PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “OSSIFICATION, PHYSIOLOGIC”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 127 records · Page 7Linked to original sources
PubMed1999

Skeletal dysplasia and defective chondrocyte differentiation by targeted overexpression of fibroblast growth factor 9 in transgenic mice.

Mutations in fibroblast growth factor receptor 3 (FGFR3) cause several human chondrodysplasias, including achondroplasia, the most common form of dwarfism in humans. From in vitro studies, the skeletal defects observed in these disorders have been attributed to constitutive activation of FGFR3. Here we show that FGF9 and FGFR3, a high-affinity receptor for this ligand, have similar developmental expression patterns, particularly in areas of active chondrogenesis. Targeted overexpression of FGF9 to cartilage of transgenic mice disturbs postnatal skeletal development and linear bone growth. The growth plate of these mice exhibits reduced proliferation and terminal differentiation of chondrocytes similar to that observed in the human disorders. The observations provide evidence that targeted, in vivo activation of endogenous FGFR3 inhibits bone growth and demonstrate that signals derived from FGF9-FGFR3 interactions can physiologically block endochondral ossification to produce a phenotype characteristic of the achondroplasia group of human chondrodysplasias.

Animals↗
PubMed2004

[Morphofunctional changes of coccyx area in posttraumatic coccygodynia].

For definition of a pathogenesis ofposttraumatic coccygodynia, a study of morpho-functional changes of the structures of coccyx's area was organized. The preparations of coccyx, removed during operative intervention from 23 different-aged patients with manifestations of disease were analyzed by roentgen, histological technique and a submicroscopy. In a cartilaginous tissue from patients with posttraumatic coccygodynia, dystrophic changes of chondrocytes down to their atrophy, a destruction of the basic material with partial replacement of a fibrillar cartilaginous tissue with a hyaline cartilage were observed with a different degree of manifestation. Vessels and sacrococcygeal nervous plexus were subjected to pathological changes. Increased post-traumatic mobility, alterations in the process of ossification, deceleration of physiological joining of coccyx vertebras and sacrococcygeal joint alter biomechanical properties of coccyx at sitting. These alterations lead to the long-lasting traumatization with degenerative - dystrophic changes, reinforcement of pain syndrome and manifestation of dysfunctions of organs of pelvis.

Adolescent↗
PubMed1989

[Studies of hip dislocation in twins].

An arbitrary series of twins is used to demonstrate that there is no increased morbidity from congenital dislocated hip joint in twins. A physiologic delay in ossification of the cartilaginously preformed parts of articulations is caught up during the first year of life. In addition, connection with pregnancy and birth is discussed and r recommendations for diagnosis and therapy using sonography are given.

Birth Weight↗
PubMed1993

Influence of electromagnetic fields on endochondral bone formation.

Endochondral ossification is a basic physiological process in limb development and is central to bone repair and linear growth. Factors which regulate endochondral ossification include several biophysical and biochemical agents and are of interest from clinical and biological perspectives. One of these agents, electric stimulation, has been shown to result in enhanced synthesis of extracellular matrix, calcification, and bone formation in a number of experimental systems and is the subject of this review. The effects of electric stimulation have been studied in embryonic limb rudiments, growth plates, and experimental endochondral ossification induced with decalcified bone matrix and, in all these models, endochondral ossification has been enhanced. It is not known definitively whether electric fields stimulate cell differentiation or modulate an increased number of molecules synthesized by committed cell population and this is a fertile area of current study.

Animals↗