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PubMed2003

Evaluation of the validity of the prosthetic upper extremity functional index for children.

OBJECTIVE: To evaluate the validity of the Prosthetic Upper Extremity Functional Index (PUFI), a parent- and older child-report measure that evaluates the extent of Prosthetic limb use, ease of task performance with and without the prosthesis, and its usefulness. DESIGN: Evaluation of discriminant validity (the PUFI's ability to detect differences between children), construct validity (between the parent-report PUFI and University of New Brunswick Test of Prosthetic Function [UNB Test]), and criterion validity (comparison of parent-report PUFI responses with an assessor's scores of a child's performance of PUFI activities). SETTING: Four pediatric amputee clinics. PARTICIPANTS: Thirty-eight children, ages 3 to 18 years, with unilateral upper-extremity amputation and a prosthesis. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: The PUFI and the UNB Test. RESULTS: The PUFI differentiated between children in high and low UNB Test score categories, and between younger and older children's functional abilities. The extent of correlation between PUFI ratings and UNB skill of performance scores was moderate for "ease of performance" and "usefulness of prosthesis" categories (r>.47, P<.05). The level of agreement between parent report and observational assessment of PUFI skills was acceptable (weighted kappa range,.44-.65). CONCLUSIONS: The PUFI showed acceptable validity and showed promise in identifying prosthetic skill and use in children of different ages and abilities.

Activities of Daily Living↗

PubMed2001

Validity, reliability, and responsiveness of the fingertip-to-floor test.

OBJECTIVE: To evaluate the validity, reliability, and responsiveness of the fingertip-to-floor test to assess total mobility when bending forward in standing position. DESIGN: Experimental, prospective, correlational. SETTING: Rehabilitation and radiology departments in a university hospital in France. PARTICIPANTS: Ten patients (6 women, 4 men; mean age, 42yr) with chronic low back pain (LBP) in the validity study; 32 LBP patients (16 women, 16 men; mean age, 52yr) in the reliability study; and 72 LBP patients (22 women, 50 men; mean age, 30yr) in the responsiveness study. INTERVENTIONS: Dynamic radiographs and fingertip-to-floor test. MAIN OUTCOME MEASURES: For the validity study, 2 lateral radiographs of the upper dorsal spine, 1 in neutral position, and then 1 in full trunk flexion, were made. Validity was assessed by means of Spearman's correlation coefficient. Reliability was studied by using intraclass correlation coefficient (ICC) and the Bland and Altman method. Responsiveness was assessed by the effect size and the standardized response mean (SRM). RESULTS: The Spearman's correlation coefficient for trunk flexion assessed by the test and the radiologic measure was excellent (r(s) = -.96). The intra- and interobserver reliability were excellent (ICC = .99). The Bland and Altman method showed no systematic trend. The values observed for the test were .97 for SRM and .87 for effect size. CONCLUSIONS: Because the fingertip-to-floor test has excellent validity, reliability, and responsiveness, it can be used in clinical practice and therapeutic trials.

Adult↗

PubMed2004

Translation and validation of study instruments for cross-cultural research.

Cross-cultural research often involves physicians, nurses, and other health care providers. In studies of fecal and urinary incontinence, cross-cultural research has been applied to quality-of-life comparisons, and instruments have been translated to foreign languages for use in other countries. This report presents some of the principal methodological issues and problems associated with translating questionnaires for use in cross-cultural research in a manner relevant to clinicians and health care practitioners who are aware that, unless these potential problems are addressed, the results of their research may be suspect. Translation is the most common method of preparing instruments for cross-cultural research and has pitfalls that threaten validity. Some of these problems are difficult to detect and may have a detrimental effect on the study results. Identification and correction of problems can enhance research quality and validity. A method for translation and validation is presented in detail. However, the specific validation method adopted is less important than the recognition that the translation process must be appropriate and the validation process rigorous.

