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PubMed2000

[Population based studies on the incidence of chronic respiratory symptoms and lung function in children from Krakow].

The epidemiologic study has been carried out in the sample of 1048 schoolchildren at the age of 11 years in order to assess the impact of various chronic respiratory symptoms on lung function. The symptoms included chronic dry cough, chronic phlegm, attacks of cough at nights, breathlessness, wheezing independent from respiratory infections or colds, attacks of wheezing at nights, and attacks of dyspnea with wheezing. Lung function was measured by the following spirometric indices: FEV1/FVC%, FEV1, FEF25-75% and PEFR. Multiple regression analysis showed strong statistical inverse relationship between FEV1/FVC% and FEF25-75% and attacks of wheezing at night and attacks of dyspnea with wheezing or asthma diagnosed by physician. The separate analysis performed in the subsample of children without asthma and asthmatic symptoms (attacks of wheezing at night and attacks of dyspnea with wheezing) found out that only chronic dry cough was related significantly to the lower values of FEV1 and PEFR in the children.

Child↗

PubMed2006

Vitamin A and lung function in CF.

Laboratory evidence suggests that vitamin A could have a protective effect on respiratory status in patients with cystic fibrosis (CF). This study shows a significant correlation between serum vitamin A concentrations and every aspect of lung function tested in 38 patients with stable CF. Serum vitamin D and vitamin E concentrations were also measured but did not show any significant correlations with lung function.

Adolescent↗

PubMed2000

Bronchial reactivity to cigarette smoke; relation to lung function, respiratory symptoms, serum-immunoglobulin E and blood eosinophil and leukocyte counts.

STUDY OBJECTIVES: The aim of the study was to investigate the relationship between the immediate bronchial response to inhaled cigarette smoke [cigarette smoke bronchial reactivity (CBR)] and lung function, respiratory symptoms and markers of allergy and inflammation. DESIGN, PARTICIPANTS AND MEASUREMENTS: This cross-sectional study included 98 smokers. Their lung function and reversibility to inhaled terbutaline was measured. Their clinical history was obtained, an allergological examination was done, and bronchial reactivity to methacholine and inhaled cigarette smoke was measured. Questionnaires about respiratory symptoms, smoking history and drug usage were completed and a blood sample was obtained. Participants were divided into three groups: with asthma, chronic bronchitis and persons without asthma or chronic bronchitis (the respiratory healthy). RESULTS: Forced expiratory volume in 1sec (FEV1) residuals were independently related to the % fall in FEV1 after 12 cigarette smoke inhalations (DFEV%) in all participants (P<001), in asthmatic smokers (P<0.01) and in smokers with chronic bronchitis (P<0.05). In smokers with asthma and chronic bronchitis FEV1 residuals explained 51% and 13% of the variation in DFEV%, respectively, but only 8% (P<0.05) and 1% (N.S.) of the variation in the methacholine bronchial reactivity. In the total population the presence of wheeze (P<0.01), attacks of breathlessness (P<0.05) and daily expectoration (P<0.001) were related to higher DFEV% readings. Serum immunonoglobulin (ES-IgE) was independently related to DFEV% in all participants (P<0.01), in smokers with chronic bronchitis (P<0.01) and in the respiratory healthy (0.05<P<0.1). The eosinophil blood count was, in similar analyses, related to DFEV% in all participants (P<0.05) and in persons with chronic bronchitis (0.05<P<0.1). CONCLUSION: Cigarette smoke bronchial reactivity was strongly associated to actual FEV1 in smokers with asthma and bronchitis, overall to most respiratory symptoms and in smokers without asthma to S-IgE. Cigarette smoke bronchial reactivity might be suitable to test further how cigarette smoke influences the pathophysiology of the bronchial wall, especially in smokers with asthma.

Adult↗

PubMed2004

Functional evaluation of emphysema using diffusion-weighted 3Helium-magnetic resonance imaging, high-resolution computed tomography, and lung function tests.

