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PubMedDate not supplied

Nutritional management of osteoporosis. To slow the advancement of osteoporosis, nurses must encourage their clients to increase their intake of calcium. For geriatric nurses, this may be a challenge.

In conclusion, no current effective therapy is available for the restoration of bone mass once osteoporosis has developed. Primary prevention is the best way to fight this problem. However, goals for the management of osteoporosis are (1) to maintain skeletal mass and integrity, (2) to slow bone resorption, and (3) to treat the symptomatic problem and its sequelae. Having a well-balanced diet containing adequate amounts of calcium, use of calcium supplements when necessary, reducing risk factors in life-style, and use of estrogen are therapeutic measures to reduce bone loss. Clients are also encouraged to exercise by walking or swimming and remain as active as possible. It is important to avoid strain on the spine, as occurs in lifting or bending, to prevent compression fractures on the vertebrae. For treating the symptoms of osteoporosis and its sequelae, it is necessary to relieve pain (by the use of analgesics), provide comfortable light mechanical support for the spine, if needed, arrange assistance in activities of daily living, coordinate a rehabilitation program, and provide emotional support and reassurance to the patient and family. This may be an area largely neglected in practice. Gerontologic nurses may be the first to take the time to thoroughly discuss osteoporosis with their elderly clients and help them to develop a comprehensive program. If through their efforts some falls and fractures can be prevented, this is nursing at its best.

Aged↗

PubMed1980

The vascularity of the lunate bone and Kienböck's disease.

The extraosseous and intraosseous vascularity of the lunate was studied in 35 fresh cadaver limbs. The specimens were injected with latex, debrided by a nondissection technique, and cleared by a modified Spalteholtz method. The extraosseous vascularity was profuse through two to three dorsal and three to four volar vessels feeding dorsal and volar capsular plexuses. One ot two nutrient vessels were observed entering the dorsal and volar poles of the lunate from both plexuses. The intraosseous vascularity formed one of three consistent patterns with anastomoses of dorsal and volar vessels in each specimen. The vascular patterns support a theory of compression fracture from repeated trauma as the most likely cause of Kienböck's disease.

Adult↗

PubMedDate not supplied

Spinal involvement of hematopoietic malignancies and metastasis: differentiation using MR imaging.

The purpose of this study was to determine the usefulness of magnetic resonance imaging (MRI) for distinguishing spinal involvement of hematopoietic malignancies (lymphoma, leukemia, and multiple myeloma) from metastasis. 62 spinal MRIs were obtained in 60 patients with hematopoietic malignancies (n = 24) and metastasis (n = 36) in clinically and pathologically proven cases. MRI findings were evaluated in each group of patients for the pattern of involvement, signal change of vertebral body, location of paraspinal mass formation, location of epidural mass formation, cortical destruction, contour change, and compression fracture. Diffuse involvements were more commonly seen in hematopoietic malignancies than in metastasis (p < 0.05). Signal change confined to anterior element was seen in 9 metastasis but was not seen in hematopoietic malignancies. Cortical destructions were more commonly seen in metastasis than in hematopoietic malignancies (p < 0.05). Other findings did not show any statistical significance in both groups. MRI findings such as diffuse involvement, posterior epidural mass formation, and cortical destruction were useful to distinguish spinal involvement of hematopoietic malignancies and metastasis.

Adolescent↗

PubMed2002

Predictive value of intraosseous venography before percutaneous vertebroplasty.

