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At least 1,351 records · Page 75Linked to original sources
PubMed1999

Comparative differences in the composition and biomechanical properties of tibiae of seven- and seventy-two-week-old male and female broiler breeder chickens.

Skeletal problems are common in both young and old poultry and are often related to bone weakness. They affect mortality on the farm and condemnations within processing plant and thus raise both welfare and economic concerns. To understand the basis of bone strength, the metaphyseal histology, composition, and the biomechanical properties of tibiae from 7- and 72-wk-old male and female broiler breeder chickens were compared. The biochemical constituents included ash, collagen, proteoglycan, transforming growth factor-beta (TGF-beta), pyridinium crosslinks, and the organic matrix-associated fluorescence. Blood variables were measured to determine the metabolic status of these birds as related to bone physiology. Although there were no differences in blood chemistry of 7-wk-old males and females, there were several differences between young and old birds. The levels of calcium, triglyceride, and iron were higher in older females than in older males. The collagen content was reduced, and the proteoglycan content increased in 72-wk-old hens. The TGF-beta content of bones from 7-wk-old females was higher than that of other groups of birds. Bone strength and stiffness, measured using loads at break and Young's modulus, respectively, were higher in older birds. The presence of medullary bones in 72-wk-old hens did not affect their bone strength, although it reduced strain values and increased Young's modulus. Compared to other groups, the 72-wk-old hens had a higher content of an inorganic matrix. The levels of hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP) and the collagenase-extractable fluorescence of the organic matrix from older birds was higher. The decalcified bone matrix from older birds also showed higher susceptibility to bacterial collagenase than their younger counterparts. Bone strength showed positive correlations with its ash content, density, pyridinium crosslinks, and the fluorescence of the matrix. However, the correlation was strong with both pyridinium crosslinks and the fluorescence of the organic matrix. These results suggest that bone strength is influenced by the content of its collagen crosslinks.

Animal Welfare↗
PubMed1994

Insufficiency fractures of the distal tibia.

Eight patients are described who had sustained insufficiency fractures of the distal tibia, in one case, bilaterally. Seven of the eight patients had RA. Features common to most patients were delay in diagnosis, low body weight, pain and swelling around the ankle joint, steroid therapy, generalized osteopenia and relatively young age. Patients with RA all had ankle joint involvement and impaired mobility.

Aged↗
PubMed1990

Cosmos 1887: morphology, histochemistry, and vasculature of the growing rat tibia.

Light microscopy, electron microscopy, and enzyme histochemistry were used to study the effects of spaceflight on metaphyseal and cortical bone of the rat tibia. Cortical cross-sectional area and perimeter were not altered by a 12.5-day spaceflight in 3-month-old male rats. The endosteal osteoblast population and the vasculature near the periosteal surface in flight rats compared with ground controls showed more pronounced changes in cortical bone than in metaphyseal bone. The osteoblasts demonstrated greater numbers of transitional Golgi vesicles, possibly caused by a decreased cellular metabolic energy source, but no difference in the large Golgi saccules or the cell membrane-associated alkaline phosphatase activity. The periosteal vasculature in the diaphysis of flight rats often showed lipid accumulations within the lumen of the vessels, occasional degeneration of the vascular wall, and degeneration of osteocytes adjacent to vessels containing intraluminal deposits. These changes were not found in the metaphyseal region of flight animals. The focal vascular changes may be due to ischemia of bone or a developing fragility of the vessel walls as a result of spaceflight.

Alkaline Phosphatase↗
PubMed1982

Immunohistochemical demonstration of epithelial differentiation in adamantinoma of the tibia.

