PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “NEOPLASMS, MULTIPLE PRIMARY”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 127 records · Page 7Linked to original sources
PubMed1986

[Second malignant neoplasms in childhood].

Sixty-six cases of multiple primary neoplasms in children in Japan were collected, including 8 cases of our own. These could be divided into 19 synchronous and 47 metachronous multiple neoplasms. Metachronous or multiple primary neoplasms comprised leukemia, osteosarcoma, mesenchymal sarcoma, epithelial carcinoma and others in contrast to synchronous neoplasms which consisted of many pairs of embryonic tumors. The presumptive factors for multiple primary neoplasms suggested radiotherapy-associated cancers in 30%, radiochemotherapy-associated in 13%, chemotherapy-associated in 34%, and genetic factor-related in 36% of cases. Chromosomal analysis was performed in 12 cases. Three of 4 leukemias revealed major karyotypic abnormalities in the leukemic cells. No 13q14, deletion was detected in 5 cases with multiple primary neoplasms developed with retinoblastoma. Frequent incidence of sister chromatid exchange (SCE) was detected in cultured fibroblasts or lymphocytes from one of 3 cases of second primary neoplasms associated with chemotherapy. The time interval between both neoplasms ranged from 2 to 15 years in the majority of cases. Chemotherapy-associated multiple primary neoplasms seemed to appear more quickly than radiotherapy-associated multiple primary neoplasms. Seven children out of 459 long-term survivors of childhood cancer developed multiple primary neoplasms during the period from 5 to 20 years after diagnosis of the first tumor at the National Cancer Center Hospital, Tokyo. The relative risk was suggested to be 14 times higher than the expected incidence of childhood cancer in Japan. Refinement of treatment, long-term monitoring and protective procedures for high-risk patients against multiple primary neoplasms are therefore warranted.

Adolescent↗
PubMed1999

Cyclin D1 and p53 overexpression predicts multiple primary malignant neoplasms of the hypopharynx and esophagus.

BACKGROUND: Multiple primary upper aerodigestive tract carcinomas can occur in up to 15% of patients. We have shown previously that half of the patients with multiple upper aerodigestive tract squamous cell carcinomas are initially seen with synchronous tumors. Most metachronous squamous cell carcinomas become manifest within 3 years. OBJECTIVE: To examine the expression of 2 proteins-cyclin D1 and p53--in an attempt to predict the occurrence of multiple primary malignant neoplasms (MPs). MATERIALS AND METHODS: Monoclonal antibodies to cyclin D1 (DCS-6 [dilution, 1:50]. Novocastra Laboratories Ltd, Newcastle, England) and p53 (DO-7 [dilution, 1-100], Dako Corp, Carpinteria, Calif) proteins were used. Resection specimens from a total of 47 patients, 12 patients with MP and 35 patients with nonmultiple primary malignant neoplasms, were analyzed. Those in the nonmultiple primary malignant neoplasm group had longer than 3 years' follow-up to ascertain the absence of MP. RESULTS: Tumor overexpression of cyclin D1 was significantly associated with the development of MP (P<.01). Tumor overexpression of p53 was also frequent in patients with MP although statistical significance was not achieved. The combination of these 2 parameters was an even greater predictor of MP (P<.001). CONCLUSIONS: Overexpression of cyclin D1 and p53 proteins was highly correlated with the development of MP. Additional studies are necessary to confirm this finding. Immunohistochemical evaluation of primary squamous cell carcinomas for cyclin D1 and p53 overexpression may become an important fact of surgical pathologic reporting for primary upper aerodigestive tract squamous cell carcinomas.

Carcinoma, Squamous Cell↗
PubMed2004

Multiple primary malignant neoplasms in urologic patients.

METHODS: Second primary cancers constitute approximately 9-10% of malignancies diagnosed in the United States. We aimed to show the risk and incidance of second primary tumor occuring associated to urologic tumors and show the distrubution of tumors in Tracia region. We retrospectively examined the patients' files with the diagnosis of malignant disease between the years 1985-2000. Hazard function analysis was performed to estimate the relative risk of secondary malignancy occuring. Age, sex and tumor number were examined to find out if they affect on mortality rate. RESULTS: A total number of 25 MPMNs were diagnosed. In 52 percent of the cases the second primary neoplasm developed within six months. The relative risk of development of a second neoplasm is found as increasing 1.111 times per month. The incidence of secondary malignancy occuring in the patients with one tumor was found as 6.31%. Age (p < 0.001) and tumor number (p < 0.001) are found as statistically effective predictor on mortality rate where the sex is not. CONCLUSIONS: In the patients with a primary tumor not only the metastasis must be investigated but also second primary tumors should be taken into consideration.

