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An evidence-based approach to benchmarking the fairness of health-sector reform in developing countries.

The Benchmarks of Fairness instrument is an evidence-based policy tool developed in generic form in 2000 for evaluating the effects of health-system reforms on equity, efficiency and accountability. By integrating measures of these effects on the central goal of fairness, the approach fills a gap that has hampered reform efforts for more than two decades. Over the past three years, projects in developing countries on three continents have adapted the generic version of these benchmarks for use at both national and subnational levels. Interdisciplinary teams of managers, providers, academics and advocates agree on the relevant criteria for assessing components of fairness and, depending on which aspects of reform they wish to evaluate, select appropriate indicators that rely on accessible information; they also agree on scoring rules for evaluating the diverse changes in the indicators. In contrast to a comprehensive index that aggregates all measured changes into a single evaluation or rank, the pattern of changes revealed by the benchmarks is used to inform policy deliberation aboutwhich aspects of the reforms have been successfully implemented, and it also allows for improvements to be made in the reforms. This approach permits useful evidence about reform to be gathered in settings where existing information is underused and where there is a weak information infrastructure. Brief descriptions of early results from Cameroon, Ecuador, Guatemala, Thailand and Zambia demonstrate that the method can produce results that are useful for policy and reveal the variety of purposes to which the approach can be put. Collaboration across sites can yield a catalogue of indicators that will facilitate further work.

Benchmarking↗

Risk-adjusted surgical audit with the POSSUM scoring system in a developing country. Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity.

BACKGROUND: The Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity (POSSUM) is an objective and appropriate scoring system for risk-adjusted comparative general surgical audit. This score was devised in the UK and has been used widely, but application of POSSUM to centres outside the UK has been limited, especially in developing countries. This prospective study validated its application in a surgical practice with a different population and level of resources. METHODS: All general surgical patients who were operated on under regional or general anaesthesia as inpatients over a 4-month period at Sarawak General Hospital in 1999 were entered into the study. All data (12 physiological and six operative factors) were analysed for mortality only with the POSSUM equation and the modified Portsmouth POSSUM (P-POSSUM) equation. Comparisons were made between predicted and observed mortality rates according to four groups of risk: 0-4, 5-14, 15-49 and 50 per cent or more using the 'linear' method of analysis. RESULTS: There were 605 patients who satisfied the criteria for the study. Some 56.7 per cent of patients were in the lowest risk group. The POSSUM predictor equation significantly overestimated the mortality in this group, by a factor of 9.3. The overall observed mortality rate was 6.1 per cent and, again, the POSSUM predictor equation overestimated it at 10.5 per cent (P < 0.01). In contrast, the observed and predicted mortality rates for all risk groups, including the predicted overall mortality rate of 4.8 per cent, were comparable when the P-POSSUM predictor equation was used. CONCLUSION: The POSSUM scoring system with the modified P-POSSUM predictor equation for mortality was applicable in Malaysia, a developing country, for risk-adjusted surgical audit. This scoring system may serve as a useful comparative audit tool for surgical practice in many geographical locations.

Adolescent↗

Membranous obstruction of the hepatic portion of the inferior vena cava: is this an underdiagnosed entity in developing countries?

Chronic liver disease due to obstructive lesion of the hepatic inferior vena cava (IVC) is common in Nepal. This study presents 10 patients with cavographically documented membranous obstruction of the hepatic IVC with minimal symptoms and a benign course. One patient with an incomplete membrane had balloon dilation of the lesion. The duration of the disease among these patients varied from 5 months to 23 yr; eight patients have been followed for periods varying from 1 to 15 yr, with an average of 6 yr. In developing countries, the possibility of hepatic IVC obstruction should be considered in the differential diagnosis of hepatomegaly or hepatosplenomegaly, even in the absence of ascites and external cava-caval collateral. Routine liver and hematology tests in these patients usually are normal, and liver biopsy findings may not always be specific. Ultrasound, however, has proved to be the best diagnostic procedure for the condition. The lesion can be demonstrated easily by cavography. The disease runs a chronic course, and, in the absence of resistant ascites or repeated variceal bleeding, surgical procedures such as cavoatrial bypass, which are a significant cause of death in developing countries, may be contra-indicated.

