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At least 127 records · Page 7Linked to original sources

[Problems of the two-stage restoration of flexor tendon injuries. II. Light- and scanning electron microscopy studies of flexor tendon sheaths from hens and from humans].

Authors examined the normal flexor tendon/tendon sheat unit of the toes of the hen and in the zone Verdan 2 of the human hand with light and scanning electron microscope. The fine structure of the synovial membrane was studied with special care. It was found, in accordance with some previous literary data, that the morphology of the hen's and human tenosynovium resemble to each other. The structures of the parietal visceral synovial membranes are described and compared, and the mechanism of the secretion of the synovial fluid is discussed. The results of the present investigations may serve, over the description of the normal anatomical relations, as a comparison to other experiments of two-phase tendon transplantations with the formation of pseudo tendon sheats and also for clinical practice.

Animals↗

Synovial sheath cell migratory response to flexor tendon injury: an experimental study in rats.

PURPOSE: We aimed to investigate the degree of participation of synovial sheath cells in the process of tendon healing by selective cell labeling and direct observation of migrational pathways. METHODS: We designed a novel rat animal model that employed vital dye staining of synovial sheath cells. The flexor digitorum profundus (FDP) tendon was removed from its sheath and vital dye was applied directly to the synovial sheath cells. A window was cut in the removed tendon before being returned to the sheath, thus placing a tendon injury adjacent to the labeled synovial sheath cells. The synovium remained intact at all times, and labeling was confirmed to be localized to the synovium. The migrational response of the synovial sheath cells to the tendon injury was observed by harvesting the tendons at 1, 3, 5, and 7 days (n = 6 for each time period) after injury and assessing tendon response with frozen sections under ultraviolet microscopy. RESULTS: Labeled synovial sheath cells were observed within the substance of the healing tendon 24 hours after injury, with numbers increasing with time for up to 5 days, but decreasing by day 7. CONCLUSIONS: This study confirms that in the rat model synovial sheath cells move into the healing tendon area and then migrate into the tendon core.

Animals↗

Distal biceps tendon injury: MR imaging diagnosis.

PURPOSE: To review the authors' experience with magnetic resonance (MR) imaging of patients with suspected injury of the distal biceps tendon. MATERIALS AND METHODS: Twenty-one patients with clinically suspected injury of the distal biceps tendon were evaluated with MR imaging. Surgical correlation was performed in 15 patients, and long-term clinical follow-up was performed in the remaining six cases. RESULTS: Twelve complete biceps tears, four partial tears, one brachialis rupture, and one ganglion were identified. Axial MR images were more valuable than sagittal images in accurately grading distal biceps tendon injury preoperatively. There was 100% agreement between MR imaging and surgical findings. MR imaging findings led to changes in clinical treatment plans in eight patients (38%). CONCLUSION: MR imaging is useful in the evaluation of patients with suspected distal biceps tendon injury. In particular, axial MR images of the distal biceps insertion are important for accurate grading of the injury.

Adult↗

Prevention of peritendinous adhesions following flexor tendon injury with seprafilm.

Peritendinous adhesions are the most important complication of flexor tendon injury. In this study, Seprafilm was used for the prevention of peritendinous adhesions following flexor tendon repair. Seprafilm Bioresorbable Membrane (Genzyme Corporation, Cambridge, MA) contains sodium hyaluronate and carboxymethyl cellulose. Thirty New Zealand white male rabbits were divided equally into 3 groups. In all groups, the deep flexor tendon of the third finger of the left back foot was cut and repaired by Kessler-Tajima suture technique. In the first study group following tendon repair, Seprafilm was wrapped around the repaired tendon. In the second study group, sodium hyaluronate gel was injected to the operation field after tendon repair. In the control group, no external material was applied to the field. The study groups had better range of motion. Histopathologically, study groups had less adhesions compared with the control groups. As a result, it was concluded that in rabbit the peritendinous adhesions following flexor tendon repairs could be lowered with Seprafilm and hyaluronic acid.

Animals↗

[Flexor tendon injuries in childhood].

Follow-up examinations were performed on 41 children with 51 flexor tendon injuries of the hand. Eighty per cent of the accidents were caused by a cut mostly from broken glass. The results were classified according to Buck-Gramcko. Primary repair (n = 32) was followed in 72% of an acceptable, good or optimal result. Half on these patients had been treated according to Kleinert's method. Secondary repair (n = 19) showed a good or optimal result in 53%. A more detailed analysis gives no evidence that the patient's age or the localisation of the injury are of major importance in achieving good results. However, primary repair, optimal surgical technique and early mobilisation according to Kleinert seem to be essential for an adequate outcome. Therefore, acute flexor tendon injuries in childhood should only be treated under optimal circumstances (e.g., daytime, surgical team). Otherwise, surgical repair should be delayed for 12 to 48 hours until the best circumstances are available. Furthermore, exact surveillance of the postoperative mobilisation is of crucial importance. In patients who need a flexor tendon transplant, early mobilisation according to Kleinert also seems to produce favourable results.

Adolescent↗

Closed tendon injuries of the hand and wrist in athletes.

Closed-tendon injuries of the hand and wrist are very common in the athletic population. Most of these injuries, if seen acutely, can be treated successfully with nonoperative management, although some do require operative treatment. It is those injuries, however, that go undiagnosed until the end of the season, which may result in permanent disability.

Athletic Injuries↗

[Errors and complications in the treatment of the nerve and tendon injuries of the digital flexors].

Retrospective analysis of mistakes and complications occurred during the treatment of 86 patients with the tendons injuries of 157 digital flexors was accomplished. The diagnosis of the tendons injury was established in 94.2% and of the nerves--in 19.6% of patients. In 88.4% of patients the flexing contracture of proximal interphalangeous joints occurred and in the majority of them an active flexing of interphalangeous joints did not restore. The majority of mistakes were caused by traumatic suturing of tendon and prolonged immobilization of the digit in flexing position.

