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PubMed2005

Running performance differences between men and women:an update.

More than a decade ago it was reported in the journal Nature that the slope of improvement in the men's and women's running records, extrapolated from mean running velocity plotted against historical time, would eventually result in a performance intersection of the sexes across a variety of running distances. The first of these intersections was to occur for 42 000 m before the 21st century. Most of the error in this prediction is probably explained by the linear mathematical treatment and extrapolation of limited performance data, since including world record-setting running performances for women before and after 1985 results in a non-linear data fit. The reality of early, disproportionate improvements in women's running that gave the appearance of an impending convergence with men is best explained by an historical social sports bias. Women's times have now reached a plateau similar to that observed for men at comparative performance milestones in the marathon. Sex differences at distances from 100 to 10 000 m show similar trends. The remaining sex gaps in performance appear biological in origin. Success in distance running and sprinting is determined largely by aerobic capacity and muscular strength, respectively. Because men possess a larger aerobic capacity and greater muscular strength, the gap in running performances between men and women is unlikely to narrow naturally.

Adult↗

PubMed1983

Dependence of shortening heat on sarcomere length in frog muscle and fiber bundles.

The relation between shortening heat and sarcomere length was studied using fiber bundles from frog semitendinosus muscles as well as using whole muscles. The initial sarcomere length was varied between 2.0 and 3.66 micron. Shortening heat was estimated as the excess heat produced after a rapid isovelocity release in a 3 sec tetanus at 0 degrees C. The isometric control heat was measured in the same tetanus, before and after the period of shortening. The unstimulated whole muscles showed a large thermoelastic absorption of heat when released at sarcomere lengths longer than 2.5 micron, and the apparent shortening heat was negative at very long sarcomere lengths. The apparent shortening heat was corrected by subtracting the thermoelastic heat absorption by assuming that the thermoelastic effect was also present in releases of active muscles. The corrected shortening heat decreased linearly with increasing sarcomere length in the range 2.29-3.66 micron, intersecting the length axis at 3.73 +/- 0.21 micron. The thermoelastic heat absorption at long sarcomere lengths was substantially reduced in fiber bundles, suggesting that the parallel elasticity responsible for the thermoelastic effect is mainly present outside muscle cells. The corrected shortening heat in fiber bundles also decreased linearly with increasing sarcomere length, intersecting the length axis at 3.84 +/- 0.25 micron. Thus the results on fiber bundles, also based on correction but the extent of which is substantially smaller than in whole muscles, are in agreement with the results on whole muscles. The results are interpreted to mean that shortening heat is produced by the interaction of thick and thin filaments in contracting muscle.

Animals↗

PubMed1991

Precautionary street crossing by elderly pedestrians.

Street crossing behavior of pedestrians was observed under varying roadway conditions and traffic volumes. The extent to which pedestrians checked for oncoming traffic before crossing signal controlled intersections on a dangerous downtown street was observed. Contrary to the stereotypical portrayal of older pedestrians as being less cognizant of the traffic environment, pedestrians in this study over the age of fifty years were the most cautious. Older pedestrians were also more cautious under the most potentially hazardous crossing conditions: when roadways were snow- or ice-covered and when traffic volumes were low or moderate, allowing vehicles to move rapidly through intersections.

Accidents, Traffic↗

PubMedDate not supplied

Older motorist yielding to pedestrians: are older drivers inattentive and unwilling to stop?

A field experiment investigated factors expected to influence yielding by motorists to a pedestrian waiting to cross a city street. One-hundred and sixty motorists passing through a marked crosswalk were participants. In addition, data were gathered on 120 baseline motorists who passed through the test intersection when a pedestrian was not present. A comparison of the age composition of the experimental sample with the baseline sample showed that the youngest group of drivers, i.e., under twenty-six years, was significantly more represented in the experimental sample and was more likely to stop for the experimental pedestrian than were motorists in other age groups. Contrary to a prediction that older motorists over age sixty-five would be less attentive to a pedestrian and, therefore, less likely to stop, this oldest group of drivers was not underrepresented in the experimental sample; i.e., their likelihood of yielding matched their likelihood of driving through the intersection. Further analysis, however, revealed that motorists over sixty-five years of age were significantly more likely than younger motorists to stop for a pedestrian who was conspicuously dressed (bright, highly visible clothing) and who was moving to cross the street rather than patiently waiting. Implications of these findings are discussed in terms of difficulties that older drivers have in judging the speed of moving objects in a traffic environment.

