FDA approval process: safety before speed.
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For the past 10 years France has tried to set up a programme to prevent and survey nosocomial infections and antibiotic resistance. A series of recommendations have been made available for hospitals. Hygiene, nosocomial infections, and resistance to antibiotics are recognized by medical doctors, nurses and administrative people as pertinent and logical quality indicators. Those indicators will probably be proposed by the French agency for accreditation and evaluation. We still need to define which events are preventable, which should be declared to the official agencies, and how to integrate infection control in a broader programme coordinating different systems of surveillance (drug, blood, ...) and risk management. We have also to make those informations available to the public in a more transparent mind.
One hundred twenty 6- to 10-year-olds were administered three measures of speed of processing, three memory span tasks, three tasks assessing phonological skill, and three articulation tasks assessing the speed with which they could say familiar stimuli aloud. Regression analyses revealed that performance on the span tasks was predicted by performance on the phonology and articulation tasks but not by age or performance on the processing speed tasks. Results are discussed in terms of the processes responsible for age-related change in memory span.
This study presents normative data for the Speed and Capacity of Language Processing (SCOLP) testfrom an older American sample. The SCOLP comprises 2 subtests: Spot-the-Word, a lexical decision task, providing an estimate of premorbid intelligence, and Speed of Comprehension, providing a measure of information processing speed. Slowed performance may resultfrom normal aging, brain damage (e.g., head injury), or dementing disorders or may represent the intact performance of someone who always performed at the low end of normal. The SCOLP enables the clinician to differentiate between these possibilities. Adequate age-appropriate norms to differentiate dementia from normal aging do not exist. We present data from 424 older community-dwelling Americans (75-94 years old). The results confirm that information processing speed slows with increasing age. By contrast, increasing age has little effect on lexical decision. Thus, our data suggest that the SCOLP shows promise as a tool to help distinguish between normal aging and the early stages of dementia.
Issues surrounding the discreteness or continuity of cognitive processes have played a major role in experimental psychology, although there has been relatively little work that directly addresses these topics. Nevertheless, there has been a shift away from discrete models and toward continuous ones. The research reported in this article demonstrates discrete processing of information in an anagram task selected because of its similarity to insight problems, which seem subjectively to produce discrete "illumination" during processing. The authors used speed-accuracy decomposition (SAD), a relatively new technique for investigating the time course of information processing. The results of 2 experiments indicate little or no partial information in the anagram tasks, in contrast to previous research with SAD, all of which has revealed partial information. General models of human information processing must therefore be able to account for both patterns.
The main aim of the present study is to compare the efficiency of executive control processes in 24 boys with attention deficit/hyperactivity disorder (ADHD) and 58 normal controls of similar age (between 8 and 11 years). Three reaction time (RT) paradigms were utilized: a dual task that requires coordination of two tasks responses, a shift task that makes it necessary to disengage attention from one task and engage into another one, and a stimulus-response spatial compatibility task that requires participants to inhibit a prepotent response. Another purpose of the study is to examine whether Barkley's (1997) executive dysfunction or Sergeant et al.'s (1999) resource allocation/arousal model best account for the behavioral deficits associated with ADHD. Examination of raw RT data showed significantly poorer performance in ADHD children with respect to age-matched controls on both the higher-level cognitive functions of executive control and on lower-level abilities (e.g., speed of processing) of all tasks of this study. However, using proportional transformations of raw RT data, we could demonstrate that, in addition to differences in processing speed, also executive control processes were significantly impaired in children with ADHD.
This study reports two mental multiplication experiments that were designed to measure age differences in central and peripheral processes. Experiment 1 varied task type (verification vs production), and Experiment 2 varied exposure duration (presentation until response, 600 ms, and 300 ms) on a production task. Neither experiment showed evidence of age differences in central processes (e.g., retrieval speed); however, there was some evidence of a peripheral-process (e.g., encoding) decrement for older adults. Specifically, there were no Age X Problem Size interactions for either experiment. Experiment 2 revealed decreasing age differences as problem difficulty increased. Indeed, for the 300-ms exposure duration, there were no age differences in RT or error rate. These results suggest that the magnitude of age differences in central processing speed are significantly less extreme than are age differences for peripheral processing speed for this type of mental arithmetic task. Also, older adults, in general, may have a higher skill level for basic fact retrieval in mental arithmetic than do young adults.
