)F1 hybrids with spontaneous lymphosarcoma.

Untreated female (NZB X NZW)F1 hybrid mice (B/W F1) were found to develop lymphosarcoma spontaneously as they aged. Tumor incidence was evaluated in B/W F1 mice immunosuppressed with total lymphoid irradiation (TLI) and in TLI-conditioned B/W F1 mice reconstituted with 3 X 10(7) BALB/c bone marrow (BM) cells. BALB/C leads to B/W F1 chimerism (79 to 89% BALB/c-type cells) was confirmed by typing peripheral blood lymphocytes with specific alloantisera and complement by using a microcytotoxicity assay. Chimeras showed no clinical signs of graft-vs-host disease (GVHD). TLI-treated mice seemed to show a slightly accelerated onset of lymphosarcoma as compared with untreated controls, but the difference was not significant (p = 0.08). BALB/c leads to B/W F1 chimeras reconstituted at 1 to 3 mo of age (25 mice) developed no tumors for an observation period of 18 mo after transplantation. In contrast, tumors developed in 24/130 of age-matched controls, and in 13/57 of TLI-treated nonreconstituted age-matched B/W F1 mice. Tumor incidence in BALB/c leads to B/W F1 chimeras transplanted at an older age (9 to 11 mo) was similar to that observed in age-matched TLI-treated B/W F1 mice and age-matched untreated controls. The data suggests that the high naturally occurring incidence of lymphosarcoma could be reversed by reconstituting TLI-treated mice with BM cells (p = 0.027). Thus, allogeneic BM transplantation may exert potent graft-vs-tumor effects (GVT) when tumor susceptible hosts are reconstituted at an early age, whereas GVT is relatively ineffective at an advanced age, which probably correlates with an advanced stage of tumor development. Allogeneic BM transplantation should be additionally explored as a potential clinical tool for eradication of certain solid tumors in adjunct to high-dose radiochemotherapy, inasmuch as GVT seems to be independent of GVHD.

Aging↗
PubMed1984

[Effectiveness of various methods of chemotherapy of lymphosarcoma].

Different methods of poly- and monochemotherapy applied to the treatment of 601 lymphosarcoma patients admitted to the All-Union Cancer Research Center, Academy of Medical Sciences of the USSR, over the recent years have been studied and compared. The treatment results have been analyzed in accordance with the morphological pattern of lymphosarcomas and the degree of tumor spreading. The most efficacious methods for drug treatment of recurrent lymphosarcomas have been defined.

Adolescent↗
PubMed1984

A prospective survey of familial canine lymphosarcoma.

The incidence and case distribution of lymphosarcoma were determined prospectively in one breed of dogs, the bull mastiff. Fifty-nine dogs from three households were followed for 3 years. Two of the households had a previous history of lymphosarcoma cases, whereas the third had no history of such cases. During the survey period, 9 of the 59 dogs died from lymphosarcoma with multiple cases occurring in each household. On the basis of this survey, the annual incidence rate in the general bull mastiff population is likely to be on the order of 5,000 cases per 100,000 dogs, which constitutes the highest incidence rate recorded in this species. The distribution of the cases displayed a familial pattern. The possible involvement of genetic and infectious factors in the development of this disease pattern is discussed.

Animals↗
PubMed1983

[Twice daily irradiation of nasopharyngeal lymphosarcomas and cancer].

The authors present the preliminary results of double daily irradiation with a 4-hour interval of patients with rhinopharyngeal cancer (30 persons) and lymphosarcoma (18). This irradiation variant was well tolerated; all the patients received radiotherapy in accordance with the plan of irradiating tumors with mean focal doses of 70-76 Gy for rhinopharyngeal cancer and 40-50 Gy for lymphosarcoma. Complete tumor regression by the end of radiotherapy was achieved in 75%, partial in 25% of patients with rhinopharyngeal cancer. In lymphosarcoma, these figures were 80 and 20%, respectively. No late injuries of the normal tissues after 6-36 months were noted in patients.

Adolescent↗
PubMed1981

Changes in hemopoiesis of mice of the C3H strain following transplantation of Gardner lymphosarcoma and infection with LDH-virus. II. Spleen and bone marrow.

Cytological examination of spleens of mice with growing Gardner lymphosarcoma contaminated with LDH virus indicates the augmentation of erythropoiesis and granulopoiesis, as well as the decrease of lymphopoiesis. Similar changes were observed after infection with LDH-virus. The counts from the bone marrow smear showed more pronounced changes only in tumorous mice, in which repeatedly increased granulopoiesis was found. When the mice bearing Gardner lymphosarcoma were treated with L-asparaginase, then the cytological findings in the spleens and marrows of femors were almost normal. The examination of spleen and bone marrow smears revealed no tumor cells. Histologically examined spleens of mice with 12-day-growing Gardner lymphosarcoma demonstrated infiltration of the follicles with tumor cells. In the marrow of sternum no infiltration of tumor cells could be established.

