Pharmacologic treatment of psychotic depression.
Explore the source record for details and available documents.
SEARCH · PubMed Health
Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.
Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
To examine clinical and psychophysiological correlates of lateral ventricular size, computerized tomographic (CT) scans were obtained on a sample of 88 patients who had experienced their first psychotic episode. Patients met DSM-III criteria for schizophrenia, schizophreniform disorder, or affective disorder with psychotic features. For patients with schizophrenia, large lateral ventricles were associated with unfavorable outcome. No association between outcome and ventricular size was found in patients with affective or schizophreniform disorder. Patients with mood disorders who had large ventricles consumed significantly greater amounts of alcohol than those with small ventricles. No differences were found between patients with large or small ventricles in premorbid functioning, smooth pursuit eye tracking, or electrodermal activity.
To assess the frequency of HIV testing and the incidence of HIV infection among patients with new-onset psychosis, the records of 811 patients referred to a military hospital for acute psychosis during a two-year period were reviewed. Records of 518 patients were excluded because they had known chronic psychotic illnesses, repeat admissions for recurrent affective disorders with psychotic features, delirium, dementia, or pre-existing HIV infection. Of the 293 patients with new-onset psychotic illness, 84 percent (N = 246) were tested for HIV antibodies. None were seropositive for HIV. Although patients with new-onset psychosis were commonly assessed for HIV infection to clarify their diagnosis, HIV infection was not associated with new-onset psychosis.
This study examined the outcome of youth previously diagnosed with psychotic disorders at a public-sector tertiary care hospital. Of 95 children and adolescents retrospectively identified, follow-up information (mean interval 3.9 years) was obtained on 24 subjects with an outcome diagnosis of schizophrenia, 9 with psychotic mood disorders, 5 with personality disorders (antisocial or borderline), and 1 with schizo-affective disorder. The schizophrenic group was more often odd premorbidly and functioned worse at outcome, while the mood-disordered group had a shorter follow-up period and was more often anxious or dysthymic premorbidly. The personality-disordered group resembled the schizophrenics in their degree of impairment and chronicity. All three groups had high rates of family disruption, low SES, substance abuse, and chronicity, and were similar in their degree of premorbid impairment, length of prodrome, age of onset, initial diagnosis, and family psychiatric history. Misdiagnosis at onset was quite common and highlights the need for systematic longitudinal assessment of early onset psychotic disorders.
Persons with psychotic disorders receive devalued labels. Despite considerable theorizing, the proposition that these labels affect the course of psychotic illness has rarely been subjected to investigation. The lack of an adequate operational measure for the labeling construct has hampered research. The present report describes the development of the Social Response Questionnaire (SRQ), a measure of the 'sick' label which incorporates moralistic attitudes, fear of dangerousness and negative expectations attached to the role of the severely psychiatrically ill. This 32-item scale, a multidimensional measure of informal labeling, which may be administered in a self-report format or to significant others, permits the study of dose-response relationships. The SRQ is internally stable. It also exhibits construct validity. Schizophrenics and persons with affective psychosis label themselves and are labeled by others more harshly than persons with Crohn's disease or normals. While self-percepts and the perceptions of significant others are fairly congruent for normals and persons with a significant physical illness, there is no agreement between the self-ratings of psychotics and their significant others. Psychotic persons view themselves more negatively than Crohn's disease sufferers or normals, but not as negatively as their therapists, families and friends. Potential uses for the SRQ in longitudinal research are addressed.
The purpose of this study was to describe, among 73 patients, the evolution of their symptoms and the conditions of their psychiatric follow-up care within two years after their first hospitalization. These patients (who had never been hospitalized before in any type of psychiatric unit) were admitted in the psychiatric emergency unit of a general hospital. Five groups were characterized: affective disorders, adaptative disorders, psychotic disorders, substancious disorders, and anxious disorders. The group of affective disorders showed only few improvements in symptoms, although a longer and more regular follow-up care was sustained. The adaptative disorders group had a good prognosis despite a high frequency of follow-up interruptions. Finally, in spite of very frequent symptom aggravations, the group of delusional disorders presented a bad acceptance of psychiatric treatment.
