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PubMedDate not supplied

Expectancies for alcohol to affect tension and anxiety as a function of time.

Alcohol outcome expectancies have been linked to drinking behavior on both empirical and theoretical grounds. Although typically measured as a static construct, we hypothesized that expectancies may be time-specific. Subjects rated their expectancies for a moderate amount of alcohol to increase, decrease, or not change their level of tension and anxiety. Ratings were repeated for when the intoxicating effects of the drinking would be: (1) "at their peak;" (2) "nearly worn off;" and (3) "completely worn off" (Time Epochs 1-3, respectively). As predicted, most subjects (72%) expected alcohol to reduce tension and anxiety at Time Epoch 1; however, significantly fewer subjects expected this effect at Time Epochs 2 and 3 (25% and 2%, respectively). Conversely, few subjects expected alcohol to worsen tension and anxiety at Time Epoch 1 (3.5%); however, significantly more subjects expected this effect at Time Epochs 2 and 3 (31% and 34%, respectively). Expectancies for Time Epoch 1 related most strongly to several measures of alcohol use, including drinking for the purpose of reducing tension (whole sample) and drinking frequency (men but not women). These findings show that tension-reduction expectancies are not stable over the course of a drinking episode and suggest the possibility of a treatment approach aimed at amplifying attention to expectancies for alcohol's more negative longer-term effects.

Adult↗
PubMed1990

Differences between personal and general alcohol-related beliefs.

The discrepancy between personal alcohol-related statements and general beliefs regarding alcohol was investigated in a community sample of 283 social drinkers. Discriminant analysis showed that subjects perceived themselves as significantly less dependent than others. "Self" statement responses accurately predicted drinking behavior, as measured by consumption; however, general statements did so less effectively. Medium-heavy drinkers considered others to be dependent on alcohol to change aversive events, suggesting that a self-fulfilling bias may have distorted their perception. For most drinkers the self-other discrepancy seemed best explained by media and societal influences rather than by a self-fulfilling bias model.

Adult↗
PubMed2005

Further examination of the psychometric properties of the comprehensive effects of alcohol questionnaire.

Although the expectancies component of the Comprehensive Effects of Alcohol Questionnaire has previously been shown to be factorially valid, the factor structure of its valuations component has not previously been examined. The aims of this paper were: (i) to replicate the factor structure of the expectancies items; (ii) to explore the factor structure of the valuations items; and (iii) to investigate the utility of using the Comprehensive Effects of Alcohol Questionnaire to predict drinking behavior. The questionnaire was administered to 1004 university students along with measures of quantity and frequency of alcohol consumption. Fromme, Stroot, and Kaplan's (1993) factor structure of the expectancies scales was replicated. The factor structures of the negative valuations scales were characterized by 2 rather than 3 factors. Negative expectancies improved upon the prediction of drinking quantity and frequency over-and-above positive expectancies, and valuations further improved prediction over-and-above expectancies. Theoretical and clinical implications are discussed.

Adult↗
PubMed2006

Social distance, perceived drinking by peers, and alcohol use by college students.

Many colleges in the United States are employing social norms marketing campaigns with the goal of reducing college students' alcohol use by correcting misperceptions about their peers' alcohol use. Although the typical message used in these campaigns describes the quantity and frequency of alcohol use by the average student on campus, many students may find such a vague comparison to others to be socially irrelevant. This study compares the relative weight of perceptions about alcohol use by distant versus proximate peers in the prediction of college students' personal drinking behavior. The results of analyzing data collected from a sample of college students at a large public northeastern university (N=276) show that, as hypothesized, perceived alcohol use by proximate peers (best friends and friends) was a stronger predictor of students' personal alcohol use than perceived alcohol use by more distant peers (such as students in general), controlling for other strong predictors of alcohol use by college students (age, gender, race, off-campus residency, and sensation-seeking tendencies). The implications of these findings for the design of more effective social norms messages are discussed.

