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Results for “ANTHRACOSILICOSIS”

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At least 145 records · Page 8Linked to original sources
PubMed1975

Long-term test on rhesus monkeys for the PVNO therapy of anthracosilicosis.

In order to test the therapeutic efficiency of intravenous PVNO injections against anthracosilicotic changes, long-term inhalation tests were performed in which rhesus monkeys were exposed to coal-quartz dust. The exposures were given over a period of 48 months. PVNO treatment at a concentration of 300 or 600 mg/kg body weight began 8 months after the end of exposure. To determine the effect of PVNO injections, hydroxyproline examinations of the urine were made. After a total duration of 70 months the test was followed by an examination of respiration and circulation. In addition to histological check-ups the organ weights were determined. Under the influence of PVNO treatment neither a regression of anthracosilicotic changes in lungs and lung lymph nodes occurred nor was the progression of these changes retarded.

Animals↗
PubMed1992

[Cytochemical research on the peripheral blood erythrocytes and neutrophils of coal miners].

A total of 140 miners, divided into 4 groups were studied. The first group consisted of 25 practically healthy people, newly employed, examined at a health center of the mine, the second of 21 patients with anthracosilicosis, the third of 36 with anthracosilicosis confirmed by X-ray, the fourth included 58 facing the first stage of anthracosilicosis. Erythrocyte histidine and catecholamine levels, myeloperoxidase and beta-glucuronidase activities, data of lysosomal cation (LC) and NBT tests in neutrophils were under study. The miners of groups 2, 3, 4 showed the increased beta-glucuronidase activity (by 47-73%) and NBT test values (37-96%), lowered levels of catecholamines (57-67%), histidine (48-60%), results of LC-test (29-32%) and myeloperoxidase activity (21-31%) in comparison with normal subjects. The findings will help diagnose the latent forms of anthracosilicosis comparatively early, when the structural changes cannot be detected by X-ray.

Adolescent↗
PubMedDate not supplied

[The cytological status of the nasal mucosa and the buccal epithelium in coal miners].

Sixty-four persons were examined. The examination was undertaken to study the cytomophological parameters of the cells of the nasal mucosa and the buccal epithelium in coal miners. Group 1 consisted of 18 donors without contact with industrial dust; Group 2 comprised 24 apparently healthy miners; Group 3 included 22 workers (drift miners) with Stage 1 anthracosilicosis, grade 1 respiratory failure. The patients with Stage 1 anthracosilicosis had noticeably worse morphofunctional characteristics of the epithelium that displayed extensive fields with pronounced structural changes, such as destruction and desquamation of the integumentary epithelium of the nasal mucosa. Nasal mucosal atrophic changes were observed in 50% of the examined miners. Examination of the buccal epithelium in apparently healthy miners (code 0) and in workers with Stage I anthracosilicosis revealed the increased proportion of microfloral (Streptococcus) contamination by 79% and 3.7 times, respectively.

Adult↗
PubMedDate not supplied

[Pulmonary surfactant and dust-induced diseases of the respiratory organs in coal miners].

Surface activity and biochemical composition of pulmonary surfactant was studied in patients with anthracosilicosis and chronic dust-induced bronchitis. Significant impairment was found of surface-active properties of the surfactant during the course of development of the above conditions but different functional state of the pulmonary surfactant system determines dissimilarity in the natural course of the conditions in question. Suppression of the phospholipids synthesis in patients with anthracosilicosis contributes to the predominance of the processes of damaging the alveolar epithelium as well as pneumofibrosis and fatty infiltration of the pulmonary tissue while increase in the amount of pulmonary surfactant in patients with dust-induced bronchitis brings about predominant development of obstructive, bronchospastic and inflammatory changes. Study of the state of pulmonary surfactant in patients with dust-induced diseases of the respiratory organs suggest it is not useful to classify anthracosilicosis and dust-induced bronchitis under the same term "dust-induced disease of the lungs".

Adult↗
PubMed2005

[Cytochemical parameters in studying the body at peripheral hemopoiesis level].

The authors used cytochemical methods to study functions of neutrophils, RBC and lymphocytes of perpheral blood in miners suffering from anthracosilicosis stage I, revealed higher phospholipids content, lower catecholamines, increased activity of monoamine oxidase, esterase, decreased glycogen, RNA and lysosomal cationic proteins, in comparison with apparently healthy individuals. These tests are considered expedient in diagnosis of early anthracosilicosis manifestations in miners.

Adult↗
PubMed1979

[Clinical aspects and prevention of pneumoconiosis caused by inorganic dusts (author's transl)].

Anthracosilicosis and asbestosis are the most important types of pneumoconioses induced by inorganic dust. They produce entirely different damage to the broncho-pulmonary system. Anthracosilicosis graded B or C roentgenographically is very often accompanied by obstructive respiratory disorders; in asbestosis restrictive disturbances predominate. The question whether obstructive lesions also tend to occur remains to be solved. Dyspnoea often accompanied by bronchitis is the main clinical feature. Anthrocosilicosis is amenable to therapeutic measures which have resulted in a considerable prolongation of the life span of these cases. Improved dust control is the most rational prophylactic measure. Abstention from smoking also plays a part.

Airway Obstruction↗