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PubMed1986

[Pancreatopathy in diabetes mellitus].

In a comparative histopathologic autopsy study, 100 patients with diabetes mellitus were compared to 100 without this condition with respect to the presence of chronic pancreatopathy. No qualitative differences in specific alterations could be identified. In diabetic patients, however, intralobular and interacinar fibrosis, lipomatosis and atrophy of the parenchyma occurred more frequently and tended to be more severe. These alterations were also associated with the duration and severity of the diabetic condition and with the age of the patient and the degree of arteriosclerosis. On the other hand alterations of the ductal system and the presence of periductal fibrosis appeared to be less frequent in the diabetic group. The more marked pancreatopathic changes which were observed in the diabetics may be interpreted as resulting from a decreased regenerative ability of the parenchyma in higher age especially in the face of arteriosclerotic circulatory deficits in diabetes. Hormonal-metabolic regulatory disturbances in the function of the acinar pancreatic parenchyma due to the insulin deficit in the capillary net may also play a role.

Arteriosclerosis↗

PubMed1989

[Ribonuclease in the experimental therapy of pancreatitis].

The influence of ribonuclease on the morphogenesis of experimental pancreatitis in the albino rats has been studied. The drug injected during edematous stage of pancreatitis caused some decrease of pancreatic enzymes level in the blood at hemorrhagic stage and its normalization at necrotic stage of pancreatitis. The development of hemorrhagic and necrotic stages of pancreatitis did not change under the influence of ribonuclease. The maturation of connective tissue of pseudocyst capsule was delayed and inflammatory infiltration of necrotic tissues and their elimination were increased under the influence of the drug. There were extensive tubular transformations of acini and early fibrosis and lipomatosis in the frontier zone. In the viable parts of pancreas moderate hypertrophy of exocrine pancreatocytes developed and chronic pancreatitis features appeared with use of ribonuclease.

Animals↗

PubMed1989

Thyroid neoplasms containing mature fat: a report of two cases and review of the literature.

Thyrolipoma or adenolipoma of the thyroid, defined as a thyroid adenoma containing mature fat tissue, is rare and has been reported only seven times. Moreover, the presence of mature fat tissue has been described in only one case of thyroid carcinoma (papillary subtype). We describe one case of thyrolipoma and one case of fat containing follicular carcinoma of the thyroid, and we reviewed the literature on the presence of adipose tissue in the thyroid. It was found that aside from the above conditions, mature adipose tissue has been reported in diffuse lipomatosis of the thyroid, some amyloid goiters, a colloid goiter, and even some normal thyroids. Aside from the presence of mature fat tissue, the clinicopathologic features of fat containing thyroid tumors are not different from those of their usual counterparts.

Adenocarcinoma↗

PubMed1989

[The pathomorphologic characteristics of the arrhythmogenic heart].

UNLABELLED: A complex pathomorphological study was carried out of 80 hearts from patients who died of cardiosclerosis with marked heart rhythm disorders and 20 control cases with the purpose of assessment of the criteria of diagnosis of the arrhythmogenic heart. METHODS USED: postmortal coronarography and cardioventriculography, microdissection, WHO standard anatomical method, morphometric histological, histochemical and histotopographic methods. The author established pathomorphological criteria of diagnosis of the arrhythmogenic heart including a separate construction with prevailing changes of the right ventricle, fibro- and lipomatosis of the myocardium, extensive coronary obstruction forming ischemia foci in the conduction system zones which are the site of formation of arrhythmogenic substances.

Arrhythmias, Cardiac↗

PubMed1989

[Morphologic characteristics of the parotid glands in monkeys in the late period following mumps].

Three monkeys of "Macaca iris" species were examined twice: 3 months and 1 year after having mumps. Morphological data of both parotid glands biopsy are presented. Macrophage lymphocytes and plasmatic cells infiltration around the widened ducts as well as between the acini, growth of fibrosis and lipomatosis, and secretory stasis in glandular cells were observed long time after the disease. These changes are typical of Sjögren disease. This fact allows the authors to consider that virus affection may also be important in the aetiology of parotid glands autoimmune processes.

