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At least 127 records · Page 7Linked to original sources
PubMed2000

Pyometra as a lower abdominal doughnut sign on a Ga-67 scan.

A 77-year-old woman was referred for Ga-67 scan to evaluate intermittent fever and chills that had lasted more than 20 days. The Ga-67 whole-body scan revealed a doughnut-shaped Ga-67 accumulation in the lower abdominal region. Combined Ga-67 and Tc-99m MDP bone scan confirmed that this activity was in the uterus, because the shape of the urinary bladder on bone scan was different from that of the Ga-67-avid lesion. Pyometra was proved during operation, and pus culture was performed.

Abdomen↗
PubMed2007

Suspected toxic shock-like syndrome in a dog with closed-cervix pyometra.

Several cases of toxic shock-like syndrome (TSLS) have been reported in dogs but no inciting cause has been identified. TSLS associated with a closed-cervix pyometra was suspected in the reported bitch. The dog was evaluated for the complaint of generalized dermatopathy (erythema and oedema) and systemic signs with multiorganic involvement (depression, fever, immature neutrophilia, hypoalbuminaemia, renal disease, vomiting and diarrhoea). Histological features consistent with TSLS included superficial dermatitis with epidermal neutrophilic exocytosis and necrotic keratinocytes. The tentative diagnosis of TSLS was based on case history, clinical presentation, laboratory and histopathological findings, and the resolution of all clinical signs following surgical removal of the localized bacterial infection.

Ampicillin↗
PubMed2002

Septic peritonitis secondary to unilateral pyometra and ovarian bursal abscessation in a dog.

A seven-year-old, female entire Labrador retriever was presented for acute-onset vomiting and lethargy, associated with weakness and generalised tremors. The clinical, radiographic, ultrasonographic and histopathological findings revealed septic peritonitis which occurred secondarily to unilateral pyometra and ovarian bursal abscessation. However, in this case, the initial clinical findings, blood parameters, radiographic and ultrasonographic findings did not allow a specific diagnosis. Repeat monitoring was required, and abdominocentesis proved to be the most useful diagnostic test, allowing a definitive diagnosis and the decision to be made as to whether or not to carry out exploratory surgery.

Abscess↗
PubMed1987

Metronidazole for the treatment of bovine pyometra.

Metronidazole, an antibiotic with specific activity against anaerobic bacteria, was assessed as a treatment for bovine pyometra. A preliminary experiment with metronidazole-neomycin was followed by an experiment in which metronidazole-ampicillin was compared with povidone iodine. Each treatment was given as a single intrauterine infusion. The success of therapy was judged by clinical examination, bacteriological examination before and after treatment and, in the second experiment, by post treatment reproductive performance. Before treatment 45 of the 84 cows in both experiments were infected with a mixture of anaerobic and aerobic bacteria, 23 cows were infected with aerobes alone and significant bacteria were not isolated from 16 cows. Complete bacteriological and clinical cures were achieved in 23 of 32 cows treated with metronidazole-neomycin, 15 of 32 cows treated with metronidazole-ampicillin and 1 of 20 cows treated with iodine. When only those cows with mixed anaerobe/aerobe infections were considered, complete cures occurred in 12 of 17 cows treated with metronidazole-neomycin, and 11 of 16 cows treated with metronidazole-ampicillin, but none of the 12 cows treated with iodine. Twenty-two of 29 cows treated with metronidazole-ampicillin conceived after treatment (mean 51.4 days), while 9 of 18 cows treated with iodine conceived (mean 58.7 days). Statistically, metronidazole-ampicillin treatment produced significantly better clinical and bacteriological cure rates than iodine treatment (P less than 0.05), but the differences in reproductive parameters were not significant.

Ampicillin↗
PubMed1985

Spontaneous perforation of a pyometra presenting as generalized peritonitis.

Eleven cases of spontaneous perforation of a pyometra have previously been reported. All were associated with, and probably secondary to, cervical occlusion. A further case is described, but differs in that the cervical canal was patent. In the absence of other possible causes of uterine perforation, the aetiology of the perforation in this case remains uncertain.