Adolescent↗

Device-associated nosocomial infections in 55 intensive care units of 8 developing countries.

BACKGROUND: Health care-associated infections from invasive medical devices in the intensive care unit (ICU) are a major threat to patient safety. Most published studies of ICU-acquired infections have come from industrialized western countries. In a Centers for Disease Control and Prevention (CDC) National Nosocomial Infections Surveillance (NNIS) System report, the U.S. pooled mean rates of central venous catheter (CVC)-related bloodstream infections, ventilator-associated pneumonia, and catheter-associated urinary tract infections were 4.0 per 1000 CVC days, 5.4 per 1000 mechanical ventilator days, and 3.9 per Foley catheter days, respectively. OBJECTIVE: To ascertain the incidence of device-associated infections in the ICUs of developing countries. DESIGN: Multicenter, prospective cohort surveillance of device-associated infection by using the CDC NNIS System definitions. SETTING: 55 ICUs of 46 hospitals in Argentina, Brazil, Colombia, India, Mexico, Morocco, Peru, and Turkey that are members of the International Nosocomial Infection Control Consortium (INICC). MEASUREMENTS: Rates of device-associated infection per 100 patients and per 1000 device days. RESULTS: During 2002-2005, 21,069 patients who were hospitalized in ICUs for an aggregate 137,740 days acquired 3095 device-associated infections for an overall rate of 14.7% or 22.5 infections per 1000 ICU days. Ventilator-associated pneumonia posed the greatest risk (41% of all device-associated infections or 24.1 cases [range, 10.0 to 52.7 cases] per 1000 ventilator days), followed by CVC-related bloodstream infections (30% of all device-associated infections or 12.5 cases [range, 7.8 to 18.5 cases] per 1000 catheter days) and catheter-associated urinary tract infections (29% of all device-associated infections or 8.9 cases [range, 1.7 to 12.8 cases] per 1000 catheter days). Notably, 84% of Staphylococcus aureus infections were caused by methicillin-resistant strains, 51% of Enterobacteriaceae isolates were resistant to ceftriaxone, and 59% of Pseudomonas aeruginosa isolates were resistant to fluoroquinolones. The crude mortality rate for patients with device-associated infections ranged from 35.2% (for CVC-associated bloodstream infection) to 44.9% (for ventilator-associated pneumonia). LIMITATIONS: These initial data are not adequate to represent any entire country, and likely variations in the efficiency of surveillance and institutional resources may have affected the rates that were detected. CONCLUSIONS: Device-associated infections in the ICUs of these developing countries pose greater threats to patient safety than in U.S. ICUs. Active infection control programs that perform surveillance of infection and implement guidelines for prevention can improve patient safety and must become a priority in every country.

Catheterization, Central Venous↗

Ultrasound screening for fetal anomalies in developing countries: wish or reality?

The main problems related to the screening of fetal anomalies in developing countries do include general ones of limited resources for health care and specific ones related to ultrasonographic practice, education, and instrumentation. The strategy to improve the detection of fetal anomalies is reliable, but has to be targeted to the following cornerstones: maintenance of obligate minimum of quality in perinatal care, establishment of three ultrasonographic examinations as a basic prerequisite of antenatal care, enhanced importance of first trimester screening, and a uniform program of education of sonographers, emphasizing the standardization of basic examination. Because of limited resources for perinatal care, we have to be highly responsible in selection of echographic instrumentation and appropriate education, subject to rigorous cost-benefit analysis.

Algorithms↗

Socioeconomic determinants of inequality and self-reported morbidity among adolescents in a developing country.

OBJECTIVE: Studies about health inequalities among adolescents have been conducted principally in developed countries. Although adolescents represent 15% of the Mexican population, no studies are available in this specific age group on health inequalities. In this study, we assess differences in the perception of morbidity severity among adolescent students, as well as their association with selected socioeconomic characteristics. METHODS: We carried out a cross-sectional study (base-line of a longitudinal study of adolescent's health) in 1999. Participants were Mexican adolescents (n=12769) aged 12-19 years, attending to public schools selected through of multistage sampling method. We measured the health status through a self-reported morbidity in 2 weeks time. We included several socioeconomic indicators and for statistical analysis we used the multinomial logistic regression model. RESULTS: The prevalence of self-reported health problems was 32%. Women had 23% increased odds for reporting health problems. Age was positively associated to frequency and severity of health problems; also, there was a positive association with the mother's occupation, one-parent homes, and not owning an automobile. CONCLUSIONS: Morbidity reporting rates are higher than expected in this population. Moderate reporting levels are found among social groups, especially when health problems were perceived as moderately severe, suggesting the importance of socioeconomic factors as determinants. Further studies should conducted using different kinds of health indicators in this age group.