Animals↗

PubMed1989

Diffuse fibrosis of the pancreas: a peculiar pattern of pancreatitis in alcoholic cirrhosis.

In order to evaluate the effects of chronic alcohol consumption on pancreas morphology we reviewed the autopsy data of 530 patients: 148 with liver alcoholic cirrhosis (group I), 39 with non alcoholic cirrhosis (group II), 47 autopsies of chronic alcohol drinkers without liver cirrhosis (group III) and 296 non alcoholic patients with normal liver, age and sex-matched with group I (group IV). In the control group (group IV) lipomatosis and intralobular fibrosis were common (57 percent and 40 percent) and increased with age. The prevalence of five elementary lesions (protein plug, dilatation of duct, epithelial atrophy, canalicular regression and perilobular fibrosis) and of one pathologic diagnosis (diffuse fibrosing pancreatitis) were higher in group I than in group IV. Duct lesions (protein plugs, canalicular regression and epithelial atrophy) were also significantly higher in drinkers without cirrhosis (group III) than in group IV. Chronic calcifying pancreatitis was rare (2 cases in group I). Thirty-six cases were classified as diffuse fibrosing pancreatitis. This constituted an homogeneous histopathologic group, significantly more frequent in the group of alcoholic cirrhosis, and was always discovered incidentally at autopsy. Because diffuse fibrosing pancreatitis might easily be confused with the morphological changes of chronic calcifying pancreatitis, we suggest to include this histopathologic entity into the Marseille's classification of pancreatitis.

Acute Disease↗

PubMed1989

Lymphoscintigraphy to confirm the clinical diagnosis of lymphedema.

Confirmation of the diagnosis of lymphedema often requires lymphangiography, a procedure that is painful for the patient and technically demanding. Radioisotope lymphoscintigraphy is a relatively new technique that uses technetium 99 m antimony trisulfide colloid to produce a diagnostic image similar to a lymphangiogram. The procedure requires a single subcutaneous injection in the involved extremity, and images are obtained 3 hours later. It is technically easy to perform, produces minimal discomfort for the patient, and has no adverse effects. We have recently used radioisotope lymphoscintigraphy to evaluate 17 patients with extremity edema. These patients initially had a presumed diagnosis of lymphedema involving the upper or lower extremity. Lymphoscintigraphy confirmed the diagnosis of lymphedema in 12 (70.6%) patients. In five of the 17 patients (29.4%) the clinical impression of lymphedema was not supported by lymphoscintigraphy, leading to alternative diagnoses such as lipomatosis, venous insufficiency (two patients), congestive heart failure, and disuse edema. In all patients with secondary lymphedema the lymphatic system in the involved extremity could be partially visualized. Conversely, three of four patients with primary lymphedema had no ascent of the tracer from the foot and no lymphatic channels could be visualized. Lymphoscintigraphy is relatively easy to perform, safe, minimally invasive, and not uncomfortable for the patient. It is useful in differentiating lymphedema from other causes of extremity edema, allowing institution of appropriate therapy.

Adolescent↗

PubMedDate not supplied

Rare presentations of ordinary lipomas of the head and neck: a review.

The ordinary lipoma is the most common neoplasm of mesenchymal origin. Only 13% of them arise in the head and neck region and most of these occur subcutaneously in the posterior neck. Rarely, they can develop in the anterior neck, infratemporal fossa, and in or around the oral cavity, pharynx, larynx, and parotid gland. Clinically, they can be confused with other benign lesions; however, CT allows a specific diagnosis to be made in virtually all cases. This article reviews the CT appearance and differential diagnoses of lipomas in these rare locations and discusses the rare infiltrating lipoma and the relationship between parotid lipomatosis and sialosis.

Adolescent↗

PubMed1988

Understanding Proteus syndrome, unmasking the elephant man, and stemming elephant fever.

