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Cutting through the obstacles and resurrecting the promise of gene therapy.

Gene therapy is a promising biomedical discipline that could potentially lead to new treatments and perhaps long-term curative effects for a plethora of diseases including hereditary disorders, cardiovascular and neurological diseases, cancer, diabetes and even infectious or autoimmune diseases. These diseases affect millions of people worldwide and the development of effective and safe gene-based drugs obviously represent a tremendous market potential. Convincing evidence continues to emerge from clinical trials demonstrating that gene therapy can be effective in patients suffering from a limited number of different diseases. Nevertheless, as with any emerging new biomedical discipline, gene therapy has also faced a number of setbacks, and there have been concerns regarding the safety of some gene delivery approaches, however, these hurdles are not insurmountable. Gene transfer technologies are improving rapidly and have led to the development of new and more efficacious gene delivery approaches with fewer side effects. The success of gene therapy is still highly dependent upon the continuous development of improved gene delivery technologies, the progress of which should hopefully and ultimately cure diseases that are refractory to current treatment paradigms.

Gene Transfer Techniques↗

Diversity in the executive suite. Modern Healthcare salutes the Top 25 Minority Executives in Healthcare, who say their colleagues still face numerous obstacles.

With minorities expected to swell to half of all U.S. residents by 2050, the healthcare C-suite needs to reflect that diversity to better meet patients' needs. We honor the Top 25 Minority Executives in Healthcare, who have found ways to help others along the way. "I've learned to navigate within a system and work with people for the greater good, says Christopher Mosley, left, who made the Top 25.

Administrative Personnel↗

Increase in obstacles to abortion: the American perspective in 2004.

This paper summarizes the barriers to abortion in the United States, including the determination of viability, cost and insurance coverage, waiting periods and parental consent laws, restrictions on medical abortion, provider unavailability, harassment, targeted regulation of abortion providers laws, refusal clauses, anti choice laws, and the fetal legal rights movement. Federally subsidized abstinence-only sex education, which has not been shown to decrease the rate of unintended pregnancy (and may increase it), has expanded and access to a full range of contraceptive options has been limited. The policies of the current and past administrations have strengthened barriers to abortion both at home and abroad. Preserving women's right to choose will require improved public and professional education, legislative and legal efforts, and advocacy by physicians and other health care professionals.

Abortion, Legal↗