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At least 1,351 records · Page 75Linked to original sources
PubMed1977

[Studies on gamma-oryzanol. III. Influence of gamma-oryzanol on circadian rhythms of serum gastrin, 11-OHCS and gastric secretion in rats (author's transl)].

In the course of investigations of gamma-oryzanol in rats, circadian rhythms in antiulcerogenic action on gamma-oryzanol were observed. Circadian rhythms in several other parameters were investigated and correlated with the antiulcerogenic action. Pretreatment of rats with gamma-oryzanol 100 mg/kg, s.c., for 5 days tended to decrease serum gastrin levels and gastric secretion, and to increase serum 11-OHCS. Suppresive patterns of serum gastrin and gastric secretion following the pretreatment with gamma-oryzanol corresponded to the circadian rhythms in antiulcerogenic action of gamma-oryzanol. A complication of our results suggests that increment of catecholamines in rat brain after gamma-oryzanol plays a role in the above mentioned actions.

11-Hydroxycorticosteroids↗
PubMed1975

Pharmacological analysis of the adrenergic control of the cerebral circulation.

The adrenergic control of the cerebral circulation was subjected to pharmacological analysis. The status of the cerebral circulation was assessed using radioisotope, electromagnetic and resistographic methods. EEG, ECG and arterial pressure were recorded. The acid-base equilibrium and oxygen tension were measured in the arterial blood and cerebrospinal fluid. The experiments showed that the sympathetic innervation plays an important role in controlling cerebral circulation and in the development of cerebrovascular disorders. This was indicated by the constriction of intracranial arteries induced by noradrenaline, stimulation of sympathetic nerves, reflex sympathetic activations and the effect of potassium chloride on the centrol nervous system. The pharmacological study demonstrated that constriction of the intracranial vessels is brought about by an activation of the sympatho-adrenal system which is mediated via alpha-adrenoreceptors of cerebral blood vessels.

Acid-Base Equilibrium↗
PubMed1988

[Effect of monoamine oxidase inhibitors with a broad range of action on the structure and phase ratio of the wakefulness-sleep cycle in the cat].

The monoamine oxidase (MAO) inhibitors disturb the structure of the sleep-wakefulness cycle and its ultradian rhythms by prolongation of the slow-wave sleep, complete suppression of the paradoxical sleep (PS) and considerable shortage of the wakefulness phase. When synchronizing action of MAO inhibitors has stopped prolongation of wakefulness is observed both before and during partial recovery of the PS. This fact is considered as an indication of the accumulation of a need of wakefulness in the course of its partial deprivation by MAO inhibitors. MAO inhibitors exert a particularly strong effect on the PS producing long-term suppression of its tonic and phasic components. Complete inhibition of the PS is apparently due to selective deterioration of the functional state of its trigger mechanisms.

Activity Cycles↗