PURPOSE: Percutaneous vertebroplasty is a novel approach for treating patients with painful vertebral body compression fractures. The use of intraosseous venography before the percutaneous injection of polymethylmethacrylate (PMMA) is not universally accepted. The purpose of this study was to determine if intraosseous venography predicts PMMA flow characteristics when injected into a vertebral body. MATERIALS AND METHODS: One hundred thirty-five intraosseous venograms were obtained during 96 vertebroplasty procedures (39 thoracic, 57 lumbar) in 61 patients (49 women, 12 men; age, 36-94 y) over a 32-month period. All venograms were obtained by injecting water-soluble contrast material through the vertebroplasty needle that had been placed percutaneously via a transpedicular approach. The venograms were retrospectively reviewed by the authors and compared in a blinded fashion with the subsequent final vertebroplasty result. RESULTS: Several venographic patterns were observed: bilateral or unilateral marrow blush with or without venous filling, direct venous filling, leakage of contrast material through an endplate or cortical defect, and stasis within the marrow space. Venograms that demonstrated a bilateral marrow blush predicted flow of PMMA across the midline to adequately fill the contralateral hemivertebrae 95% of the time (40 of 42 cases). A unilateral marrow blush predicted the necessity of a second puncture 97% of the time (32 of 33 cases). Intraosseous venography predicted PMMA entering endplate/cortical defects in all cases (22 of 22) and venous structures in 29% (22 of 75) of cases. Direct venous filling was observed during two vertebroplasty procedures and gelatin foam embolization was performed before PMMA instillation. Stasis of contrast material in the marrow space was observed in 15 cases. Overall, in 83% (80 of 96) of the vertebroplasty procedures, intraosseous venography was believed to predict the flow characteristics of PMMA. CONCLUSION: Intraosseous venography provides useful information in predicting PMMA flow characteristics within the vertebral body and in predicting potential undesirable sites of cement deposition, such as through cortical defects and within venous structures.

Adult↗

PubMed2002

Lack of preoperative spinous process tenderness does not affect clinical success of percutaneous vertebroplasty.

PURPOSE: Some operators use the lack of point tenderness over compression fractures to exclude patients from undergoing percutaneous vertebroplasty procedures. The purpose of this study was to determine whether this lack of tenderness portends a poorer clinical outcome after vertebroplasty than is achieved in patients with such tenderness. MATERIALS AND METHODS: The authors conducted a retrospective review of consecutive percutaneous vertebroplasty procedures performed at their institution to define two populations. Group 1 included 90 patients with tenderness to palpation over the spinous process of the fractured vertebra, whereas group 2 included 10 patients without such tenderness. This second group presented with back pain and demonstrated tenderness distant from the fracture (n = 5), tenderness lateral to the fracture (n = 4), or no focal tenderness at all (n = 1). All were treated because of edema seen on magnetic resonance (MR) imaging and/or increased activity on bone scan. Clinical outcomes were assessed by quantitative measurements of pre- and postoperative levels of pain (11-point scale) and mobility (five-point scale). RESULTS: Pain improvement of three points or greater occurred in 77 of the 85 patients (91%) in group 1 who complied with follow-up and nine of nine such patients (100%) in group 2, with mean postoperative pain levels of 1.82 and 0.33 points, respectively (P =.14). Forty of 45 patients (89%) in group 1 with impaired preoperative mobility reported improvement postoperatively, as did two of three such patients (67%) in group 2. Mean levels of postoperative impaired mobility for groups 1 and 2 were 0.27 and 0.67 points, respectively (P =.27). CONCLUSION: Pain on palpation over the fractured vertebra is not a necessary requirement in selecting patients who will benefit from percutaneous vertebroplasty. Other factors, such as MR evidence of edema or increased uptake on bone scan, should be weighed considerably in the decision to treat a patient.

Aged↗

PubMedDate not supplied

Sprained ankle syndrome: prevalence and analysis of 639 acute injuries.