Adolescent↗
PubMed2001

Assessment of motor behavior using a video system and a clinical rating scale in parkinsonian monkeys lesioned by MPTP.

The best current model of Parkinson's disease is the primate treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Quantification of animal movement is important for the study of severity of parkinsonian syndrome induced by MPTP and response to drug treatments. Both require clinical rating scales that measure motor behavior with well-defined objective items. However, evaluations using these scales depend on the observer scoring the different items, according to his/her experience. The video image analyzer system, which produces an activity curve in correlation with the visual study of animal motor behavior, offers an automatic evaluation method that is observer-independent and reproducible. Using such an system we defined items correlated with those used in clinical rating scales that are sensitive to animal motor changes, decrease in movements with MPTP intoxication and alleviation afforded by levodopa: global locomotor activity and specific activities (climbing, social interactions, eating and drinking behaviors).

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine↗
PubMed2003

The moderation of genetic and shared-environmental influences on adolescent drinking by levels of parental drinking.

OBJECTIVE: Research has consistently shown an association between levels of parental drinking and adolescent alcohol use. Different mechanisms offered to explain this association include environmental mechanisms such as social learning and biological mechanisms such as genetic transmission. To integrate these perspectives, this study examines the moderation of environmental and genetic influences on adolescent alcohol use by parental drinking behaviors. METHOD: The data used were 1,833 pairs drawn from the National Longitudinal Study of Adolescent Health's monozygotic twins, dizygotic twins, fill-sibling and half-sibling pairs. Analyses used Defries-Fulker (DF) models to estimate genetic and shared environmental influences and to evaluate the potential moderation of these influences by household parental drinking. RESULTS: Full sample results revealed that genetic influences (h2 = 0.46, p < .05) were significant but that shared environmental influences (c2 = 0.10, p > .05) were not. Separate DF analyses for male, female and mixed-gender pairs found the magnitude of genetic and shared environmental influences on adolescents to be similar across male and female pairs. Results for mixed-gender pairs, however, were ambiguous. Extended DF models examining interactions between parental drinking and the expression of genetic and shared environmental influences found parental drinking was associated with a higher expression of genetic influences among male pairs but not among female or mixed-gender pairs. CONCLUSIONS: The main inferences to be drawn are that, at least for male adolescents, genetic influences on drinking appear to be potentiated by exposure to parental drinking.

Adolescent↗
PubMed2004

Sound level of background music and alcohol consumption: an empirical evaluation.

The effect of background music on alcohol consumption has been widely researched in the literature, but few studies have tested the effect of sound level on drinking behavior. An experiment was carried out in two bars to test patrons' response to music's loudness. Using random assignment, patrons were exposed to a sound level which was higher than that usually employed in the bars in which the study took place. Analysis showed that a higher sound level than usual was associated with consuming more drinks. An "arousal" hypothesis is used to explain the findings.

Alcohol Drinking↗
PubMed1980

Relationship of alcoholic personality subtypes to treatment follow-up measures.

The present study investigated the relationship of a multivariate classification of alcoholic patients based upon Minnesota Multiphasic Personality Inventory profiles taken at admission to psychopathology and drinking behavior at a 6- to 12-month follow-up interval. It was found that a subtype of patients characterized as psychoneurotic, with reactive anxiety and/or depression, evidenced significantly higher levels of psychopathology at follow-up than the remaining three subtypes. Furthermore, this subtype demonstrated higher levels of physical, social, and psychological impairment from post-treatment drinking episodes. No differences were found among the four subtypes with respect to outpatient therapists' ratings of personality change and adjustment. The findings suggest that such a multivariate classification of Minnesota Multiphasic Personality Inventory profiles has predictive utility. The results also suggest that the present subtypes would be useful in investigating the potential utility of differential therapeutic intervention strategies for different patients.

Alcohol Drinking↗
PubMed1987

A biracial comparison of adolescent alcohol use.

