PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “Tooth”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,333 records · Page 74Linked to original sources

Validity of self-reported tooth counts during a telephone screening interview.

OBJECTIVES: Telephone screening has become a common method used in health services research to identify efficiently persons in specific populations of interest. In this research, we used a large-scale telephone screening survey to assess: (1) the effectiveness of the telephone method in gathering tooth count information by measuring response rate (cooperation) to specific questions and (2) the validity of subjects' reports of the number of remaining natural teeth. METHODS: We used a telephone screening methodology to identify dentate persons (at least one natural tooth remaining) who were 45 years old or older and resided in one of four counties of north Florida. At a second stage, a sample of the telephone screening participants was selected for further study, which consisted of a baseline in-person interview and a clinical examination. We compared the number of remaining teeth reported during the telephone interview with the number determined at baseline examination. RESULTS: The telephone method was effective at gathering tooth count information, although response rates varied with the level of specificity required. Almost all subjects reported the number of teeth at least at the nominal and ordinal levels, but fewer than three-fourths reported the number at the interval level. When the unit of analysis was the overall sample, self-reported number of teeth was a valid measure of the true number. When the unit of analysis was the individual subject, validity was associated with certain clinical and sociodemographic factors. CONCLUSIONS: When the unit of analysis is the overall sample, these results suggest that self-reported tooth counts during a telephone interview are sufficiently valid to meet all but the most stringent data requirements. When the unit of analysis is the individual subject, these tooth counts may not be valid, depending upon the degree of specificity required and subject characteristics.

Age Factors↗

Some anatomical and electrophysiological properties of tooth-pulp afferents in the cat.

1. The responses of nerves which could be excited by electrical stimulation of the canine tooth-pulp were recorded from the trigeminal ganglion. 2. Preliminary experiments showed that the responses of mandibular canine pulpal afferents were recorded from the postero-lateral part of the trigeminal ganglion whereas the responses of maxillary canine pulpal afferents were recorded from the central part of the ganglion. 3. The conduction velocity differed in various parts of these nerves; the conduction velocity inside the tooth tended to be slower than that from the tooth to the trigeminal ganglion; the mean conduction velocity in the part of the nerve peripheral to the trigeminal ganglion was faster than that in the part central to the ganglion, and in the central part the conduction velocity decreased caudally. 4. Collision experiments combining tooth stimulation and stimulation of sites in the trigeminal sensory nuclear complex were carried out to investigate the projections of individual pulpal afferents. 5. The results of these experiments showed that some tooth-pulp afferents bifurcate and project to both the main sensory nucleus and the nucleus caudalis. For other pulpal afferents only a projection to the main sensory nucleus or the nucleus caudalis could be demonstrated. 6. Pulpal afferents that bifurcated had faster conduction velocities than those for which no bifurcation could be shown.

Afferent Pathways↗

Effects of acupuncture on c-Fos expression in brain after noxious tooth stimulation of the rat.

Clinically, acupuncture therapy is useful for the control of acute or chronic pain. This study was designed to elucidate the antinociceptive mechanism of acupuncture and the mechanisms underlying cardiovascular reflex elicited by toothache. Expression of c-Fos, a neuronal activation marker, and the phenylethanalamine-N-methyltransferase (PNMT) were examined 1.5 hours after noxious intrapulpal tooth stimulation. Manual acupuncture was performed 20 min before noxious intrapulpal stimulation by 2 M KCl injection into upper or lower anterior tooth pulp. The acupuncture points were Li4 (Hegu) between the 1st and 2nd metacarpal bones or St36 (Zusanli) between the anterior crest of the tibial tuberosity and the fibula head below the patella. After noxious intrapulpal tooth stimulation, Fos-immunoreactive (IR) neurons were identified in the trigeminal subnucleus caudalis (Vc) and the transitional region between the subnucleus caudalis and the subnucleus interpolaris (Vi), in the inferior olivory nucleus (IO) connecting the cerebellum and other brain regions, and also the thalamic ventral posteromedial (VPM) nucleus and centrolateral (CL) nucleus, respectively. In addition, Fos-IR neurons were found in the central cardiovasuclar regulation centers, such as the hypothalamus supraoptic nucleus (SON) and paraventricular nucleus (PVN), and nucleus tractus solitarius (NTS) and rostral ventromedulla (RVLM). All acupuncture at St36 or Li4 significantly suppressed Fos-IR neurons in all Fos-expressed brain areas except the IO nucleus and attenuated the increases in arterial blood pressure (BP) and heart rate (HR) after noxious intrapulpal stimulation. Its Fos-suppressive effects were mostly blocked by naloxone, an opioid antagonist. In addition, acupuncture at St36 or Li4 significantly decreased Fos-containing PNMT, and this effect was also reversed by naloxone. These results suggest that: 1) tooth pulpal noxious signals transmit to the Vc and Vc/Vi transitional region and the 2nd afferent neuron synapse in the thalamic VPM and CL, 2) tooth pulpal pain elicits cardiovascular reflex mediated by NTS, VLM, hypothalamic SON and PVN, and 3) acupuncture reduces cardiovascular reflex elicited by toothache, is associated with the adrenergic system.