Adult↗

PubMed1976

Differences between right and left lateral chest radiographs.

Differences between 150 normal right lateral chest teleroentgenographs and 150 left laterals (infants, children, and adults) were evaluated and determined to be greater than has been generally appreciated. On the left lateral view the left leaf is distinguished from the right leaf by the following generalizations: anteriorly the left leaf is lower; posteriorly it is higher as is its costrophrenic sulcus; it intersects the relatively flattened right leaf near the posterior heart border; the stomach bubble and/or colon are immediately subjacent; there is no segmental obliteration by the inferior vena cava as there often is with the right leaf; in adults the outline of the left leaf is often sharper. When both major fissures can be identified, the left almost always intersects its diaphragmatic leaf posterior to and more vertically than the right fissure.

Adult↗

PubMed1986

Multiple-angle, variable-interval, nonorthogonal MRI.

Multiple-angle, variable-interval, nonorthogonal (MAVIN) MRI is a new, time-saving technique that allows for the independent choice of slice angle and position for each slice in a multiangle pulse sequence. By appropriate adjustment of the slice-select radiofrequency pulse and the slice-select and readout magnetic-field gradients, the interval and angle of each slice may be individually chosen. MAVIN can reduce examination time in studies of the lumbar spine, orbits, knees, and heart, where nonparallel oblique scanning may be necessary and would otherwise require the use of additional pulse sequences. Loss of signal in the region of intersection of multiple planes due to local changes in effective repetition time is a practical limitation. For this reason, scan planes are chosen so that the intersection does not overlie the region of interest.

Humans↗

PubMed2004

Corsi's block-tapping test: some characteristics of the spatial path which influence memory.

By using a sequence of digits it is possible to indicate the path of Corsi's block-tapping test by drawing a line to join the central points of the cubes which make up the sequence. By doing this one can analyze the sequence of digits according to quantitative parameters. There were three characteristics of the spatial path taken into consideration in this research: the number of cubes which constitute a series of digits, the number of times the path intersected itself, and the length of the path measured in millimeters. The experiment, carried out with 70 university students, showed that all three factors were significant on analysis of variance, and also that there were differences between the sexes, the men performing better. No interactions were significant. Despite this, additional significant differences were found among the series with the same number of cubes, intersections, and length, meaning that other variables influence the difficulty of the spatial path.

Adult↗

PubMed1997

Estimation of relative bioavailability of nutrients using SAS procedures.

The General Linear Models procedure (PROC GLM) in SAS/STAT software can be programmed to perform the standard statistical analyses used for relative bioavailability studies. The first steps are validity checks to test for statistical validity (linearity), fundamental validity (intersection of regression lines at 0 supplemental level), and equality of the basal diet mean to the point of intersection. The CLASS variable capabilities of PROC GLM can be exploited to expedite these tests. After the validity checks, the GLM procedure can be used to obtain parameter estimates for calculation of relative bioavailability. Optional output provides an inverse matrix to calculate standard errors of slopes and slope ratios. Logarithmic and other transformations of the dependent variable to reduce variance heterogeneity or achieve linearity for subsequent calculation of appropriate bioavailability values also can be accomplished within the SAS System. When nonlinear regression models are more appropriate than linear models, the NLIN procedure can be used.

Animals↗

PubMed2004

A morphological study on the classification of maxillary dental arches.

