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PubMed2002

Two experimental tests of a fluctuation-induced first-order phase transition: intensity fluctuation microscopy at the nematic-smectic-A transition.

We have developed a new, extremely sensitive real-space technique (intensity fluctuation microscopy) to probe the order of the nematic-smectic-A (NA) transition. Using this technique, we show that the NA transition in 4'-n-octyl-4-cyanobiphenyl (8CB) is clearly first order, contrary to calorimetric studies but in agreement with conclusions drawn from front-velocity measurements. We characterize the strength of the discontinuity at the first-order transition by the dimensionless quantity t(0)=(T(NA)-T*)/T(*). By precisely measuring t(0), we have made the first detailed tests of predictions based on the Halperin-Lubensky-Ma (HLM) theory of fluctuation-induced, first-order phase transitions. First, we explore the effect of an external magnetic field on the NA transition. Although modest fields (of order 10 T) are predicted to drive the weakly first-order transition in pure 8CB second order, we observe no such effect; we establish instead that the lower bound on this critical field is approximately 30 T. Likewise, we observe no effect in mixtures of 8CB with its longer chemical homolog 4'-n-decyl-4-cyanobiphenyl (10CB). Second, we examine the dependence of t(0) as a function of 8CB-10CB mixture concentration and find that the data in mixtures with small nematic temperature range are well-fit by the parameters derived by Anisimov et al. based on calorimetric measurements. As we increase the nematic range (by using concentrations closer to pure 8CB), the measured t(0) deviates more and more from the HLM predictions. Smectic fluctuations, which are neglected in the HLM calculation, are an obvious candidate to explain such a discrepancy, but one's naive expectation is that they would reduce t(0) below the HLM levels, whereas the observed values are too large. However, a recent renormalization-group calculation concludes that smectic fluctuations, surprisingly, should indeed increase t(0), explaining the observations presented here.

Journal Article↗
PubMed1983

Effect of quinidine on membrane properties. Depression of the lipid phase transition temperature and changes in the permeability of the lipid bilayer.

The influence of an antiarrhythmic drug, quinidine, on the physical state of membrane phospholipids was investigated using model membranes, liposomes. Turbidimetric measurements on liposomes prepared from neutral (dipalmitoyl phosphatidylcholine) and acidic (dipalmitoyl phosphatidic acid) phospholipids showed that quinidine reduces the temp of the gel to liquid-crystalline phase transition and broadens the temp range of the transition. The effect of quinidine on the thermal behaviour of model membranes depends on both the pH and the type of phospholipids used. It is markedly stronger for acidic than for neutral phospholipids, suggesting the importance of electrostatic effects in drug-membrane interaction. The ability of quinidine to interact with the lipid bilayer was confirmed by permeability measurements with the use of a self-quenched fluorescent compound, calcein. It is suggested that quinidine-phospholipid interaction may contribute to the mechanisms by which the drug exerts its physiological and pharmacological effects.

Animals↗
PubMed1989

Propranolol-induced alterations in rat erythrocyte membrane fluidity and apparent phase-transition temperatures. A depth-dependent process.

Propranolol-induced alterations of membrane structure were studied in rat erythrocytes using electron spin resonance techniques. Propranolol produced a concentration-dependent change in membrane fluidity in hydrophobic membrane regions, while producing virtually no change in hydrophilic membrane regions. The changes were associated with depth-dependent alterations in "apparent" phase-transition profiles and transition temperatures. The effects of propranolol on these membrane characteristics were similar to those produced by cholesterol. Propranolol fluidized erythrocyte membranes in a depth-specific fashion, by virtue of its association with the rigid phospholipid acyl chains and cholesterol sterol rings in the hydrophilic regions of the membrane, which produced distant perturbations within the hydrophilic regions of the membrane.

Animals↗
PubMed2001

Phase-transition-driven synaptic exocytosis: a hypothesis and its physiological and evolutionary implications.

It is proposed that the plasma membrane in the active zones of synaptic terminals contains self-assembling cooperative domains whose Ca2+-induced solidification may be the driving force of the fast neurotransmitter release in the central synapses. This hypothesis and a qualitative model of the phase-transition-driven exocytosis provide formulation of a unitary approach to a number of general problems in the physiology of animals. It allows answering the following questions, among others: (i) What is the physical reason for the existence of a narrow optimum range of body temperatures in warm-blooded species? (ii) What is the physical reason for the inevitable necessity of regular sleep in animals? (iii) Does there indeed exist any general mechanism of general anesthesia?

Anesthetics, General↗
PubMed2004

Reinvestigation of the structure of BaCuSi(2)O(6) -- evidence for a phase transition at high temperature.

Superstructure reflections have been observed in the room-temperature X-ray diffraction pattern of BaCuSi(2)O(6), barium copper disilicate. The tetragonal structure has a fourfold unit-cell volume compared with the original structure determined by Finger et al. At T(s) = 610 K BaCuSi(2)O(6) undergoes a structural phase transition upon which the superstructure reflections disappear. The description of the structure in the larger cell removes the crystal-chemical inconsistencies observed for the original structure.

