[Duodenal motor function in juvenile diabetes].
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Microgravity effects on human factor were studied through a series of manual control experiments conducted in the First Material Processing Test. The Japanese Payload Specialist operated a finger stick for 130 seconds to maintain a light spot movement around the center of a vertical LED array display. The stick angle is doubly integrated to make the controlled element motion. The light spot position indicates the difference between the motion and pseudo-random wave patterns which drives the man-machine tracking system. 24 runs were conducted in each of 2 months before launch, immediately pre-flight, and post-flight experiments. During the flight experiments, the PS felt pain in fast eye movement. He was obliged to fix his line of sight at the center of display and to watch the displayed error movement using peripheral view. He also felt difficulty in supporting his body against reaction force of his hand movement. During a few days after landing, disturbance was observed in the PS's posture. The operator describing function analysis revealed the disappearance of the "regression" phenomenon and increment of the effective time delay. As the result, the flight describing function showed better fit to the simplified model of lead with pure time delay.
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In acute experiments on cats and in chronic experiments on dogs the contractile activity of the esophagus and the cardiac sphincter was recorded with a ballon pulled from the stomach to the esophagus connected to a catheter. The intravenous injection of Metoclopramide in doses of 0.5--0.6 mg/kg to cats and subcutaneous injection of Metoclopramide in doses of 0.1--0.15 mg/kg to dogs elevated the pressure in the cardiac sphincter significantly increased the motility of the distal esophagus and stimulated the esophago-gastric inhibitory reflex. These effects persisted for 2.5--3 hrs; they were phasic in nature and were preserved after vagotomy in dogs. A conclusion was drawn that Metoclopramide could be useful in pathology of the distal esophagus, including the cardiac sphincter.
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