To evaluate the morphology of dental arches, 62 (male: 36, female: 26) paired casts having normal dentitions and occlusion were selected from 396 (age: 18 to 26 years old; male: 257, female: 139) sets of dental study models. The maxillary dentitions were preliminarily classified as square, round-square, round and round V-shaped arches based on the conventional morphological descriptions. Midpoints of the incisor edge (I1(R), I1(L), I2(R), & I2(L), summits of the cuspids (CR & CL), buccal cusps of the premolars (P1(R), P1(L), P2(R), & P2L), mesial buccal cusps of the first and second molars (M1(R), M1(L), M2(R), & M2(L)), and the midpoint (A) of line I1(R)-I1(L) were designated as reference points. From A, let a vertical line intersected line M2(R)-M2(L) at reference point B. The line A-B intersected C(R)-C(L) at reference point E. We evaluated 1) the protrusion of the cuspids by (1) angle I2(R)-C(R)-P1(R) (angle R) + angle I2(L)-C(L)-P1(L) (angle L); 2) the curvature of the anterior teeth by (2) A-B/C(R)-C(L), (3) 180 degrees - angle C(R)-A-C(L), and (4) A-E/C(R)-C(L); 3) the length to width ratio of the dental arch by (5) A-B/M2(R)-M2(L); 4) the degree of roundness of the maxillary arch by estimation of (6) (rtheta5 - rtheta4)R + (rtheta5 - rtheta4)L; and 5) an item (7) for the differentiation of type I and type II round-square arches by relating the bilateral contour and position of break line P1-P2-M1-M2 (i) to line P1-M2 (ii). The data of items (1), (2), (3), (4), (5), and (6) were further standardized and summarized into three essential principal components: 1) the curvature of the anterior teeth, 2) the curvilinear contour of the dental arch, and 3) the length-to-width ratio of the dental arch. The results indicated that: 1) 60% of the maxillary dentitions were round-square arches which showed no prominent principal component; 2) square maxillary arches distinctly showed a small (1) angle R + angle L; 3) round arches were characteristic by small (6) (rtheta5 - rtheta4)R + (rtheta5 - rtheta4)L values; and 4) round V-shaped arches had large (1), (3) and (4) values.

Adolescent↗

PubMed2005

Morphological classification of mandibular dental arch forms by correlation and principal component analyses.

To evaluate the morphology of dental arches, 53 (male: 29, female: 24) paired casts having normal dentitions and occlusion were selected from 396 (age: 18 to 26 years old; male: 257, female: 139) sets of dental study models. The mandibular dentitions were preliminarily classified as square, round-square, round and round V-shaped arches based on the conventional morphological descriptions. Midpoints of the incisor edge (I1R, I1L, I2R, & I2L), summits of the cuspids (CR & CL), buccal cusps of the premolars (P1R, P1L, P2R, & P2L), mesial buccal cusps of the first and second molars (M1R, M1L, M2R, & M2L), and the midpoint (A) of line I1R-I1L were designated as reference points. From A, let a vertical line intersected line M2R-M2L at reference point B. The line A-B intersected CR-CL at reference point E. We evaluated 1) the protrusion of the cuspids by 1. angle I2R-CR-P1R (angle R) + angle I2L-CL-P1L (angle L); 2) the curvature of the anterior teeth by 2. (A-B)/(CR-CL), 3. (180 degrees-angle(CR-A-CL), and 4. (A-E)/(CR-CL); 3) the length to width ratio of the dental arch by 5. (A-B)/(M2R-M2L); 4) the degree of roundness of the mandibular arch by estimation of 6. (rtheta5 - rtheta4)R + (rtheta5 - rtheta4)L; and 5) an item 7. for the differentiation of type I and type II round-square arches by relating the bilateral contour and position of break line P1-P2-M1-M2 (i) to line P1-M2 (ii). The data of items 1., 2., 3., 4., 5., and 6. were further standardized and summarized into three essential principal components: 1) the curvature of the anterior teeth, 2) the curvilinear contour of the dental arch, and 3) the length-to-width ratio of the dental arch. The results indicated that: 1) 36 cases (67.9%) of the mandibular dentitions were round-square arches which showed no prominent principal component. 11 cases (20.8%) were square arches and 6 cases (11.3%) were round V-shaped arches; no round arches was found in mandibular dentitions. 2) Statistical analysis indicated significant differences of items 3., 4. and 6. in various mandibular arches (Student's t-test). 3) By examination of the three principal components, significant differences of item 5. between the round V-shaped arches and square and round-square mandibular arches were evident (Student's t-test). The present study elucidated that morphology of the mandibular arch was determined by a parameters representing the curvature of anterior teeth (composed of items 2., 3. and 4., and another parameter (item 6.) representing roundness of the mandibular arch.

