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Science to practice: what is new about detecting emphysema?

Through the use of diffusion-weighted 3He MR imaging, Fain et al in this issue of Radiology demonstrated the potential for detection of early emphysema in the lungs of healthy smokers. The technique possibly could become an important tool for understanding the pulmonary processes that occur with emphysema, for implementing treatment before clinical symptoms occur, and for monitoring the effect of treatment.

Diffusion Magnetic Resonance Imaging↗

A commentary on the NRC report "Science and judgment in risk assessment".

This article provides a brief overview of the report "Science and Judgment in Risk Assessment," prepared by a Committee of the National Research Council/National Academy of Science in response to a U.S. Environmental Protection Agency request mandated by the Clean Air Act Amendments of 1990 (CAAA-1990). The report critiques EPA's current approaches for characterizing human cancer risks from exposure to chemicals and offers recommendations for the conduct of future cancer risk assessments, especially those required in implementing the CAAA-1990 provisions which are concerned with hazardous air pollutants. The report offers specific recommendations that address the role of default options, data needs, methods and models, uncertainty, variability, and the aggregation of data. A cross-cutting theme of the report is the use of an iterative approach in which screening assessments with limited data and, of necessity, default options used in the absence of specific scientific data may be performed initially followed by subsequent assessments, as needed, in which increasing amounts of data are developed and incorporated. In some instances, the specific data on a given chemical or pollutant source will replace conservative default options used in earlier assignments. The report includes two authored appendices that address issues related to the use of default options and their replacement by specific scientific information. One appendix by Finkel advocates a principle of "plausible conservatism" for choosing and altering default options and in making cancer risk estimates. A second appendix by McClellan and North advocates the full use of scientific information in the risk assessment process. This article gives major attention to the key aspects of the NRC/NAS report, especially those dealing with the use and replacement of default options. The default options and the extent to which the options are replaced with specific science have major impact on the final quantitation of cancer risk for exposure to chemicals.

Air Pollution↗

[Evaluating quality and effectiveness in the promotion of health: approaches and methods of public health and social sciences].

Health promotion and health education have often been limited to evaluation of the effectiveness of actions and programmes. However, since 1996 with the Third European Conference on Health Promotion and Education Effectiveness, many researchers have become interested in "quality assessment" and new ways of thinking have emerged. Quality assurance is a concept and activity developed in industry with the objective of increasing production efficiency. There are two distinct approaches: External Standard Inspection (ESI) and Continuous Quality Improvement (CQI). ESI involves establishing criteria of quality, evaluating them and improving whatever needs improvement. CQI views the activity or service as a process and includes the quality assessment as part of the process. This article attempts to answer the questions of whether these methods are sufficient and suitable for operationalising the concepts of evaluation, effectiveness and quality in health promotion and education, whether it is necessary to complement them with other methods, and whether the ESI approach is appropriate. The first section of the article explains that health promotion is based on various paradigms from epidemiology to psychology and anthropology. Many authors warn against the exclusive use of public health disciplines for understanding, implementing and evaluating health promotion. The author argues that in practice, health promotion: -integrates preventive actions with those aiming to maintain and improve health, a characteristic which widens the actions of health promotion from those of classic public health which include essentially an epidemiological or "risk" focus; -aims to replace vertical approaches to prevention with a global approach based on educational sciences; -involves a community approach which includes the individual in a "central position of power" as much in the definition of needs as in the evaluation of services; -includes the participation and socio-political actions which necessitate the use of varied and specific instruments for action and evaluation. With the choice of health promotion ideology, there exist corresponding theories, concepts of quality, and therefore methods and techniques that differ from those used until now. The educational sciences have led to a widening of the definition of process to include both "throughput and input", which has meant that the methods of needs analysis, objective and priority setting and project development in health promotion have become objects of quality assessment. Also, the modes of action and interaction among actors are included, which has led to evaluation of ethical and ideological aspects of projects. The second section of the article discusses quality assessment versus evaluation of effectiveness. Different paradigms of evaluation such as the public health approach based on the measurement of (epidemiological) effectiveness, social marketing and communication, and the anthropological approach are briefly discussed, pointing out that there are many approaches which can both complement and contradict one another. The author explains the difference between impact (the intermediate effects, direct or indirect, planned or not planned, changes in practical or theoretical knowledge, perceptions, and attitudes) and results (final effects of mid to long term changes such as changes in morbidity, mortality, or access to services or cost of health care). He argues that by being too concerned with results of programmes, we have often ignored the issue of impact. Also, by limiting ourselves to evaluating effectiveness (i.e. that the expected effects were obtained), we ignore other possible unexpected, unplanned and positive and negative secondary effects. There are therefore many reasons to: -evaluate all possible effects rather than only those lined to objectives; -evaluate the entire process rather than only the resources, procedures and costs; -evaluate the impact rather than results; -evalu