Adolescent↗

An economic analysis of a pneumococcal vaccine programme in people aged over 64 years in a developed country setting.

BACKGROUND: Polysaccharide pneumococcal vaccination for older adults is being introduced in developed country settings. Evidence of protection by this vaccine against pneumococcal pneumonia, or confirmation that illness and death from bacteraemia are prevented, is currently limited. Decisions are often made based on partial information. We examined the policy implications by exploring the potential economic benefit to society and the health sector of pneumococcal vaccination in older adults. METHODS: A model to estimate the potential cost savings and cost-effectiveness of a polysaccharide pneumococcal vaccine programme was based on costs collected from patients, the literature, and routine health-services data. The effect of a pneumococcal vaccine (compared with no vaccination) was examined in a hypothetical cohort aged over 64 years. The duration of protection was assumed to be 10 years, with or without a booster at 5 years. RESULTS: If it were effective against morbidity from pneumococcal pneumonia, the main burden from pneumococcal disease, the vaccine could be cost-neutral to society or the health sector at low efficacy (28 and 37.5%, respectively, without boosting and with 70% coverage). If it were effective against morbidity from bacteraemia only, the vaccine's efficacy would need to be 75 and 89%, respectively. If protection against both morbidity and mortality from pneumococcal bacteraemia was 50%, the net cost to society would be 2500 pounds per year of life saved ( 3365 pounds from the health-sector perspective). Results were sensitive to incidence, case-fatality rates, and costs of illness. CONCLUSIONS: A vaccine with moderate efficacy against bacteraemic illness and death would be cost-effective. If it also protected against pneumonia, it would be cost-effective even if its efficacy were low.

Aged↗

A computer simulation of household sampling schemes for health surveys in developing countries.

BACKGROUND: Cluster sample surveys of health and nutrition in rural areas of developing countries frequently utilize the EPI (Expanded Programme on Immunization) method of selecting households where complete enumeration and systematic or simple random sampling (SRS) is considered impractical. The first household is selected by choosing a random direction from the centre of the community, counting the houses along that route, and picking one at random. Subsequent households are chosen by visiting that house which is nearest to the preceding one. METHODS: Using a computer, and data from a survey of all children in 30 villages in Uganda, we simulated the selection of samples of size 7, 15 and 30 children from each village using SRS, the EPI method, and four different modifications of the EPI method. RESULTS: The choice of sampling scheme for households had very little effect on the precision or bias of estimates of prevalence of malnutrition, or of recent morbidity, with EPI performing as well as SRS. However, the EPI scheme was inefficient and showed bias for variables relating to child care and for socioeconomic variables. Two of the modified EPI schemes (taking every fifth house and taking separate EPI samples in each quarter of the community) performed in general much better than EPI and almost as well as SRS. CONCLUSIONS: These results suggest that the unmodified EPI household sampling scheme may be adequate for rapid appraisal of morbidity prevalence or nutritional status of communities, but that it may not be appropriate for surveys which cover a wider range of topics such as health care, or seek to examine the association of health or nutrition with explanatory factors such as education and socioeconomic status. Other factors such as cost and the ability to monitor interviewers' performance should also be taken into account.

Bias↗

Predictors of hearing loss in school entrants in a developing country.