Journal Article↗
PubMed1982

[Effect of excess cooling on rat liver mitochondria: release of K+ and malate dehydrogenase at lipid phase transition temperatures].

The effects of cooling within the temperature range of 0-25 degrees on the state of mitochondrial membranes was studied. The increase in membrane permeability for K+ and malate dehydrogenase which is localized in mitochondrial matrix, served as an index of membrane structural damage within the given temperature interval. In order to prevent crystallization of the aqueous phase upon cooling ethylene glycol was added to the medium to reach a final concentration of 40%. The decrease of temperature resulted both in the release of K+ and in the increase of the activity of free malate dehydrogenase. A drastic increase in the mitochondrial membrane permeability to K+ and malate dehydrogenase was observed within the temperature range of -6 -- -14 degrees, showing a maximum at -10 degrees. At -14 degrees the rate of K+ and malate dehydrogenase release was lower; however, further cooling (down to -20 degrees) induced another increase of permeability. The disruption of mitochondrial at negative temperatures after addition of 1.25 M NaCl to the incubation mixture caused a temperature-dependent release of the proteins into the supernatant. After ultracentrifugation of the membrane fragments at 140 000 g for 60 min the soluble proteins were detected in the samples coled down to -10 degrees. It was concluded that the changes in the state of mitochondrial membranes are due to the phase transitions of the inner membrane lipids.

Animals↗
PubMed2006

Isotropic-nematic phase transition of nonaqueous suspensions of natural clay rods.

A novel model system for studying the behavior of hard colloidal rods is presented, consisting of sterically stabilized particles of natural sepiolite clay. Electron microscopy and scattering results confirmed that the organophilic clay particles were individual, rigid rods when dispersed in organic solvents. With a length-to-diameter ratio of approximately 27, the particles showed nematic ordering for volume fractions phi > 0.06. Polarizing microscopy revealed that the phase separation process involved nucleation, growth, and coalescence of nematic domains. The phase volumes and particle concentrations in the coexisting phases were determined. The dependence of these quantities on the total concentration of the suspension agrees well with Onsager's [Ann. N. Y. Acad. Sci. 51, 627 (1949)] isotropic-nematic phase transition theory extended to bidisperse and polydisperse rod systems, and with previous experimental results for rigid rodlike particles. Particle size distributions were obtained by analyzing transmission electron microscopy images. A significant fractionation with respect to rod length (but not diameter) was observed in the coexisting isotropic and nematic phases. The relative polydispersity of both daughter phases was distinctly smaller than that of the parent suspension. The phase behavior of these daughter fractions agrees well with the predictions for hard spherocylinders of corresponding aspect ratios. An isotropic-nematic-nematic phase equilibrium was seen to develop in phase separated samples after 1 month standing and is ascribed to the effect of polydispersity and possibly gravity. The second nematic phase appearing is dominated by very long rods.

Journal Article↗
PubMed1978

A study of molecular dynamics and freezing phase transition in tissues by proton spin relaxation.

Muscle, spleen, and kidney tissues from 4-wk-old C57 black mice were studied by proton magnetic resonance. Spin-lattice relaxation times at high fields and in the rotating frame, as well as the spin-spin relaxation times, are reported as a function of temperature in the liquid and frozen phase. Motions of large molecules and of water molecules and their changes at the freezing phase transition are studied. The shortcomings of the two-state fast-exchange relaxation model are discussed.

Animals↗
PubMed2003

Network-induced nonequilibrium phase transition in the "game of Life".

A cellular automation model of the "game of Life" on a two-dimensional small-world network is presented in order to count in long-range interactions among living individuals in social or biological systems. The density of the life and its fluctuation are calculated, respectively. The present model exhibits a nonequilibrium phase transition from an "inactive-sparse" state to an "active-dense" one at a certain intermediate value of the network disorder. Employing finite-size scaling analysis, we estimate the location of the critical point with p(c)( infinity ) approximately 0.3685. The transition is of the "second-order" type with power-law diverging length. We obtain the critical exponents 1/nu approximately 1.70, beta approximately 0.50, and beta/nu approximately 0.85. The calculated results indicate that the present model may belong to the universality class of directed percolation.

Journal Article↗
PubMed2002

Quantum phase transition in one-dimensional arrays of resistively shunted small Josephson junctions.

We have observed a superconductor-insulator transition in one-dimensional (1D) arrays of small Josephson junctions by changing both the resistance R(S) of normal metal resistors shunting each junction and the ratio of the Josephson coupling energy E(J) to the charging energy E(C). The phase boundary lies at R(S) approximately R(Q) (R(Q) identical with h/4e(2)=6.45 kOmega) when E(J)/E(C) is smaller than about unity. We discuss the obtained phase diagram in terms of theoretical models of the dissipation-driven quantum phase transition, with particular attention to differences from 2D arrays.

Journal Article↗
PubMed1994

Molecular motions and phase transitions in solid bis-n-propylammonium pentabromoantimonate.