The nature of the neoplastic cells in a case of adamantinoma of the tibia was studied with an immunocytochemical method. The antigens investigated were factor VIII-related antigen and keratin, as markers for endothelial cells and epithelial cells, respectively. The tumor cells of adamantinoma stained strongly for keratin but were completely negative for factor VIII-related antigen. These results strongly suggest that cells of tibial adamantinomas are of epithelial rather than endothelial nature, thus confirming previous light-microscopic observations and electron-microscopic studies performed on this tumor. Although the negativity for factor VIII-related antigen does not rule out by itself the presence of an endothelial component, the fact that the tumor cells are positive for keratin makes this possibility highly unlikely. Additional cases of this entity should be studied with these cytoplasmic markers in order to confirm the findings here presented.

Adult↗
PubMed1995

An unusual round cell tumor of the tibia with granular cells.

We present the clinical, radiographic and histopathologic findings of an unusual tumor that originated in the diaphysis of the tibia in a 10-year-old boy. Clinical symptoms had been present for approximately 2 years and radiographic abnormalities for > or = 8 months before biopsy and subsequent resection of the neoplasm. The child is doing well 4 1/2 years later. Microscopically, the tumor was not typical of any bone tumor with which we are familiar. It was a round-cell tumor with extensive fibrosis, prominent cytoplasmic granularity, and isolated immunoreactivity for vimentin, epithelial membrane antigen, and antichymotrypsin. Ultrastructural examination uncovered the presence of both well-formed desmosomes and cell-associated basement membrane material in addition to abundant phagolysosomes. Classification of this tumor is a challenge; the differential diagnosis includes atypical adamantinoma, atypical Ewing's sarcoma, and small-cell osteosarcoma. We favor the former interpretation, although we raise the possibility that it may be a unique lesion.

Bone Neoplasms↗
PubMed1996

The rationales of interlocking nailing of the femur, tibia, and humerus.

Interlocking nailing has been increasingly used to treat acute and chronic afflictions of long bones. Although the interlocking construct is similar, regardless of the anatomic area of application, the results and complications of this type of fixation in the femur, tibia, and humerus differ. This review compares the anatomy, biologic response to injury, and functional expectations of these 3 distinct long bones with respect to interlocking nailing. Final results seem related more closely to the bony anatomy and soft tissue injury than to any inherent success of interlocking techniques.

Bone Nails↗
PubMed2002

Intramedullary fixation and bone grafting for congenital pseudarthrosis of the tibia.

Eleven consecutive patients with 12 congenital pseudarthroses of the tibia had intramedullary fixation and autogenous bone grafting as an initial treatment. None of these patients had previous surgeries or other concomitant procedures. The average age of the patients at the time of surgery was 2.5 years (range, 0.5-8.8 years). Four patients achieved initial union after the first index operation; two patients achieved union with no additional procedures, and three patients required an exchange intramedullary fixation for persistent nonunion after refractures that eventually healed. Seven patients did not achieve union after the first index operation; four patients achieved healing after multiple procedures including repeat intramedullary fixation, free vascularized fibular grafting, or both; two patients eventually had below-knee amputations after multiple procedures failed; and one patient did not achieve union of the pseudarthrosis. The important factors leading to failure of union were the distal location of the tibial pseudarthrosis and the presence of concomitant pseudarthrosis of the fibula.

Bone Transplantation↗
PubMedDate not supplied

Ilizarov treatment of congenital pseudarthroses of the tibia.

Eleven children with congenital pseudarthrosis of the tibia were treated with the Ilizarov device. This was successful in nine of 11 patients with an average of 322 days in the fixator and 1.6 additional surgeries. Two patients eventually had amputations. These results demonstrate this to be an effective tool for this complex condition, but amputation should be considered if union is not achievable with this method and other procedures have previously been attempted.

Adolescent↗
PubMedDate not supplied

Orthotic treatment of infantile tibia vara.