Adolescent↗

PubMed2004

Competition for teats and feeding behavior by group-housed dairy calves.

Many farms using teat-based systems for supplying milk for calves provide only one or a small number of teats for a group of calves, but no previous research has addressed how competition for teats affects calf behavior or milk intake. The aim of this study was to determine how restricted access to teats affects calf competitive behavior, meal-based feeding patterns, and milk intake. Female calves (n=15) were divided into 5 groups of 3 calves each and fed with a teat-to-calf ratio that varied daily from 1:3 to 4:3 using a switchback design. Feeding behavior was recorded by scoring the time and duration of each sucking event. We defined meals using the frequency distribution of log intervals between visits to the teat and identified the within-meal and between-meal distributions intersection points. Three classes of intervals were identified based on the intersection points of the distributions: 1) intervals <2 min, representing small breaks away from the teat within a meal; 2) intervals >41 min, providing an objective definition of a new meal; and 3) an intermediate distribution of intervals from 2 to 41 min could be included in either of the other 2 classes. Meal number showed no significant decrease with decreasing teat number. However, total time on the teat decreased from 40.2 to 32.7 (+/-2.6) min/d, and milk consumption declined from 14.0 to 11.4 (+/-0.8) L/d as teat number declined from 4 to 1. In addition, competitive interactions became more frequent when teat access was reduced; the number of times calves displaced one another from a teat increased from 18 to 41 (+/-5) times/d when teat number decreased from 4 to 1. In conclusion, reduced access to teats increases competitive interactions, decreases feeding time and decreases milk intake by group-housed calves.

Animal Husbandry↗

PubMed2026

Gut microbiota-derived metabolites target C5AR1/KDM2A/HCAR3 axis in inflammatory bowel disease: a multi-machine learning algorithms and molecular docking study.

BACKGROUND: Inflammatory bowel disease (IBD) is a chronic recurrent disorder. Gut microbiota-derived metabolites regulate intestinal homeostasis, but their molecular mechanisms in IBD remain unclear. Current studies lack systematic "microbiota-metabolite-target" network mining with multi-method validation. This study integrates network pharmacology, three machine learning algorithms, and molecular docking to construct this regulatory network in IBD. METHODS: Transcriptome data were obtained from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were identified using limma (p < 0.05, |log2FC| > 0.5). Weighted gene co-expression network analysis (WGCNA) with an optimal soft threshold of β = 7 was performed to identify key module genes. Candidate genes were obtained by intersecting DEGs, gut microbiota-associated genes from the gutMGene database, and WGCNA module genes. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were conducted to explore the functional roles of candidate genes. Core genes were identified using three machine learning algorithms (LASSO, Boruta, and SVM-RFE), followed by protein-protein interaction (PPI) network analysis. Molecular docking was performed to assess the binding affinities between hub proteins and gut microbiota-derived metabolites. RESULTS: A total of 885 DEGs were identified between the IBD and control groups, including 463 upregulated and 422 downregulated genes. WGCNA identified 280 key module genes from the purple and yellow modules. The intersection of DEGs, gut microbiota-associated genes, and WGCNA module genes yielded 19 core candidate genes. PPI network analysis combined with three machine learning algorithms jointly identified C5AR1, KDM2A, and HCAR3 as core hub genes. ROC curve analysis demonstrated that all three hub genes achieved AUC values greater than 0.7 in both the training and validation sets, indicating excellent diagnostic performance for IBD. Enrichment analysis revealed significant associations with the TNF, NF-κB, and IL-17 signaling pathways. Molecular docking confirmed stable binding of C5AR1 with 1,3-Diphenylpropan-2-Ol (-7.87 ± 0.83 kcal·mol-¹) and HCAR3 with 3-Indolepropionic Acid (-6.35 ± 0.70 kcal·mol-¹), both below -5.0 kcal·mol-¹. CONCLUSION: This study first constructs a "gut microbiota-metabolite-hub gene" axis in IBD, providing a computational framework for microbiota-targeted precision therapy, and identifying C5AR1/KDM2A/HCAR3 as computationally predicted diagnostic biomarkers and 1,3-Diphenylpropan-2-Ol/3-Indolepropionic Acid as candidate intervention molecules that warrant further experimental validation.

