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At least 1,261 records · Page 70Linked to original sources
PubMed1990

Light-gazing by visually impaired children.

This study assessed the prevalence and characteristics of light-gazing by all visually impaired children referred during a 2 1/2-year period. Light-gazing (compulsive staring into lights) is one of the many clinical signs of cortical visual impairment (CVI), and in the present study it occurred in 60 per cent of children with CVI. The authors believe that light-gazing by any child with ocular lesions indicates some degree of CNS involvement. Visually impaired children who flicker their fingers in front of their eyes against a light source demonstrate an extension of this compulsive behaviour. This and other studies suggest that blind mannerisms have specific neuropathological substrata and therefore are useful clinical signs.

Blindness↗
PubMed1974

Compulsive gnawing in rats after implantation of drugs into the ventral thalamus. A contribution to the mechanism of morphine action.

1 Implantation of morphine into various parts of the corpus striatum of rats evokes only weak gnawing responses.2 Deposition of apomorphine, morphine or methadone in the region of the nucleus ventralis thalami produces a biphasic response, i.e. general excitation, followed by a period of intense gnawing.3 The effect of both apomorphine and morphine is blocked by chlorpromazine, haloperidol and pimozide. However, pretreatment with alpha-methyltyrosine methyl ester or alpha-methyldopa prevents only the gnawing response to morphine, but not to apomorphine.4 Systemic nalorphine, morphine or pethidine suppress the gnawing response, evoked by thalamic implants of apomorphine or morphine.5 Systemic amphetamine potentiates the effect of thalamic deposits of morphine.6 Compulsive gnawing, following implantation of morphine into the ventral region of the thalamus, probably results from enhanced production and release of catecholamines.

Amphetamine↗
PubMed2006

Multidisciplinary perspectives on impaired control over substance use.

This article presents the proceedings of a symposium held at the June 2005 meeting of the Research Society on Alcoholism in Santa Barbara, California. Impaired control over substance use has long been considered a central feature of alcohol and drug dependence. However, much remains to be learned about the nature of impaired control, the mechanisms by which acute and chronic substance use can lead to impaired control, and how this construct is best assessed in the laboratory and the clinic. The goal of this symposium was to describe current perspectives on impaired control over alcohol and drug use from diverse research areas, to promote future multidisciplinary work in this area. Four speakers described their work on impaired control using human clinical samples (Dr. Chung), animal models (Dr. Miczek), experimental laboratory paradigms in humans (Dr. Fillmore), and neuroimaging studies (Dr. Easdon). Taken together, the talks highlighted the heterogeneous nature of constructs such as impaired inhibitory control, and patterns of impulsive and compulsive substance use. Future clinical and experimental research should attempt to carefully define and measure particular aspects of impaired control and to seek insights from other disciplines.

Alcoholism↗
PubMed1988

Obsessions/counter-obsessions: a construction/reconstruction of meaning.

In this article, obsessions and phobic responses are examined in relation to the maintenance and development of a cross-generational coalition organized by a premise about exclusivity, as well as the specific, idiosyncratic "signature premises" characteristic to each case. It is suggested that the obsession develops when a developmental or situational crisis conflicts with the exclusive relationship definition (that is, coalition). Two forms of intervention for disrupting obsessions--the "conversation" and the "counter-obsession"--are discussed and illustrated. Both interventions conceptualize the obsession as an oscillation between remaining in the coalition and not remaining in the coalition, and both interventions challenge the signature premise that defines the coalition.

Compulsive Behavior↗
PubMed1975

Depression: Predisposing factors.

Factors predisposing to a depressive state had been investigated in a prospective study on a stratified population, accounted for in the preceding article (Nyström & Lindegård (1975a) ). Of the 114 persons seeking psychiatric care during the period of observation, 37 had a depression as the main diagnosis. As compared to their 370 matched controls, these patients showed a significant overrepresentation of psychasthenic traits (subvalidity according to Sjöbring), a tendency to ruminate, shyness in company and lack of endurance, certain asthenic subclinical symptoms such as habitual fatigue and irritability, certain depressive subclinical phenomena, various expressions of anxiousness, all kinds of insomnia, and certain forms of medical care and examinations. The findings can be used for mental hygienic purposes. It can be recommended that the environmental pressure within occupational as well as within private life, should be kept as low as possible, expecially for persons with characteristics shown to indicate mental vulnerability.

Anxiety↗
PubMed1975

Relationship of certain childhood 'traits' to adult psychiatric disorders.

An investigation of 174 adult psychiatric outpatients reporting on nine different difficulties they may have experienced as children suggests certain links between childhood difficulties and lifelong personality traits, as well as adult psychiatric symptomatology. Findings suggest that the childhood traits related to schizophrenia might be manifestations of minimal organic brain dysfunctioning.

Adult↗
PubMed1977

Rape: a sexual deviation.

Clinical work with offenders and victims is cited to support the concept of rape as a sexual deviation, as well as a sexual offense. It is suggested that rape is directed toward the sexual expression and gratification of needs that are not basically sexual, and that it represents a developmental crisis for the offender, which in turn triggers a situational crisis for the victim.

Aggression↗