Four patients with Proteus syndrome are reported; 3 of the 4 died of unusual causes. Current findings of the syndrome are reviewed, and the present state of its delineation is assessed with emphasis on what is known about natural history. Differential diagnosis includes neurofibromatosis, Klippel-Trénaunay-Weber syndrome, Maffucci syndrome, epidermal nevus syndrome, and the combination of Bannayan-Zonana syndrome, Riley-Smith syndrome, and Ruvalcaba-Myhre syndrome, now thought to constitute a single disorder. Conditions that may possibly overlap with Proteus syndrome--encephalocraniocutaneous lipomatosis and Thanos syndrome--receive special attention. Various suggested diagnoses for the elephant man's disorder are evaluated, and it is concluded that he suffered from Proteus syndrome, not neurofibromatosis. Finally, the psychosocial significance of elephant fever (EF) is discussed, and a plea is made for taking the EF out of NF.

Adult↗

PubMed1988

Juvenile nephronophthisis with calcification of basal ganglia and pancreatic insufficiency.

Juvenile nephronophthisis is a major cause of progressive renal failure in children. Its manifestations are varied and protean. It is a multisystem syndrome, encompassing and overlapping related disorders. We treated a 4-year-old girl who presented with various manifestations of progressive renal failure characteristic of juvenile nephronophthisis, in addition to calcification of the basal ganglia and pancreatic lipomatosis, two associated conditions hitherto undescribed. It is hoped that further reports of other associated conditions may help to clarify further the nature of this complex syndrome.

Basal Ganglia Diseases↗

PubMed1986

Effect of dietary protein on N-nitrosobis(2-oxopropyl)amine-induced carcinogenesis and on spontaneous diseases in Syrian golden hamsters.

For assessment of the effect of dietary protein on spontaneous diseases and on the carcinogenicity of N-nitrosobis(2-oxopropyl)amine [(BOP) CAS: 60599-38-4], Syrian golden hamsters were fed either low protein (LP; 9% casein), medium protein (MP; 18% casein), or high protein (HP; 36% casein) in a diet containing a medium fat (corn oil) level. The experimental design permitted distinguishing between the effects of protein levels on initiation and development of various lesions in hamsters, in comparison with a control group that was given MP diet for life. When fed after BOP treatment, HP diet inhibited, among induced tumors, pulmonary adenomas in males. Among spontaneous diseases, LP diet fed before 8 weeks of age enhanced colitis in both males and females, renal and adrenal gland amyloidosis in males, and gastric vascular calcinosis in males but inhibited liver abscesses and liver cysts in both males and females. When fed after 8 weeks of age, LP diet enhanced gastric and renal vascular calcification and parathyroid gland adenomas in both sexes but inhibited hepatic, renal, and adrenal gland amyloidosis in females and liver abscesses and liver cysts in both males and females. The feeding of HP diet before 8 weeks of age enhanced the development of colitis and adrenal gland lipomatosis in both males and females but inhibited the development of adrenal gland amyloidosis and adrenal cortical cell hyperplasia in males. When fed to hamsters after 8 weeks of age, HP diet increased the incidence of adrenal gland amyloidosis in females and colitis in both males and females but reduced the frequency of liver cysts in both males and females and of adrenal cortical cell hyperplasia in males. The overall data and literature review indicate that the effect of dietary protein on tumorigenesis is tissue, sex, species, and strain related.

Amyloidosis↗

PubMed1987

[Effect of tageflar, a synthetic analog of L-enkephalin, on the morphogenesis of experimental pancreatitis].

It has been substantiated that the use of a new synthetic drug tageflar analogous to L-enkephalin was accompanied by the depression in pancreatic enzyme activity in the blood of rats, acceleration of necrotic and lytic processes in irreversibly damaged exocrine pancreocytes in the course of experimental pancreatitis. The drug promoted microcirculation retention in the injury zone and acceleration of the arrangement and elimination of necrotic glandular tissue. The influence of tagaflar diminished the extent of perifocal necrobiotic zone and suppressed sclerotic processes and pancreatic lipomatosis.