Acupuncture Points↗

Morphology of primary somatosensory cortical neurons receiving input from the tooth pulp.

1. To elucidate the morphological and electrophysiological characteristics of tooth pulp-driven neurons (TPNs) in the primary somatosensory cortex (SI), we injected neurobiotin into TPNs whose electrophysiological characteristics had been identified. 2. TPNs, responsive to electrical stimulation of the tooth pulp, were recorded intracellularly and injected from areas 3a and 3b of SI. A total of 58 TPNs in SI were successfully injected and reconstructed. Nineteen of these TPNs were located in area 3a and 39 in area 3b. Three area 3a TPNs were identified in lamina II, eight in lamina III, seven in lamina V, and one in lamina VI. Five 3b TPNs were identified in lamina II, 19 in lamina III, 7 in lamina IV, 7 in lamina V, and 1 in lamina VI. 3. Thalamic and tooth pulp latencies of lamina III and IV TPNs were shorter than those of lamina II and V TPNs. On the other hand, lingual and masseteric nerve latencies of TPNs were not consistent with thalamic and tooth pulp latencies. 4. Three of 19 area 3a TPNs and 7 of 39 area 3b TPNs were classified as pulp-specific TPNs, which received only tooth pulp input. Thirteen of 19 area 3a TPNs and 24 of 32 area 3b TPNs were classified as low-threshold mechanoreceptive TPNs, which responded to nonnoxious mechanical stimulation of the receptive field, and only 2 area 3b TPNs were classified as wide-dynamic range TPNs. Six of the area 3a TPNs and 14 of the area 3b TPNs responded to electrical stimulation of the lingual and/or masseteric nerves. Nociceptive-specific TPNs were not recorded in this study. 5. Lamina II TPNs in areas 3a and 3b had small somata, and those in area 3a had dendrites spreading into laminae I-II. Two TPNs in area 3a had axon collaterals extending into area 4. In contrast, area 3b TPNs in lamina II have dendrites spreading into laminae I-III. Their axons did not extend deeply into the subcortical regions, and the axon collaterals reached into area 3a. 6. Lamina III TPNs were classified according to their morphological characteristics as pyramidal or nonpyramidal stellate TPNs. Pyramidal lamina III TPNs had typical pyramidal somata, like those of lamina V pyramidal cells. Furthermore, those in areas 3a and 3b had dendrites with numerous spines spreading into laminae I-III, and some of the area 3a TPNs have axons with collaterals projecting into area 4. Lamina III area 3b TPNs had morphological properties similar to those in area 3a.(ABSTRACT TRUNCATED AT 400 WORDS)

Afferent Pathways↗

Tooth-brushing practices of parents and toddlers: a study of home-based videotaped sessions.