This study used a survey design to compare the drinking behaviors of Black and White students from two urban high schools in the city of Cleveland. Data are presented from 1,096 students who completed a 28-item self-report questionnaire measuring adolescent alcohol use and several factors which influence it. White males demonstrated the highest amount of alcohol use on all measures, while White females demonstrated drinking rates comparable to Black males. Blacks of both sexes exhibited the highest percentage of nondrinkers and the highest lifetime abstention rates. White respondents tended to have their initial drinking experiences almost a year earlier than their Black counterparts and perceived greater parental permissiveness regarding drinking. Relaxation was the most popular reason given for drinking by all groups of students. Higher percentages of White than Black students felt that conviviality and problem avoidance were benefits associated with drinking. Subcultural variations were also seen in the perceptions about parental influences on drinking. Implications for service delivery are discussed.

Adolescent↗
PubMed1998

Drive-up liquor windows and convicted drunk drivers: a comparative analysis of place of purchase.

This study examined alcohol purchase locations of convicted drunk drivers to determine the characteristics and arrest circumstances of offenders who bought alcohol at a drive-up liquor window compared with those who obtained alcohol elsewhere. Logistic regression analyses were used to assess the relationship between purchase location and the characteristics of 2,544 drunk drivers convicted in Santa Fe, NM, from 1986 to 1995. Analyses were performed to determine whether the place of purchase was related to arrest circumstances. The results revealed that drive-up windows were the preferred place of purchase of package liquor by offenders who bought the alcohol that they drank prior to arrest. The odds of being Hispanic (p < 0.0001), a high-risk problem drinker (p < 0.01), and drinking in the vehicle prior to arrest (p < 0.01) were significantly higher for drive-up window users than for offenders who purchased package liquor elsewhere. Based on these analyses, this study concludes that a statistically significant relationship exists between the use of drive-up windows and certain high-risk drinking behaviors. This increased use among vulnerable populations suggests that drive-up windows may facilitate alcohol misuse in these populations and thereby contribute to drunk driving.

Accidents, Traffic↗
PubMed1998

Effect of castration and gonadal hormones on insulin-induced drinking.

Female Wistar rats in any of the estrual phases have been shown to drink significantly more water than males (p < 0.05), after a single I.P. insulin injection (5 U/kg b.wt.). Sexual differences in insulin-induced drinking persisted after castration when it was made in adult rats (4.6 +/- 1.2 ml/2 h, males = 8; vs. 13.0 +/- 3.1 ml/2 h, females = 8; p < 0.05). On the other hand, when animals were castrated before puberty or when newborn, sexual differences in insulin-induced drinking disappeared. Hence, insulin-induced drinking seems to be a sex-dependent phenomenon that differentiates just before or during puberty since it is abolished by castration prior to sexual maturation. Sex hormone administration in male and female rats castrated at different ages showed a variety of actions on insulin-induced drinking. A pattern emerged showing that androgenized (testosterone treated) rats drank usually less in response to insulin than estrogen-treated rats (independent of their genetic sex). According to the above results, we can conclude that insulin-induced drinking is a phenomenon sensible to gonadal hormones, both by conditioning the differentiation of some physiological structure or mechanisms that underlay drinking behavior in that paradigm and by a direct action on these or other related mechanisms.

Animals↗
PubMed1981

The Cleveland NIAAA prospective alcohol-in-pregnancy study: the first year.

Data from 2,913 antepartum gravidas screened for alcohol problems during the first year of a large prospective study designed to relate antenatal drinking behavior to infant outcome have been analyzed. The Michigan Alcoholism Screening Test (MAST) appears to separate two populations of pregnant patients. Differences between positive and negative MAST responders indicate variables, such as ethnicity, previous pregnancies, nutrition and cigarette smoking, which will require control when infant outcome data are evaluated. Positive MAST responders were found to be more likely to drink alcohol, to drink greater volumes and to drink more frequently than matched negative responders. They obtained a smaller proportion of their alcohol intake from wine and were more likely to drink a combination of beer, wine and/or liquor than the negative responders. The positive responders significantly decreased their alcohol intake as pregnancy progressed, while negative responders did not, suggesting the possibility that abstinence oriented therapy may be helpful. Problems with quantitating alcohol intake by humans and strategies for separating chronic and acute alcohol effects are discussed.