Cross-Cultural Comparison↗

PubMed2000

Development and validation of the Cancer Dyspnoea Scale: a multidimensional, brief, self-rating scale.

Dyspnoea is one of the most frequent and refractory symptoms in cancer patients. Lack of an appropriate assessment tool for dyspnoea seems to disturb establishment of management strategy. The purpose of this study was to develop and validate a brief self-rating scale to assess the multidimensional nature of dyspnoea in cancer patients. We developed a 12-item scale, the Cancer Dyspnoea Scale (CDS), composed of three factors (sense of effort/sense of anxiety/sense of discomfort), by using factor analysis. One hundred and sixty-six patients with advanced or recurrent lung cancer participated in the validation phase. The CDS showed good feasibility (average time required to complete it was 140 s). Construct validity, confirmed by repeating factor analysis, was good. Convergent validity, confirmed by a relation to Visual Analogue Scale of dyspnoea and modified Borg's scale, was also good (average: r= 0.57 and 0.52, respectively, and both P < 0.001). The CDS had good internal consistency (average Cronbach's alpha = 0.86) and stability (average test-retest reliability r = 0.66, P < 0.005). The present study demonstrated that the CDS is a brief, valid and feasible scale for assessing the multidimensional nature of dyspnoea in cancer patients.

Dyspnea↗

PubMedDate not supplied

[II. Validity and sensitivity to change of the Musculoskeletal Functional Assessment Questionnaire in primary gonarthrosis and total endoprosthetic joint replacement].

INTRODUCTION: Scoring systems used so far in total knee arthroplasty are limited by their non-fulfillment of basic test criteria. The aim of the study was to demonstrate the validity and responsiveness of a German version of the new short musculoskeletal function assessment questionnaire (SMFA-D) in patients with primary osteoarthritis and total knee arthroplasty. METHODS: 66 patients with a tricompartmental cemented PFC-Sigma total knee arthroplasty completed the SMFA-D and the WOMAC questionnaire preoperatively and at 12 to 16 weeks follow-up. Preoperatively, physicians' rating of function of the leg, patients' self-selected walking speed, pain and arthritis severity score were registered for demonstration of criterion validity. Construct validity was evaluated with the WOMAC. Discriminant validity was assessed by comparing patients with or without previous surgery at the knee, use of pain medication and use of walking aids. The function and bother indexes of the SMFA-D were correlated with these parameters. Standardized response means were calculated. RESULTS: The function index correlated with physicians' rating (r = 0.51), walking speed (r = 0.61), pain (r = 0.36) and the arthritis severity index (r = 0.36). The bother index correlated with pain (r = 0.37) and the arthritis severity index (r = 0.25). The function and bother index correlated with the WOMAC (r = 0.77) and (r = 0.81), respectively. Patient groups with or without walking aids (p = 0.02) and with or without pain medication (p = 0.001) differed in the function index. The bother index of patients with or without pain medication (p < 0.001) and with or without walking aids (p < 0.006) differed. Function and bother index improved from 46 (SD 17) to 34 (SD 19, p < 0.001) and 43 (SD 18) to 33 (SD 22 p < 0.001), respectively. The standardized response mean was 0.86 for the function index and 0.53 for the bother index. CONCLUSIONS: The SMFA-D questionnaire is valid and responsive in patients with primary osteoarthritis of the knee and total knee arthroplasty. It measures function and bother from the perspective of these patients.

Aged↗

PubMed2004

[Evaluating the reliability, validity and responsiveness of the german short musculoskeletal function assessment questionnaire, SMFA-D, in inpatient rehabilitation of patients with conservative treatment for hip osteoarthritis].

