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Twin study of central auditory processing disorder.

We compared auditory, cognitive, and language test results in a pair of dizygotic twins, one of whom showed symptoms of central auditory processing disorder (CAPD). Results highlight the importance of testing binaural function. In particular, electrophysiologic measures of dichotic listening effectively demonstrated the auditory-specific nature of this child's listening problems. The importance of a thorough and comprehensive evaluation of children suspected of CAPD is stressed.

Audiometry, Pure-Tone↗

Temporolimbic or transcallosal connections: where is the primary lesion in schizophrenia and what is its nature?

A critique of the article by Bogerts on the temporolimbic system theory is presented. Schizophrenia is conceived as arising as a component of the diversity of interhemisphric (callosal) connectivity associated with the evolution of language, a process that occurred through a genetic change (the speciation event) that allowed the hemispheres to develop with a degree of independence. Language and psychosis thus have a common evolutionary origin. The anatomical changes can be considered as a boundary component of the anatomical variation that is characteristic of the species.

Biological Evolution↗

Pragmatic versus form-based accounts of referential contrast: evidence for effects of informativity expectations.

Characterizing the relationship between form-based linguistic knowledge and representation of context has long been of importance in the study of on-line language processing. Recent experimental research has shown evidence of very rapid effects of referential context in resolving local indeterminacies on-line. However, there has been no consensus regarding the nature of these context effects. The current paper summarizes recent work covering a range of phenomena for which referential contrast has been shown to influence on-line processing, including prenominal and post-nominal modification, focus operators, and intonational focus. The results of the body of work suggest that referential context effects are not limited to situations in which the linguistic form of the utterance directly specifies the point of contact with context. Rather, context effects of a pragmatic, Gricean nature appear to be possible, suggesting the relationship between linguistic form and context in rapid on-line processing can be of a very indirect nature.

Cognition↗

Diagnostic follow-up to consultant physicians by computer feedback.

A computer follow-up system has been developed which automatically prepares follow-up summaries for consultant physicians. This makes it possible to provide reliable feedback of diagnostic information in place of the traditional but haphazard word-of-mouth process. This system has been tested initially for surgical and autopsy-pathology follow-up of neuroradiology and nuclear medicine consultations using report conclusions available from the UCLA Natural Language Information Storage and Retrieval System.

Computers↗

Is language lateralization in temporal lobe epilepsy patients related to the nature of the epileptogenic lesion?

PURPOSE: Early acquired lesions are considered to be a risk factor for atypical language lateralization in epilepsy, whereas developmental lesions are not. Hippocampal sclerosis (HS) can be understood as an early, acquired lesion, whereas developmental tumors (DT) are thought to originate in utero. We assessed whether language lateralization differs between these groups of temporal lobe epilepsy patients. METHODS: We used 3-Tesla functional MRI (fMRI) to assess 41 patients (16 DT, 25 HS) and 50 controls, performing a noun-verb-generation task. fMRI data were processed by using SPM2. A laterality index (LI) was calculated based on the number of activated voxels in left- and right-sided frontal lobe language areas. Atypical lateralization was considered if the index was < or = 0.2. RESULTS: Patients had a lower LI (0.42 +/- 0.5) than controls (0.6 +/- 0.3; p < or = 0.05), but the LI was not different between DT (0.44 +/- 0.5) and HS patients (0.43 +/- 0.4; p = 0.9). The frequency of atypical lateralization was increased in patients (27%) compared with controls (8%) but was similar in both patient groups (DT, 31%; HS, 24%). HS patients had an earlier onset and longer duration of epilepsy and a higher frequency of significant antecedent events (p < or = 0.05). CONCLUSIONS: Patients with TLE demonstrate a deviation toward atypical language lateralization. However, language lateralization was not different between patients with presumably acquired lesions compared with patients with developmental pathology. This suggests that the nature of the temporal lobe lesion does not influence overall language lateralization.

Adult↗

The leading-edge: the significance of sentence disruptions in the development of grammar.