Adult↗
PubMed2006

DOVER and QUVER-new marker combinations to detect and monitor at-risk drinking.

BACKGROUND: At-risk drinking is a common medical problem. "Objective" laboratory tests are widely used, especially in situations where it might be favorable for the patient to dissimulate the existing alcohol problem. In this study, we report a new approach to combine the biological markers % carbohydrate-deficient transferrin (%CDT) and gamma-glutamyltransferase (gammaGT) to increase diagnostic properties to identify patients with at-risk drinking behavior. METHODS: Fifty-eight general practitioners (GPs) participated in the study at 2 study sites in South-West Germany. Patients filled in a questionnaire that included the Alcohol Use Disorders Identification Test (AUDIT) and gave a blood sample. The GP recorded his assessment about the presence of an alcohol-related disorder in the patient. Screening results of 1 test center were used as a calculation sample. The results at the other site were used to cross-validate the study outcomes. The markers were combined by 2 methods. The first approach used the AUDIT (QUestionnaire VERified; QUVER), and the second was performed using the clinical judgment of the treating GP (DOctor VERified; DOVER). The formulas were calculated using linear and logistic regression models, respectively. RESULTS: A total of 2,940 patients participated in the study, of whom 2,496 completed data sets that could be used for further analysis. In the receiver-operating characteristics (ROC) curves with the reference standard of an AUDIT> or =8, the area under the curve (AUC) of 78.8% for DOVER and 80.6% (QUVER) are in a higher range than the values for gamma-%CDT (75.4%) or gamma-GT (66.3%) and %CDT (74.3%) and suggest a clear superiority of the proposed marker combinations. Regarding the combinations DOVER and QUVER, the cross-validation results were almost identical, with 78.4/78.8% and 80.6/79.5%, respectively. CONCLUSION: Our study is to date the largest practice-based trial that examines the value of the markers CDT and gamma-GT and their combinations for the screening of at-risk drinking in general practice under routine conditions. Our ROC analysis clearly demonstrated that the combination of the markers gamma-GT and %CDT under routine conditions with a behaviorally oriented reference standard leads to an improvement of diagnostic performance, more so than the use of single markers.

Adult↗
PubMed1997

Insulin in the arcuate nucleus of the hypothalamus reduces fat consumption in rats.

Data are accumulating that insulin acting in the central nervous system is a physiological regulator of food intake and body weight, presumably via its effect in the hypothalamus. The present study investigated whether infusion of a small dose of insulin into two major hypothalamic insulin-binding areas also has an effect on diet selection and behavior. At the beginning of the dark period, rats received local bilateral infusions of 4 microU of insulin or vehicle during 34 min into the arcuate (ARC) or paraventricular (PVN) nucleus of the hypothalamus. Consumption of carbohydrate (C)-, protein (P)-, and fat (F)-enriched food and time spent on certain behaviors (drinking, resting, grooming, rearing, exploring/sniffing) were assessed during the first nocturnal hour. In addition, 21-h diet selection was assessed. The percentage contribution of macronutrients (C/P/F) to total energy content of the C-, P-, and F-enriched diets was 71.9/17.2/10.9, 45.8/43.4/10.8, and 47.1/17.5/35.4, respectively. During the first hour, infusion of insulin into the PVN increased grooming behavior compared to infusion of the vehicle. Although infusion of insulin had no effect on diet selection during the first hour, insulin infused in the ARC caused a reduction in F-enriched food consumption and total intake of F (as a macronutrient) over the 21-h period without altering total food intake. Infusion of a higher dose of insulin (10 microU) into the third ventricle had no effect on any of the assessed parameters. The data are explained to indicate that insulin (being an indicator of a positive energy balance) adjusts body weight homeostasis by modulating the preference for fat, at least at the level of the ARC, but not at the PVN.

