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[Analysis of the structural features of the sperm chromatin of amphibia].

Deoxyribonucleoproteid (DNP) organisation of the sperm from amphibian species (Rana temporaria, Triturus vulgaris, Bufo bufo) with different sperm chromosomal basic proteins has been analysed by nuclease fragmentation. Electrophoretic distribution of chromatin fragments reveals regular organisation of DNP in the sperm of the species investigated. In spermal DNP of the frog Rana temporaria, 3 sub-fractions of histone H1 were found. In the sperm of the newt Triturus vulgaris and the toad Bufo bufo, abundant arginin-rich histones H3 and H4 as well as the presence of low molecular weight protamine-like proteins were noted. Spermal chromatin of all the species studied exhibits high content of chromosomal RNA which is resistant to the effect of exogenous RNAse.

Animals↗
PubMed1976

[Clinical findings concerning a comparative study of several structural features of depression].

The author studied 321 patients with depressive states of a different nature (reactive, symptomatical and endogenous). An attempt is made to establish connections between atypical neurotical states and hallucinatory-paranoid symptoms on the one hand and certain depressive emotions on the other. The opinion is expressed that anguish to a greater extent prevents the polymorphism of a depressive affect and the appearance of nonemotional disorders.

Adolescent↗
PubMed2002

[Dopaminergic receptors: structural features and functional implications].

During the last decade, molecular biology methods have primarily contributed to the fine characterisation of five subtypes of dopaminergic receptors leading to the classification of the D1-like (D1 and D5) and D2-like (D2, D3 and D4) subclasses. Biochemical methods have provided evidences for a large diversity of transduction mechanisms associated to these different receptors which can contribute to explain the multiple actions of dopamine at cellular level in the brain, from changes in membrane excitability to influences of gene expression. Moreover, the characteristic intracerebral distribution of these receptors subtypes supports the involvement of the neurotransmitter in different aspects of behaviour, from motor to limbic and cognitive aspects. In this respect, in Parkinson's disease dopamine depletion will favour adaptive responses at the cellular level which likely involve differentially the dopaminergic receptor subtypes. Such adaptive responses involving long-lasting processes of intercellular communication will either act to limit the symptoms of the disease or, more likely, to contribute to the expression of clinical signs. The development of appropriate agonists to selectively stimulate the different subsets of receptors still remains a challenge but, actually, already contributes to efficiently compensate for the motor signs of Parkinson's disease. In any case, such dopaminergic agonists are considered as an essential strategy to limit the motor side effects of L-DOPAtherapy. Thus, the development of more selective agonists of the different subsets of the dopamine receptors may contribute to compensate for the other clinical signs of the disease, and particularly for cognitive deficits.

Dopamine↗
PubMed2002

[Structural features of a neutral heteropolysaccharide CPB-4 from Cynanchum paniculatum].

OBJECTIVE: To study the chemical features of CPB-4, a heteropolysaccharide obtained from Cynanchum paniculatum. METHOD: Sugar composition analysis, methylation analysis, partial hydrolysis and carbon-13 nuclear magnetic resonance were used to determine the sugar composition, linkages, main chain, branch chains and branching points. RESULT: CPB-4 is composed of L-arabinose, L-xylose, L-rhamnose and D-galactose in closely molar ratios of 0.8:0.2:0.2:1.0. Its main chain is comprised of 1, 5 linked galactose and side chains are comprised of terminal xylose, terminal arabinose, oligosaccharide of arabinose and oligosaccharide of arabinose, rhamnose and galactose. The branching points are located at C-6 and C-2 of galactose. CONCLUSION: CPB-4 is a new heteropolysaccharide from C. paniculatum.

Arabinose↗