UNLABELLED: The success of cell salvage varies depending upon how many shed red blood cells (RBC) are captured from the surgical wound and returned to the patient. Here, the authors hypothesized that pneumatic disk (PD) processing might provide better RBC recovery when compared with traditional Latham bowl (LB) techniques. Comparison of the speed of processing, product hemoglobin and salvage efficiency was made between the two machines when their reservoirs were loaded with blood volumes ranging from 100 mL to 1000 mL. The PD provided a consistent hemoglobin concentration (21.7 +/- 0.8 g/dL; mean +/- SD), whereas the LB provided varying hemoglobin concentrations dependent upon the starting volume (range, 2.9 +/- 0.7 g/dL to 18.4 +/- 0.8 g/dL). The PD also provided more efficiency versus full LB only (79.4% versus 56.3%; P = 0.001). When all RBCs were processed, the LB technology provided statistically larger degrees of RBC return (79.4% versus 83.6% for the PD versus LB, respectively; P < 0.001). The processing speed of the LB was faster at all starting volumes. In conclusion, for small volumes of blood loss where a full LB is not achieved, the PD will return a larger number of cells with a more consistent hemoglobin per volume of blood processed. IMPLICATIONS: This study compared two types of cell salvage equipment. Pneumatic disk processing may offer advantages over traditional devices when small blood loss is anticipated.
Decline of cognitive function with age may be due, in part, to atherosclerotic changes. The aim of the present study was to determine the relative contribution of vascular risk factors to cognitive functioning in a non-clinical sample of men. Cognitive tests were administered to 400 independently living men aged 40-80 years. The measures included short-term memory, speed of information processing, verbal and visual long-term memory, word fluency, cognitive flexibility, an estimate of verbal intelligence, and general cognitive status. Systolic blood pressure, serum cholesterol, glucose levels, smoking, alcohol intake, body mass index, homocysteine and peak expiratory flow rate were entered as independent variables into a multiple regression model, after adjustment for age and education. Hierarchical regression analyses revealed independent contributions of the combination of vascular risk factors in explaining the observed variance in performance on tests of cognitive functioning targeted at information processing capacity and speed and general cognitive status. Of the individual predictor variables, alcohol intake and homocysteine levels were significantly associated with processing capacity and speed, and peak expiratory flow rate was significantly associated with general cognitive status. Our results indicate that the combination of several independent vascular risk factors predicts performance on cognitive tests of information processing capacity and speed in a population-based sample of middle-aged and elderly men.
It has often been proposed that faster central nervous system (CNS) processing amounts to a smarter brain. One way to index speed of CNS processing is through the assessment of brain oscillations via electroencephalogram (EEG) recordings. The dominant frequency (peak frequency) with which neuronal feedback loops in an adult human brain oscillate in a relaxed state is around 10 cycles/sec, but large individual differences exist in peak frequencies. Earlier studies have found high peak frequencies to be associated with higher intelligence. In the present study, data from 271 extended twin families (688 participants) were collected as part of a large, ongoing project on the genetics of adult brain function and cognition. IQ was assessed with the Dutch version of the Wechsler Adult Intelligence Scale (WAIS-IIIR), from which four dimensions were calculated (verbal comprehension, working memory, perceptual organization, and processing speed). Individual peak frequencies were picked according to the method described by Klimesch (1999) and averaged 9.9 Hz (SD 1.01). Structural equation modeling indicated that both peak frequency and the dimensions of IQ were highly heritable (range, 66% to 83%). A large part of the genetic variance in alpha peak frequency as well as in working memory and processing speed was due to nonadditive factors. There was no evidence of a genetic correlation between alpha peak frequency and any of the four WAIS dimensions: Smarter brains do not seem to run faster.
The speed and volume requirements of MEDLARS necessitate the use of high-speed data processing equipment, including paper-tape typewriters, a digital computer, and a special device for producing photo-composed output. Input to the system is of three types: variable source data, including citations from the literature and search requests; changes to such master files as the medical subject headings list and the journal record file; and operating instructions such as computer programs and procedures for machine operators. MEDLARS builds two major stores of data on magnetic tape. The Processed Citation File includes bibliographic citations in expanded form for high-quality printing at periodic intervals. The Compressed Citation File is a coded, time-sequential citation store which is used for high-speed searching against demand request input. Major design considerations include converting variable-length, alphanumeric data to mechanical form quickly and accurately; serial searching by the computer within a reasonable period of time; high-speed printing that must be of graphic quality; and efficient maintenance of various complex computer files.