The aim of this pilot study was to investigate the tooth-brushing behaviour of parents and toddlers, by analysis of tooth-brushing sessions videotaped in families' homes. Eighteen families (self-selected from an ongoing preventive-intervention study) videotaped all home tooth-brushing sessions involving their toddler (average age 2.5 years) over a 24-hour period. The vast majority of families (89%) engaged in at least two sessions per day, usually supervised by mothers. The average length of the sessions was 142 s, although the brush tended to be in the child's mouth for less than half of that time. On average, only 10 s were spent brushing the front teeth, 13 s the back teeth, and 29 s spent on non-brushing activities (e.g., biting brush, sucking water). Three styles of brushing were identified, and families tended to be consistent in their use of these styles: exclusively parent-led (least common), exclusively child-led, and shared between parent and child (most common). In contrast with these poor behavioural outcomes, feedback from parents indicated that they were generally confident that the sessions had been effective in achieving clean teeth. These findings suggest that home-based tooth-brushing activity falls far short of professional expectations. Tooth-brushing, even with fluoride toothpaste, may be seriously compromised as a method of reducing caries in toddlers because teeth are being brushed too briefly.

Child, Preschool↗

Gelatinase A (MMP-2) in developing tooth tissues and amelogenin hydrolysis.

Matrix metalloproteinases (MMPs) are thought to play important roles during enamel and dentin biomineralization. Previously, membrane type-1 matrix metalloproteinase (MT1-MMP) was localized to the plasma membranes of ameloblasts and odontoblasts of the developing tooth. The best-characterized function of MT1-MMP is to initiate the activation of gelatinase A (MMP-2). Thus, we hypothesized that gelatinase A may also be expressed by developing tooth tissues. A full-length porcine gelatinase A mRNA was isolated by RT-PCR homology cloning of an enamel-organ-specific cDNA library. Northern blot and in situ hybridization analyses demonstrated gelatinase A expression in developing tooth tissues. Immunohistochemical analysis localized gelatinase A close to the plasma membrane of these tissues. Furthermore, recombinant gelatinase A was demonstrated to cleave recombinant amelogenin into several fragments of differing molecular masses. Thus, gelatinase A is expressed by developing tooth tissues along with its activator MT1-MMP and may, therefore, play an important role during tooth development.

Ameloblasts↗

A modified stethoscope to assist in the identification of tooth coloured restorations.

Forensic odontologists are often called upon to assist in the identification of bodies. Since identification of the body relies on comparison of the post-mortem chart with the ante-mortem record it is important that all restorations present in the deceased's teeth are identified and correctly charted. If a restoration is present in an ante-mortem record then its absence in the post-mortem chart means that the two records cannot belong to the same person. However, tooth-coloured restorations can be difficult to identify, especially in the less than ideal conditions under which the odontologist may have to work. This study was designed to evaluate a simple technique for identifying tooth-coloured restorations, exploiting the difference between the surface roughness of restorative materials and that of the surrounding tooth substance. A conventional dental probe was substituted for the bell of a stethoscope. Differences in the surface texture of the tooth are reflected in changes in the sound heard by the examiner. The modified stethoscope is a useful and easily fabricated device, which may reduce the likelihood of small tooth-coloured restorations going unnoticed in post-mortem examinations. The ability to detect fissure sealants using the device may also prove useful in epidemiological studies.

Adult↗

Radiographic study of the maxillary canine tooth in mesaticephalic dogs.

Radiology is the most important diagnostic technique for evaluation of the radicular structure of the tooth and adjacent areas. However, superimposition of other oral or nasal structures often creates difficulties when interpreting radiographic images. The purpose of this study was to identify and locate any anatomical structures that may be superimposed over the root of the maxillary canine tooth in radiographs of dogs. Results showed that the nasal conchae minimally interfere with the visualization of the tooth. The vomer bone and maxillary structures (the conchal crest, the line of conjunction between the maxillary body and the palatine process, and the palatine sulcus) are visible as linear radiopacities, and were found to be responsible for most of the radiographic features in this area. The incisivomaxillary canal and the palatine fissure caused radiolucent images. The incisivomaxillary suture and the nasoincisive suture may appear as radiolucent images in young skulls and linear radiopacities in older skulls. It appears from this study that a compromise between minimal superimposition of dental and non-dental structures and small image distortion is needed to obtain diagnostic radiographic views of the maxillary canine tooth in mesaticephalic dogs. The relative positions of the conchal crest, the line of conjunction between the vertical body of the maxilla and its palatine process, the incisivomaxillary canal, and the tooth, cannot be changed radiographically because of the close anatomic position of these structures.

Animals↗

Treatment of asymptomatic internal resorption of a maxillary premolar tooth in a military working dog.