Aged↗
PubMed1975

Unconjugated oestrogen and progesterone concentrations in the blood of bitches with false pregnancy and pyometra.

The changes in total unconjugated oestrogen and progesterone concentrations in the peripheral blood of one bitch throughout a false pregnancy were measured. The levels of these hormones detected in 11 bitches when examined during a false pregnancy, and in 13 other bitches with pyometa are also reported. Oestrogen and progesterone concentrations were within normal limits in both of these conditions where single samples were obtained, but the bitch with false pregnancy studied in detail showed a raised oestrogen level during metoestrus. The significance of these results is discussed in relation to previous studies on the aetiology of false pregnancy and pyometra.

Animals↗
PubMedDate not supplied

The relationship between some plasma clearance methods for estimation of glomerular filtration rate in dogs with pyometra.

The purpose of the present study was to compare different pharmacokinetic models for estimation of glomerular filtration rate (GFR) in 50 dogs with pyometra. GFR was estimated by plasma clearance (CLplasma) of iohexol by four 1-compartment methods (CL1c), a 2-compartment method (CL2c), and the trapezoidal method (CLtr). Regression analysis was performed to establish correction formulas for prediction of CLtr from the CL1c values and to find optimal times of sampling. Standardization of clearance values to body weight (kg), body surface area (m2) and extracellular fluid volume (ECFV) was compared by ranking of values. CLtr and CL2c values were similar, whereas CL1c overestimated CLtr. CLtr could be predicted from 2 samples at 2 and 3 hours after injection, using the formula CLtr = 4.52 + 0.84CL1c - 0.00080(CL1c)2 (R2 = .97). Similar relationships were found when sampling at 2 and 4 hours or at 2, 3 and 4 hours after injection, whereas predictions from the 3- and 4-hour estimates were not optimal (R2 = .79). The 2-sample methods for calculating GFR/ECFV generally produced unreliable predictions of the complete curve GFR/ECFV values. For some dogs, the choice of standardization procedure substantially changed the apparent level of renal function relative to other dogs in the study. We conclude that by applying an appropriate correction formula, GFR may be estimated using 2 blood samples at 2 and 3, or 2 and 4 hours after injection of iohexol when renal function is normal or moderately reduced. The method of standardizing the analysis with respect to body size may influence interpretation of the results substantially.

Animals↗
PubMedDate not supplied

Pyovagina and stump pyometra in a neutered XX sex-reversed beagle: a case report.

An 18-month-old, neutered male beagle presented with acute abdominal signs and a suppurative infection of the urogenital tract. Chromosomal sex was female (78, XX), gonadal sex was male (testicles), and phenotypic sex was ambiguous, with evidence of both male and female duct systems. The internal and external genitalia consisted of epididymides, an underdeveloped uterus with an immature spermatic cord, communication between the uterus or cranial vagina and the membranous urethra, a urethrographically male urethra, a hypoplastic os penis, and a hypoplastic penis with hypospadia. Based on these findings and the familial history of a similarly affected litter mate, the dog was diagnosed as having the XX male syndrome with pyovagina and uterine stump pyometra. Radiographic and ultrasonographic investigations are described, and abnormalities of chromosomal sex, gonadal sex, and phenotypic sex are discussed.

Animals↗
PubMed1999

Pyometra in a Siberian Polecat (Mustela eversmanni).

