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PubMed2005

Dynamics of assessments of time intervals by patients with heroin addiction.

The perception of 12-sec time intervals time by patients with heroin addiction was assessed in 10 trials with precision of up to 0.1 sec. A total of 82 patients with heroin addiction were studied in the withdrawal and post-withdrawal periods. The results obtained in patients were comparable to measurements obtained in 52 healthy subjects. The time interval estimated by patients as an overall group was shorter than that in healthy subjects during the first two days of in-patient treatment (during development of withdrawal syndrome); the 12-sec period was reproduced accurately at 5-6 days, after which the period was exceeded; perception of time again became accurate on days 15-16 (the post-withdrawal period). Changes in the subjective perception of time were found to depend on the duration of addiction and the individual characteristics of interhemisphere brain asymmetry.

Adolescent↗
PubMed2004

An empirical analysis of milk addiction.

We show the estimable rational addiction model tends to yield spurious evidence in favor of the rational addiction hypothesis when aggregate data are used. Direct application of the canonical model yields results seemingly indicative that non-addictive commodities such as milk, eggs, and oranges are rationally addictive. Monte Carlo simulation demonstrates that such results are likely to obtain whenever the commodity under scrutiny exhibits high serial correlation, or when even a small amount of the variation in prices is endogenous, or when overidentified instrumental variables estimators are used, or when commonly imposed restrictions are employed. We conclude that time-series data will often be insufficient to differentiate rational addiction from serial correlation in the consumption series.

Animals↗
PubMed2001

Theories of drug craving, ancient and modern.

This paper reviews the principal theoretical models of drug craving and provides some directions for future research. The main models are classified broadly into three categories: (1) phenomenological models; based on clinical observation and description; these have been influential in classification systems of addictive disorders and in the development of pharmacological therapies; (2) conditioning models: based on conditioning theory; these have been influential in the development of cue exposure treatments; (3) cognitive theories; based on cognitive social learning theory: these have been influential in the development of cognitive therapies of addiction. It is concluded that no one specific theory provides a complete explanation of the phenomenon of craving. However, theories of craving grounded in general theories of human behaviour offer greatest promise, and generate more specific and testable research hypotheses. Theories that do not require craving to be present for relapse to occur have more empirical support than those that provide simplistic causal explanations. The cue-reactivity model shows promise in the exploration of the relationship between craving and relapse. However, further attention to the phenomenology of craving could help to advise the future measurement and study of drug craving, particularly in the context of research in which drugs are available to human subjects, with adequate ethical safeguards. There is a need for further study of the temporal dynamics of craving and consensus in the field on the most appropriate methods of measurement. Finally, new psychotherapies such as cue exposure and pharmacotherapies that aim to attenuate drinking behaviour, such as naltrexone and acamprosate, provide opportunities to improve understanding of the nature and significance of craving. However, the relatively uncritical assumption that craving is the underlying basis of addiction and represents the most appropriate target for treatment is challenged.

Behavior, Addictive↗
PubMed2004

[Addictions in young people with different backgrounds].

The research, carried out among young people of selected groups from different environments estimated the occurrence of addictions, the degree of danger of nicotine addiction, alcoholism and pharmacomania. A questionnaire of the interview standardized into smokers and non-smokers was used among students. Evaluation of addiction to alcohol, drugs and nicotine among young people treated at the Toxicology Ward was done on the basis of clinical material of toxemias. Addiction to psychoactive substances among students amounts to on average of 30%. Most of the smokers would like to drop the habit. Frequency of addictions among young people hospitalized in the clinic is much higher in comparison with the group occupationally passive or working, especially in big cities. Acute toxemias among addicts, especially in the group of alcohols, drugs and psychotropic drugs were quite serious. Toxic coma accompanying toxemia is a danger to health and life.

Adolescent↗
PubMed2005

Ontogeny of additive and maternal genetic effects: lessons from domestic mammals.

Evolution of size and growth depends on heritable variation arising from additive and maternal genetic effects. Levels of heritable (and nonheritable) variation might change over ontogeny, increasing through "variance compounding" or decreasing through "compensatory growth." We test for these processes using a meta-analysis of age-specific weight traits in domestic ungulates. Generally, mean standardized variance components decrease with age, consistent with compensatory growth. Phenotypic convergence among adult sheep occurs through decreasing environmental and maternal genetic variation. Maternal variation similarly declines in cattle. Maternal genetic effects are thus reduced with age (both in absolute and relative terms). Significant trends in heritability (decreasing in cattle, increasing in sheep) result from declining maternal and environmental components rather than from changing additive variation. There was no evidence for increasing standardized variance components. Any compounding must therefore be masked by more important compensatory processes. While extrapolation of these patterns to processes in natural population is difficult, our results highlight the inadequacy of assuming constancy in genetic parameters over ontogeny. Negative covariance between direct and maternal genetic effects was common. Negative correlations with additive and maternal genetic variances indicate that antagonistic pleiotropy (between additive and maternal genetic effects) may maintain genetic variance and limit responses to selection.