The ankle sprain is often thought of as an injury involving only the lateral ankle ligaments. Frequently other structures are also injured. However, the literature describes only some of the associated injuries. The authors feel that a thorough analysis of each structure injured with the inversion and eversion ankle sprain along with the incidence would be invaluable in making an accurate diagnosis and providing appropriate treatment. The authors conducted a prospective study using a standardized evaluation during the initial examination of patients reporting with an ankle sprain. Over a 33-month period, 639 patients were studied at Oakwood Hospital Downriver Center Emergency Room and Occupational Medicine Clinic. Of the 639 patients, 92 had an associated avulsion or compression fracture of the foot or ankle. Of the remaining 547 patients, the anterior talofibular ligament was injured 453 times, the calcaneal fibular ligament was injured 366 times, and the posterior talofibular ligament was injured 187 times. Injuries to the ankle joint capsule were noted in 180 cases, the extensor digitorum brevis was involved in 111 cases, the sinus tarsi was involved in 88 cases, the peroneal tendons in 83 cases, the Achilles tendon in 67 cases, the calcaneal-cuboid ligament in 41 cases, and the syndesmosis was injured in 31 cases. Additionally, neuritis was seen in 80 patients presenting with a sprained ankle. Because of the varied and multiple components to the common sprained ankle, the authors feel that this condition would more appropriately be designated as the sprained ankle syndrome. The findings of this study may aid the examiner in exploring a more knowledgeable approach in evaluation, leading to an accurate diagnosis and appropriate treatment.

Acute Disease↗

PubMed2002

Kyphoplasty.

A variant of vertebroplasty known as "kyphoplasty" has been suggested for correcting vertebral compression fractures. A balloon placed inside the vertebral body is inflated to create a cavity, thereby restoring vertebral body height and allowing low-pressure cement injection. This procedure is gaining popularity in the United States. Over 1000 patients had been treated by the end of 2000. However, kyphoplasty is costly (chiefly because the balloon is disposable) and has not been evaluated in carefully designed studies. Although retrospective findings have been reported as highly promising, they are not sufficient to validate this procedure. The principle is innovative and the procedure deserves further investigation as a potentially effective means of correcting loss of vertebral height. Furthermore, use of a bone substitute instead of cement deserves investigation.

Humans↗

PubMed2001

Effect of high doses of oral risedronate (20 mg/day) on serum parathyroid hormone levels and urinary collagen cross-link excretion in postmenopausal women with spinal osteoporosis.

The present study describes the biological effects of risedronate, a pyridinyl bisphosphonate, on bone and assesses the safety and tolerability of risedronate when given at high doses, with or without calcium, to postmenopausal women with spinal osteoporosis. This single-center descriptive, double-blind, placebo-controlled, randomized, parallel group study included 32 postmenopausal white women with at least one radiographically confirmed vertebral compression fracture. Patients were randomized to one of four different dose regimen groups: (i) R-P, risedronate 20 mg/day for 14 days, followed by placebo for 42 days; (ii) R-CP-P, risedronate 20 mg/day for 14 days, followed by elemental calcium 1000 mg/day and placebo for 14 days, then by placebo for 28 days; (iii) R-CP-R-CP, risedronate 20 mg/day for 7 days, followed by elemental calcium 1000 mg/day and placebo for 21 days, then risedronate 20 mg/day for 7 days, and finally elemental calcium 1000 mg/day and placebo for 21 days; and (iv) P, placebo for 56 days. The biological response was investigated by measuring serum calcium, parathyroid hormone (PTH), and 2 h urinary pyridinoline/creatinine (Pyr/Cr) and deoxypyridinoline/creatinine (DPyr/Cr) ratios at baseline and at days 3, 7, 14, 21, 28, 35, 42, 49, 56, and 84. Overall, there were no consistent trends observed between the active group and placebo for serum calcium. In groups R-P, R-CP-P, and R-CP-R-CP, mean serum PTH levels were elevated above baseline values for the entire 56 day treatment period and remained elevated, although to a lesser extent, at the day 84 follow-up visit. The effect of calcium supplementation on PTH was variable. Urinary Pyr/Cr and DPyr/Cr ratios were decreased from baseline over the entire study period in all groups receiving risedronate. The maximum observed percent decreases from baseline for Pyr/Cr and DPyr/Cr were -46.9% and -58.8%, respectively, at day 49 in the R-CP-R-CP group. In conclusion, risedronate given orally at a dose of 20 mg/day, continuously for 7 or 14 days, resulted in the expected biological response in osteoporotic women. The time course of changes in PTH levels following cessation of dosing was unaffected by calcium supplementation. There was no evidence of a PTH-mediated rebound in bone resorption following cessation of therapy. Furthermore, based on collagen cross-link data, patients did not show an excessive reduction in bone turnover.