BACKGROUND: Hearing loss is a prevalent and significant disability that impairs functional development and educational attainment of school children in developing countries. Lack of a simple and practical screening protocol often deters routine and systematic hearing screening at school entry. AIM: To identify predictors of hearing loss for a practical screening model in school-aged children. SETTINGS AND DESIGN: Community-based, retrospective case-control study of school entrants in an inner city. METHODS: Results from the audiologic and non-audiologic examination of 50 hearing impaired children in randomly selected mainstream schools were compared with those of a control group of 150 normal hearing children, matched for age and sex from the same population. The non-audiologic evaluation consisted of medical history, general physical examination, anthropometry, motor skills, intelligence and visual acuity while the audiologic assessment consisted of otoscopy, audiometry and tympanometry. STATISTICAL ANALYSIS: Multiple logistic regression analysis of significant variables derived from univariate analysis incorporating student t-test and chi-square. RESULTS: Besides parental literacy (OR:0.3; 95% CI:0.16-0.68), non-audiologic variables showed no association with hearing loss. In contrast, most audiologic indicators, enlarged nasal turbinate (OR:3.3; 95% CI:0.98-11.31), debris or foreign bodies in the ear canal (OR:5.4; 95% CI:1.0-36.03), impacted cerumen (OR:6.2; 95% CI:2.12-14.33), dull tympanic membrane (OR:2.2; 95% CI:1.10-4.46), perforated ear drum (OR:24.3; 95% CI:2.93-1100.17) and otitis media with effusion OME (OR:14.2; 95% CI:6.22-33.09), were associated with hearing loss. However, only parental literacy (OR:0.3; 95% CI:0.16-0.69), impacted cerumen (OR:4.0; 95% CI:1.66-9.43) and OME (OR:11.0; 95% CI:4.74-25.62) emerged as predictors. CONCLUSION: Selective screening based on the identification of impacted cerumen and OME will facilitate the detection of a significant proportion of hearing impaired school entrants.

Case-Control Studies↗

Oxytocics in developing countries.

OBJECTIVES: A prospective multicenter study of obstetric practices was conducted in three developing countries (Benin, Congo and Senegal) to analyze oxytocic use during labor. One of the objectives was to assess the possible negative effects of the treatment regimens instituted during the labor monitoring phase. METHODS: Four health districts participated in the study. All women who gave birth in one of the participating health facilities over a 6-month period in Benin and Congo, and over a 3-month period in Senegal, were recruited. The number of deliveries studied in each district varied from 457 to 1048. For each case a partogram was used to assess the progress of labor and the onset of dysfunctional labor. Information was collected on the risk factors for dysfunctional labor, stillbirths and resuscitation of the neonate. RESULTS: Each of the four collaborating centers used oxytocics preferentially to treat dysfunctional labor, but even in normal labor (i.e. with a normal partogram) oxytocics were used in 4.4-21.5% of cases. In normal labor the incidence of neonatal resuscitation was higher in cases with than in those without oxytocic use: the relative risks (R.R.) varied from 1.9 to 5.6; the odds ratios varied from 2.4 to 7.0, and both were statistically significant in the four settings. In addition the stillbirth rate was always higher, though not significantly, when oxytocics were used in normal labor (R.R. 1.2-2.2). When the data of the four centers were pooled, the global relative risk for stillbirths was 1.9, and the 95% confidence interval was 1.1-3.4. Logistic regression analysis was carried out for five confounding factors (primiparity, a previous complicated delivery, presence of meconium, ruptured membranes and educational level) to adjust the odds ratio for the risk of neonatal resuscitation when oxytocics were used in normal labor. Except in the case of Abomey in Benin, where the variable 'presence of meconium' decreased the odds ratio from 6.4 to 3.4, the adjusted odds ratios remained similar to their non-adjusted values. In cases of non-dysfunctional labor, nurses and midwives used oxytocics more often than lesser trained health personnel (R.R. 4.0 [3.2-5.1]). CONCLUSION: Our results show that an obstetric treatment which is safe when used in certain well-defined indications, may have significant negative effects when used in situations where the same technical quality of care cannot be guaranteed.

Developing Countries↗

Child development: risk factors for adverse outcomes in developing countries.

Poverty and associated health, nutrition, and social factors prevent at least 200 million children in developing countries from attaining their developmental potential. We review the evidence linking compromised development with modifiable biological and psychosocial risks encountered by children from birth to 5 years of age. We identify four key risk factors where the need for intervention is urgent: stunting, inadequate cognitive stimulation, iodine deficiency, and iron deficiency anaemia. The evidence is also sufficient to warrant interventions for malaria, intrauterine growth restriction, maternal depression, exposure to violence, and exposure to heavy metals. We discuss the research needed to clarify the effect of other potential risk factors on child development. The prevalence of the risk factors and their effect on development and human potential are substantial. Furthermore, risks often occur together or cumulatively, with concomitant increased adverse effects on the development of the world's poorest children.