Aging↗
PubMed2006

Does a failed quit attempt reduce cigarette consumption following resumption of smoking? The effects of time and quit attempts on the longitudinal analysis of self-reported cigarette smoking intensity.

California Tobacco Survey respondents were asked the intensity of their cigarette smoking 1 year previously and at the time of the survey. Respondents reported a generally lower smoking intensity at survey time compared with 1 year previously. Multivariable statistical models on the change in smoking intensity in the past year were fitted to assess the effects of low-tar cigarette use, a quit attempt in the past year, smoking intensity 1 year previously, and demographic variables (age, education, income, and race). The most important predictor of change in intensity was the intensity 1 year previously. The next most important predictor was whether a quit attempt had been made in the previous year. The demographic variables also were found to have a significant effect, although their effects were of smaller magnitude. Low-tar cigarette use was not a significant predictor of change in intensity in multivariable analysis. The effect of a quit attempt on the reduction in intensity of smoking suggests that periods of cessation may reduce the intensity of smoking and the level of addiction for several months following relapse. Consequently, it may be important to control for cessation activity in studies comparing exposures from conventional tobacco products to exposures from new products that purport to offer lower harm.

Attitude to Health↗
PubMed1993

Young adult offspring and their families of origin: cohesion, adaptability, and addiction.

This study examined relationships among measures of family functioning (FACES-II), number of family addictions, and risk of alcoholism (Short Michigan Alcoholism Screening Test, SMAST) in a college sample. Multiple regression analyses indicated that the number of family addictions and the additively combined FACES-II scales each predicted scores on the SMAST. Thus, addictions in the family contribute to offspring alcoholism both directly, through their presence, and indirectly, through family functioning. Information on the history of a wide range of family addictions and on the functioning style of the family of origin can be valuable in assessing and addressing addiction risk.

Adaptation, Psychological↗
PubMed2003

Irritability following abstinence from cocaine predicts euphoric effects of cocaine administration.

This study evaluated the association between negative affective symptoms during initial abstinence and euphorigenic response to experimentally administered cocaine. Cocaine-dependent individuals achieved 5 days of abstinence in a hospital setting. Forty milligrams of cocaine was given intravenously on the fifth day of abstinence, and participants were asked to rate the subjective effects produced by the drug. The associations between irritability, self-reported depression, and the subjective "high" produced by cocaine were evaluated. Increased levels of irritability and depression both correlated positively and statistically significantly with heightened response to experimentally administered cocaine as indexed by self-reported subjective "high." The positive association between irritability and subjective "high" remained after controlling for self-reported depressive symptoms. The opponent process model predicts that increased levels of negative affect should be associated with diminished euphoric response to cocaine; however, the opposite was observed. If these findings are replicated in a larger sample, then it may be necessary to reconsider the applicability of the opponent process model to cocaine addiction in humans.

Adult↗
PubMed1993

Addiction as a social construction: a postempirical view.

I examined the role of society and psychology as its agent in the growing problem of addiction in America. The social institutions of a given society establish and maintain a character structure unique to a particular era. The quality of that character is reflected in its inhabitants' individual psychological natures as either health or pathology. I examined the philosophical roots of psychology, its theories and their effect on perpetuating current erroneous beliefs about addiction, and psychology's role in finding real solutions.

Alcoholism↗
PubMed2004

Acute toxic effects of club drugs.

This article summarizes the short-term physiological toxicity and the adverse behavioral effects of four substances (GHB, ketamine, MDMA, and Rohypnol) that have been used at latenight dance clubs. The two primary data sources were case studies of human fatalities and experimental studies with laboratory animals. A safety ratio was calculated for each substance based on its estimated lethal dose and its customary recreational dose. GHB (gamma-hydroxybutyrate) appears to be the most physiologically toxic; Rohypnol (flunitrazepam) appears to be the least physiologically toxic. The single most risk-producing behavior of club drug users is combining psychoactive substances, usually involving alcohol. Hazardous drug-use sequelae such as accidents, aggressive behavior, and addiction were not factored into the safety ratio estimates.

Alcohol Drinking↗
PubMedDate not supplied

Improving continuity of care in a public addiction treatment system with clinical case management.

Philadelphia attempted to expand the access to and continuity of addiction treatment by focusing on the 15% of patients who received multiple, detoxification-only (MDO) treatments each year. Clinical Case Managers at five detoxification centers encouraged MDO patients to continue care following detoxification in methadone, residential, or outpatient rehabilitation, and sustain improvements, and they recommended opening detoxification access for additional patients as well. System administrative information was available for one year prior and three years during the intervention. Counts of unduplicated patients within each year and measures of the length and type of treatment episodes determined the intervention effects. Records from a sub-sample of 100 MDO patients were examined to assess specific changes in system utilization. Over three years, 890 MDO patients were case managed and had received assessment, referral, and transport to health care and sober living. The sub-sample of case-managed MDO patients showed a 55% reduction in detoxification-only admissions, a 70% increase in use of rehabilitation, and a twenty-day increase in the average length of stay per episode. Though there are noted limitations in the evaluation design, the findings are consistent with the view that individual case management of MDO patients may improve the clinical appropriateness and administrative efficiency of public addiction treatment.

Adult↗