Aged↗

PubMed1998

Intestinal calcium absorption in men with spinal osteoporosis.

OBJECTIVE: To investigate the role of serum 1,25-dihydroxyvitamin D (1,25D) in the decreased calcium absorption found in men with osteoporosis. DESIGN: Prospective study of patients referred to a university teaching hospital clinic for investigation of possible osteoporosis. PATIENTS: Male patients referred for investigation for osteoporosis, from 1981 to 1995, because of specific risk factors or radiological suspicion of osteoporosis. Men with vertebral compression fractures were compared with those without. MEASUREMENTS: Height and weight, radiocalcium absorption, serum 1,25D and fasting urinary calcium and hydroxyproline excretion. RESULTS: The men with vertebral fractures had higher fasting urinary hydroxyproline excretion (P = 0.003) and lower calcium absorption (P = 0.002) than the men without. Calcium absorption was positively related to 1,25D in both groups but the estimated calcium absorption at zero 1,25D was lower in the osteoporotic than the normal group. 1,25D was lower in the osteoporotic group than in the normal group. However this difference could only explain about half of the difference in calcium absorption between the groups. CONCLUSIONS: Calcium absorption is low in men with osteoporosis. About half of the deficit is due to low serum 1,25-dihydroxy vitamin D levels but there appears, in addition, to be some intestinal resistance to its effect on calcium absorption.

Adult↗

PubMed2003

Desmoplastic malignant mesothelioma of the pleura: autopsy reveals asbestos exposure.

Desmoplastic mesothelioma is a rare subtype of diffuse malignant mesothelioma, and is often difficult to distinguish from reactive pleural fibrosis because of associated extensive collagen fibrosis. An 82-year-old woman with a severe cough was revealed to have pleural effusion and diffuse pleural thickening on the right side. Antibiotics were ineffective, and a compression fracture of the ninth and tenth thoracic vertebral bodies was recognized on X-ray. Autopsy revealed a diffuse pleural thickening with hyalinized collagen tissue in the central part of the pleura. However, the peripheral part of the fibrous tissue was composed of spindle and polygonal cell proliferation that were immunohistochemically positive for antibodies against cytokeratin and vimentin. In addition, the ninth and tenth thoracic spines were infiltrated by similar cells. The condition was diagnosed as desmoplastic mesothelioma with bone metastases. Asbestos bodies were detected in the thickened pleura and fibrosed alveolar septa, and it was suggested retrospectively that the patient had been exposed to asbestos. Thus, autopsy analyses of fibrous pleurisy are necessary to detect a desmoplastic variant of mesothelioma of the pleura and its association with asbestos exposure.

Aged↗

PubMed2005

Percutaneous vertebroplasty: an update.

Percutaneous vertebroplasty is an imaging-guided interventional technique in which surgical polymethylmethacrylate is injected via a large bore needle into a painful compressed vertebral body. This technique is safe and effective, and provides increased strength and pain relief in vertebrae weakened by bone diseases. Among the current indications for vertebroplasty are intractable nonradicular pain caused by compression fractures due to osteoporosis, myeloma, metastasis, and aggressive vertebral hemangioma. Contraindications include bleeding disorder, unstable fracture, and lack of definable vertebral collapse. The preprocedural evaluation, technique, complications, and expected results of performing this procedure are also reviewed.

Adult↗

PubMed2001

Rapid increase in bone mineral density in a child with osteoporosis and autoimmune hypoparathyroidism treated with PTH 1-34.