Adult↗
PubMed2005

Multiple primary intrathoracic neoplasms: case report and a review of the literature.

This is a case report of a patient diagnosed with three distinct primary intrathoracic tumors (mesothelioma, carcinoid and B-cell lymphoma). The patient had previously had mycosis fungoides. The occurrence of multiple neoplasms in a single patient, synchronous or metasynchronous, is not a rare phenomenon; the incidence varies from 1-11% of all neoplasms. They can be hereditary, or connected with some environmental agents or previous therapies. The incidence of multiple neoplasms increases with age. We report an extremely rare case of multiple intrathoracic neoplasms in a 71-year-old man. A left upper lobectomy was performed, followed by 6 courses of chemotherapy and irradiation of the sternum. The patient was stable two years later.

Aged↗
PubMed1975

Multiple primary malignant neoplasms. A search for an immunogenetic basis.

The occurrence of multiple primary malignant neoplasms in single individuals is well documented. Although many hypotheses have been advanced to explain this occurrence, there has been no study to determine if a presumed "increased susceptibility to cancer" has an immunogenetic basis. We evaluated the cellular immunity and histocompatibility antigens of 42 patients who had had from two to four multiple primary malignant neoplasms. We failed to demonstrate a preexisting impairment of immunocompetence or abnormal HL-A antigen frequencies in these patients. The occurrence of multiple primary malignant neoplasms in related tissues, eg, lung/larynx/oral cavity, and the occurrence of successive primary malignant neoplasms at a time interval consistent with the patient's being cured of preceding malignant neoplasms suggest that multiple primary malignant neoplasms result from repetitive induction by the same or similar etiologic factors in patients who are cured after treatment of the first malignant neoplasm.

Adult↗
PubMed1977

Multiple primary malignant neoplasms. The Connecticut experience, 1935-1964.

Results for non-simultaneously diagnosed malignant tumors from Connecticut indicate that individuals with one malignant neoplasm have 1.29 times the risk of developing a new independent primary tumor when compared to individuals who never had cancer (P less than 0.01). However, the increased risk of multiple primary tumors is highly selective on a site-specific basis. Table 135 presents Connecticut Registry data indicating the risk of a subsequent primary malignancy by anatomic site of the later primary in patients with a first primary cancer. Tables 136 and 137 present tabulations for anatomic sites with statistically significant excesses and deficiencies, with an analysis by time interval between the two malignancies. Finally, Table 138 presents figures showing histologic confirmation for site-group paris with significant excesses of observed-over-expected later primary malignant neoplasms. The reader should bear in mind that just as the risk of subsequent primaries varies with the anatomic site of the subsequent primary (Table 135), the risk is also highly dependent upon the anatomic site of the first primary cancer (Chapters 6-12).

Aged↗
PubMed1995

[Multiple primary malignant neoplasms].

The laryngological ward of the district hospital in Piła has been carrying out the diagnosis of neoplastic cases. There were 34 cases of carcinoma of the larynx and or with the lower part of the pharynx were discovered. 4 out of there were confirmed to have second primary neoplastic region. Two patients the neoplasm synchronously developed and in two other patients the neoplasm metachronously developed. In there cases the region of second primary neoplasm was found in the area of the head and neck (thyroid gland, lower lip and the side of the nose) and in one case the second region was found in the urinary bladder, Amongst the patients treated for neoplasms in the laryngological ward of the district hospital in Piła in 1994, 11.7% were patients with second primary malignant neoplasm.

Aged↗
PubMed1995

Multiple primary malignant neoplasms in urologic patients.

One hundred and four patients with multiple primary malignant neoplasm (MPN) with at least one genitourinary organ involved were analyzed. The 104 patients represented 0.9% of all cancer patients and 9.0% of all urologic tumor cases. Tumors of the prostate and bladder in urologic cancers and tumors of the gastrointestinal tract, particularly stomach cancer, in non-urologic cancers were predominantly involved. In 79 cases (76.0%), the second tumors were discovered within 5 years from the diagnosis of the first cancer. Renal cell carcinoma tended to be discovered incidentally and concomitantly. In contrast, bladder cancer tended to be an initial primary tumor presenting with symptoms, and tumor of prostate tended to be found incidentally, as a second cancer in metachronous cancer associations. All second tumors of the liver were found incidentally with ultrasonographic examination after a small interval. Strict follow-up at regular intervals at least the initial 5 years are essential for the detection of second malignant neoplasms.

Adult↗