Animals↗

PubMed1986

[Significance of nonspecific histopathologic changes in the myocardium in sudden coronary death].

Informative value of non-specific histopathological myocardial changes was determined on the material of 31 autopsy cases of a sudden coronary death (SCD) and comparison of two groups: 18 observations of violent death and 17 observations of an acute alcoholic intoxication. Informative value was assessed using Kullback's criterion. Large- and small-focal cardiosclerosis and cardiomyocyte hyperthrophy were of a high informative value for SCD. Sclerosis of the intramural arteries, congestion on venas and capillaries, muscle fiber fragmentation had an informative value for SCD versus a violent death, and haemorrhages for SCD versus an alcoholic group. Cardiomyocyte vacuolisation and wavelike deformation of muscle fibers were of a low informative value. Cardiomyocyte atrophy and lymphohistiocytic infiltration were informative for SCD when compared to a violent death and for an alcoholic group when compared to SCD. Endothelial proliferation of the microcirculation vessels, myolysis, sludge-phenomenon, lypofuscinosis, stromal lipomatosis were of informative value for the alcoholic group and not for SCD.

Accidents, Occupational↗

PubMed1986

[Fine structural changes in degenerative tendinopathy].

50 tendons were examined by electron microscopy. Although they did not demonstrate any signs of inflammation or lipomatosis marked hypoxic changes in the tenocytes were evident on ultrastructural examination. The most frequent alterations were longitudinal splitting, disintegration, angulation and the so-called "kink deformation" of the collagen fibers.

Adult↗

PubMed1985

Mixed glioma of the cerebellopontine angle.

A rare case of mixed ependymoma and astrocytoma of the cerebellopontine angle is reported. Its clinical presentation, characteristics on evaluation, and prognosis are compared with those of the acoustic neuroma and glioma. The central form of von Recklinghausen's disease and familial multiple lipomatosis as it applies to the patient is also discussed.

Astrocytoma↗

PubMed1985

[When is computed tomography indicated in dilatation of the retrorectal space?].

The reasonable use of computed tomography in the diagnosis of an enlarged retrorectal space was analysed in 92 cases. CT is useful in differentiation of a pathologically enlarged retrorectal space without mucosal lesions of the rectum. It enables the separation between tumourous masses, proliferation of connective tissue (in retrorectal fibrosis or inflammatory disease) and pelvic lipomatosis. If simultaneous mucosal involvement in barium enema or rectoscopy--especially in rectal carcinoma or recurrent carcinoma of the rectum- is found, CT may show the perirectal extension of tumorous masses and thus help to clarify local operability.

Colonic Diseases↗

PubMed1979

[Changes in the thyroid gland in Itsenko-Cushing's disease and corticosteroma].

Histological and ultrastructural examinations and stereological analysis of the thyroid gland of 16 patients with Itsenko--Cushing disease and corticosteroma with glucocorticoid hyperproduction showed signs of a decrease in its functional activity. An increase in the colloid mass in follicles was accompanied by its irregular staining, flattening of the epithelium, lipomatosis of the stroma and ultrastructural signs of low activity of thyreocytes. The assumption of a spherical shape of the follicles was shown to be unjustified. The accurate quantitative evaluation of the structural changes in the thyroid gland requires information on the spacial organization of its components and shape of individual follicles.

Adrenal Rest Tumor↗

PubMed1979

[Chronic pancreatitis from histo- and cytological study data].

Biopsies of pancreatic tissue in 54 patients with chronic pancreatitis were studied histologically and electron microscopically. Pathomorphological criteria of this disease include: dyscomplexation of acini, necroses, hemorrhages, inflammatory reaction, pseudocystosis, lipomatosis, condensation of secretory masses, and formation of concrements, hyperplasia, metaplasia, and increased desquamation of ductular epithelium, hyperplasia of Langerhans islands, damage of the vessels and perineural spaces, fibrosis. The increased permeability of ductal epithelium, increased synthesis of protein substances, formation of concrements and specific antibody are conducive to exacerbation of chronic pancreatitis.

Chronic Disease↗