PURPOSE: To assess the emphysematous enlargement of distal airspaces and concomitant large and small airway disease using diffusion-weighted Helium-magnetic resonance imaging (MRI), high-resolution computed tomography (HRCT), and lung function tests (LFT). METHODS: Seven patients were examined after single lung transplantation (LTx) and 1 before double LTx for various forms of emphysema. Five patients after double LTx served as controls. Patients were assessed by Helium-MRI (apparent diffusion coefficient [ADC]), HRCT (mean lung density [MLD], emphysema index [EI]), and LFT. RESULTS: Transplanted lungs: mean ADC = 0.17 cm/s, MLD = -848 H, EI = 22%. Emphysematous lungs: mean ADC = 0.33 cm/s, MLD = -922 H; EI = 54%. Good correlations were found between ADC and MLD (r = 0.6), EI (r = 0.8), intrathoracic gas volume (r = 0.7), forced expiratory volume in 1 second (r = 0.7), and forced expiratory flows (r = 0.7). In contrast, HRCT only provided moderate correlations with LFT (EI: r = 0.5; MLD: r [le] 0.4). CONCLUSION: In this initial study, He-MRI yield good correlations with HRCT and agrees better than HRCT with the functional characterization of emphysema regarding hyperinflation, large and small airway disease as provided by LFT.

Female↗

PubMed1989

[Bronchoalveolar lavage fluid findings and lung function in psittacosis].

Three familial cases of psittacosis presented with fever and arthralgia. The first case was a 54-year-old man whose chest X ray film showed ground glass appearance in left S6. Ga scintigraphy revealed stronger accumulation in left lower lobe. Bronchoalveolar lavage fluid was examined in 2 of the cases and activated helper T cells were increased in both of the cases. Lung function was studied in all 3 cases in different phases. Their basic lung functions were different, but there was a similar change in courses, i.e. decrease of small airway flow and the increase of RV. These findings suggest that lung lesion of psittacosis may be related to allergic reaction and diffuse lung disease.

Adult↗

PubMed1994

Anthropometry and lung function of 10- to 12-year-old Bolivian boys.

Anthropometric measurements of 23 HAHSES, 44 HALSES, 43 LAHSES, and 28 LALSES boys (see Introduction to this Supplement) are presented here. They include body height (H), body weight (BW), upper arm circumference (UAC), and skinfold thickness taken at four locations. From these measurements, body fat, lean body mass, and body mass index (BMI = BW/H2) were calculated. The degree of maturation was assessed according to Tanner, orchidometry, and by quantification of testosterone in saliva. Lung function data include: vital capacity (VC), forced expired volume per 1 s (FEV1), functional residual capacity (FRC), residual volume (RV), and total lung capacity (TLC). The results show enhanced lung volumes in both HA groups in comparison to LA groups, with HALSES boys having the greatest increase, even though the LSES boys were significantly smaller compared to the HSES boys at both altitudes and their growth was delayed by approximately 2 years. From the anthropometric data it appears that physical growth of prepubertal boys is dependent on SES but not on high-altitude exposure. We tentatively conclude that chronic hypoxia per se does not affect physical growth in prepubertal boys in an Andean environment and that development of lung function is accelerated in relation to linear growth as has been suggested by other authors (15).

Altitude↗

PubMed1984

Subclinical effects of smoking. Physiologic comparison of healthy middle-aged smokers and nonsmokers and interrelationships of lung function measurements.

Measurements of ventilatory function, distribution of ventilation, diffusing capacity, and lung mechanics were made on healthy middle-aged smokers and nonsmokers drawn from a randomly selected population in order to assess the effects of cigarette smoking and the interrelationships of the several indices of lung function. Although very few subjects had abnormal function, there were significant differences in most indices of function between smokers and nonsmokers. For the total group studied, there were significant correlations between various indices of function. A significant proportion of the variance in diffusing capacity and in diffusing capacity per liter of lung volume can be accounted for by an index of lung recoil which may, in turn, be related to size of terminal air spaces.

Adult↗

PubMed1992

Lung function measurements in awake compared to sleeping newborn infants.