Animals↗
PubMed2003

Aldehyde dehydrogenase 2 genotypes, alcohol flushing symptoms and drinking patterns in Thai men.

The drinking behavior, alcohol-induced facial flushing and ALDH2 genotypes were determined in 283 Thai men comprising 85 who were alcohol-dependent, 62 hazardous/harmful drinkers and 136 non-drinkers or infrequent drinkers. A structured interview questionnaire, containing the 'tri-level' method and the Alcohol-Use Disorders and Associated Disabilities Schedule, was used to determine the quantity of drinking and the number of alcohol-related adverse experiences. The study revealed the mutant ALDH2*2 allele in 44 (15.5%) subjects. The risks of being alcohol-dependent and of having hazardous/harmful drinking were lower in individuals with heterozygous ALDH2*1/*2, compared with homozygous ALDH2*1/*1 [relative probability ratios (95% CI) 0.14 (0.05-0.41) and 0.23 (0.08-0.61), respectively]. Eighty percent of those who were heterozygous and 28% of those who were homozygous ALDH2*1 reported flush symptoms after drinking alcohol. Twenty-nine percent of homozygous ALDH2*1 individuals, but only 9% of heterozygous subjects, drank almost everyday (24-30 days/month). Similarly, higher percentages of people drinking beyond the safety limit (>60 g/day) and having alcohol-related problems were observed in homozygous ALDH2*1 compared with heterozygous individuals: 32% vs. 5% and 27% vs. 12%, respectively. Overall, the study supports the role of the mutant ALDH2*2 allele in preventing high alcohol consumption and the development of alcohol dependence in a Thai population.

Adult↗
PubMed1998

[Genetic evaluation of tolerance to alcohol].

Alcohol sensitivity which is genetically controlled changes the risk of alcoholic diseases development in such individuals. There are differences in the allelic frequencies of the ALDH2, ADH2 and ADH3 loci, between alcoholics and nonalcoholics. It was shown that the atypical ALDH2/2 is an alcohol-rejecting gene and the usual ALDH1/2 gene is a major "alcoholic" gene. The kinetic differences of ADH2 isozymes may also affect drinking behavior. In conclusion, genetic polymorphism of the ALDH and ADH genes influence the risk of alcoholism development. It may be possible to control alcoholism by suppression of "alcoholic" genes expression through genomic intervention.

Alcohol Dehydrogenase↗
PubMed1994

Differential neuronal responses to angiotensin III from the subfornical organ of normotensive and spontaneously hypertensive rats.

We previously reported that chronic central administration of angiotensin III (AIII) fails to produce sustained drinking behavior in spontaneously hypertensive rats (SHR), possibly because of the development of early desensitization of the angiotensin receptors. The present study extended these findings to the cellular level, using brain-slice preparation from Wistar-Kyoto rats (WKY) and SHR, in conjunction with single-neuron recording in the subfornical organ (SFO), a target site for angiotensin II-induced drinking. We found that a majority of the SFO neurons studied (13/18 in WKY, 20/28 in SHR) responded in a dose-related manner to AIII, given in the range of 10(-6)-10(-5) M. This excitation was receptor-specific, since it was reversed by Ile7-AIII (10(-4)-10(-3) M), the selective AIII antagonist. Bestatin (10(-5)-10(-4) M), an aminopeptidase B inhibitor, did not discernibly affect basal spike frequency when delivered alone. Nevertheless, given in combination with the heptapeptide, bestatin reduced the intensity and duration of SFO neuronal response in WKY to the higher dose (10(-5) M), and in SHR to both doses (10(-6) or 10(-5) M), of AIII. These data suggest that the SFO may also be a central site of action for AIII. Moreover, prolonging the action of AIII by protecting it from being metabolized with bestatin may produce desensitization of the angiotensin receptors on SFO neurons. This was particularly so in the SHR, which are thought to be defective in the degradation of the heptapeptide in the brain.

Aminopeptidases↗