Molecular Docking Simulation↗

PubMed2006

The effects of stimulus rotation and familiarity in visual search.

Rauschenberger and Yantis (2006) observed that an intersecting circle-line combination enjoyed significantly greater search efficiency when it was oriented to resemble a "Q" than when it was oriented so that the intersecting line was vertical (cf. Treisman and Souther, 1985). Although a control experiment made it unlikely that the obliqueness of the line was responsible for the observed benefit, there was no direct evidence that this benefit was attributable to the "Q-ness" of the stimulus. In the present study, a subset of Rauschenberger and Yantis's experiments was repeated with Chinese subjects, who had never been exposed to the Latin alphabet. For these subjects, there was no benefit for the"Q"-like stimulus, in contrast to the results of Rauschenberger and Yantis's study. These results show that a simple 45 degrees rotation of a stimulus can affect search efficiency significantly--but only when this rotation bestows meaning, or familiarity, to that stimulus.

Adult↗

PubMed1990

Identity imposition and its role in a stereokinetic effect.

Lines of constant curvature, a circle or a straight line, have no distinguishable parts. Yet they are perceived as if they did. When they move and intersect, they are perceived to slide across each other as if one of them had parts that can be seen to move in relation to the other line. With no such parts present in stimulation, they are products of perception. It was found that a third line of constant curvature, the helix, is also seen to slide when two helixes intersect and are in motion. Another manifestation of perceived identical parts is that rotating circles and similar shapes are perceived not to rotate even when cues for rotation are present. Furthermore, changes between merely perceived identical parts can result in apparent depth. Evidence is presented that such depth, known as the stereokinetic effect, results from kinetic depth-effects that are based on perceived identical parts instead of on actually identical parts, and that depth is seen when the intervals between such perceived parts change length and orientation simultaneously.

Attention↗

PubMed2000

Three elemental illusions determine the Zöllner illusion.

We have discovered an apparent contraction illusion of acute angles in a special form of the Zöllner figure at the intersecting angles between 36 degrees and 83 degrees (i.e., a reversal of the Zöllner illusion). The necessary condition for this illusion is that inducing lines are long enough and the induced line (test line) is single. When an illusory line is used as the induced line, the magnitude of contraction increases. Short inducing lines give no illusion or a slight expansion of acute angles at the intersecting angle of 45 degrees. We have ascertained that the source of this expansion is the narrow region in the vicinity of the induced line, whereas the source of the contraction is much broader regions. Furthermore, we have discovered another expansion mechanism, which is generated by the symmetrical configuration of the standard Zöllner figure.

Adult↗

PubMed2026

New insights into diagnostic values and mechanisms of ferroptosis associated with immune infiltration in diabetic kidney disease.