Child Development↗

Nursing ethics in a developing country.

Nursing is a true profession, distinguished by its philosophy of care, its full-time commitment to human wellbeing, its particular blend of knowledge and skills and its valuable service to the community (Curtin & Flaherty, 1982:92). Ethics is vital to nursing. Being a professional implies ethical behaviour and knowledge of what it means to be ethical (Pera & Van Tonder, 1996:v). Ethics is the foundation of committed service to humankind. When nurses practice is an ethical manner they should adhere to ethical principles like autonomy, beneficence, justice, veracity, fidelity, confidentiality and privacy. From this conceptual framework two questions can be asked, namely: Does the behaviour of nurses in health services in South Africa comply with the principles of ethics? How can ethical behaviour be facilitated in nurses in South Africa? The first question was answered by doing a critical analysis of thirty-two case studies of recent ethical phenomena in health services. The ethical principles will be used as criteria for this analysis. Some of the ethical case studies will be presented in this paper to indicate the problems in relation to autonomy, beneficence, justice, veracity and fidelity. It will be demonstrated that from deontological ethical theories nurses are not doing their duty as advocates for the vulnerable patient and from utilitarianism the poor and uneducated patients are being exploited. To empower patients in developing countries it is of vital importance for nurses to behave in an ethical manner. From a literature study a program for rational interaction for moral sensitivity (Rossouw, 1995) and virtue-based ethics in Nursing Education is identified to facilitate moral behaviour amongst nurses in developing countries.

Attitude of Health Personnel↗

The state of food production and nutrition in the developing countries.

The genesis of the problem of food production and nutrition of African, Asian and Central and South American countries can be traced back to the beginning of 'inter-continental trade' and the emergence of colonialism. Indigenous food patterns and social and economic orders that had evolved to befit the inhabitants and the environment were destroyed. A nutritional framework and an agricultural and economic policy designed to benefit the colonising nations were fostered. At present, millions of people in the developing countries suffer from endemic undernutrition and associated diseases. Famine is always present under the surface claiming families and individual hamlets and breaks through when the semblance of equilibrium between minimal food requirement for survival and supply is disturbed by natural or man-made disaster. Landlessness, an uneven distribution of wealth, overemphasis on cash-crop production, neglect of peasant agriculture in favour of unnecessary expenditure on military hardware and other misguided projects, and crop specialisation are some of the factors responsible for food shortage and undernutrition. Moreover, most of the staple foods of the developing countries are of low energy density and deficient in some essential nutrients. The cycle of undernutrition, hunger, disease and death can only be broken by instituting a well planned, peasant-orientated, integrated development programme based on self-reliance and self-sufficiency.

Developing Countries↗

Safety and impact of chlorhexidine antisepsis interventions for improving neonatal health in developing countries.

Affordable, efficacious, and safe interventions to prevent infections and improve neonatal survival in low-resource settings are needed. Chlorhexidine is a broad-spectrum antiseptic that has been used extensively for many decades in hospital and other clinical settings. It has also been given as maternal vaginal lavage, full-body newborn skin cleansing, and/or umbilical cord cleansing to prevent infection in neonates. Recent evidence suggests that these chlorhexidine interventions may have significant public health impact on the burden of neonatal infection and mortality in developing countries. This review examines the available data from randomized and nonrandomized studies of chlorhexidine cleansing, with a primary focus on potential uses in low-resource settings. Safety issues related to chlorhexidine use in newborns are reviewed, and future research priorities for chlorhexidine interventions for neonatal health in developing countries are discussed. We conclude that maternal vaginal cleansing combined with newborn skin cleansing could reduce neonatal infections and mortality in hospitals of sub-Saharan Africa, but the individual impact of these interventions must be determined, particularly in community settings. There is evidence for a protective benefit of newborn skin and umbilical cord cleansing with chlorhexidine in the community in south Asia. Effectiveness trials in that region are required to address the feasibility of community-based delivery methods such as incorporating these interventions into clean birth kits or training programs for minimally skilled delivery assistants or family members. Efficacy trials for all chlorhexidine interventions are needed in low-resource settings in Africa, and the benefit of maternal vaginal cleansing beyond that provided by newborn skin cleansing needs to be determined.