An asymptomatic pink discoloration of a maxillary right fourth premolar tooth was discovered during a routine oral examination on a 9 year-old Belgian Malinois dog. A radiolucent lesion was seen in the pulpal chamber on radiographic examination. The lesion had perforated the mesiobuccal root of the tooth. The primary differential diagnosis was idiopathic internal resorption. The tooth was treated by partial resection (removal of the mesiobuccal root and associated crown). A vital pulpotomy and amalgam restoration was performed on the remaining tooth structure. A follow-up 1 year later demonstrated a successful treatment outcome. The animal was asymptomatic and able to perform military duties. Clinical and radiographic signs of healing were evident and the tooth was functional.

Animals↗

MSX1 and orofacial clefting with and without tooth agenesis.

MSX1 has been considered a strong candidate for orofacial clefting, based on mouse expression studies and knockout models, as well as association and linkage studies in humans. MSX1 mutations are also causal for hereditary tooth agenesis. We tested the hypothesis that individuals with orofacial clefting with or without tooth agenesis have MSX1 coding mutations by screening 33 individuals with cleft lip with or without cleft palate (CL/P) and 19 individuals with both orofacial clefting and tooth agenesis. Although no MSX1 coding mutations were identified, the known 101C > G variant occurred more often in subjects with both CL/P and tooth agenesis (p = 0.0008), while the *6C-T variant was found more often in CL/P subjects (p = 0.001). Coding mutations in MSX1 are not the cause of orofacial clefting with or without tooth agenesis in this study population. However, the significant association of MSX1 with both phenotypes implies that MSX1 regulatory elements may be mutated.

Adolescent↗

Epithelial-mesenchymal interactions are required for msx 1 and msx 2 gene expression in the developing murine molar tooth.

Duplication of the msh-like homeobox gene of Drosophila may be related to the evolution of the vertebrate head. The murine homologues of this gene, msx 1 and msx 2 are expressed in the developing craniofacial complex including the branchial arches, especially in regions of epithelial-mesenchymal organogenesis including the developing tooth. By performing in vitro recombination experiments using homochronic dental and non-dental epithelial and mesenchymal tissues from E10 to E18 mouse embryos, we have found that the maintenance of homeobox gene expression in the tooth is dependent upon tissue interactions. In homotypic recombinants, dental-type tissue interactions occur, leading to expression of both genes in a manner similar to that seen during in vivo development. msx 1 is expressed exclusively in mesenchyme, both in the dental papilla and follicle. msx 2 is expressed in the dental epithelium and only in the mesenchyme of the dental papilla. In heterotypic recombinants, the dental epithelium is able to induce msx 1 expression in non-dental mesenchyme, this potential being lost at the bell stage. In these recombinants msx 2 was induced by presumptive dental epithelium prior to the bud stage but not thereafter. The expression of msx 1 and msx 2 in dental mesenchyme requires the presence of epithelium until the early bell stage. However, whereas non-dental, oral epithelium is capable of maintaining expression of msx 1 in dental mesenchyme throughout tooth development, induction of msx 2 was temporally restricted suggesting regulation by a specific epithelial-mesenchymal interaction related to the inductive events of tooth formation. msx 1 and msx 2, as putative transcription factors, may play a role in regulating the expression of other genes during tooth formation. We conclude that expression of msx 1 in jaw mesenchyme requires a non-specific epithelial signal, whereas msx 2 expression in either epithelium or mesenchyme requires reciprocal interactions between specialized dental cell populations.

Animals↗

[Effects of tooth pulp stimulation on single unit activity of the amygdala in cats].

Responses induced by tooth pulp stimulation were studied in 27 gallamine immobilized adult cats. Single units were recorded from the amygdala using stainless steel microelectrodes. Of 57 amygdaloid neurons, 8 were responsive to only non-nociceptive (tap and/or hair bending) stimuli, 7 were responsive to both nociceptive (pinch) and non-nociceptive stimuli, 18 were responsive to nociceptive stimuli, non-nociceptive stimuli and tooth pulp stimulation, and the others did not respond to these stimuli. The neurons in the amygdala responsive to tooth pulp stimulation were localized in the nucleus amygdaloideus centralis (pars lateralis) [Acl], nucleus amygdaloideus centralis (pars medialis) [Acl] and nucleus amygdaloideus basalis (pars magnocellularis) [Abm]. The response induced by tooth pulp stimulation was depressed by morphine and reversed by naloxone. These results suggest that Acl, Acm and Abm in the amygdala may receive pain sensation evoked by tooth pulp stimulation. Moreover, there is a possibility that these nuclei may be related to the emotional component involved in nociceptive processing.