BACKGROUND: Modern patient based outcome measures like the SMFA-D (German Short Musculoskeletal Function Assessment Questionnaire) are able to detect the impairment and functional capacity of patients with musculoskeletal extremity disorders. The SMFA-D was successfully evaluated in several cohorts treated operatively for osteoarthritis of the knee and hip, rotator cuff tears and rheumatoid arthritis. The aim of the present study was the evaluation of the SMFA-D in patients with conservative treatment for hip osteoarthritis. PATIENTS AND METHODS: 69 patients with osteoarthritis of the hip were enrolled in a prospective controlled clinical trial. All patients completed the SMFA-D, SF-36, WOMAC, FFbH-OA. A standardized test of walking speed and the functional status of the patient as judged by the physician were recorded. Statistical analysis were done for the following: re-test reliability (ICC), internal consistency (Cronbach's alpha), validity and responsiveness. RESULTS: Internal consistency (Cronbach's alpha) was alpha = 0.89 and alpha = 0.97 for the SMFA-D scales. The retest reliability (ICC, unjust, mixed effect) was 0.91 (p < 0.001) for the function index and 0.73 (p < 0.001) for the bother index. Both indices correlated significantly with the FFbH-OA (r = 0.66 to r = 0.84), the WOMAC (r = 0.55 to r = 0.86) and the scales of the SF-36 (r = - 0.34 to r = - 0.85) on all three time points, which supports construct validity. There was mainly a significant correlation between the SMFA-D scales and the functional status of the patient (r = 0.21 to r = 0.44), pain reported by the patient (r = 0.43 to = 0.54) and the self selected walking speed (r = 0.28 to r = 0.51), which supports external validity. We were able to differentiate operatively and conservatively treated patients (discriminant construct validity). At the end of the rehabilitation program we were able to demonstrate small to medium treatment effects in SMFA-D and SF-36. The WOMAC and FFbH-OA were not able to demonstrate these treatment effects. CONCLUSION: Even in patients with conservative treatment of hip osteoarthritis the SMFA-D represents a reliable, valid and responsive measure. The use of the SMFA-D can be recommended as a patient based outcome measure.

Activities of Daily Living↗

PubMed1989

Development of valid pulmonary function equations for trained athletes.

The validity of commonly recommended pulmonary function prediction equations (Bulletin Européen de Physiopathologie Respiratoire, Clinical Respiratory Physiology) was tested with two samples (n1 = 156; n2 = 218) of well-trained athletes. Pulmonary function measures (FVC, TLC, RV, FEF25%-75%, FEV1.0, PEF, RV/TCL ratio, FEV1.0/FVC ratio) were typically very reliable but inaccurately predicted with recommended equations based upon anthropometric characteristics. Newly developed "unisex" regression equations were developed with "dummy" coding of gender (i.e., 0 = female; 1 = male), age, height, weight, and various interactions. The new equations were validated with a subsample of group one, cross-validated with the remaining portion of group one, and then cross-validated again with the 218 subjects from sample two. The newly created pulmonary function prediction equations are more valid for well-trained athletes than the equations in use for the general population.

Adult↗

PubMed1997

Validity of near-infrared interactance for estimating relative body fat in female high school gymnasts.

The present investigation examined the validity of near-infrared interactance (NIR) estimates of relative body fat (% fat) from the Futrex-5000 (F5000), Futrex-5000A (F5000 A), and Futrex-1000 (F1000) instruments. Ninety-eight female high school gymnasts (X age+/-SD = 15.7+/-1.2 yr) participated in this investigation. Subsamples were used to cross-validate the F5000 (n = 52), F5000A (n = 46), and F1000 (n = 89) instruments. The NIR % fat estimates were validated against criterion % fat from underwater weighing (UWW) using the adult conversion constants of Brozek et al. (6) (UWWB) and the female age-specific constants of Lohman (23) (UWWL). The cross-validation statistical analysis included examination of the constant error (CE), standard error of estimate (SEE), r, and total error (TE). In addition, full-model multiple regression analyses were used to predict UWWB or UWWL from body weight (BW) and height (HT). BW and HT were correlated with % fat at R = 0.65-0.70, while the validity coefficients for the NIR instruments ranged from r = 0.40-0.78. The F5000 resulted in nonsignificant CE values (-0.3 % fat vs UWWB and 1.5 % fat vs UWWL; p > 0.008) as well as the lowest TE values (TE = 3.1 % fat vs UWWB and 4.0 % fat vs UWWL). All other NIR estimates of % fat resulted in TE values > or = 6.3 % fat. In addition, for all NIR instruments there were negative correlations for the plots of the CE versus the mean of predicted and criterion (UWWB and UWWL) % fat. Therefore, the present findings indicated that the F5000 provided more accurate estimates of % fat than the F5000A or F1000 instruments, but may underestimate the desired minimal body weight for female gymnasts at the low end of the % fat distribution.