Anthropology↗

In situ stabilisation/solidification: project lifecycle.

The successful application of any remedial technology, including stabilisation/solidification, begins with the site investigation. Following a review of the data collected during the site investigation, a treatability study (TS) and pilot study (PS) are prerequisites to full-scale implementation as they show the effects and delivery of binders to the soils, the geochemistry of the soils, and binder dosages necessary for the existing geology. Further, evaluating the data gathered during the TS and PS can help in accurately estimating and executing full-scale operations. Invariably, deviations from the TS and PS regarding soil characteristics and soil chemistry may exist, but the experience gained via the TS and PS aids in making decisions when faced with new and unexpected conditions in the field. This paper will discuss the execution of typical TS and PS applications and their implementation for full-scale treatment. Because the long-term performance durability of design mixes and technology applications are not generally addressed in remediation, post-remediation monitoring and sampling data must be made available to the public to advance the science and art of stabilisation/solidification. As a first step in advancing this technology, this paper follows the lifecycle of stabilisation/ solidification projects from the site investigation through the completion of full-scale work. A 10-year post-remediation sampling event also evidences the long-term viability of the technology.

Aluminum Silicates↗

Modeling transmission of directly transmitted infectious diseases using colored stochastic Petri nets.

In order to improve our understanding of directly transmitted pathogens within host populations, epidemic models should take into account individual heterogeneities as well as stochastic fluctuations in individual parameters. The associated cost results in an increasing level of complexity of the mathematical models which generally lack consistent formalisms. In this paper, we demonstrate that complex epidemic models could be expressed as colored stochastic Petri nets (CSPN). CSPN is a mathematical tool developed in computer science. The concept is based on the Markov Chain theory and on a standard well codified graphical formalism. This approach presents an alternative to other computer simulation methods since it offers both a theoretical formalism and a graphical representation that facilitate the implementation, the understanding and thus the replication or modification of the model. We explain how common concepts of epidemic models--such as the incidence function--can be easily translated into an individual based point of view in the CSPN formalism. We then illustrate this approach by using the well documented susceptible-infected model with recruitment and death.

Animals↗

Hearing nurses' voices through reflection in women's studies.

Women's studies is an elective offered through the Faculty of Nursing and Health Sciences, Griffith University-Gold Coast, Australia, and is attended primarily by female nursing students. The main objective of this subject is for students to gain an improved understanding and application of feminist perspectives. One of the teaching/learning strategies we have recently implemented was that of reflective processes that allowed us to explore how students' thoughts were changed during the course of the subject. As a result of engaging with women's studies, students also described how in the future they may incorporate an awareness of feminist theories and frameworks into personal and occupational roles. This paper describes the common themes identified from this learning process and offers a set of empowering stories from female nursing students.

Curriculum↗

The art and science of incorporating cost effectiveness into evidence-based recommendations for clinical preventive services.