We describe a 16-year-old girl with autoimmune polyglandular syndrome type 1 including hypoparathyroidism, who had osteoporosis that improved rapidly with parathyroid hormone replacement therapy. Patients with hypoparathyroidism usually have high bone mass. Our patient developed vertebral compression fractures at age 10, shortly after hypoparathyroidism was diagnosed. She continued to have low lumbar bone mass until age 16, when a dual energy x-ray absorptiometry (DEXA) revealed a Z score of - 2.2 SD. Several factors including decreased physical activity, total body magnesium depletion, and intermittent ketoconazole and short-term prednisone treatment, may have contributed to the development and progression of osteoporosis. Therapy with synthetic human parathyroid hormone (PTH) 1-34 rapidly normalized lumbar bone mass, as assessed by DEXA.

Adolescent↗

PubMedDate not supplied

[Lumbar discogenic pain].

Lumbar discogenic pain in the sense of an internal disc disruption (IDD) represents a nociceptive pain syndrome with the source of pain in the innervated outer third of the annulus. Such discs anatomically appear with almost normal contours. Neither clinical nor technical assessments have any diagnostic value, with the exception of MRI which has been shown, if present in symptomatic patients, to have a positive predictive value of up to 89 % to indicate a strong correlation to a painful grade 3 or 4 fissure. However, only the stimulation of a disc (controlled provocation discography) with a subsequent CT scan is of exclusive diagnostic value. As an underlying pathomechanism, a compression fracture of the superior subchondral endplate like a fatigue fracture is discussed. In this way, a deterioration of the homogeneous intradiscal stress distribution could occur with consecutive damage to the internal disc environment and the expression of a radial fissure. The clinical picture of discogenic pain is non-specific. It does not correlate with degenerative changes. It does not differ from any other back pain. Thus, it has to be differentiated from zygapophysial joint pain as well as from sacroiliac joint pain and muscular-ligamentous pain sources. In a single study of American workers, the prevalence of IDD was 39 %, rendering it one of the most important causes for patients with a specified source of back pain.

Diagnosis, Differential↗

PubMedDate not supplied

[Minimally-invasive computer-assisted fluoroscopic navigation for kyphoplasty].

AIM: The transpedicular placement of a hollow needle into vertebral bodies for kyphoplasty requires utmost accuracy and thereby permanent multiplanar X-ray control. Facing the increasing number of vertebral compression fractures, the aim of this work was the implementation of computer-assistance to optimise the issue. Prior to clinical implementation, experimental trials were undertaken to analyse the quality-improving options of the technique. METHOD: The virtual image of the planning and the puncture were correlated with the postoperative X-ray image of the needle. The real canal in the bone was then correlated with the preoperative planning in a CT-based 3D model and differences were calculated. As a measure of accuracy the deviation of the needle from the ideal intruding vector and the distance between its top and the centre of a predefined target were scrutinised and related to the indications of the navigation system. Operating time, radiation exposure and general applicability were additionally assessed. All data were compared with those of a conventional control group. RESULTS: Planning and navigation could be executed with high accuracy. With an exactly transpedicular approach, neural structures were safely circumnavigated without once missing the target. In the control group the distance fault was up to 9 mm. The navigated drilling differed from the ideal trajectory by 1 degrees to max. 4 degrees. Conventional C-arm control led to a divergence of 4 degrees to 8 degrees . Radiation exposure could be reduced through computer assistance by 76 % to a fourth of the conventionally resulting amount and the pure operating time thereby decreased by 40 %. The inconvenient course of repeated positioning of the C-arm was overcome. CONCLUSION: In challenging cases of deteriorated anatomy and difficult radiomorphologic orientation, especially of the lower thoracic spine, the CAOS-procedure succeeds in finding the optimal pedicular approach to the vertebral body, helps to avoid collateral damage and minimises the overall risk of the procedure. High accuracy and reduced radiation exposure justify the clinical use of fluoroscopic navigation for transpedicular instrumentation.

Decompression, Surgical↗

PubMed2005

[Vertebroplasty--basic science, indications and technique].