Adipose Tissue↗

PubMed2004

Experimental Peptide Identification Repository (EPIR): an integrated peptide-centric platform for validation and mining of tandem mass spectrometry data.

LC MS/MS has become an established technology in proteomic studies, and with the maturation of the technology the bottleneck has shifted from data generation to data validation and mining. To address this bottleneck we developed Experimental Peptide Identification Repository (EPIR), which is an integrated software platform for storage, validation, and mining of LC MS/MS-derived peptide evidence. EPIR is a cumulative data repository where precursor ions are linked to peptide assignments and protein associations returned by a search engine (e.g. Mascot, Sequest, or PepSea). Any number of datasets can be parsed into EPIR and subsequently validated and mined using a set of software modules that overlay the database. These include a peptide validation module, a protein grouping module, a generic module for extracting quantitative data, a comparative module, and additional modules for extracting statistical information. In the present study, the utility of EPIR and associated software tools is demonstrated on LC MS/MS data derived from a set of model proteins and complex protein mixtures derived from MCF-7 breast cancer cells. Emphasis is placed on the key strengths of EPIR, including the ability to validate and mine multiple combined datasets, and presentation of protein-level evidence in concise, nonredundant protein groups that are based on shared peptide evidence.

Breast Neoplasms↗

PubMed2000

Questioning validity in the area of ergonomics/human factors.

This paper focuses on the analysis of deviation in findings within ergonomics/human factors (E/HF) research. The current terms used to address the analysis of deviation in empirical research revolve around the notion of validity. In E/HF research papers, 'validity' is widely interpreted and includes its common parlance usage. More importantly, analysis frequently limits 'validation' to the equivalent of 'verification', eventually resulting in 'validity' as a label of little significance. To clarify the analysis of deviation, 'investigative syntaxes' are introduced to show what exactly should or can be questioned when deviation is observed, i.e. either empirical findings or propositions, and how this questioning can be structured. The possibility is discussed that, with or without the help of these syntaxes, validation may become a method of inquiry; a productive means of generating significant theoretical questions which bear directly on empirical work.

Body Height↗

PubMed2001

Interobserver repeatability and validity of an observation method to assess physical loads imposed on the upper extremities.

Interobserver repeatability and validity were assessed for a new semiquantitative, time-based observation method for the estimation of physical loads imposed on the upper extremities. Six risk factors of upper extremity disorders were included in the method: repetitive use of hand, use of hand force, pinch grip, non-neutral wrist posture, elevation of upper arm, local mechanical pressure. Two occupational health nurses were trained to use the method. They observed 127 work cycles at a food-processing plant and a paper mill. The method was validated against expert observations from the video, continuous recordings of myoelectric activity (EMG) of forearm muscles, and wrist posture measured with goniometers. Interobserver repeatability was good or moderate for repetitive use of hand, hand force, pinch grip (range kappa = 0.58-0.71 on the right; 0.60-0.61 on the left side). Interobserver repeatability was moderate or poor for non-neutral wrist posture, elevation of the upper arm and local mechanical pressure. Validity ranged from moderate to good for repetitive use of hand, use of hand force, pinch grip and non-neutral wrist posture when expert observation was used as reference standard. When observations were validated against force estimations (EMG) and wrist goniometer data, validity was poor. In the absence of generally accepted reference values, arbitrarily chosen limits were used for the proportional duration of some physical load factors. Studies should be carried out to assess the limits that best differentiate between safe and hazardous jobs.