As medical technology continues to expand and the cost of using all effective clinical services exceeds available resources, decisions about health care delivery may increasingly rely on assessing the cost-effectiveness of medical services. Cost-effectiveness is particularly relevant for decisions about how to implement preventive services, because these decisions typically represent major investments in the future health of large populations. As such, decisions regarding the implementation of preventive services frequently involve, implicitly if not explicitly, consideration of costs. Cost-effectiveness analysis summarizes the expected benefits, harms, and costs of alternative strategies to improve health and has become an important tool for explicitly incorporating economic considerations into clinical decision making. Acknowledging the usefulness of this tool, the third U.S. Preventive Services Task Force (USPSTF) has initiated a process for systematically reviewing cost-effectiveness analyses as an aid in making recommendations about clinical preventive services. In this paper, we provide an overview and examples of roles for using cost-effectiveness analyses to inform preventive services recommendations, discuss limitations of cost-effectiveness data in shaping evidence-based preventive health care policies, outline the USPSTF approach to using cost-effectiveness analyses, and discuss the methods the USPSTF is developing to assess the quality and results of cost-effectiveness studies. While this paper focuses on clinical preventive services (i.e., screening, counseling, immunizations, and chemoprevention), the framework we have developed should be broadly portable to other health care services.

Advisory Committees↗

When are students most at risk of encountering academic difficulty? A study of the 1992 matriculants to U.S. medical schools.

The authors carried out the study reported here to assess which variables are most predictive of the risk of medical students' experiencing academic difficulties and to assess when these students are most susceptible to encountering those difficulties. The entering class of 1992 was chosen as the study population because it was the first matriculating class in which the majority of students (88%) applied to medical school with scores from the revised Medical College Admission Test (MCAT), first implemented in 1991. The primary event of interest in this study was the first occurrence of one of the following events because of academic difficulty: withdrawal, leave of absence, dismissal, or delay of graduation date. The variables examined were MCAT scores undergraduate science GPA, undergraduate institutional selectivity, undergraduate major, racial-ethnic background, sex, and age upon entering medical school. Survival analysis was used to assess which variables were most predictive of the risk of academic difficulty and when students with different characteristics were most at risk. The results of the survival analysis indicated that (1) while the risk and timing of academic difficulty varied across the groups studied, a majority of the students who experienced academic difficulty eventually graduated from medical school and (2) students with non-science undergraduate majors did not have a greater risk of academic difficulty. The results confirm previous findings that increased risk of academic difficulty is associated with low MCAT scores, low science GPA, low undergraduate institutional selectivity, being a woman, being a member of a racial-ethnic underrepresented minority, or being older. The study findings can be generalized to help in early identification of students who are more likely to be at risk of experiencing academic difficulty. Knowing when these students are more likely to be at risk can help medical schools develop targeted remedial and enrichment programs. Further studies are needed to investigate school-related factors associated with risk.

Adult↗

Introducing nutrition education.

A significant increase in nutrition knowledge followed a short-term nutrition education series among junior high school students in two local schools. This increase in knowledge was measured by pretests and posttests and was determined to be statistically significant. Ideally, nutrition education should be instituted in early childhood rather than delaying until adolescence; but the educational process must begin somewhere regardless of income, cultural, social or economic practices or level of education. Until the process can be implemented at an early age, every opportunity must be taken to reach individuals.

Achievement↗

Massage and aromatherapy massage: nursing art and science.

This article begins by reviewing the place of complementary therapies in palliative care from the perspective of UK professional organizations, namely the Nursing and Midwifery Council (NMC) (formerly the United Kingdom Central Council for Nursing, Midwifery and Health Visiting (UKCC)) and the British Medical Association (BMA). It then reviews recent research on the use of massage and aromatherapy massage in palliative care and comments on their credibility and implications, thereby addressing nursing science. The art of nursing is explored through four case histories where massage was used intuitively when words were difficult or seemed inadequate. To conclude, by focusing on the therapies provided by a UK hospice, there is consideration of the practicalities of implementing massage and aromatherapy massage in a specialist palliative care unit.

Adolescent↗

Improving client satisfaction and clinic revenues through systems simulation: the case of a university nutrition clinic.

