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Acute meningoencephalomyelitis in a rabbit infected with Pasteurella multocida.

Pasteurella multocida was isolated in pure culture from the optic chiasm of a rabbit that was euthanatized subsequent to acute development of neurological signs. Histopathologically, there was meningoencephalomyelitis, bilateral otitis interna, retrobulbar cellulitis, optic neuritis and iritis. The ocular involvement, severity of the spinal lesions and the lack of otitis media was unusual.

Acute Disease↗

Systemic Pasteurella haemolytica infection as a rare sequel to avirulent live Pasteurella haemolytica vaccination in cattle.

Eleven cases of systemic Pasteurella haemolytica infection in cattle were identified from routine diagnostic laboratory submissions during the falls of 1988, 1989, and 1991. All cases came with a history of recent vaccination with an avirulent live culture P. haemolytica product. Nine of 11 cases involved cattle vaccinated between 2 and 18 days previously with this product. Ten of 11 cases involved 182-227-kg beef calves that were vaccinated between September and November during routine processing for entry into feedlots. The morbidity and mortality was generally low. The major pathologic findings included meningitis, injection site abscessation and/or cellulitis, and polyarthritis. Systemic infection was indicated in all cases by the isolation of P. haemolytica from 2 or more organs or distinct anatomical sites. In 6 cases, the vaccine injection site was cultured, and in all 6 cases, P. haemolytica was isolated. Three separate P. haemolytica isolates from 2 cases were further studied by restriction enzyme analysis (REA). These isolates were from tissues with suppurative inflammation, including the brain, joint, and injection site. The REA patterns of each of these 3 isolates were identical to the REA pattern of the vaccine masterseed, which strongly suggested that the organisms causing systemic infection were the same as the organism used to produce the vaccine. Because the overall incidence was quite low, other factors, such as stress, probably played a major role in the expression of this syndrome.

Animals↗

Pasteurella multocida infection in Singapore.

A case of Pasteurella multocida infection in Singapore is presented. The patient was a 21-year-old Chinese male who developed fever and cellulitis with abscess formation of his right index finger after it was bitten by a stray cat. The organism was isolated in pure culture and identified as Pasteurella multocida subspecies septica. The patient responded to antibiotic therapy and had an uneventful recovery.

Adult↗

Recurrent outbreaks of a cutaneous form of Pasteurella multocida infection in turkeys.

Cutaneous infection caused by Pasteurella multocida was diagnosed in a flock of seven thousand 17-to-22-week old male turkeys. The affected grow-out facility had an annual outbreak of fowl cholera, in which a cutaneous infection ventral and lateral to the tail was the predominant lesion. P. multocida serotypes 1 and 14 were the predominant isolates. The exact source of the infection was not determined.

Animals↗

Use of TUNEL staining to detect apoptotic cells in the lungs of cattle experimentally infected with Pasteurella haemolytica.

Lung sections taken from calves with experimental Pasteurella haemolytica respiratory infection exhibited increased numbers of TUNEL positive cells with time after challenge. This finding suggests that P. haemolytica, or toxins and other components released by the organism, induces apoptosis in bovine leukocytes in vivo. By so doing this might impair host defense and contribute in part to the severe pneumonia that characterizes bovine pasteurellosis.

Animals↗