Adult↗

PubMed1990

Two promising shame and guilt scales: a construct validity comparison.

This study compared the validity of two promising measures of shame and guilt proneness: revisions of the Harder Personal Feelings Questionnaire (PFQ2; Harder & Lewis, 1987) and the Hoblitzelle Adapted Shame and Guilt Scale (ASGS; Hoblitzelle, 1982). Internal consistency, test-retest stability, factor structure, and construct validity with convergent and discriminant personality dimensions were examined for both scales. In addition to the shame and guilt measures, 63 (37 male, 26 female) mostly freshman college students completed a randomly ordered battery of personality scales theoretically relevant to shame and guilt proneness. Results support the reliability and shame/guilt factor structure of each scale. ASGS Shame correlations appeared marginally more valid with 11 external construct variables than PFQ2 Shame, whereas PFQ2 Guilt was clearly more valid than its corresponding ASGS subscale. New, potentially improved scales were constructed from the factor analyses and from item analyses. However, the resulting scales did not show improved validity.

Adolescent↗

PubMed1998

Is real-time ultrasonic bladder volume estimation reliable and valid? A systematic overview.

To assess the reliability and validity of real-time ultrasonic estimation of bladder volume we conducted an overview of the published literature identified using MEDLINE search (1966-96) and scanning of the bibliographies of known primary and review articles. Short-listed papers were classified into reliability (observer agreement) and validity (comparison of ultrasound estimation with actual bladder volume) studies. Study selection and data extraction were performed independently in duplicate. There were 81 subjects enrolled in 3 reliability studies and 504 subjects in 16 validity studies. Where reported, the index of concordance for reliability ranged from 0.923 to 1.00, while for validity it ranged from 0.914 to 0.983. However, there were several inadequacies in the design, conduct and analysis of these studies, leaving some doubt about the trustworthiness of the high levels of reliability and validity reported in the literature.

Female↗

PubMed1999

Development and validation of a mood measure for adolescents.

The aim of this study was to develop and validate a shortened version of the Profile of Mood States suitable for use with adolescents. The Profile of Mood States-Adolescents (POMS-A) was administered to 1693 participants from two populations: school children and young athletes. Confirmatory factor analysis supported the factorial validity of a 24-item six-factor model using both independent and multi-sample analyses. Correlations of POMS-A scores with previously validated inventories, which were consistent with theoretical predictions, provided evidence of criterion validity. It is proposed that the POMS-A is a valid instrument for the assessment of mood in adolescents.

Adolescent↗

PubMed2001

Measuring subjective quality of life following spinal cord injury: a validation study of the assistive technology device predisposition assessment.

PURPOSE: Assesses the validity of a subset of items of the Assistive Technology Device Predisposition Assessment (ATD PA) as a measure of quality of life (QOL) for persons with new spinal cord injury. METHOD: Subjects completed the ATD PA QOL subset, Satisfaction with Life Scale (SWLS), and Brief Symptom Inventory (BSI) while in acute rehabilitation. The internal reliability of the QOL subset of the ATD PA was assessed. Concurrent validity of the ATD PA's QOL subset with the SWLS and construct validity with the BSI depression subscale was assessed using Spearman correlations. Subjects were recruited while acute rehabilitation inpatients in a general hospital and consisted of twenty persons with newly acquired SCI (10 males and 10 females). RESULTS: Significant positive correlations between the ATD PA's QOL subset and SWLS (and significant negative correlations with the BSI depression subscale) suggest the QOL subset has concurrent and construct validity. CONCLUSIONS: The ATD PA's QOL subset appears to be a valid measure and, thus, it can be useful both in identifying subjective quality of life and predispositions to AT use early in rehabilitation.

Adult↗

PubMed2000

Validation of parachlorobenzotrifluoride, benzotrifluoride, and monochlorotoluene on diffusive samplers.