Difficulty differentiating physiologic genu varum from early Blount's disease persists. Drennan's metaphyseal-diaphyseal (MD) angle remains the most consistently valuable radiographic parameter despite measurement error. Clinical risk factors also should be considered. All patients receiving orthoses for genu varum since 1985 were reviewed. The focus of the study was those patients with an MD angle of >16 degrees or between 9 and 16 degrees with a clinical risk factor for progression. Risk factors considered were ligamentous instability, obesity, asymmetry, and being female, black, or Hispanic. Thirty-eight patients with 60 tibiae were included. The success rate was 90%. Risk factors for failure (six cases) were instability, obesity, and delayed bracing. In cases with MD angles >16 degrees, the success rate was 86%. The results of orthotic treatment, restricted to patients meeting the stated parameters, represent improvement on the reported natural history.

Body Weight↗
PubMedDate not supplied

Treatment of late-onset tibia vara using afghan percutaneous osteotomy and orthofix external fixation.

The Afghan osteotomy was combined with external fixation on 19 patients (23 extremities) with late-onset tibia vara. The average weight was 258 lb and all patients weighed >95th percentile. The average preoperative deformity was 28.2 degrees. The average intraoperative correction was 27.6 degrees. Average healing time was 141 days. The mean follow-up was 2.7 years. Based on radiographic correction, at long-term follow-up, there were 15 excellent, two fair, and six poor results. The quality of the initial correction was the only significant variable, and it was borderline (p = 0.0587). Complications included loss of alignment, peroneal nerve palsy, superficial pin tract infection, deep infection, and fracture. This method offers a technically simple procedure with a relatively low complication rate. It allows early mobilization and provides the ability to manipulate the correction postoperatively. An excellent long-term outcome is predicated on achieving an acceptable initial correction as determined by intraoperative mechanical axis radiographs.

Adolescent↗
PubMedDate not supplied

Internal derotation osteotomy of the tibia: pre- and postoperative gait analysis in persons with high sacral myelomeningocele.

Rotational deformities of the lower extremities are common in patients with myelomeningocele. In these situations, surgical correction is often necessary. We conducted a retrospective review of eight ambulatory patients with high sacral myelomeningocele and external tibial torsion who underwent 10 distal tibia and fibular internal derotation osteotomies. All patients had an increased valgus knee stress preoperatively. Pre- and postoperative three-dimensional gait analysis was used to evaluate coronal plane knee moments and dynamic sagittal plane knee motion. Postoperatively, a significant improvement in the abnormal internal knee varus moment (p < 0.005) as well as a significant increase in the stance phase knee extension (p < 0.01) was seen. Three patients had resolution of preoperative knee pain. We believe that patients with increased knee stress secondary to excessive external tibial torsion will benefit from a tibial derotation osteotomy that could delay or prevent the onset of late degenerative changes about the knee.

Adolescent↗
PubMedDate not supplied

Transphyseal osteotomy of the distal tibia for correction of valgus/varus deformities of the ankle.

This study is a retrospective review of the results of consecutive cases of a transphyseal osteotomy of the distal tibia. Indications for the procedure are significant valgus or varus deformities of the ankle needing acute correction because of problems with the skin and brace fit as well as progressive deformity. Twenty-one patients with a variety of underlying diagnoses, five with bilateral deformities, underwent this procedure. The technique involved making either a medially based closing or opening wedge with the distal limb of the osteotomy through the physis or the physeal scar so that it was very close to the ankle joint. A fibular osteotomy was not necessary except in three ankles. All osteotomies healed. All patients were able to ambulate and use their braces as soon as their osteotomies healed, and none had any further pressure sores or brace-related problems, although some had mild residual valgus or varus deformities. There were no significant leg-length discrepancy problems as a result of the surgery. This osteotomy is a treatment alternative for significant angular deformities of the ankle that require acute correction.

Adolescent↗
PubMed1983

Computed tomography of ossifying fibroma of the tibia.

Two ossifying fibromas of the tibia were studied by computed tomography, which showed that the lesions were composed predominantly of high density tissue and that they were located in the cortex. The tissue density indicated that the tumors were diffusely ossified or calcified. The intracortical site is typical of ossifying fibroma, but it is unusual in other lesions of similar appearance.

