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Monoamine oxidase, psychoenergizers, and tranquilizers.

1-Benzyl-2-methyl-5-methoxytryptamine (BAS) inhibits monoamine oxidase in man. This finding confirms the findings of Woolley in mice. Since BAS, a tranquilizing agent, and Marsilid, a psychoenergizer, are both monoamine oxidase inhibitors, doubt is cast upon the hypothesis, that the stimulatory effect of Marsilid is due to its ability to inhibit monoamine oxidase.

Animals↗

Metabolism of adrenaline after blockade of monoamine oxidase and catechol-O-methyltransferase.

Experiments in cats infused with 5 micromole of dl-adrenaline-2-C(14) showed that blockade of either monoamine oxidase or catechol-O-methyltransferase is largely compensated for by the activity of the intact enzyme system; combined blockade of both enzyme systems results in the formation of a new adrenaline catabolite and in the increased production of acidic, mainly conjugated, catabolites, the identity of which remains to be established.

Animals↗

Histochemical demonstration in rat of monoamine oxidase inhibition of beta-phenyl-isopropyl hydrazine.

A histochemical method for demonstration of monoamine oxidase activity was found to be almost as sensitive as a biochemical method when used for revealing total inhibition of monoamine oxidase in rat tissues after administration of beta-phenyl-isopropyl hydrazine. The histochemical method is of special value in the study of monoamine oxidase inhibition in the complex structures of the brain.

Animals↗