Thyroglossal cyst carcinoma: a case report and review of the literature.
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Epidermal inclusion cyst (EIC) is a recognized cause of an anterior neck mass in children. Controversy exists as to the proper surgical management of an anterior neck EIC: is simple excision adequate treatment, or is a Sistrunk procedure necessary? A retrospective review of the operative logs of the two senior authors (M.M.A., R.F.W.) from 1993 to the present revealed 16 children, ages 6 months to 9 years (mean, 4.5 years), with a diagnosis of anterior neck EIC. An accurate intraoperative diagnosis of an EIC in all cases allowed for a simple excision of the mass rather than a Sistrunk procedure. The final histologic diagnosis was EIC in all 16 patients. Follow-up of these 16 patients for a mean of 4.5 years revealed no recurrences or complications. When the diagnosis of EIC can be made confidently in the operating room, simple excision is an adequate surgical treatment.
Lingual thyroid and intra lingual thyro-glossal cyst are two benign tumours of similar embryological pathogenesis respectively with the arrest in the ectopic position of the thyroid gland during its downward migration and from abnormal persistence of the thyro-glossal tract for the cyst. The occurrence of lingual thyroid is rare 1/100,000 patients and outnumbers the incidence of intra-lingual cyst which represents an estimated 2.1% of the thyro-glossal cysts or fistulas. Both lesions are a rare cause of dysphagia and dyspnoea due to oropharyngeal obstruction, and radionuclide scintigraphy combined with CT and/or MRI will establish the diagnosis. Surgical pharyngotomy with an infra-hyoid approach provides excellent access to the lesions and complete removal of the tumours.
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INTRODUCTION: Thyroglossal duct cysts account for approximately 70% of congenital neck abnormalities. Hoarseness of voice and the extension of the cyst into the larynx are very uncommon. CLINICAL PICTURE: We present a patient with a long history of a large thyroglossal cyst who developed progressive hoarseness of voice. The cyst had protruded into the larynx producing the appearance of a laryngeal neoplasm. Computed tomography (CT) clearly demonstrated the nature of the cyst and its encroachment into the larynx. TREATMENT: This was safely excised with a Sistrunk procedure and a temporary tracheostomy to maintain a secure airway, in view of the possibility of postoperative supraglottic oedema. CONCLUSION: Endolaryngeal extension of the thyroglossal duct cyst is rare. Evaluation of unusual large midline neck masses should include a CT scan. The intralaryngeal component of the cyst can be easily dissected off from the neighbouring structures during dissection in the Sistrunk procedure. A tracheostomy may be needed.
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BACKGROUND: Thyroglossal duct cysts are the most common congenital abnormality of thyroid development. They represent the most common midline neck masses in childhood, however, can be found in adults. Less than 1% of these cases are malignant. Our patient was a 28-yr-old man and his chief complaint was a progressively enlarged paramedian neck mass for a duration of 6 months. RESULTS: We describe the imaging and pathologic characteristics of papillary carcinoma of thyroglossal duct cyst in a 28 years old man and subsequent treatment recommendations. The pathologic examination revealed papillary carcinoma of thyroglossal duct cyst followed by a total thyroidectomy. An axial CT scan of the neck showed a left Paramedian cyst,measuring 15 x 18 mm in the submental region. Neck dissection was done followed by 131I ablation. CONCLUSIONS: Base upon our past and current experience,we recommend that thyroglossal duct cyst with a microscopic focus of papillary carcinoma without cyst wall invasion be managed with Sistrunk procedure along with effective suppressant dose of thyroxine.
The thyroglossal duct cyst is the most common anomaly in thyroid development. However, carcinomas arising in a thyroglossal duct cyst are rare entities. To date, approximately 125 cases have been reported, the majority being papillary thyroid carcinomas. In most cases the diagnosis is established only after excision of a clinically benign thyroglossal duct cyst. The etiology of such tumors remains unclear but de novo origin is generally proposed. Controversies exist in relation to a rational and effective therapeutic approach. A further case of thyroglossal duct papillary carcinoma affecting a 55 year-old Spanish man is presented to highlight the clinicopathological features of this condition. Preoperative computed tomography performed on our patient showed irregular calcium deposits adjacent to the hyoid bone. Cytohistological and immunohistochemical studies showed a papillary thyroid carcinoma with abundant psammoma bodies. Surgery consisted only of a Sistrunk procedure. In view of the prolonged course of papillary carcinoma, long-term follow-up is mandatory.
Two new cases of thyroglossal cyst carcinoma are reported. Such cancers concern rather young women. The diagnosis must be suspected whenever a thyroglossal cyst is associated with cervical adenopathies. The most performing investigation seems to be fine-needle aspiration guided by echography. The malignant diagnosis is made during surgery by frozen section of the lesion, confirmed by histology. Two type of cancer must be distinguished: squamous cell carcinoma and carcinoma of thyroid type. The management of squamous cell carcinoma includes a large resection. For thyroid type carcinomas, total thyroidectomy and bilateral neck dissection are to be considered. Because of up-to-date insufficiency following, it is difficult to make a prognosis.
The thyroglossal duct cyst (TGDC) is the most common congenital neck mass and the second most common of all childhood cervical masses. An anterior midline neck mass presenting before the age of twenty and displaying vertical movement with tongue protrusion and swallowing is characteristic of this lesion. Though concomitant agenesis of the thyroid is extremely rare, documentation of a normal thyroid preoperatively has become a legally protective requirement. Carcinoma in a TGDC is unusual and is rarely detected preoperatively, but a fine needle aspiration is helpful if a malignancy is suspected. Regardless, the treatment is a Sistrunk procedure: excision of the cyst, the tract connecting it to the foramen cecum, and the central portion of the hyoid bone.
Thyroglossal-tract cyst should be included in the differential diagnosis of any mass found in the anterior midline of the neck. A discussion and review of forty-two cases diagnosed between 1970 and 1976 at Wilford Hall USAF Medical Center are presented.
The thyroglossal duct cyst is the most common congenital cyst found in the neck, classically presenting as a paramidline mass in a healthy young adult. Fifty-three cases managed at the Brigham and Women's Hospital and Boston's Beth Israel Hospital over the past 10 years were reviewed. The unique presentation of papillary adenocarcinoma in TGDCs and findings in the elderly population are discussed. These cases represent both diagnostic and therapeutic challenges. The existing literature is correlated with our data, providing a treatise on management.
INTRODUCTION: A thyroglossal cyst (TGC) is an unusual neck lesion that is occassionally diagnosed in a general hospital that mostly attend adult patients. The aim of the current study was to analyze our experience in the management of these lesions. MATERIAL AND METHODS: The records of 43 patients operated on at the Social Security Hospital in Quito (Ecuador) from 1980 to 1998 for a thyroglossal duct cyst or fistula, were reviewed. RESULTS: Distribution was similar in both sexes. Mean age was 23. Thirty-five patients presented with a cystic lesion located in the midline or slightly laterally in the neck, closely related to the hyoid bone; the other 8 patients had a cutaneous fistula at the same place. All of the patients but one, underwent a radical Sistrunk procedure; complications were minor. In 5 patients (12%), a papillary thyroid carcinoma within the TGC was reported at the histologic study. No recurrence developed after a mean 23-month follow-up. CONCLUSIONS: A cyst or a fistula located at the level of the hyoid bone suggest a thyroglossal duct lesion. A papillary carcinoma can rarely occur within the TGC. A Sistrunk procedure is usually curative.