This research explored the relationship between sentence disruptions and the length and complexity of sentences spoken by children developing grammar. The study was cross-sectional in design and used samples of naturalistic, conversational interaction between 26 typically developing children (ages 2;6 to 4;0) and a primary caregiver. The active, declarative sentences produced by these children were coded for the presence of disruption, length in morphemes and words, and clausal complexity. The results showed that, for the majority of the children, disrupted sentences tended to be longer and more complex than fluent sentences. The magnitude of the differences in length and complexity was positively correlated with the children's grammatical development, as measured by the Index of Productive Syntax. It was also found that differences between the average complexity of disrupted versus fluent sentences increased with grammatical development even when sentence length was held constant. As grammatical development proceeded, disrupted sentences were more apt to be sentences on the "leading-edge" of the child's production capacity. Although these more advanced grammatical structures are part of the child's grammatical competence, the child cannot produce these sentences without an increased risk of processing difficulty. The results are congruent with proposals concerning the incremental and procedural nature of adult sentence production.

Child Language↗

Spontaneous number representation in semi-free-ranging rhesus monkeys.

Previous research has shown that animals possess considerable numerical abilities. However, this work was based on experiments involving extensive training, a small number of captive subjects and relatively artificial testing procedures. We present the results of experiments on over 200 semi-free-ranging rhesus monkeys using a task which involves no training and mimics a natural foraging problem. The subjects observed two experimenters place pieces of apple, one at a time, into each of two opaque containers. The experimenters then walked away so that the subjects could approach. The monkeys chose the container with the greater number of apple slices when the comparisons were one versus two, two versus three, three versus four and three versus five slices. They failed at four versus five, four versus six, four versus eight and three versus eight slices. Controls established that it was the representation of number which underlay their successful choices rather than the amount of time spent placing apple pieces into the box or the volume of apple placed in the box. The failures at values greater than three slices stand in striking contrast to other animal studies where training was involved and in which far superior numerical abilities were demonstrated. The range of success achieved by rhesus monkeys in this spontaneous-number task matches the range achieved by human infants and corresponds to the range encoded in the syntax of natural languages.

Animals↗

[Probability and strategy: an event-related potential study of processing syntactic anomalies].

Syntactic ambiguities requiring additional processing usually elicit positive going waveforms with onset latencies between 300 and 600 ms in the event-related potential (ERP). It is still unclear to what extent these components can be viewed either (a) as language specific in nature or (b) as members of the domain-unspecific P300 family of components. The present study investigates this question by means of probability manipulations applied to German sentences with subject-object ambiguities. Non-preferred object-subject (OS) word order requires structural revisions whereas the initially preferred subject-object (SO) word order does not. In the present experiment, the proportions of OS and SO structures were varied across experimental blocks (i.e., .25/.75 vs. .75/.25). The data of 20 participants reveal that ERP components were predominantly influenced when the subjects were explicitly informed about the actual proportions before each single block. In this case an early frontal positive component at about 400 ms and a subsequent posterior positivity were elicited by rare sentence structures irrespective of word order, suggesting that sentence processing was under strategic control. Conversely, participants that were not informed about sentence proportions showed larger positivities to the unpreferred OS sentences. Probability manipulations did not affect this pattern significantly. The data suggest that positivities evoked by syntactic ambiguities respond differently to probability manipulations than the P300 component.

Adult↗

Convergence of complex cognitive abilities in cetaceans and primates.

What examples of convergence in higher-level complex cognitive characteristics exist in the animal kingdom? In this paper I will provide evidence that convergent intelligence has occurred in two distantly related mammalian taxa. One of these is the order Cetacea (dolphins, whales and porpoises) and the other is our own order Primates, and in particular the suborder anthropoid primates (monkeys, apes, and humans). Despite a deep evolutionary divergence, adaptation to physically dissimilar environments, and very different neuroanatomical organization, some primates and cetaceans show striking convergence in social behavior, artificial 'language' comprehension, and self-recognition ability. Taken together, these findings have important implications for understanding the generality and specificity of those processes that underlie cognition in different species and the nature of the evolution of intelligence.

Animal Communication↗

The reading Miscue Inventory. A promising approach to diagnosis of the reading-disabled.

Reading Miscue Inventory--RMI--opens avenues of dealing with the reading process in a scientific and process-oriented fashion which can lead to further refining of the theoretical base upon which reading is founded as well as providing diagnostic information for use by reading specialists. From such information, reading specialists are able to develop remediation on an individualized basis. Appropriate materials, procedures, and practices are developed from the qualitative analysis of miscues rather than from the information provided by standardized achievement or diagnostic reading tests. In sights are gained regarding a child's ability to use the complex process of reading. Remediation of disability, at the appropriate place in the process, is based on assumptions regarding the interrelationship of thought and language. Reading specialists are looking to psycholinguists for theoretical bases upon which to build models of the reading process. Qualitative miscue analysis is based upon recently proposed notions of the psycholinguistic nature of reading. Common concepts and understanding regarding reading and assessment of reading disability may facilitate learning disability teams in their diagnostic and remedial procedures. Until recently, these discussions have occurred mainly in reading-related research and in education circles, but learing disabilities teams are beginning to participate in the refining and clarifying of these notions of assessment and remediation. Regardless of the eventual outcome, the necessity for considering these views is basic to a fuller understanding of ways in which learning-disabled children may be helped.