Anti-Infective Agents↗

Epidemiological surveillance in Peace Corps Volunteers: a model for monitoring health in temporary residents of developing countries.

In 1985, the US Peace Corps developed a computerized epidemiological surveillance system to monitor health trends in over 5500 Peace Corps Volunteers working in development projects in 62 countries worldwide. Data on 31 health conditions and events are collected monthly from each country; quarterly and annual incidence rates are then calculated, and the analysed data are distributed. In 1987, the most commonly reported health problems were diarrhoea (unclassified), 48 cases per 100 volunteers per year; amoebiasis, 24 per 100 volunteers per year; injuries, 20 per 100 volunteers per year; bacterial skin infections, 19 per 100 volunteers per year; and giardiasis 17 per 100 volunteers per year. Tracking each of these common problems, as well as other selected health conditions, guides design of more specific studies and disease control efforts. Health problems with very low rates (less than 1.0/100 volunteers/year) include hepatitis, schistosomiasis, non-falciparum malaria, and filariasis. The epidemiological surveillance system provides the health data needed to plan, implement, and evaluate health programmes for Peace Corps Volunteers, and provides a model for surveillance in other groups of temporary and permanent residents of developing countries.

Adult↗

[Veterinary Services: how to establish quality assurance in developing countries].

The authors put forward a methodological proposal for introducing quality assurance into animal health service provision in developing countries, based on the experience of Brazil. This proposal is based on three key elements. The first and most important element is the continuing development of those involved in the process, not only from the technical and administrative standpoint (know-how), but also in terms of modelling new forms of behaviour and attitudes for the provision of services (social and personal skills). This requires a culture of ethical values, motivation and team working to ensure that those involved in the process become committed, highly effective employees who identify with the Veterinary Service's objectives as if they were their own. The second key element of this methodology is to consider the various health services to be provided as processes and to treat each of these services as a set of activities, inputs and procedures that are systematically organised for delivering the specified animal health service. Working with processes not only makes it possible to properly plan each service, it also facilitates the identification, analysis and effective resolution of any problems that may arise while the service is being delivered. The third key element of the proposed methodology is the constant control and improvement of the processes making up the various health services, in particular using the Deming cycle (plan--do--check--act). The proposed strategy calls for realism and pragmatism in order to avoid creating false expectations by developing over-ambitious quality systems. It is advisable to avoid major publicity at the start of activities and to create well-defined, localised improvement programmes with anticipated results that are simple, direct and discernible to any observer within a short time frame. In the early stages, the term "quality" needs to be replaced with "better service delivery". It is necessary to ensure that staff is given some type of acknowledgement or feedback when positive results are achieved. Great emphasis must be placed on staff motivation and awareness-raising activities.

Animals↗

Local evaluation of a rapid HIV assay for use in developing countries.

We present a research scheme for evaluating inexpensive HIV rapid tests in a developing country setting and assess the field validity of the Sero Strip HIV 1/2 rapid test. The research design features the random allocation of 100 true HIV-positive and 100 true HIV-negative serum specimens to 4 groups, followed by blind testing for HIV status. After one short training session, laboratory technicians at 4 township hospitals (25-35 beds) located 20-50 km from Yangon, Myanmar were sent 800 sera labelled with only an identification number and divided into four groups of 200 specimens each, half being HIV-positive and half HIV-negative. Testing was done in the field with the Sero-Strip HIV 1/2. Determination of the test's validity was based on 399 true HIV positive and 401 true HIV negative sera. All true positives were correctly identified, as were all but two of the true negatives. The sensitivity (% of true positives that test positive) was 100%, and the specificity (% of true negatives that test negative) was 99.5%. The research was completed by in-country scientists who are best suited to evaluate the validity of HIV tests conducted in local environments.

Developing Countries↗

Shiftwork in developing countries: current issues and trends.

This chapter reviews a few studies on shiftwork in countries of Asia and South America. The developing countries need a different approach to managing shiftwork from those used in developed nations--one that concentrates more on the social consequences of shiftwork, particularly for the large proportion of female workers engaged in permanent nightwork.

Asia↗