A 2-year-old Siberian polecat (Mustela eversmanni) from a breeding colony presented for ultrasound evaluation for pregnancy. It was paired with a male for 2.75 months and had remained absent of pregnancy signs when it was anesthetized and clinically evaluated. Until this time, the animal had eaten well and shown no outward signs of debility. On palpation, the animal had a fluid-filled tubular structure in the caudal abdomen, consistent in location and size with the uterus. No sign of vaginal discharge was present. Ultrasonography revealed 10 fluid-filled evaginations (approximately 12 mm in diameter) of the uterine horns. A presumptive diagnosis of a fluid-filled reproductive tract and likely reproductive failure was made in light of the animal's history, its clinical signs, and the ultrasound findings. Euthanasia was performed because the animal was nonreproductive and might yield information relevant to the breeding colony as a whole. Necropsy of the polecat revealed a distended fluctuant uterus containing mildly odiferous, thick, yellow-green, purulent material. Histopathology confirmed the diagnosis of pyometra. A pure and heavy growth of Enterococcus fecalis was cultured from the uterine contents. In light of results from routine minimal inhibitory concentration antibiotic sensitivity screening, this isolate was resistant to all antibiotics tested in the standard teaching hospital screen.

Journal Article↗
PubMed2002

Characterization of Escherichia coli strains associated with canine pyometra.

The purpose of this study was to characterize E. coli isolates from canine pyometra which were isolated in pure culture. The E. coli strains were obtained in 128 cases, from 143 animals which were submitted to ovariohisterectomy. Biochemical analysis of all strains examined was possible on separation of 10 primary biotypes. The majority of the strains (87.5%) belonged to biotype 9, 1, 13 and 15. Dulcitol was fermented by 93% of all isolates. Haemolysin and colicin production was found in 53.9% and 26.6% of the strains, respectively. Approximately 37% of strains expressed resistance to two or more antibacterial agents. No plasmid was detected in 4.6% of the isolates. Plasmid profiles of all plasmid-containing isolates revealed plasmid bands corresponding to molecular weight ranging from 1 kb to 160 kb. Many of the strains examined had a single plasmid of 110 kb (46.1%), or two plasmids 110:65 kb (18.8%). Both plasmids appearing alone or in combination with other plasmids were detected in 90.1% of isolates with plasmid content. It was established that among haemolytic, colicinogenic and motile strains, the presence of both plasmids was 91.3, 94.1 and 91.4%, respectively. The appearance of both plasmids among dulcitol-positive and raffinose-negative strains was estimated at 88.2 and 88.3%, respectively. In a group of colicinogenic strains the presence of a single plasmid of molecular weight 110 kb was estimated at 5.9%. When both plasmids were present (profile 110:65), the percentage of these strains was 70.6%.

Animals↗
PubMed1992

[The pathogenesis of the "endometritis-pyometra complex" in the female dog].

Based on investigations in 51 bitches (uteri and ovaries after ovariohysterectomy), suffering from "endometritis-pyometra-complex" (without, n = 38; with, n = 13, hormonal pretreatment), morphologic-functional endometrial characteristics (light microscopy, scanning electron microscopy, enzyme histochemistry, immunohistochemical estrogen receptor analysis) are correlated with ovarian findings, plasma estradiol and progesterone levels as well as microbiological results. The estrous phase of all cycling patients was determined as "diestrus". Plasma estradiol and progesterone concentrations fluctuate within physiological variations. In all cases, not including those, pretreated with progestagen, histological signs of irregular hyperproliferation of uterine glands are obvious, closely related with enzyme histochemical aberrations and atypical endometrial estrogen receptor state. This is interpreted as indicative for prolonged periestrous estrogen induced effects, undergoing different stages of secretory transformation due to the species specific long lasting corpus luteum period. A comparable pathogenesis is supposed deriving from estrogen applications (e. a. after mismating) due to intensified hormonal stimulation and sensibilization of the endometrium, predisposing to ascendant infections by facultative pathogenic bacteria (e. a. E. coli, Streptococcus sp.). Patients without ovarian cyclicity, resulting from progestagen application, exhibit findings, that indicate hormonal imbalances: secretory hypertrophy, irregular regeneration, fibrous atrophy and rigid secretion, resembling those possibly occurring in women after long administration of oral contraceptives.

Animals↗
PubMed2005

Cystic endometrial hyperplasia-pyometra complex in cats. A review.