Tidal breathing flow-volume loops were recorded in 19 healthy newborn infants when awake and asleep. This preceded and followed measurements of passive lung mechanics (by single breath occlusion). Our aim was to evaluate possible differences in lung function due to state of arousal or any influence of the occlusion technique. Expiratory volumes and flow rates were larger in awake than in sleeping infants before, but not after occlusion measurements. In sleeping, but not in awake infants, expiratory volumes and flow rates were higher after occlusion than before. Respiratory system compliance was significantly larger in sleeping than awake infants, while differences in respiratory system resistance and airway plateau pressure did not reach a significant level. Our results show that lung function can be measured in awake as well as sleeping infants, but differs significantly according to their arousal state, and whether tidal expiratory flow measurements are performed before or after airway occlusion measurements. Separate reference values for awake and sleeping infants may, therefore, be required. Marked intrasubject variability was found in the occlusion measurements, and criteria for acceptable measurements need to be defined.

Arousal↗

PubMed1992

Effects of thromboxane synthase and cyclooxygenase inhibition on PAF-induced changes in lung function and arachidonic acid metabolism.

PAF was administered as an intravenous bolus (0.1 micrograms/kg) to eight chronically instrumented awake sheep. The effects of pretreatment with an inhibitor of cyclooxygenase (meclofenamate) on PAF-induced changes in lung function were compared to those observed with a specific inhibitor of thromboxane synthase (DP1904). Each animal was studied four times in varied order: PAF alone, PAF + DP1904, PAF + meclofenamate, and DP1904 alone. Saline alone (control), DP1904 alone, and meclofenamate alone did not cause changes in any of the measured variables. DP1904 and meclofenamate significantly attenuated the PAF-induced fall in lung compliance, elevation in peak pulmonary artery pressure, and increased lung lymph flow. Both drugs abolished the PAF-induced increases in lung lymph thromboxane B2 concentrations. Meclofenamate, but not DP1904, blocked the rise in lymph 6-keto-PGF1 alpha. Although meclofenamate blocked the rise in lymph PGE2, DP1904 resulted in levels 2.7 times higher than PAF alone. We conclude that: (1) inhibition of thromboxane synthase is as effective as inhibition of cyclooxygenase in attenuating PAF-induced changes in lung function, and (2) thromboxane synthase inhibition results in augmented production of PGE2 following PAF administration in vivo.

Animals↗

PubMed2000

Inhaled nebulized adrenaline improves lung function in infants with acute bronchiolitis.

Beta2-agonists have questionable symptomatic effect in infants with acute bronchiolitis, whereas inhaled, nebulized racemic adrenaline, commonly used in Norway, appears (clinically) to be effective. Limited lung function observations during acute bronchiolitis exists, and less for assessing possible effects inhaled adrenaline. In this preliminary study, tidal flow-volume loops were measured in 16 infants with acute bronchiolitis and seven healthy controls (mean age 7.9 and 4.4 months, respectively), with repeated measurements 15 min after inhaled nebulized racemic adrenaline (4 mg diluted in 2 ml saline) in nine bronchiolitis patients. The ratio of time to reach peak tidal expiratory flow to total expiratory time (tPTEF/tE) was significantly reduced in children with acute bronchiolitis (mean, 95% CI) (0.08, 0.05-0.10) compared to controls (0.31, 0.18-0.43), with significant improvement after inhaled racemic adrenaline 0.19 (0.13-0.25), parallel with significant clinical improvement. Lung function (tPTEF/tE) was reduced in infants with acute bronchiolitis and improved significantly after inhaled racemic adrenaline. Inhaled racemic adrenaline is potentially an important alternative for treating infants with acute bronchiolitis.

Acute Disease↗

PubMed1984

Respiratory symptoms and lung function in a group of solderers.

A total of 1611 women working in a large electronics company were interviewed using a modified version of the Medical Research Council's questionnaire on respiratory symptoms, and their lung function was tested using a Vitalograph dry wedge spirometer. When the prevalence of symptoms was compared using the chi 2 test among four occupational groups--namely, solderers, ex-solderers, non-solderers, and office workers--few significant differences were found. The group of ex-solderers tended to have a greater prevalence of symptoms than the other three groups. Forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) were measured, and when these were compared for smokers, the office workers were found to have a greater mean age adjusted FVC and FEV1 than the three other groups. The pattern was less distinct for non-smokers. When duration of exposure to solder fumes was allowed for, differences in lung function were more suggestive of being related to smoking habit than occupational exposure to solder fumes.

Adult↗

PubMed2004

Using liquid ventilation to improve lung function in patients with respiratory distress syndrome: a comprehensive review of the literature.