The proton nuclear magnetic resonance (NMR) second moment and spin-lattice relaxation time for polycrystalline bis-n-propylammonium pentabromoantimonate (nPBA) have been measured from 70 to 290 K. The results are interpreted in terms of the CH3 and NH3 group reorientations for which the activation parameters have been determined. A structural phase transition evidenced at about 220 K is found in the polycrystalline sample of nPBA.

Antimony↗
PubMed2001

Phase transition of a quasi-one-dimensional system.

The statistical mechanics of the quasi-one-dimensional system of DNA is studied with the Morse and Deng-Fan potentials for the interstrand hydrogen bonds of nucleotide pairs. The intrastrand interactions between nucleotides are characterized by a simple harmonic potential in which the coupling strength has a significant effect on the phase transition of the DNA system.

Journal Article↗
PubMed2006

Multipartite entanglement signature of quantum phase transitions.

We derive a general relation between the nonanalyticities of the ground state energy and those of a subclass of the multipartite generalized global entanglement (GGE) measure defined by de Oliveira et al. [Phys. Rev. A 73, 010305(R) (2006)] for many-particle systems. We show that GGE signals both a critical point location and the order of a quantum phase transition (QPT). We also show that GGE allows us to study the relation between multipartite entanglement and QPTs, suggesting that multipartite but not bipartite entanglement is favored at the critical point. Finally, using GGE we were able, at a second-order QPT, to define a diverging entanglement length (EL) in terms of the usual correlation length. We exemplify this with the XY spin-1/2 chain and show that the EL is half the correlation length.

Journal Article↗
PubMed2002

The DMPC lipid phase transition influences differently the first and the second electron transfer reactions in bacterial reaction centers.

Photosynthetic reaction centers (RCs) from Rhodobacter sphaeroides were incorporated in dimyristoylphosphatidylcholine (DMPC) liposomes. The first and second electron transfer rates (k(AB)(1) and k(AB)(2), respectively) between the first and the second quinone electron acceptors have been measured as a function of temperature, across the phase transition of DMPC (23 degrees C). The Eyring plots of k(AB)(1) display straight lines. In contrast, the Eyring plots for k(AB)(2) in proteoliposomes show a break at about 23.5 degrees C. This physical discrimination between the two electron transfer reactions demonstrates that the stiffness of the lipid environment of the RCs and/or the protein-protein interactions influence the parameters governing k(AB)(2), but not the gating process limiting k(AB)(1).

Cryoelectron Microscopy↗
PubMed2001

Direct determination of interfacial magnetic moments with a magnetic phase transition in Co nanoclusters on Au(111).

The spin, in-plane and out-of-plane orbital and magnetic dipole moments of almost purely interfacial Co atoms were directly determined for Au/2-monolayer Co nanoclusters/Au(111) by angle-dependent magnetic circular x-ray dichroism (MCXD) measurements. The field- and temperature-dependent MCXD evidences a ferromagnetic(FM)-to-superparamagnetic phase transition in single-domain clusters with decreasing size. The interfacial moments are remarkably enhanced as compared with bulk values, verifying theoretical predictions. The FM clusters show strong perpendicular magnetic anisotropy, providing promise of applications for nanoscale magnetic bits.

Journal Article↗
PubMed1998

Phase transitions of CdS microcrystals under high pressure.

The experiment under high pressure using a diamond anvil cell (DAC) requires the utilization of synchrotron radiation. High-pressure experiments were performed using a DAC on CdS microcrystals, both in the far-IR and in the X-ray regions, in order to study the lattice dynamics and lattice stability concerned with the phase transitions. From these experiments, experimental evidence is presented indicating that a CdS microcrystal of smaller diameter shows a higher transition pressure for lattice transformation under pressure. The origin of such an increase in the transition pressure in the microcrystals is discussed in relation to the surface tension.

Journal Article↗
PubMed2005

The effect of chilling on membrane lipid phase transition in human oocytes and zygotes.

BACKGROUND: Chilling injury occurs when the cell membrane undergoes a transition from the liquid state to the gel state. Human oocytes and single-cell zygotes are of similar shape and size but the post-thawing survival rate of oocytes is poorer. We set out to investigate the possible difference in membrane lipid phase transition (LPT) temperature between the two cell types. METHODS: The LPT temperature was measured with a Fourier Transform Infrared analyser, which detects the change in the vibration frequency of the CH2 bond stretches of the membrane lipid molecules during temperature change. The LPT temperatures of unfertilized human oocytes, in vitro-matured oocytes, and immature germinal vesicle (GV) stage oocytes were compared with that of abnormally fertilized human zygotes. RESULTS: The LPT temperatures of zygotes and of mature and immature GV oocytes differ significantly from each other (10.0 +/- 1.2, 16.9 +/- 0.9 and 24.4 +/- 1.6 degrees C respectively; P < 0.05). CONCLUSIONS: Zygotes show a higher resistance to chilling injury compared to oocytes at different developmental stages; this might explain the relatively poor survival rates of cryopreserved human oocytes and indicates the necessity to adjust the cryopreservation protocols in order to minimize cryoinjury.

Cell Membrane↗