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At least 127 records · Page 7Linked to original sources
PubMed1983

[Intratumoral proliferation of the blood vessels].

The growth of vessels in experimental neoplasm occurs within 2-7 days after implantation. Newly formed vessels penetrate into the tumor only from the tissues of the tumor-carrying host. Vessels are formed in the tumor by budding. Proliferation of tumor cells begins only after the contact between them and the developing vascular network has been established. Myofibroblasts play an important role in the development of vessels. The intensity of new vessel formation is more than twice as high as in the wound process. The number of capillaries in developed tumors varies with an average of 30,000 in 1 mm2. Blood supply even within the same tumor is variable both in the form and location of the vessels. With increasing tumor volume intercapillary distances, diameter and length of the capillaries increase while the vascular bed volume, the general and local blood flow decrease. Reparation of the vascular bed in tumors occurs both due to preexisting vessels and by additional formation of new vessels. The muscular layer and innervation are lacking in the newly formed vessels. In the process of growth, compensatory-adaptative reactions directed to improvement of hemodynamics constantly develop in tumor tissues.

Animals↗
PubMed1978

Potential anticancer agents. XVII. New developments in the benzoic acid nitrogen mustards area.

In order to obtain aromatic nitrogen mustards with improved therapeutic index against experimental neoplasms, greater than 75 new compounds were synthetized and studied. Their structure-activity relationship analysis led to the following conclusions: (a) the carboxylic group (especially when located in the meta position with respect to the nitrogen mustard group) exerts a favorable effect on the biologic properties of such compounds, probably by improving their transport characteristics; (b) a linear relationship was found between the chemical reactivity (expressed as alkylation rate, log k66) and toxicity (LD50) of 31 investigated compounds; and (c) the ortho effects also seem to be of importance in this area for a more accurate control of the nitrogen mustard activity. Other criteria (ie, log P, nucleophilicity of the target centers) involved in the rational design of aromatic nitrogen mustards are discussed. The design of new derivatives was oriented toward compounds which (a) were able to couple with selected proteins (ie, antibodies) leaving the cytotoxic moiety intact, and (b) were obtained by coupling of the 3-N,N-bis(2-chloroethyl)amino-4-methyl-benzoyl moiety with selected carriers (steroids, chromanones, etc) by way of an esteric bond.

Aminobenzoates↗