This article is a review of the research findings on the subject of liquid ventilation and how it has shown to improve lung function in patients with respiratory distress syndrome. An overview of the physiology behind the success of liquid ventilation, including current research outcomes, is presented. The literature documenting research data was obtained through an internet search of articles published from 1962 to 2002. Respiratory distress syndrome is a potential complication for any patient that has suffered damage to the lungs. It continues to carry a significantly high mortality rate, in spite of multiple conventional treatments currently in use. The latest clinical research has led to the development of a new treatment for the syndrome called liquid ventilation, whereby chemicals called perfluorocarbons are used as a medium to transport vital respiratory gases into and out of the lungs. Research on animal and human subjects has shown that liquid ventilation therapy can improve lung function in certain patients with severe pulmonary dysfunction when conventional treatments have failed.

Animals↗

PubMed2000

High frequency ventilation trial. Nine year follow up of lung function.

The high frequency ventilation (HIFI) trial for hyaline membrane disease (HMD) showed no advantage of high frequency over conventional ventilation in pulmonary outcomes after 24 months. The present study tested the hypothesis that there would be no significant difference in childhood lung function between patients who had been ventilated by either method. Thirty-two children aged 8-9 years who completed the HIFI trial were asked to return for pulmonary function tests. For purposes of analysis, the patient population was divided according to mode of ventilation, and by diagnosis of bronchopulmonary dysplasia (BPD) or HMD. Results were compared to those of 15 term-born, matched, controls. Lung function tests showed a mildly obstructive pattern in prematurely born children. More severe obstruction was seen in those children who had physician-diagnosed asthma or who had used bronchodilators in the past. The prevalence of mild obstructive pattern on pulmonary function testing in preterm infants with HMD or BPD was similar in those who received high frequency vs. conventional ventilation. Factors other than the mode of ventilation exert greater influence on pulmonary outcome in survivors of lung disease of prematurity.

Albuterol↗

PubMed1988

[The effect of hyperosmolar mixed solution of sodium chloride and beta 2 sympathomimetics on lung function in asthmatic children and adolescents].

In infants paradoxical bronchoconstriction instead of dilatation was observed after beta-2-agonist inhalation and was thought to be due to an osmolality and pH change of the inhalation mixture in the nebuliser cup. Therefore, we measured lung function in 11 asthmatic children and adolescents, and in a healthy control group, after inhalation of a hyperosmolar beta-2-NaCl mixture. 0.5 ml salbutamol in 1.5 ml physiological saline (2 ml total) or 1.0 ml salbutamol in 3 ml NaCl, respectively, were nebulised for 10 minutes. Following nebulisation the patients were asked to inhale for 5 minutes from the residue in the cup. Before and after this procedure lung function was measured. All the patients were symptom-free and were tested on two days at the same time after being off medication for at least 24 hours. Baseline osmolality of the mixtures at the start of nebulisation was 235 +/- 5.0 mmol/kg and increased in the cup after 10 minutes to 322 +/- 7.5 mmol/kg for the low initial volume (2 ml) and to 261 +/- 2.0 mmol/kg for the high initial volume (4 ml). After the 5 minutes' inhalation session osmolality rose further to 460 +/- 25.0 mmol/kg (2 ml) and 278 +/- 1.0 mmol/kg (4 ml), respectively. In all asthmatic children significant changes (p less than 0.01, paired t-test) before and after inhalation occurred (decrease of airway resistance, increase of FEV1, increase of maximal expiratory flows at 75%, 50% and 25% of vital capacity, increase of peak expiratory flow. Thoracic gas volume, residual volume and vital capacity remained unchanged). No changes were seen in the control group.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

PubMed2001

[Changes in lung function in patients with newly-diagnosed tuberculosis during treatment with short courses of controlled drug therapy].

In 54 new cases of tuberculosis, VC, FVC, FEV1, FEV1/VC%, PEF, MEF25, MEF50, MEF75, PaO2, PaCO2 were measured before, during, and after a short-term intensive controlled chemotherapy. Lung function improved in 57.4% of patients and deteriorated in 22.2%. There was a combination of better and worse lung function in 7.4%. The direction of functional changes depended on the form of tuberculosis, the extent of a tuberculous process, the duration and efficiency of chemotherapy.

