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At least 127 records · Page 7Linked to original sources
PubMed2001

The relevance of the CD4+ CD26- subset in the identification of circulating Sézary cells.

BACKGROUND: The lack of specific markers for the phenotyping of circulating neoplastic T cells in Sézary syndrome (SS) patients makes it difficult both to ascertain the presence of clonal cells and to quantify the tumour burden in the peripheral blood. In previous reports we showed that the lack of CD26 (dipeptidyl-aminopeptidase IV) is a characteristic feature of circulating Sézary cells (SC). OBJECTIVES: The purpose of this study was to ascertain, by means of high-resolution two-, three- or four-parameter flow cytometry, the relationship between CD26 expression on peripheral blood lymphocytes and peripheral blood involvement in cutaneous T-cell lymphoma patients and to assess its significance in SS diagnosis. METHODS: The patient population included 52 SS patients, 151 mycosis fungoides (MF) patients at different clinical stages (including 14 with blood involvement, B1-MF), 88 patients with erythrodermic inflammatory skin diseases (EISD) and 72 healthy donors (HD). CD26+ values were available in all cases, whereas CD4+ CD26- level measurement was performed in 23 SS, 141 MF, 71 EISD and 72 HD. RESULTS: CD4+ CD26- percentage values were higher than 30% in all but one B1-MF and higher than 40% in all SS cases, whereas HD, EISD and B0-MF patient values were always lower than 30%. A statistically significant difference was found in both CD26- and CD4+ CD26- percentage and absolute values between SS and HD, EISD and B0-MF patients. The CD26- and CD4+ CD26- percentage values (but not the absolute values) were significantly higher in B1-MF compared with HD, EISD and B0-MF patients (P < 0.001). Moreover, CD26- absolute values and CD4+ CD26- percentage and absolute values were significantly higher in SS than in B1-MF (P < 0.001). A statistically significant direct relationship was found between CD4+ CD26- percentage values and the percentage of circulating SC within the lymphoid population in SS and B1-MF (r = 0.77; P < 0.001). The lack of CD26 was confirmed on phenotypically clonal cells in patients with an expanded circulating TCRvbeta population or a T-cell antigen loss. Sorted CD4+ CD26- cells from both SS patients and HD showed the characteristic cerebriform nuclei of SC. CONCLUSIONS: We feel that a CD4+ CD26- percentage value higher than 30% of peripheral blood lymphocytes could correctly identify the presence of peripheral blood involvement in SS and MF patients.

Adult↗
PubMed1999

[Therapy for kidney cell carcinoma with cava thrombus. Importance of extracorporeal circulation and prognostic value of cranial tumor extension].

In approximately 4-10 % of patients presenting with renal cell cancer the transluminal propagation of a tumor thrombus into the vena cava inferior or the right atrium comes to diagnosis. Recent investigations have indicated that the presence of neoplastic extension into the venous system does not reveal independent prognostic value regarding the clinical course of the disease. Although the complete surgical removal of vena cava thrombosis in patients without simultaneously occurring regional lymph node or distant metastases has become a well established treatment modality, several questions concerning this surgical strategy still remain the subject of ongoing discussions. In the present investigation that included 92 patients with renal cell cancer and intracaval neoplastic extension it was clearly demonstrated that the use of cardiopulmonary bypass, deep hypothermia and circulatory arrest preferably during the removal of intracaval thrombosis extending into the right atrium does not result in a substantially increased treatment-related intra- or postoperative mortality. However, in contrast to a previously reported observation this treatment option did not reveal any substantial impact on the long-term survival of the patients following surgical therapy. Accordingly, the cranial extension of intracaval thrombosis was not identified as a biological variable of any prognostic importance for renal cell cancer patients.

Adult↗
PubMed1988

Arterial occlusion reduces tumour cell lodgement in the rat liver.

