PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “TUBERCULOSIS/experimental”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 127 records · Page 7Linked to original sources
PubMed1961

Effect of vaccines prepared from Histoplasma capsulatum and other yeasts on experimental tuberculosis.

Hedgecock, Loyd W. (Veterans Administration Hospital, Kansas City, Mo.). Effect of vaccines prepared from Histoplasma capsulatum and other yeasts on experimental tuberculosis. J. Bacteriol. 82:115-123. 1961.-Resistance to experimental tuberculosis was enhanced by the injection of a nonviable vaccine prepared from Histoplasma capsulatum in the mycelial phase but not by the organism in the yeast phase. Acquired resistance was established within 7 days or less and usually maintained for at least 29 days. When both mycelium vaccine of H. capsulatum and a vaccine prepared from tubercle bacilli were utilized in vaccination, the results were additive (in terms of acquired resistance) provided that an interval of 3 weeks was maintained between injection of each of the vaccines. Resistance to tuberculosis was also demonstrable 14 days after the injection of nonviable preparations of Brucella abortus and Cryptococcus neoformans, as well as by yeast and mycelial vaccines of Blastomyces dermatitidis and Sporotrichum schenckii. Resistance decreased significantly when the animals were challenged 29 days after vaccination, with the exception of those injected with the yeast phase of B. dermatitidis.

Animals↗
PubMed1962

Fate of tubercle bacilli in lipopoly-saccharide- and BCG-treated mice.

Kochan, Ivan (Baylor University, Dallas, Texas) and Sandra R. Rose. Fate of tubercle bacilli in lipopolysaccharide- and BCG-treated mice. J. Bacteriol. 84:291-294. 1962-The fate of intravenously injected tubercle bacilli in lipopolysaccharide (LPS)- and BCG-treated mice was compared in this study to that in BCG-vaccinated and untreated mice. The potentiality of the treatments in development of "nonspecific immunity" was evaluated by determining numbers of tubercle bacilli in tissue homogenized suspensions rather than by the usually employed survival time of infected animals. The results indicate that during the experimental period the fate of tubercle bacilli of the challenge infection was the same in LPS-treated and heat-killed BCG-treated mice as in the untreated animals. Shortly after infection, the bacillary number increased during a 4-day period; after this time their number declined, reaching about half of the original number by 10 days. The vaccination of animals with live BCG induced good immunity. The same numbers of tubercle bacilli in LPS-and BCG-treated as in normal mice raise doubts as to the efficacy of "nonspecific immunity" in the suppression of bacteria in treated animals.

Animals↗