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At least 145 records · Page 8Linked to original sources

PubMed1979

[The epidemiology of breast neoplasms].

In an epidemiologic study the risks of breast cancer were assessed. An evaluation of the distribution of different tumor stages revealed that more information, in a larger sense more civilization, workship and the life in town makes women more curious and brings them to go sooner to the doctor. A lack of information correlates with more advanced stage of tumor. Significantly more childless women suffer of breast cancer, but a high number of children is no protection. In women with 3 and more children yet more advanced stages were seen. This may be interpreted by isolation, lack of information and distress. A significantly high number of breast cancer patients lost one of their parents by death before the age of 20, which confirms the psychosomatic theory of cancerogenesis (overcoming of the "Objektverlust" in early childhood). The incidence of depressive states before the onset of the disease is significantly higher. A reduced capacity to communicate was also observed. The exploration of sexual behaviour showed more frequently a reduced sexual activity correlated to cohabitarche, number of partners, alibidimia, unwanted pregnancy and masturbation. The ability of adequate sexual life was deeply disturbed by disease and therapy. Following primary therapy intelligent guidance of the patient may avoid occurrence of disturbances of sexual communication.

Breast Neoplasms↗

PubMed1978

[Therapeutic advances in breast neoplasms achieved through multimodal treatment].

The epidemiology of breast cancer and the frustrating stagnation of present primary care by local means such as surgery (with or without postoperative radiotherapy) are reviewed. The unsolved problem of early occult micrometastases in breast cancer--as in many other tumors--renders unlikely any real further progress towards higher curability in mammary carcinoma by "optimizing" or even "minimizing" local therapy alone. In contrast, higher remission rates and prolonged tumor control in metastatic breast cancer have been achieved during the last 10 years by advances in combination chemo- or chemo-hormono-therapy. Current controlled studies with adjuvant chemotherapy added to radical mastectomy show encouraging results, such as decreased over-all recurrence rates within 3--4 years and possibly also increased survival. Recent data of Swiss and foreign randomized adjuvant studies in primary breast cancer are reviewed and analyzed. Since mode of administration, duration and patient selection are not yet sufficiently clarified and standardized, routine use of "adjuvant chemotherapy" cannot be advocated on a large scale basis at the present time. There is, however, an urgent need for controlled patient trials with the inclusion of hormonal and possibly immunological "adjuvant regimens", to assure critical evaluation of clinical benefit and protect future patient cohorts from the possible long-term risks of additional primary cytotoxic therapy.

Antineoplastic Agents↗

PubMed1978

[Steroid receptors--their meaning in the treatment of breast neoplasms].

Quantitation of estrogen and progesterone receptors in breast cancer has contributed to a better understanding of the prognosis of hormone treatment. In case of lymph node involvement adjuvant chemotherapy is indicated in estrogen receptor negative tumours. In patients with positive estrogen receptor pattern, hormone treatment eventually combined with chemotherapy is recommended. Comparable results are found after treatment with antiestrogens, side-effects, however, are found less frequently.

Breast Neoplasms↗

PubMed1997

[Imaging of breast neoplasms].

Imaging is crucial in early diagnosis of breast cancer. Mammography is still the most simple and reproducible method, except in dense breast. In these circumstances, ultrasonography may be helpful. Magnetic resonance imaging has some indications such as the diagnosis of local relapses and preoperative staging.

Adult↗

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