The pathogenesis of diabetic kidney disease (DKD) is complex and closely related to ferroptosis and immune dysregulation, but the relevance is unclear. The present study investigates the potential mechanisms of ferroptosis-related genes (FRGs) in DKD and their relationship with the immune-inflammatory response. It searches for new diagnostic biomarkers to help diagnose and treat DKD. Four Gene Expression Omnibus (GEO) datasets, GSE30528, GSE30529 and GSE30122 as the test set, and GSE96804 for validation, were analyzed. FRGs were obtained from GeneCards, and 47 ferroptosis-related differentially expressed genes (FRDEGs) were identified by intersecting with DKD-related differentially expressed genes. Functional enrichment analyses, including Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, Gene Set Enrichment Analysis and Gene Set Variation Analysis, revealed that these FRDEGs are primarily associated with ferroptosis, hypoxia response and immune inflammation. Subsequently, the weighted gene co-expression network analysis (WGCNA) was employed to expand the ferroptosis-related gene network, and intersection of the 47 FRDEGs with key WGCNA module genes yielded 10 key genes. Based on the 10 key genes, the least absolute shrinkage and selection operator and support vector machine algorithms identified three hub genes [chemokine ligand 5 (CCL5), forkhead box C1 (FOXC1) and lactotransferrin (LTF)] for DKD diagnosis. Receiver operating characteristic curves confirmed their diagnostic value, with FOXC1 and LTF validated in the independent dataset. Immune infiltration analysis via CIBERSORT revealed eight immune cell types with significantly different infiltration levels between the DKD and control group in the integrated GEO datasets. Notably, both LTF and CCL5 showed a significant positive correlation with gamma delta T cells (γδT). Quantitative PCR results confirmed differential expression of the three hub genes in the DKD group, with elevated expression observed in DKD mice following intervention with rosiglitazone and hyperoside.

bioinformatics analysis↗

PubMed2026

Integrative Network Analysis of Bioactive Compounds from Punica granatum L. Peel: Multi-Target Mechanisms in Wound Healing.

BACKGROUND: Wound-healing agents often have limited efficacy and require prolonged recovery times, prompting growing interest in developing herbal-based formulations. Among these, Punica granatum L. has attracted considerable attention because of its high polyphenolic content. Despite its widespread use, the precise pharmacological targets underlying its wound-healing effects remain poorly understood and require systematic investigation. OBJECTIVES: This study aimed to elucidate the underlying pharmacological mechanisms of the topical wound-healing properties of P. granatum L. using a network pharmacology approach. METHODS: Bioactive compounds of P. granatum L. and their potential target genes were identified using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), Similarity Ensemble Approach (SEA), and SwissTargetPrediction databases. Wound healing-related genes were retrieved from the GeneCards database. Genes intersecting P. granatum L. targets and wound healing-associated genes were subjected to functional enrichment analyses, including protein-protein interaction (PPI), Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses. The PPI network was further analyzed using Cytoscape, and the phytoconstituent-target interaction network was visualized using Gephi. These findings were validated using molecular docking. RESULTS: A total of 40 intersecting genes were identified as potential P. granatum L. targets involved in wound healing. Among these, EGFR, PTPN11, HRAS, IGF1R, and ESR1 were identified as key hub genes. Functional enrichment analysis indicated that the most significantly enriched signaling pathways included the MAPK, PI3K-Akt, EGFR tyrosine kinase inhibitor resistance, focal adhesion, and FoxO signaling pathways. Molecular docking analysis confirmed favorable binding of quercetin and ellagic acid to the hub targets EGFR, IGF1R, and ESR1. CONCLUSIONS: These findings elucidate the pharmacological pathways underlying P. granatum-mediated wound healing and suggest that P. granatum L. acts as a multi-target modulator in the wound-healing process.

Focal Adhesion↗

PubMed1978

Kinetic studies of ampicillin action on Escherichia coli and their spheroplasts.

Kinetic studies of ampicillin action were made on exponentially growing Escherichia coli and on E. coli-spheroplasts using a range of inhibitory and subinhibitory concentrations of ampicillin. For each concentration, the value (ko--ka) representing the difference in generation rates of ampicillin-free culture (ko) and the generation rate of the culture with ampicillin (ka) was calculated and plotted against ampicillin concentration. A straight line relation was obtained with E. coli cells, its intersection with the abscissa, where (ko--ka) = o, give the concentration of ampicillin which exerts no inhibitory action on the cells (0.25 microgram/ml). When ka was plotted against ampicillin concentration, the relation was also linear. Its intersection with the abscissa gives the minimum lethal concentration of ampicillin on the bacterial cells (1.05 microgram/ml). With E. coli-spheroplasts such plots were non-linear which means that a different order of reaction was involved. This difference is probably due to a different mechanism of ampicillin action as revealed by the electroscanning microscopy.

Ampicillin↗