A client-responsive strategy was developed based upon input from nutrition clinic personnel, administrators, and clients. Systems simulation identified the strategy most likely to lead to client satisfaction while also meeting the needs of clinic personnel and administration. The strategy was subsequently introduced into the clinic and patient satisfaction and operating revenues were monitored following implementation. Both measures of impact demonstrated significant improvement.

Ambulatory Care Facilities↗

Evolving technology thwarts aim of cost analyses.

Paucity of financial data obscures the risks and rewards of telemedicine and may have public policy implications. Study findings suggest potential private benefits to hospitals that implement the service, but tracking and analysis are critical.

Accounting↗

Introduction to the Special Section on Cognitive Science and Psychological Assessment.

This introduction to the Special Section on Cognitive Science and Psychological Assessment begins with a brief overview of cognitive science and its interface with the clinical assessment of cognitive functioning. Concepts and themes permeating the articles in this section are then taken up. Included are cognitive-model architectures and model parameters, differential emphasis on efficiency versus content of cognition, and implementation of stochastic and dynamical aspects of cognitive processes. Selected distinguishing attributes of the respective contributions are highlighted.

Cognition Disorders↗

The role of the general practitioner and the dietitian in patient nutrition management.

There is mounting evidence that nutrition plays an important role in the aetiology and management of many diseases affecting Australians. Nutrition counselling provides a strategy for not only reducing patient suffering, but also for reducing the health care costs associated with these illnesses. At the forefront of providing nutrition counselling to Australians are General Practitioners (GPs) and Dietitians. Australian data shows that GPs encounter many patients with the chronic diseases that have nutrition in their aetiology and management. Although this presents opportunities to provide nutrition counselling, overseas literature suggests that often nutrition counselling opportunities are not taken up. At present, there is little evidence to support whether this problem exists in Australia, or the magnitude of the problem. Whilst evidence suggests there are barriers for GPs in providing nutrition counselling, there is conflicting evidence on how these influence the GP's decision to provide such counselling. Overseas studies have also identified barriers for GPs to refer to dietitians to provide nutrition counselling, however there is no evidence to identify whether these barriers exist in Australia. Whilst various strategies have been implemented to aid in the provision of effective nutrition management to the Australian public, there is little evidence on the efficacy of these. Research is needed in the above areas if effective patient nutrition management is to be implemented in Australia.

Australia↗

Breastfeeding promotion and protection in the Czech Republic.

The purpose of the article is to present the National Breastfeeding Promotion Programme in the Czech Republic in the course of the last decade. It summarizes the main strategies, education and training activities of the National Breastfeeding Committee, its collaboration with the Government, Parliament, IBFAN and UNICEF. The article reviews the relevant studies on infant feeding which illustrate the increase of the prevalence of breastfeeding in the course of the 1990's and reflect the effect of the programme. Recent negotiations with the Ministry of Health have outlined the implementation of the WHO global strategy for infant and young child feeding in the Czech Republic.

Breast Feeding↗

Poison center rotation for health science students.

There is a conspicuous absence of formal clinical toxicology education in health science programs. Routinely, clinical toxicology is not a required or elective course, yet an estimated 5% of emergency department visits and hospital admission are toxicologically related. In response to this need, a didactic and practicum program in clinical toxicology was developed and implemented within the operating framework of a regional poison information center. This model is based on a four week rotation, and participants include 5th year pharmacy students, 4th year medical students, 2nd and 3rd year emergency medicine residents. The didactic portion includes formal lecture on a core curriculum and self-directed study of select current review articles. With one-on-one supervision by the faculty member, the student participates in initial poison information consults, formulating toxicity assessments, implementing therapy recommendations, and follow-up calls. Participants present two seminars on toxicology topics during the rotation. At the conclusion of the rotation the participant is given a written multiple-choice examination to assess their knowledge of a required core of information. The examination is then reviewed with the participant to strengthen any obvious deficits in their learning experience.

Curriculum↗