Adolescent↗

The role of antibiotics and timing of repair in flexor tendon injuries of the hand.

The use of antibiotics and the timing of repair in the management of flexor tendon injuries of the hand have never been specifically addressed in the literature. In a retrospective study, 140 patients treated for simple open flexor tendon injuries were evaluated for postoperative wound infection. Patients were divided into four groups on the basis of early or late repair and use of parenteral perioperative antibiotic therapy. No significant differences were found among groups with respect to the low incidence of infectious complications observed. There is no evidence that mandates the use of prophylactic antibiotics and immediate repair in these types of injuries.

Adult↗

[Pathology of acute and chronic tendon injuries].

The load limit of a tendon is expressed by the not linear force/lengthening behavior. It is determined by the interrelation between load and load-bearing capacity. The load of a tendon results from exogenous, endogenous and temporal factors. The property factors and the aging influence the load-bearing capacity of a tendon. Partial ruptures show necrosis, calcification and fiber swelling. The attachment area shows a mineralization of the cartilage zone, a loss of the collagen fibrils and calcifications. The tendon rupture knows extrinsic and intrinsic causes. Primary are micro and macrovascular tendon alterations, usually favour the rupture of tendons.

Achilles Tendon↗

Tendon injury and tendinopathy: healing and repair.

Tendon disorders are frequent and are responsible for substantial morbidity both in sports and in the workplace. Tendinopathy, as opposed to tendinitis or tendinosis, is the best generic descriptive term for the clinical conditions in and around tendons arising from overuse. Tendinopathy is a difficult problem requiring lengthy management, and patients often respond poorly to treatment. Preexisting degeneration has been implicated as a risk factor for acute tendon rupture. Several physical modalities have been developed to treat tendinopathy. There is limited and mixed high-level evidence to support the, albeit common, clinical use of these modalities. Further research and scientific evaluation are required before biological solutions become realistic options.

Genetic Therapy↗

[Cicatrization of tendon injuries].

In the digital canal, the tendon healing has a double origin: the extrinsic one, where the synovial sheet and the paratendinous tissues (paratendon) are invading the tendon wound, permitting the growth of the fibroblasts; the latter produces collagen fibres, which constitute the tendinous callus; the intrinsic one, where the proper cells of the tendon from the epitenon (epitenocytes) and of the endotenon (endotenocytes), also produce fibroblasts, which is a source of collagen fibres. The experimentation has shown, on one hand, that the preservation of the synovial sheet, and, on the other hand, that early mobilisation, as far as the tendon suture has been protected, enhance the intrinsic type of cicatrisation against the extrinsic one, and sofare the functional result.

Cicatrix↗

Early active mobilization for extensor tendon injuries. The Norwich regime.

Dynamic splinting following extensor tendon repair gives better results than static splinting, but involves cumbersome splints and recommended protocols are often complicated. We prefer controlled active mobilization of extensor tendon repairs without dynamic splinting. Six weeks after repair, excellent or good function was obtained in 22 out of 24 simple extensor tendon injuries and in 11 out of 13 complex injuries. The results of this prospective study are comparable with those reported after dynamic splinting; this regime does not require outrigger splintage and is simple to follow.

Adult↗

A collagen prolyl 4-hydroxylase inhibitor reduces adhesions after tendon injury.

Collagen synthesis inhibition potentially can reduce adhesion formation after tendon injury but also may affect cutaneous wound healing. We hypothesized that a novel orally administered collagen synthesis inhibitor (CPHI-I) would substantially reduce flexor tendon adhesions after injury, without any clinically important effect on cutaneous wound healing. The experiments were performed in a rat model with an in-continuity crush injury model in the rat hindfoot flexor tendon to provoke adhesion formation. Assays of dermal collagen production and the rate of healing of an excised wound were performed to assess cutaneous wound healing. Animals in the treatment groups received CPHI-I for 1, 2, or 6 weeks and were assessed at either 2 or 6 weeks. The work of flexion in the injured digit was reduced in the CPHI-I-treated animals compared with control animals, (0.188 J versus 0.0307 J at 2 weeks, and 0.0231 J versus 0.0331 J at 6 weeks) The cutaneous wound healing rate was similar in all animals, but dermal collagen synthesis was reduced in the treated animals. The CPHI-I seems to reduce tendon adhesion, and although collagen synthesis was reduced in cutaneous wounds, CPHI-I did not retard wound healing.

Administration, Oral↗

Complications in tendon injury and surgery.

Despite continued improvement in the methods used to treat tendon injury, problems still arise. Careful attention paid to the details of surgical indications, technique, and postoperative management will prevent or reduce the effects of complications in this difficult area of hand surgery.

Contracture↗

[Suture and functional after care of flexor tendon injuries of the hand by the Kleinert method. Experiences and results following 346 flexor tendon sutures].

The restitution of flexor tendon injuries of the hand according to the tissue-sparing method and functional follow-up treatment indicated by H. Kleinert and his collaborators has become very important in the acute treatment of fresh injuries of the hand. Having applied this method in the treatment of 176 patients suffering from 346 separated flexor tendons in 235 fingers, we are now able to present the limited indication. The surgical proceeding and the complications occurred are described, and the results found in the cases submitted to a follow-up examination (141 patients, 284 resutured flexor tendons in 194 fingers) are presented.

Adolescent↗

Sports-related tendon injuries of the foot and ankle.

Treatment of major tendon injuries is a complex and challenging subject. It is necessary to have a thorough understanding of the mechanism of injury to successfully treat these soft tissue injuries of the foot and ankle.

Achilles Tendon↗