Afferent Pathways↗

Frequency and correlates of the saw-tooth pattern of flow-volume curves in an epidemiological survey.

The object of this report was to assess the possibility of identifying saw-tooth patterns on flow-volume curves in men aged 28 to 58 years. We studied the frequency of these patterns and their relationships with two indirect signs of UAO increase in FEV1/PEF and FEF50%/FIF50% ratios--as well as with clinical and functional data. Twenty-six of the 360 subjects surveyed, ie, 7.2 percent, had flow oscillations in the inspiratory and/or expiratory part of flow-volume curves, corresponding to the definition of the saw-tooth pattern. We observed significant relationships between the saw-tooth pattern and the mean FEV1/PEF ratio. In 97 subjects, the proportion of those with saw-tooth patterns was 13.4 percent, and the mean FEF50%/FIF50% ratio was 1.53 in those with the pattern vs 1.07 in those without it. These results show that the saw-tooth pattern was not rare in these men.

Adult↗

The induction of enamel and dentin complexes by subcutaneous implantation of reconstructed human and murine tooth germ elements.

Tooth induction by xenogenic graft of reconstructed human tooth germ components has never been attempted. Here we report our first attempt at a transplantation of human tooth germ components, heterologously recombined with mouse dental epithelia, into immunocompromised animals. Human third molar tooth germs enucleated from young patients as prophylactic treatment for orthodontic reasons were collected. The whole or minced human dental papilla was reconstructed with human- or mouse molar enamel epithelium, and transplanted in the dorsal aspect of C.B-17/Icr-scid Jcl mice. The transplant of human dental papilla reconstructed with human enamel epithelium formed thin dentin and immature enamel layers by 3 to 4 weeks, but remained extremely small in quantity due to a shortage of epithelial components in the graft. The addition of E16 mouse molar enamel organs (n=10-12) to each graft augmented the formation of tooth germ-like structures, but the differentiation of mouse molar ameloblasts was suppressed. However, once a solid layer of mineralized dentin was established, mouse ameloblasts accelerated their differentiation, and completed the enamel matrix formation and maturation within the following 4 weeks, whereas human ameloblasts, which had interacted with human dental papilla, remained in the stage of matrix formation during the same period. These data imply that, in reconstructed transplants, the differentiation of mouse dental epithelia is restrained by putative suppressive factors derived from human dental papilla until they are separated by mineralized dentin layers that serve as a diffusion barrier. The mouse enamel organ nevertheless retains its own phenotypic characteristics and intrinsic timing of cell differentiation and function.

Amelogenin↗

Effects of tooth pulp deafferentation on brainstem neurons of the rat trigeminal subnucleus oralis.

The effects of tooth pulp deafferentation on brainstem neuronal properties were examined in the rat trigeminal (V) subnucleus oralis. Deafferentation was produced by removal of the coronal tooth pulp of all left mandibular molars. Neurons in the subnucleus oralis were then electrophysiologically characterized in chloralose/urethane-anesthetized rats at a single postoperative time. The mechanoreceptive field and response properties of low-threshold mechanoreceptive (LTM) neurons in rats studied at postoperative times of 3-4 days, 7-13 days, and 28-40 days were compared to those in control (unoperated) rats. Functional changes in oralis LTM neurons were observed in all tooth-pulp-deafferented rats, but most statistically significant changes were apparent only at the 7- to 13-day postoperative period. In 7- to 13-day pulp-deafferented rats, there was a significant increase in the incidence of neurons with a two-divisional mechanoreceptive field, accompanied by a significant decrease in the incidence of neurons with a maxillary mechanoreceptive field. This group of rats also showed a significant increase in the incidence of neurons with a mechanoreceptive field involving both mandibular and maxillary divisions. For neurons that could be activated by light mechanical stimulation of one or more mandibular or maxillary teeth, the 7- to 13-day pulp-deafferented rats showed a significant increase in the incidence of neurons with such periodontal mechanosensitive inputs involving both mandibular and maxillary divisions. There was also a significant increase in the incidence of spontaneously active neurons in this group of rats. For neurons with a mechanoreceptive field involving mystacial vibrissae, there was a significant increase in all three groups of pulp-deafferented rats in the maximal width of the vibrissal row (i.e., the number of vibrissae in the longest horizontal row of vibrissae, stimulation of which was effective in activating a given neuron). No significant differences were found between groups in the incidence of neurons with a mandibular mechanoreceptive field or in the proportions of neurons with a mechanoreceptive field located in each of several defined orofacial regions. There was also no significant difference between groups in the mean latency to electrical stimulation of the neuronal mechanoreceptive field, or in the proportions of rapidly adapting (RA) and slowly adapting (SA) neurons. These results show many similarities with the functional changes of oralis LTM neurons in the cat following tooth pulp deafferentation, and indicate that the rat may serve as a very useful model for V brainstem neuroplasticity induced by tooth pulp deafferentation.