Adult↗
PubMed1991

Healing patterns of transverse and oblique osteotomies in the canine tibia under external fixation.

Healing patterns were compared between transverse and 60 degrees oblique osteotomies in canine tibiae stabilized under external fixation. Under similar in vitro testing conditions (osteotomy ends in contact), the axial stiffness of the oblique osteotomy under external fixation was 45% of the paired transverse osteotomy. Under torsion and bending, the two sides exhibited similar fixation rigidity. The animals put significantly less weight on the oblique side than on the transverse side in the early phases of bone healing (p less than 0.05 for static and p = 0.024 for dynamic weight bearing). The osteotomy bending stiffness at 60 days (in vivo) and the torsional stiffness of osteotomy union measured after sacrifice at 90 days were significantly higher on the transverse side (p = 0.013 and p = 0.016, respectively). Intracortical new bone formation was significantly higher on the transverse side (p less than 0.01), indicating a difference in the rate of cortical healing and remodeling. The average pin removal torque was significantly lower on the oblique side (p less than 0.05), a sign of increased pin loosening. In the clinical situation, unstable oblique or spiral fractures should be protected from weight bearing even under stable external fixation due to the delayed recovery of bone union stiffness property as well as increased pin tract problems.

Animals↗
PubMed1991

Induction and prevention of pin loosening in external fixation: an in vivo study on sheep tibiae.

In external fixation of fractures, pin loosening is a major concern. Preloading the pins is generally done to ensure their stability within the bone cortex. The effect of radial preload and bending preload in reducing resorption at the pin/bone interface was tested. Schanz screws were fixed to live sheep tibiae using a pneumatically operated external fixator frame. Evaluation was based on radiological observation and fluorochrome histology using sequential labels. Though not completely absent, bone resorption was minimal in the radial preload group, compared with the two other groups. More important, the bone-to-pin contact surface in the radial preload group was found to be almost intact after 5 weeks. In this study, radial preload appears to be superior to bending preload in terms of minimizing the problems of pin loosening.

Animals↗
PubMed1994

Distribution of clindamycin in cortical bone during direct local infusion of the canine tibia.

The distribution of clindamycin in tibial cortical bone, administered via direct local infusion with an implantable pump, is described. Clindamycin concentrations in cortical bone were measured after 3, 7, and 21 days of intraosseous infusion. The tibia were divided into four quadrants relative to the outflow infusion catheter site located in the medial aspect of the mid-diaphysis. A gradient of 5-30 mm from the infusion site was documented in all four quadrants (proximal lateral, proximal medial, distal lateral, and distal medial). At all sampling times, clindamycin concentrations in all quadrants exceeded the minimum inhibitory concentrations for gram-positive aerobic bacteria, including Staphylococcus aureus and S. epidermidis, and both the gram-positive and gram-negative anaerobes, including Peptostreptococcus species and Bacteroides species. The data suggest that gravitational forces affect the diffusion of the clindamycin because concentrations in both distal quadrants were greater than in corresponding proximal quadrants.

Animals↗
PubMed1999

Bone grafting from the proximal tibia.

OBJECTIVE: A retrospective study was undertaken to analyze the results of proximal tibial bone grafts with immediate postoperative weight bearing. METHODS: Over a 2-year period, 54 patients underwent bone grafting harvested from the proximal tibia. Postoperatively patients were allowed to bear weight as tolerated on the donor site. Mean follow-up was 26.4 weeks, with a range of 6 to 80 weeks. Indications for bone grafting were fresh fractures with primary grafting and nonunions. RESULTS: The overall complication rate was 1.9%, with one patient suffering a local hematoma. No major complications such as fracture, sensory deficit, or wound infection were observed. Immediate postoperative weight bearing did not have any deleterious effects. Higher complication rates for iliac graft sites have been reported. The amount of bone that can be harvested is usually more than adequate. CONCLUSION: Complication rates are low without significant patient morbidity. Most importantly, the patients may start weight bearing immediately after surgery.

Adult↗