Three solvents (OXSOL 10, monochlorotoluene or mixed isomers of 1- chloro-2-methyl benzene and 1-chloro-4-methyl benzene; OXSOL 100, parachlorobenzotrifluoride or 1-chloro-4-(trifluoromethyl) benzene; and OXSOL 2000, benzotrifluoride or trifluoromethyl benzene) produced by Occidental Chemical Corporation (Niagara Falls, NY) were considered as candidates for SKC, Inc.'s on-going diffusive sampler validation program. The 575-series diffusive sampler contains coconut-shell charcoal (575-001) or Anasorb 747 (575-002). Both samplers were used in this study. Desorption efficiency was tested at loadings equivalent to eight-hour time-weighted average (TWA) exposures to 0.01-2 times the Occidental Chemical Corporation in-house limit values (respectively: 50 ppm, 25 ppm, and 100 ppm,. All results met the National Institute for Occupational Safety and Health (NIOSH) criteria of > 75 percent, and, except for the lower loadings of parachlorobenzotrifluoride, the results were in the range of 90-110 percent. The calculated uptake rates were verified for different periods of exposure, up to eight hours, and found to be within 5 percent of the calculated for all three compounds on both samplers. A detailed comparison of the results from different time periods indicated no significant reverse diffusion effects for any combination of sampler and analyte. Samplers exposed to standard atmospheres of each compound were stored for three weeks at ambient temperatures and reanalyzed with results between 94 and 107 percent of expected. Based on full validation of samplers for the lower homologue (benzene), the bi-level theory of sample validation as endorsed by international validation protocols establishes this as a complete validation of the featured samplers for sampling vapors of these chemicals in air.

Air Pollution↗

PubMed2006

Validation of a QSAR model for acute toxicity.

In the present study, a quantitative structure--activity relationship (QSAR) model has been developed for predicting acute toxicity to the fathead minnow (Pimephales promelas), the aim being to demonstrate how statistical validation and domain definition are both required to establish model validity and to provide reliable predictions. A dataset of 408 heterogeneous chemicals was modelled by a diverse set of theoretical molecular descriptors by using multivariate linear regression (MLR) and Genetic Algorithm-Variable Subset Selection (GA-VSS). This QSAR model was developed to generate reliable predictions of toxicity for organic chemicals not yet tested, so particular emphasis was given to statistical validity and applicability domain. External validation was performed by using OECD Screening Information Data Set (SIDS) data for 177 High Production Volume (HPV) chemicals, and a good predictivity was obtained (=72.1). The model was evaluated according to the OECD principles for QSAR validation, and compliance with all five principles was established. The model could therefore be useful for the regulatory assessment of chemicals. For example, it could be used to fill data gaps within its chemical domain and contribute to the prioritization of chemicals for aquatic toxicity testing.

Animals↗

PubMed2006

Criterion validity of the Occupational Therapy Adult Perceptual Screening Test (OT-APST).

This paper reports on the criterion validity of the Occupational Therapy Adult Perceptual Screening Test (OT-APST) including concurrent criterion validity and its sensitivity and specificity. The performance of 208 people following stroke on the OT-APST and a reference tool (either the Loewenstein Occupational Therapy Cognitive Assessment (LOTCA) or the LOTCA--Geriatric version (LOTCA-G)) was compared. The OT-APST subscale scores and performance outcome (intact or impaired) on related subscales of the reference tool was analyzed to evaluate the concurrent criterion validity of the OT-APST and its sensitivity and specificity at selected cut-off scores. Significant correlations were found between participants' performance (intact or impaired) on the reference tool and scores on the OT-APST. The sensitivity and specificity of the OT-APST were analyzed at selected cut-off scores to explore the validity of decisions based on OT-APST performance when compared with the reference tool. This study shows that the OT-APST is a tool with demonstrated concurrent criterion validity for the assessment of visual perception.

Adult↗