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PubMed1990

[Diagnostic value of the NBT-PABA test in chronic pancreatitis].

The aim of this study was an assessment of the usefulness of indirect test NBT-PABA in evaluation of pancreatic exocrine function in patients from our department treated for chronic pancreatitis. The study was carried out on 67 persons divided in three groups: I - healthy controls (n = 23), II - patients with non-pancreatic diseases (n = 17), III - patients with chronic pancreatitis (n = 27). On the basis of degree of impairment of exocrine function in the secretin-pancreozymin test (SPT), group III was divided in three subgroups: with mild (A), moderate (B), severe (C) exocrine insufficiency. NBT-PABA test was performed using reagents (firm's Hoffman-La Roche) in accordance with the added instructions. In healthy persons (I) average PABA excretion in urine was 62% and lower normal limit was 30%. In patients with non-pancreatic diseases (II) mean urinary PABA excretion was 52% and in the group with chronic pancreatitis (III) markedly lower results were obtained (mean = 26%), p less than 0.05. In order to evaluate diagnostic sensitivity in relation to the degree of pancreatic insufficiency, results of NBT-PABA test were compared with the results of SPT. The results of both tests completely coincided in subgroups III B, and III C, but in subgroups III A, in only 43% of cases it was observed. The specificity of NBT-PABA test (i.e. frequency of normal results in controls and patients with non-pancreatic diseases) was 87%. Our results suggest that NBT-PABA test may be a useful procedure in diagnosis of chronic pancreatitis with severe and moderate exocrine insufficiency. In cases of mild exocrine dysfunction its value is limited.

4-Aminobenzoic Acid↗
PubMed1990

[High lactose content of the Lundh test meal adversely affects the reliability of the ALTAB test].

UNLABELLED: The exocrine pancreatic function was examined in 20 patient without any detectable gastrointestinal disorder. We used 1 g 4(N-acetyl-L-thyrosil) aminobenzoic acid (ALTAB) an Lundh's test meal containing 25 g lactose, and the test was repeated with 3 g lactase (Galantase). The urine was collected for 6 hours to check PABA excretion in urine. Lactose intolerance was diagnosed in 10 patients on the basis of an increase of H2 in the breath at least 15 ppm after Lundh's test meal and/or diarrhoea after test in two hours if this diarrhoea could be prevented by giving Galantase orally. We measured PABA excretion in patients with and without lactose intolerance after Lundh's test meal: 17.8% (SD = 6.7) and 47% (SD = 13) respectively (p less than 0.001), and after Lundh's test meal with Galantase: 34.3% (SD = 12.7) and 43.6% (SD = 10.9) respectively. The increase after Galantase in the group with lactose intolerance was significant (p less than 0.01). CONCLUSIONS: 1. Lactose content of Lundh's test meal causes a considerable lactose load in patients with lactose intolerance. 2. Oral lactase enzyme usually normalises the result of ALTAB test. 3. It is necessary to detect lactose intolerance before use of Lundh's test meal.

4-Aminobenzoic Acid↗
PubMed1977

[Changes in the concentration of catecholamines in the organs of animals with experimental myocardial infarcts under the influence of malaben].

The content of adrenaline and noradrenaline in the tissues of the heart, adrenal glands, spleen and brain of rats was studied in experimental myocardial infarction. A significant decrease in the catecholamine levels was revealed in the tissues. Malaben promoted normalization of the catecholamine tissue content in myocardial infarction. It is suggested that the said effect of malaben is due to its antihistaminic properties.

4-Aminobenzoic Acid↗
PubMed1978

Oral administration of chymotrypsin labile peptide for a new test of exocrine pancreatic function (PET) in comparison and pancreozymin-secretin test.

A new test using N-benzoyl-L-tyrosyl-p-aminobenzoic acid (N-BT-PABA) for an evaluation of exocrine pancreatic function was compared with a pancreozymin-secretin test in 38 subjects. Urinary recovery of PABA, which is absorbed from the intestine and conjugated in the liver after an oral administration of N-BT-PABA, depends mainly on chymotrypsin activity. The recovery rate of PABA in urine decreases in chronic pancreatitis, in which chymotrypsin activity in the duodenal juice is disturbed. The recovery rate of PABA in calcifying chronic pancreatitis was 40.2 +/- 15% and significantly less than 81.2 +/- 7.4% in normal subjects (P less than 0.01). The amount of PABA in urine during eight hours was correlated with parameters of volume output- bicarbonate concentration and amylase output stimulated by injections of pancreozymin and secretin (P-S test). The new test using N-BT-PABA is useful for the evaluation of exocrine pancreatic function in general practice.

4-Aminobenzoic Acid↗
PubMed1979

[Exocrine pancreatic function test by N-benzoyl-L-tyrosyl-p-aminobenzoic acid (author's transl)].

Urinary excretion of p-aminobenzoic acid (PABA) within 6 h after oral administration of N-benzoyl-L-tyrosyl-P-aminobenzoic acid (Peptide-PABA) was measured. In healthy subjects PABA-excretion rate was not different after 150 mg and 1 g Peptide-PABA. PABA-recovery was significantly lower in patients with chronic pancreatitis. Seperation between healthy persons and patients with chronic pancreatic insufficiency was better with 1 g Peptide-PABA.

4-Aminobenzoic Acid↗