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Large needle aspiration biopsy results of palpable thyroid nodules diagnosed by fine-needle aspiration as a microfollicular nodule with atypical cells or suspected cancer.

Among 1875 patients with palpable thyroid nodules examined with FNA cytology and LNAB histology, 132 with a preoperative FNA diagnosis of microfollicular nodule with atypical cells (n = 50) or suspected cancer (n = 82) were operated on. The 50 nodules showed the following preoperative LNAB finding: inadequate (8), benign (15), microfollicular (20), microfollicular with atypical cells (5), suspected cancer (2). The postoperative cancer incidence in the nodules with the benign LNAB diagnosis was 0% while it was 10%, 60% (P = 0.008), 100% (P = 0.007) in the other three LNAB diagnostic categories. The 82 nodules showed the following preoperative LNAB finding: inadequate (21), benign (21), microfollicular (15), microfollicular with atypical cells (15), suspected cancer (10). The postoperative incidence of cancer in the 21 (14%) and 10 (80%) nodules diagnosed by LNAB as benign nodule or suspected cancer, respectively, was significantly different (P = 0.0007). These data suggest that LNAB can be used for the preoperative selection of the palpable thyroid nodules diagnosed by FNA as a microfollicular nodule with atypical cells or suspected cancer.

Adenocarcinoma, Follicular↗
PubMed1982

Does oral premedication increase the risk of gastric aspiration? A study to compare the effect of diazepam given orally and intramuscularly on the volume and acidity of gastric aspirate.

In a clinical study including 40 patients, who all underwent elective gynaecological surgery, the quantity and acidity of the gastric contents were compared for patients premedicated with diazepam (Apozepam) intramuscularly and orally, respectively. A significant difference was found with regard to both the quantity and acidity of the gastric fluid. The volume of gastric fluid was smaller after oral than after intramuscular premedication with diazepam (1.5 ml and 20 ml, respectively). The acidity of the gastric fluid was also less after oral than after intramuscular premedication (pH 2.4 and 1.8, respectively).

Administration, Oral↗