Paranoid symptoms were found in 40% of patients admitted to a university general hospital psychiatric unit during a ten-month period. Fifty-eight percent of this group had frank paranoid delusions, while the rest had ideas of reference or generalized suspiciousness. Only one half of those who had paranoid delusions had paranoid schizophrenia. A significant number had affective disorders or organic brain disorder. Ideas of reference and suspiciousness were found in many patients who were not psychotic. The therapeutic implications of these findings are reported in three patients who were inadequately treated for affective disorders because the presence of paranoid symptomatology had led to an incorrect diagnosis of schizophrenia.
Three male chronically psychotic patients (mean age 33.0 +/- S.D. 7.2 years), two with schizoaffective disorder and one with organic affective disorder, received carbamazepine (CBZ) because of affective symptoms (and, in one case, partial complex seizures) refractory to management with antipsychotic drugs. Coincident with CBZ administration (and clinical improvement), hyponatremia developed thought to be due to the antidiuretic effect of this drug. Lithium was added to counteract the antidiuretic effect of CBZ. Further clinical improvement ensured, serum sodium levels became normal, and there was an increase in the white blood cell count in each patient. The clinical implications of our findings are discussed.
Explore the source record for details and available documents.
DSM-III tightened the criteria for diagnosis of schizophrenia by excluding patients who exhibit a full affective syndrome before the onset of psychotic symptoms; such patients are to receive a diagnosis of affective disorder. The impact of this change on psychiatric diagnostic practices in Veterans Administration facilities before and after publication of DSM-III was assessed. Diagnoses of schizophrenia increased about half as much as would be expected based on the overall increase in psychiatric diagnoses, while diagnoses of affective disorders rose about two and a half times as much as would be expected. Patients whose diagnoses were changed from schizophrenic to affective disorders after publication of DSM-III had significantly fewer hospitalizations in both time periods than patients who retained diagnoses of schizophrenia. However, greater diagnostic inconsistency was found after implementation of DSM-III.
L-DOPA has progressively replaced atropinic substances in the treatment of the Parkinson's disease but its superiority is not evident in all domains. The same as these substances, it can occasion a secondary psychical pathology essentially presented by affective disorders and psychotic phenomena. The proposed study lays on the comparison between two parkinsonian groups, one undergoing a dopaminergic treatment the other one not. The hallucinary and confusing properties and to a lesser degree the depressive properties of L-DOPA are correlated to risk factors amongst which the average advanced age of the patients has the greatest place.
The authors studied the dexamethasone suppression test (DST) on a series of 112 inpatients including 65 patients with major depressive disorder (21 bipolars: 4 with, 17 without psychotic symptoms; 44 unipolars: 13 with, 31 without psychotic symptoms), 15 patients with depressive disorder, 10 schizoaffective and 22 schizophrenic patients. Using different diagnostic criteria, they confirm the best performances of the DST in depression for the diagnosis of a major depressive disorder, primarily endogenous. They also examined the potential influence of psychotic symptoms, suicidal behavior and family history of affective illness on the DST. The only significant difference found is in the cortisol plasma level at 4 p.m. in bipolar patients with psychotic symptoms. That fact and the high rate of abnormality of the DST in schizoaffective and schizophrenic patients indicate that psychotic symptoms per se may play a role in a dysregulation of the hypothalamo-pituitary adrenal axis.
The family-heredity findings serving as criteria for the classification of functional psychoses are discussed, presenting recent data. The global morbidity risk of the resp. psychosis showing secondary cases similar (homotypical) to the index case and no increased incidence of cases of the other type may be interpreted by the theory of two separated genetically transmitted diseases (schizophrenias and affective disorders). The classical schizophrenic subtypes differ in their global schizophrenia morbidity risk and show a tendency toward homotypical secondary cases. Monopolar and bipolar affective disorders were found to be very close together concerning family-genetic data-Schizo-affective psychotics were found to have among their relatives the highest incidence of all types of functional psychoses at all, a high rate of schizophrenics (esp. catatonic type) and affective psychotics and no homotypical secondary cases.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.