Afferent Pathways↗

[The experimental study of the delayed replantation after cryopreservation of mature tooth in dogs].

OBJECTIVE: To study the conditions of healing of mature tooth in dogs after long cryopreservation followed by replantation. METHODS: The tooth was extracted after filling the root canals and then preserved for one week and three months respectively by Schwartz's method of cryopreservation of periodontal membrane. The specimens were took out eight weeks after replantation. It was demineralized in a 5% solution of formic acid,and then sectioned perpendicular to the long axes of tooth at a thickness of 5microm. The tooth were sectioned in step-serial sections at 500 microm intervals. The sections were stained with hematoxylin-eosin and followed by evaluation according to Andreasen. RESULTS: The percentage of healing of periodontal membrane (PHPM) of the group of cryopreservation for one week was 64.53%. It was lower than the PHPM of the group of immediate replantation (85%), but the difference demonstrated no significance (P>0.05). The PHPM of the group of cryopreservation for three months was 50.3%. It was lower than the PHPM of the group of immediate replantation significantly (P<0.05). CONCLUSION: The human's periodontal membrane may be cryopreserved longly and heals after the replantation of tooth as the human's tissues of corneas, skin, islets, et al may be done. The alveolar cavities to be newly made affect the healing of periodontal membrane in some degree.

English Abstract↗

Emotional effects of tooth loss in community-dwelling elderly people in Hong Kong.

PURPOSE: This study investigated the emotional effects of tooth loss among community-dwelling elderly people in Hong Kong and compared the effects among edentulous and partially dentate elderly. MATERIALS AND METHODS: A questionnaire study involved 233 southern Chinese elderly who were recruited and interviewed at social centers for elderly people throughout Hong Kong. Data were analyzed using chi-square or chi-square exact tests. RESULTS: Twenty-two percent of the participants reported difficulty accepting tooth loss, with no difference between the edentulous and partially dentate. However, 95% stated that their confidence was unaffected. For more than half of elderly people, tooth loss had a negative effect on food choice and enjoyment of food, with removable denture wearers having greater restrictions. Avoiding going out, eating in public, and forming close relationships were less-common problems. Twenty-two percent felt unprepared for the effects of tooth loss, and more than half said that better communication with the dentist would have helped. CONCLUSION: The emotional effects of tooth loss were not marked among elderly people, and there were no differences between edentulous and partially dentate individuals. However, significant disability was experienced because of restrictions in daily living activities. Restrictions were more severe in people who had lost enough teeth to necessitate denture wearing.

Adaptation, Psychological↗

[Relationship between estrogen-receptor genotype and tooth loss in postmenopausal women].

Tooth loss is known to be influenced by environmental factors, but the role of genetic factors remains unknown. It is likely that the estrogen-receptor (ER) gene could be associated with tooth loss in women because recent studies in the United State reported the protective effect of estrogen replacement therapy on tooth retention in the elderly. We first demonstrated relationship between ER genotype and tooth loss in post-menopausal women. However, further investigation is necessary to clarify unknown pathways in which ER genotype contributes to tooth loss in women.

English Abstract↗