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Results for “Lymphatic Metastasis”

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At least 127 records · Page 7Linked to original sources
PubMed1977

Lymphatic metastasis with childhood rhabdomyosarcoma.

Clinico-pathologic reviews of series of children with rhabdomyosarcoma have yielded conflicting information regarding frequency of lymphatic spread of this disease. The 264 eligible entries in the Intergroup Rhabdomyosarcoma Study (from November 1972 to September 1975) have been categorized by a prospective staging system and pre-treatment characteristics and pathologic findings reviewed. Data accumulated thus far have revealed a higher than expected incidence of lymphatic metastases from extremity (17%) and genito-urinary sites (19%) with a somewhat lower incidence from the orbit (0%), the head and neck region (3%), and trunk (10%). These differences in regard to lymphatic metastases were found to have no relationship to age, sex, tumor size, or histologic type when these factors were simultaneously examined.

Adolescent↗
PubMed1993

An animal model of lymphatic metastasis using the ascites-form of the murine testicular teratocarcinoma (402AX).

We examined the ascites-form of the murine testicular teratocarcinoma (402AX) as an animal model of spontaneous metastasis. We inoculated 2 x 10(5) cells into a total of seven hundred and twenty-seven 129/J strain mice. They showed clinically manifested ascites approximately two weeks later and died three to nine weeks later. Metastases were seen in lungs and hilar lymph nodes two to three weeks later. We performed staging and developed a definition of metastasis. Pulmonary metastases were quantified by mapping and counting the number of metastatic nodules in the lungs. Lymph node metastases were quantified by measuring the maximum diameter of metastatic lymph nodes (tumors). Additional sectioning was shown to be beneficial to demonstrate lymph node metastasis. The macroscopical metastatic rate was much less than the microscopical metastatic rate. The metastatic rate of the natural-death mice was much higher than that of the sacrificed mice. Lymph node metastatic rate was much higher than pulmonary metastatic rate. The metastatic rate had a direct relationship with the volume of ascites. This animal model can be used to study spontaneous metastasis.

Animals↗
PubMed2004

Expression of vascular endothelial growth factor-C and the relationship between lymphangiogenesis and lymphatic metastasis in colorectal cancer.

AIM: To investigate the expression of vascular endothelial growth factor-C (VEGF-C) and the relationship between VEGF-C and lymphangiogenesis, lymph node metastasis in colorectal cancer. METHODS: Fifty six cases of colorectal cancer were selected randomly. Expression of VEGF-C was detected by immunohistochemistry, and lymphatic vessels were stained by enzyme histochemical method. RESULTS: VEGF-C expression was found in 66.7% (37/56) patients. In VEGF-C positive and negative patients, the lymphatic vessel density was 25.16+/-7.52 and 17.14+/-7.22, respectively (P<0.05). The rate of lymph node metastasis in VEGF-C positive patients (81.1%) was significantly higher than that in the negative group (42.1%). CONCLUSION: VEGF-C expression may induce lymphangiogenesis in colorectal cancer, as a result, tumor cells can entry the lymphatic vessels easily. VEGF-C may serve as a useful prognotic factor in colorectal carcinoma.

Adult↗