Presentation of complex cystic endometrial hyperplasia-pyometra is not very common in cats. As in bitches, hormonal influences result in environmental and histological changes in the uterus leading to predisposition to bacterial growth. Its influence on the organism provokes certain clinical signs. Diagnosis and treatment must be fast and aggressive. Depending on the clinical status and queen purpose, it can be both surgical or medical. Both of them offer a high rate of success if the detailed protocols are followed.

Animals↗
PubMed2005

[Secondary peritonitis due to rupture of pyometra in cervical cancer].

Only 8 cases of spontaneous uterine rupture in untreated cervical cancer have been reported in the literature. We present the case of a 52-year-old female, who was admitted to the emergency room due to hypovolemic shock and signs of peritonitis. A 6x4x4 cm cervical tumor was detected at physical exam. At laparotomy 2000 mL of purulent material were found and a 1-cm perforation in the posterior portion of the uterine segment was identified. A subtotal hysterectomy was performed. The patient received antibiotic and support at Intensive Care Unit. Finally, the patient presented ascendant flaccid paralysis and died due to bronchoaspiration. Spontaneous pyometra rupture in untreated cervical cancer is a rare condition and must be considered in postmenopausal women with cervical tumors and peritonitis signs.

Fatal Outcome↗
PubMedDate not supplied

[Acute abdomen secondary to spontaneous uterine rupture associated with pyometra].

A 71-year-old female with rheumatoid arthritis and chronic use of corticosteroids presented to the emergency room with 2 weeks of urinary symptoms, abdominal pain and a mass located in hypo-mesogastrium and both flanks. An X-ray film of the abdomen showed that bowels were displaced by the mass. Laboratory studies showed thrombocytosis (549,000/mm(3)) and leukocytosis (41,800/mm(3)). Several hours after her arrival the patient developed acute abdomen and surgery was indicated. A urinary catheter drained 2100 ml of urine and the abdominal mass was reduced in size but did not disappear. Surgery demonstrated that the urinary bladder covered the fundus and the anterior face of the uterus, where extensive necrosis and a 3-cm perforation were found; 400 ml of foul-smelling pus was drained from the uterine cavity. Due to necrosis, a hysterectomy was performed. The histopathological report indicated necrosis, atrophic cervicitis and endometritis; pus culture developed Escherichia coli and Proteus vulgaris. Despite administration of broad-spectrum antibiotics, the patient developed severe sepsis and died 11 days postoperatively. During a literature review, only one similar case was found. Acute abdomen due to uterine perforation secondary to pyometra and associated with chronic use of corticosteroids is a rare complication.

Abdomen, Acute↗
PubMedDate not supplied

Pyometra and its complications.

The management of animals with cystic hyperplasia-pyometra complex can be a challenge. Careful interpretation of the history and physical examination, radiographic, and clinicopathologic findings will lead to an accurate diagnosis. Appropriate and rapid stabilization of the animal before surgical removal of the uterus will greatly decrease morbidity and mortality. Precise surgical technique when performing ovariohysterectomy will decrease postoperative complications.

Animals↗
PubMed1989

A retrospective study of 40 cases of canine pyometra-metritis treated with prostaglandin F-2 alpha and broad-spectrum antibacterial drugs.

Bitches with pyometra were treated with dinoprost, a prostaglandin F-2 alpha-THAM salt or luprostiol, a synthetic PG analogue and oral broad-spectrum antibacterial drugs. PGF-2 alpha treatment lasted 2-26 days and dosage varied from 26.8 to 258 micrograms/kg. Clinical cure from symptoms was achieved in 33/40 bitches. Of 14 bitches from which the owners opted to breed, 9 eventually produced litters. Long-term complications were anoestrus, recurrence of metritis, failure to conceive and abortion. One or more of these complications were recorded in 9 of 20 bitches for which long term information was available.

Amoxicillin↗
PubMed1989

[Pyometra in an ovariectomized cat following treatment with proligestone].

A nine-year-old cat was presented for a purulent vaginal discharge which had been present for five months. She had been ovariectomised at the age of one; for the last two years she was treated with proligestone because of a dermatological condition. A pyometra was found to be present on laparotomy.

Animals↗