The lodgement of tumour cells (TCs) is a key event in the development of metastases in distant organs. Experimental and clinical studies have shown that ligation of the hepatic artery may reduce the mass of established metastases. In the present study the effect of hepatic artery or portal vein occlusion on the early phase of metastasis development, i.e. TC lodgement, was investigated. Occlusion of the hepatic artery immediately before intraportal TC infusion reduced TC lodgement, while a temporary occlusion of the portal vein directly after the TC infusion led to increased TC lodgement. It is speculated that the decrease in TC lodgement after arterial occlusion is due to local increase in blood flow, which might enhance the passage of the TCs through the liver, and to a decrease in pH causing an increased rate of TC destruction. The increased TC lodgement after portal vein occlusion, on the other hand, should mainly be due to flow reduction, promoting TC trapping in the liver microvasculature.

Animals↗
PubMed1986

Vena occlusive disease simulated by a metastasis of gastric cancer during pregnancy.

A 20-year-old woman was treated because of her complaint and symptoms which were thought to be the results or complication of her pregnancy. Based on the cardinal symptom inferior cavography was carried out, and the diagnosis of occlusion of inferior vena cava was established. The woman was treated accordingly but died after a short period. The patient's family supposed neglection and therapeutic misadventure and raised an objection to the medical treatment. Forensic autopsy was carried out to clear up the case. Autopsy showed her basic disease to be gastric cancer with several metastases in the liver. One of them was in the lobus caudatus Spigeli and compressed the inferior vena cava. The compression caused a turbulence in the given contrast material so that thrombosis was suggested. The diagnosis was based on this misleading sign. Negligence was not verified.

Adenocarcinoma, Mucinous↗
PubMed2002

[Rapidly growing renal angiomyolipoma during pregnancy with tumor thrombus into the inferior vena cava: a case report].

A case of renal angiomyolipoma rapidly growing during pregnancy with tumor thrombus into the inferior vena cava is reported. Angiomyolipoma in a 31-year-old woman was incidentally found by ultrasonography. CT scan revealed a fat-containing tumor in the right kidney with 4 cm in diameter. The patient was followed at outpatient clinic without any treatment. Fifteen months later, the post-delivery follow-up CT scan showed that tumor size had grown up to 11 cm in diameter. Although laparoscopic right nephrectomy was tried, open transperitoneal right nephrectomy was performed because the tumor thrombus extending into the inferior vena cava was found during the laparoscopic procedure. Pathological diagnosis was angiomyolipoma of the kidney. There are several reports that indicate angiomyolipoma grows rapidly during pregnancy. Our case demonstrates that careful follow-up is required for angiomyolipoma in women with possible conception and delivery.

Adult↗
PubMed1996

[A case of metastatic choriocarcinoma associated with cerebral thrombosis and aneurysmal formation].

A rare case of metastatic choriocarcinoma with cerebral thrombosis and subsequent neoplastic aneurysm formation and rupture is reported. Three months after normal pregnancy and normal delivery, a 16-year-old woman was admitted with the chief complaints of speech disturbance and paresthesia of her right upper extremity on June 4, 1992. Both CT and MRI demonstrated cerebral infarction in the left insula. A cerebral angiogram revealed that the left middle cerebral artery (about 2 mm in diameter) was occluded in the distal M2 segment. On the 34th day, a follow up angiogram demonstrated a fusiform aneurysm at the same point of the arterial occlusion that had been already recanalized. On the 37th day, she suddenly had severe headaches and consciousness disturbance. CT showed subarachnoid hemorrhage. Resection of the aneurysm and left STA-MCA anastomosis were performed. Histological examination revealed that the aneurysmal walls were invaded by choriocarcinoma. On the 60th day, she was transferŕed to the department of obstetrics and gynecology for chemotherapy. On the 65th day and the 71st day, the patient suffered from intracerebral hemorrhage in the left basal ganglia, which originated from a different point of aneurysmectomy. She died because of the rapid growth of liver metastases 7 months after initial admission. Because chest CT and roentgenogram detected no lesion in the lungs, neoplastic embolus was unlikely as a cause of occlusion of the cerebral artery of about 2 mm in diameter. It would be more reasonable to believe that choriocarcinoma metastasized to the cerebral arterial walls initially and formed a thrombus which occluded the artery. As the neoplastic invasion weakened the arterial wall, a fusiform aneurysm was formed when the vessel was recanalized. There has been no case reported in the literature of neoplastic aneurysms of choriocarcinoma in which the course from aneurysmal formation to rupture was followed angiographically.

Adolescent↗