Child↗

Deviant neurophysiological responses to phonological regularities in speech in dyslexic children.

Developmental dyslexia is strongly associated with a phonological deficit. Yet, implicit phonological processing (in)capacities in dyslexia remain relatively unexplored. Here we use a neurophysiological response sensitive to experience-dependent auditory memory traces, the mismatch negativity (MMN), to investigate implicit phonological processing of natural speech in dyslexic and normally reading children. In a modified passive oddball design that minimizes the contribution of acoustic processes, we presented non-words that differed by the degree of phonotactic probability, i.e. the distributional frequency of phoneme combinations in a given language. Overall morphology of ERP responses to the non-words indicated comparable processing of acoustic-phonetic stimulus differences in both children groups. Consistent with previous findings in adults, normally reading children showed a significantly stronger MMN response to the non-word with high phonotactic probability (notsel) as compared to the non-word with low phonotactic probability (notkel), suggesting auditory cortical tuning to statistical regularities of phoneme combinations. In contrast, dyslexic children did not show this sensitivity to phonotactic probability. These findings indicate that the phonological problems often reported in dyslexia relate to a subtle deficit in the implicit phonetic-phonological processing of natural speech.

Acoustic Stimulation↗

Knowing the meaning, getting the point, bridging the gap, and carrying the message: aspects of discourse following closed head injury in childhood and adolescence.

Pragmatic communication or discourse was studied in 33 children and adolescents following closed head injury. Three-quarters of the sample was impaired on at least one of four discourse tests (knowing the alternate meanings of ambiguous words in context; getting the point of figurative or metaphoric expressions; bridging the inferential gaps between events in stereotyped social situations; and producing speech acts that express the apparent intentions of others). Resolution of ambiguity was correlated with word fluency and verbal domain knowledge, but not with object naming; understanding of metaphor was correlated with verbal domain knowledge, but not with literal sentence comprehension or with the formation of analogies; making inferences was correlated with working memory capacity but not with social knowledge; and producing speech acts was not correlated either with sentence construction or with social knowledge. These associations and dissociations reveal some of the correlates of impaired discourse processing after closed head injury in childhood and adolescence, as well as bearing on theoretical questions concerning the nature of normally developing discourse processes.

Adolescent↗

Familiarity effects in visual comparison tasks and their implications for studying human intelligence.

Two experiments were carried out to study the effect of prior knowledge on cognitive processes related to human intelligence by examining its role in defining task novelty. In Experiment 1, Ss performed a letter-matching task involving same-different judgments based on 4 rules of sameness: physical identity, form, system, and name. When the stimuli were unfamiliar, performance on the name classification task was correlated with measures of fluid abilities, whereas when the stimuli were familiar, performance on this task was not correlated with measures of fluid abilities. In Experiment 2, Ss performed 3 different forms of a mental rotation task. When the stimuli were unfamiliar, the slope of the rotation function was correlated with a test of fluid ability, whereas when the stimuli were familiar, the slope of the rotation function was not correlated with a test of fluid ability. These results are discussed in terms of their implications for understanding the nature of task complexity and the way knowledge and processing interact in the development of skilled performance.

Adult↗

Online measures of basic language skills in children with early focal brain lesions.

Twenty children with early focal lesions were compared with 150 age-matched control subjects on 11 online measures of the basic skills underlying language processing, a digit span task, and 6 standardized measures. Although most of the children with brain injury scored within the normal range on the majority of the tasks, they also had a disproportionately high number of outlier scores on the reaction time tests. This evidence for a moderate impairment of the basic skills underlying language processing contrasts with other evidence suggesting that these children acquire normal control of the functional use of language. Furthermore, these children scored within the normal range on a measure of general cognitive ability, suggesting that there is no particular sparing of linguistic functions at the expense of general cognitive functions. Using the MPD procedure (Valdés-Pérez & Pericliev, 1997), we found that the controls and the five clinical groups could be best distinguished with two measures of online processing (word repetition and visual number naming) and one standardized test subcomponent (the CELF Oral Directions subtest). The 12 children with left hemisphere lesions scored significantly lower than the 8 other children on the CELF-RS measure. Within the group of children with cerebral infarct, the nature of the processing disability could be linked fairly well to site of lesion. Otherwise, there was little relation between site or size of lesion and the pattern of deficit. These results support a model in which damage to the complex functional circuits subserving language leads to only minor deficits in process efficiency, because of the plasticity of developmental processes.

