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At least 127 records · Page 7Linked to original sources
PubMed1987

Characterization of Lyt-2-, L3T4- class I-specific cytolytic clones in C3H-gld/gld mice. Implications for functions of accessory molecules and programmed development.

We report the first demonstration of Thy-1+, Lyt-2-, L3T4- MHC-specific CTL clones derived from the Lyt-2-, L3T4- subset of lymph node cells of C3H-gld/gld mice. These clones express alpha/beta heterodimeric TCRs on the cell surface and specifically recognize class I molecules on target cells. Lyt-2 and L3T4 molecules are therefore not essential for the induction, recognition, and killing of antigen-specific CTL. In addition, these studies suggest that antigen specificity development for class I structures may occur before Lyt-2 gene activation in the differentiation of T cells.

Animals↗
PubMedDate not supplied

Research program development in a tertiary care setting.

The Committee on Clinical Nursing Research was established in April 1979 at the Hospital of the University of Pennsylvania, Philadelphia, not only to encourage clinical nursing research for the provision of optimal care and the development and evaluation of nursing practice, but also to monitor consumer safety vis-à-vis the research effort. The development of the committee and relevant issues are discussed.

Education, Nursing↗