[Effect of 15-methyl-prostaglandin F2 alpha used for dilating the cervix uteri before abortion on endogenous prostaglandin F2 alpha synthesis].
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A dose of 2.5 mg of Minprostin F2 alpha in hydroxy -cellulose gel was intracervically applied to 30 primigravidae on the eve of planned interruption. Blood samples were taken to determine prostaglandin concentrations. Rise in PG F2 alpha concentrations was recordable from peripheral venous blood of the majority of patients. - A relationship was found to exist between the extent of side effects, clinical success, and circulatory resorption of PG F2 alpha.
PGE2 and PGF2 alpha were isolated from the decidua of an early pregnancy, following medical termination. The biosynthetic capacity for 6-keto-F1 alpha was tested by incubation, using 3H-labelled arachidonic acid. Prostaglandin concentrations in the decidua differed strongly from steroid hormones in plasma. Steroid hormone concentrations increased with continuity, whereas prostaglandin values remained extremely low.
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