INTRODUCTION: Vertebroplasty is a relatively new procedure for the treatment of vertebral body fractures of different origin. Due to early promising results the rate of performed procedures increases constantly. Indeed an increasing number of partially severe complications are reported. A summary of the existing findings seems therefore necessary. METHODS: On the basis of a medline inquiry important aspects of vertebroplasty in the fields of basic science, diagnostics, indications, contraindications, technique, results and complications were compiled. RESULTS: Especially for the field of indications, possible longterm effects and for the "ideal" technique open questions exist, mainly due to missing prospective, randomized long-term clinical trials. CONCLUSIONS: A final assessment of the significance of vertebroplasty for osteoporotic fractures in comparison to conservative treatment is actually not possible. In contrast vertebroplasty is a therapeutical option for malignomas in selected cases.

Biomechanical Phenomena↗

PubMed1998

[1H MR spectroscopy of the lumbar spine in diffuse osteopenia due to plasmacytoma or osteoporosis].

PURPOSE: To evaluate the role of in vivo 1H MR spectroscopic determination of relaxation times and of fat and water content to differentiate between infiltration of multiple myeloma or osteoporosis in patients with roentgenologic unclear demineralization of the lumbar spine. PATIENTS, MATERIALS AND METHODS: Ten patients each with osteoporotic reduction of bone mineral density (BMD), histologically proven multiple myeloma who showed only diffuse tumor manifestations without tumor compression fractures in the spine, and volunteers were investigated. Osteoporosis was confirmed by dual-energy X-ray absorptiometry (DXA) (Hologic QDR 2000 device, Siemens Medical Systems). The MR investigations were performed with a 1.5 T whole body system (Gyroscan S15/ACS II, Philips Medical Systems). Localized MR spectra from a cubic volume of about 8 cm3 were acquired by the PRESS technique. Chemical shift selective T1 relaxation times were obtained from an IR series, T2 was measured by variation of the interval between the first and the second echo in the volume selection scheme. Statistical analysis was done using the Kruskal-Wallis test and the Mann-Whitney test with the software SPSS. RESULTS: There were highly significant differences in T2 values and fat content between patients with osteoporosis and multiple myeloma. T2 values were decreased in osteoporosis (37 ms and 59 ms vs. 44 ms and 70 ms in plasmocytoma) and fat content was decreased in multiple myeloma (20% vs 31% and 34% in volunteers and osteoporosis). Between volunteers and patients with osteoporosis the differences in the T2 of the fat component was significantly different. CONCLUSIONS: In our preliminary experience MRS is helpful in the differential diagnosis of bony demineralization. It enables a differentiation between osteoporosis and diffuse multiple myeloma. T2 value measurements may be helpful in the diagnostic trial of osteoporosis.

Adult↗

PubMed1990

[Osteoporosis and pre- and postpartal heparin therapy].

Multiple vertebral compression fractures occurred in the 33rd week of pregnancy in a breast-feeding mother receiving heparin (20,000-25,000 units/die over 5 months), for deep vein thrombosis. Osteoporosis under heparin therapy is a rare complication and this diagnosis was not made despite obvious clinical signs. It follows from this observation, that heparin therapy should be substituted by oral anticoagulant therapy and discontinued directly after delivery.

Adult↗

PubMedDate not supplied

[Bone density measurements of the proximal femur in relation to torsion of the femoral neck].

The DEXA-method allows for bone mineral density measurements of different regions of the skeletal system. It is known that results obtained from the spine with this two-dimensional method may be biased in cases of spondylosis, spondylarthritis, and compression fractures; similarly biased results can be expected at the proximal femur due to morphometric peculiarities. The influence of anteversion and rotation of the femoral neck has been investigated in the present study. The results indicate that errors due to rotation as occurring in incorrect positioning or in arthrogenic variabilities mainly have effects on measurements of Ward's triangle: The average measurement error at 20 degrees external rotation amounts to 33.8% with a maximum of 66.5%. Measurements of the trochanteric region and of femoral neck region show a variation of 6.2% and 9.7%, respectively.

Absorptiometry, Photon↗