Brain Diseases↗

Visual and auditory event-related potentials elicited by linguistic and non-linguistic incongruities.

To test the hypothesis that violation of overlearned relations between stimuli in a sequence is critical for eliciting the event-related potential (ERP) N400, we recorded scalp ERPs in sequences where interstimulus relations were either overlearned (sentences or famous songs) or not (geometric figures or scale notes): 25% of the sequences ended with an incongruous stimulus. N400 occurred after incongruous words in sentences only. It seems to index the further processing necessary to specify the nature of the mismatch detected between attended and expected stimuli, when complex information is involved. Earlier components also varied as a function of experimental factors.

Adolescent↗

Lexical entries and rules of language: a multidisciplinary study of German inflection.

Following much work in linguistic theory, it is hypothesized that the language faculty has a modular structure and consists of two basic components, a lexicon of (structured) entries and a computational system of combinatorial operations to form larger linguistic expressions from lexical entries. This target article provides evidence for the dual nature of the language faculty by describing recent results of a multidisciplinary investigation of German inflection. We have examined: (1) its linguistic representation, focussing on noun plurals and verb inflection (participles), (2) processes involved in the way adults produce and comprehend inflected words, (3) brain potentials generated during the processing of inflected words, and (4) the way children acquire and use inflection. It will be shown that the evidence from all these sources converges and supports the distinction between lexical entries and combinatorial operations. Our experimental results indicate that adults have access to two distinct processing routes, one accessing (irregularly) inflected entries from the mental lexicon and another involving morphological decomposition of (regularly) inflected words into stem + affix representations. These two processing routes correspond to the dual structure of the linguistic system. Results from event-related potentials confirm this linguistic distinction at the level of brain structures. In children's language, we have also found these two processes to be clearly dissociated; regular and irregular inflection are used under different circumstances, and the constraints under which children apply them are identical to those of the adult linguistic system. Our findings will be explained in terms of a linguistic model that maintains the distinction between the lexicon and the computational system but replaces the traditional view of the lexicon as a simple list of idiosyncrasies with the notion of internally structured lexical representations.

Adult↗

Auditory scene analysis in dyslexics.

It has been argued that dyslexics suffer from temporal sensory processing deficits which affect their ability to discriminate speech in quiet environments. The impact of auditory deficits on non-language aspects of perception, however, is poorly understood. In almost every natural-listening environment, one must constantly construct scenes of the auditory world by grouping and analyzing sounds generated by multiple sources. We investigated whether dyslexics have difficulties grouping sounds. The results demonstrate that dyslexics have an impairment in grouping auditory objects that depends both on the sounds' frequency and presentation rate (i.e. the spectrotemporal context of the sound). We conclude that dyslexics have difficulty constructing scenes of the auditory world, and that these deficits can contribute to learning impairments.

Adolescent↗

Can prosody aid the automatic classification of dialog acts in conversational speech?

Identifying whether an utterance is a statement, question, greeting, and so forth is integral to effective automatic understanding of natural dialog. Little is known, however, about how such dialog acts (DAs) can be automatically classified in truly natural conversation. This study asks whether current approaches, which use mainly word information, could be improved by adding prosodic information. The study is based on more than 1000 conversations from the Switchboard corpus. DAs were hand-annotated, and prosodic features (duration, pause, F0, energy, and speaking rate) were automatically extracted for each DA. In training, decision trees based on these features were inferred; trees were then applied to unseen test data to evaluate performance. Performance was evaluated for prosody models alone, and after combining the prosody models with word information--either from true words or from the output of an automatic speech recognizer. For an overall classification task, as well as three subtasks, prosody made significant contributions to classification. Feature-specific analyses further revealed that although canonical features (such as F0 for questions) were important, less obvious features could compensate if canonical features were removed. Finally, in each task, integrating the prosodic model with a DA-specific statistical language model improved performance over that of the language model alone, especially for the case of recognized words. Results suggest that DAs are redundantly marked in natural conversation, and that a variety of automatically extractable prosodic features could aid dialog processing in speech applications.

Decision Trees↗