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PubMed1988

[CO2 laser therapy and typing of human papilloma virus in follow-up studies of cervix intraepithelial neoplasms].

In 104 woman patients with cervical intraepithelial neoplasia (CIN) I-III who had been treated between 1981 and May 1986 in the dysplasia consulting-room of the Department of Gynecology by means of conisation effected by laser, we checked on therapeutic success via cytology and colposcopy as well as by human papilloma virus (HPV) typing. In 90.3% of the cases 1.25 laser treatments sufficed for healing of the lesion. Relapses occurred mainly in severe intraepithelial neoplasias with identified HPV 16/18. Incidence of HPV was reduced from 56% before therapy to 13.3% after therapy. This shows that laser therapy can be regarded as an effective treatment of the causes of the disease even in CIN associated with HPV. The markedly increased relapse rate in CIN III (24%) makes a reliable follow-up mandatory especially in such cases.

Cervix Uteri↗
PubMed2003

Systemic therapy for gynecological neoplasms: ovary, cervix and endometrium.

Early-stage endometrial carcinomas should be treated by total abdominal hysterectomy and bilateral salpingo-oophorectomy. In a small subset of patients, who wish to have children, conservative treatment (hormonal therapy) could be considered. The most effective agents for palliation of advanced disease are doxorubicin plus cisplatin.

Antineoplastic Agents↗
PubMedDate not supplied

Cancer mortality in Italy, 1998.

This short report provides data and statistics of cancer mortality in Italy in 1998, updating previous work on the issue. The material and methods of this report are similar to those previously described. Briefly, cancer death certification numbers by cause and estimates of the resident population in 1998, stratified by sex and quinquennia of age, were abstracted from data provided by the Istituto Nazionale di Statistica (ISTAT). All cancers or groups of cancers, classified according to the standard International Classification of Diseases (ICD), Ninth Revision, were grouped in 31 categories, besides total cancer mortality and other and unspecified sites. We grouped together all intestinal sites, melanomas and non-melanomatous skin neoplasms, all uterine neoplasms (cervix and corpus), all neoplasms of the brain and nerves (benign and malignant), all leukemias, and all non-Hodgkin's lymphomas. Eight tables were produced, including the following statistics: 1) number of deaths, crude and age-standardized death certification rates, and percentages of all cancer deaths for population at all ages and truncated 35-64 years (Table 1 for males and Table 2 for females). Two different standards were used: i) the 1971 Italian census population, corrected for census undercount and subdivided into 16 quinquennia of age from 0-4 to 75-79, plus 80 and over, and ii) the world standard population, for purposes of comparison with other countries; 2) age-specific death certification rates for each sex and quinquennium of age from 0-4 to 75-79, plus 80 and over (Table 3 for males and Table 4 for females); 3) total number of registered deaths for each cancer or group of cancers, sex and age group (Table 5 for males and Table 6 for females); 4) percentage of all cancer deaths for each sex and age group (Table 7 for males and Table 8 for females). A few comments are included, mainly in order to assist reading and interpretation of data for major cancer sites, and to recall underlying long-term tendencies. Any inference should in any case be based on age-standardized rates, and, essentially, on detailed inspection of age-specific rates.

Adolescent↗
PubMed1995

[Early gastric cancer as a metachronic or synchronic tumor. Report of 6 cases].

Through a period of 16 years, 108 cases of early gastric cancer (EGC) were diagnosed at Hospital Mexico, a leading teaching hospital of Costa Rica's social security system and the University of Costa Rica. It was found that in four cases, the gastric neoplasia was a second primary tumor, and in the two remaining cases, the EGC developed synchronously to another neoplasm. Two of the four metachronic EGC were preceded by a uterine cervix neoplasm on stage lla; the third one was preceded by a breast adenocarcinoma, and the fourth one by a larynx cancer in a heavy male smoker. The treatment received for the first cancer was radiation therapy only, except for the breast cancer patient in whom surgery was employed as well. One of the patients with uterine cervix cancer developed an epidermoid bronchogenic cancer 17 years after the first tumor and 8 years after her EGC. In the two male patients with synchro tumors, the EGC developed together with a squasmous cell carcinoma of esophagus, and in the remaining one the EGC appeared simultaneously with a peritoneal mesothelioma. It is important to emphasize the presence of radiation therapy in the metachronous tumors, as well as the antecedent of smoking in the patient with three primary cancers, the esophagus one, and the larynx cancer patient.

Aged↗