Adolescent↗

PubMed2005

Childhood IQ and social factors on smoking behaviour, lung function and smoking-related outcomes in adulthood: linking the Scottish Mental Survey 1932 and the Midspan studies.

OBJECTIVE: To investigate the associations of childhood IQ and adult social factors, and smoking behaviour, lung function (forced expiratory volume in one second; FEV(1)), and smoking-related outcomes in adulthood. DESIGN: Retrospective cohort study. METHOD: Participants were from the Midspan prospective studies conducted on Scottish adults in the 1970s. The sample consisted of 938 Midspan participants born in 1921 who were successfully matched with their cognitive ability test results on the Scottish Mental Survey 1932. RESULTS: Structural equation modelling showed that age 11 IQ was not directly associated with smoking consumption, but that IQ and adult social class had indirect effects on smoking consumption via deprivation category. The influence of IQ on FEV(1) was partly indirect via social class. Gender influenced smoking consumption and also IQ and social class. There was a 21% higher risk of having a smoking-related hospital admission, cancer, or death during 25 years of follow-up for each standard deviation disadvantage in IQ. Adjustment for adult social class, deprivation category, and smoking reduced the association to 10%. CONCLUSION: Childhood IQ was associated with social factors which influenced lung function in adulthood, but was not associated directly with smoking consumption. In future studies, it is important to consider other pathways which may account for variance in the link between childhood IQ and health in later life.

Adult↗

PubMed2003

Reduced lung function and risk of atrial fibrillation in the Copenhagen City Heart Study.

Chronic obstructive pulmonary disease has been associated with a high frequency of arrhythmias. Few studies have analysed the role of reduced lung function in predicting atrial fibrillation (AF). The aim of the present study was to investigate the relationship between forced expiratory volume in one second (FEV1) and risk of first episode of AF in a prospective study. Data from 13,430 males and females without previous myocardial infarction, who participated in the Copenhagen City Heart Study, were analysed. New AF was assessed at re-examination after 5 yrs and by hospital admission for AF during a period of 13 yrs. Multivariate analyses were used with adjustment for cardiopulmonary risk factors. There were 62 new cases of AF at 5-yr follow-up (0.58%) and 290 cases (2.20%) diagnosed at hospitalisations. Risk of new AF at re-examination was 1.8-times higher for FEV1 between 60-80% of predicted compared with FEV1 > or = 80% after adjustment for sex, age, smoking, blood pressure, diabetes and body mass index. The risk of AF hospitalisation was 1.3-times higher for FEV1 between 60-80% and 1.8-times higher for FEV1 < 60% compared with FEV1 > or = 80%, when additional adjustment was made for education, treatment with diuretics and chest pain at activity. The authors conclude that reduced lung function is an independent predictor for incident atrial fibrillation.

Adult↗

PubMed2001

[Effect of surgical positioning and spinal anesthesia on lung function].

BACKGROUND: Various surgical positions, e.g., lithotomy, prone, or head-down positions influence respiratory mechanics. The aim of the present paper was to investigate whether particular surgical positions (lithotomy, lithotomy with head-down tilt, prone, prone with a roller placed under the abdomen) as well as spinal anaesthesia in lithotomy position impair the pulmonary function to a greater extent than supine position and whether they have to be considered as increasing the perioperative risk in elderly patients and patients with ventilatory disorders. METHODS: In two separate experimental series, we examined a) the influence of the surgical positions on the pulmonary function in 45 subjects (25 without and 20 with ventilatory disorders) and b) the effects of spinal anaesthesia in 25 urologic patients (9 without and 16 with ventilatory disorders). Static and dynamic lung function parameters were determined. Under spinal anaesthesia, the arterial O2 saturation and the end-expiratory partial pressure of CO2 were measured additionally. RESULTS: The most pronounced lung function decrease occurred with the transition from seated to supine position. Lithotomy and prone positions impaired the respiratory function only slightly. In elderly persons and in patients with ventilatory disorders, the spirometric changes tended to be stronger than in young persons, but were not considered to increase the perioperative pulmonary risk. A combination of lithotomy position and spinal anaesthesia did likewise not remarkably impair the respiratory function. CONCLUSIONS: Lithotomy and prone positions as well as spinal anaesthesia are not considered to be an additional risk factor for pulmonary function.

Adult↗