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PubMed1987

[Effect of a NaCl gradient on the transport of para-aminohippuric acid into the vesicles of the basolateral membrane of the kidney cortex].

Basolateral membrane vesicles were isolated from the rat kidney cortex by a modified method of cation precipitation. Different steps of preparation were analysed using the marker enzymes: Na+,K+-ATPase (for basolateral membrane), alkaline phosphatase (for apical membrane), glucose-6-phosphatase (for membranes of endoplasmic reticulum) and succinate dehydrogenase (for mitochondria). The basolateral membrane was purified by a 8-9-fold treatment with Na+,K+-ATPase, while other membrane contaminations were as low as 2% (as compared to homogenate). The transport of 3H-p-aminohippurate (3H-PAH) by basolateral membrane vesicles was measured under different experimental conditions. The 3H-PAH uptake was found to be Na-gradient dependent. The initial rate of 3H-PAH uptake in the presence of NaCl gradient (500 pM/mg X min) was higher than without the gradient (88 pM/mg X min). It is concluded that the PAH transfer across the basolateral membrane may be energized by the Na+ chemical gradient.

Aminohippuric Acids↗
PubMed1984

[A new method for the determination of the maximal tubular transport of p-aminohippuric acid without urine analysis in children with transplanted kidney].

For the clearance investigations of children who underwent renal transplant operations methods without indwelling catheters in the urinary bladder are necessary. The determination of GFR and ERPF takes place by means of single injection of radioactively labelled clearance substances. The maximum tubular secretory function may be established by means of the Tm PAH. Up to now for this purpose the quantitative determination of PAH in the urine was necessary. By means of an on principle other method by determination of the 125J-hippuran clearance under infusion of PAH the Tm-PAH may be indirectly calculated without investigation of the urine. In nine children with renal diseases the parallel determination was performed with classical and new method (r = 0.89, p less than 0.01), in order to prove the good correspondence of the results of the two methods. The Tm PAH in seven children who underwent renal transplant operations shows at first an at ERPF relatively decreased, after several years a relatively increased Tm PAH.

Aminohippuric Acids↗