Animals↗
PubMed1994

[The clinicoimmunological characteristics of blast transformation in lymphosarcomas].

The authors studied a blast cell immunological phenotype in 50 adults with lymphosarcoma undergoing leukemization following the pattern of acute leukemia. Among the patients there were 12 females and 38 males aged 14-61. Immunological phenotyping of tumor cells was performed using a panel of monoclonal antibodies to T- and B-lymphocyte antigens, to myelomonocytic cells, some nonlinear and activation antigens. T, B and zero variants of blast cells were identified. Occasionally, blast cells carried nonlymphoid antigens and those corresponding to the common lymphosarcoma subvariant. Leukemization in the direction of lymphoblastic leukemia is associated with greater frequency of lymphosarcoma T subvariant (46%). B-cell and zero subvariants occurred in 28% and 20% of the patients, respectively. The number of complete remissions in the group of patients with T-cell subvariant was greater than in the group with B-cell subvariant. The survival in these two groups, however, was almost similar (median up to 8-12 months). Further studies into lymphoblastic leukemization immunophenotyping can help design programs of differentiated polychemotherapy.

Adolescent↗
PubMedDate not supplied

[Computed tomography in the diagnosis of abdominal and retroperitoneal lymphosarcomas].

Analysis of the data of 87 computer-aided tomographic examinations of patients with peritoneal and retroperitoneal lymphosarcomas permitted the authors single out a peculiar computer-tomographic "semeiotics" of this condition. Four states in computer-tomographic changes of the lymph nodes in this area were distinguished, each of them corresponding to specific clinical manifestations of the suffering. The authors came to such a conclusion as a result of detecting in the same 18 patients of a clear-cut correlation between the type of computer-tomographic semeiotics and lymphosarcoma phase in the process of therapy and after it, during remission. Not denying a high value of computer-aided tomography in the diagnosis of peritoneal and retroperitoneal lymphosarcomas, the authors confirm the well-known diagnostic potentialities of ultrasonic examination and consider that ultrasound should remain the primary diagnostic instrument in such conditions.

Adult↗
PubMed1998

Function and Conformation of Wild-Type p53 Protein Are Influenced by Mutations in Bovine Leukemia Virus-Induced B-Cell Lymphosarcoma

The mutations of the p53 gene previously represented one of several genetic changes involved in the development of bovine leukemia virus (BLV)-induced lymphosarcoma, while the effects of these mutations on the function of p53 are unknown. We identified four mutations of p53 gene in BLV-infected cattle with lymphosarcoma and demonstrated clearly the existence of two functionally distinct groups of mutants: (i) the mutant forms with substitutions at codons 241 and 242, which were mapped within an evolutionally conserved region and corresponded to the human "hot-spot" mutations, had completely lost the capacities for transactivation and growth suppression and gained transdominant repression activity in p53-null SAOS-2 cells; and (ii) the mutations at codons 206 and 207 were located outside the evolutionally conserved regions. These mutants partially retained the capacity for transactivation and growth suppression and failed to inhibit the transactivation activity of coexpressed wild-type p53, instead showing an enhancement of this activity. In addition, protein analysis using an antibody specific for the mutant form revealed that the mutations at codons 206 and 242 induced a "mutant" conformation of the bovine p53 proteins. Collectively, these results show that mutations of p53 gene in BLV-infected cattle with lymphosarcoma can potentially alter its physiological function and may play an important role in BLV-induced leukemogenesis. Copyright 1998 Academic Press.

Journal Article↗
PubMed1998

Function and conformation of wild-type p53 protein are influenced by mutations in bovine leukemia virus-induced B-cell lymphosarcoma.

The mutations of the p53 gene previously represented one of several genetic changes involved in the development of bovine leukemia virus (BLV)-induced lymphosarcoma, while the effects of these mutations on the function of p53 are unknown. We identified four mutations of p53 gene in BLV-infected cattle with lymphosarcoma and demonstrated clearly the existence of two functionally distinct groups of mutants: (i) the mutant forms with substitutions at codons 241 and 242, which were mapped within an evolutionally conserved region and corresponded to the human "hot-spot" mutations, had completely lost the capacities for transactivation and growth suppression and gained transdominant repression activity in p53-null SAOS-2 cells; and (ii) the mutations at codons 206 and 207 were located outside the evolutionally conserved regions. These mutants partially retained the capacity for transactivation and growth suppression and failed to inhibit the transactivation activity of coexpressed wild-type p53, instead showing an enhancement of this activity. In addition, protein analysis using an antibody specific for the mutant form revealed that the mutations at codons 206 and 242 induced a "mutant" conformation of the bovine p53 proteins. Collectively, these results show that mutations of p53 gene in BLV-infected cattle with lymphosarcoma can potentially alter its physiological function and may play an important role in BLV-induced leukemogenesis.

Animals↗