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At least 145 records · Page 8Linked to original sources

PubMed1991

[A case of respiratory dyskinesia due to clebopride malate].

Clebopride malate is therapeutically used for the treatment of peptic ulcer. This drug has potent antidopaminergic activity that causes acute dystonic reaction, parkinsonism and tardive dyskinesia as adverse effects. Here, we have reported an 86-year-old man who developed abnormal involuntary movement of respiratory muscles and lower limb muscles after this drug had been given for four months. This involuntary movement appeared spontaneously at resting state and disappeared during sleep. Surface EMG demonstrated a synchronous grouping discharge in m. orbicularis oris, m. sternocleidomastoideus and m. interstales which synchronized with diaphragmatic movement on cinefluorography. Involuntary movement of the lower limbs was synchronous bilaterally and had little relationship with diaphragmatic movement. This involuntary movement was irregular not only in rhythm but also in duration. According to this irregular nature, we diagnosed this involuntary movement as respiratory dyskinesia with limb dyskinesia that belongs to tardive dyskinesia. After cessation of clebopride malate limb dyskinesia disappeared rapidly and respiratory dyskinesia markedly decreased. We emphasize that respiratory dyskinesia should be differentiated from psychogenic hyperventilation as easily misdiagnosed on initial examination.

Aged↗

PubMed1982

A long term study on treating velopharyngeal insufficiency by teflon injection.

Thirty-five individuals with velopharyngeal insufficiency, including eight with failed pharyngeal flaps, were treated with injectable Teflon and followed postoperatively for an average of three years. The patients' speech and voice quality were evaluated pre- and postoperatively, and an outcome was judged successful only if there was total elimination of the preoperative symptoms of hypernasality and inappropriate nasal air emission. All patients were evaluated preoperatively with cinefluorography, and an attempt was made to obtain serial postoperative films in order to determine the stability of the Teflon pad with time. An overall success rate of 74% was achieved. Success for patients with VPI, excluding those patients with pharyngeal flaps was 78%. In treating the failed pharyngeal flap cases we achieved a 62% success rate. The stability of the implanted Teflon was assessed over time as determined from measurements made on patients who received two or more postoperative cine films. Statistical analysis revealed no significant change in thickness of the pad over a period of time. Our conclusions are that with careful case selection, the injectable Teflon procedure is safe, effective and that the implant remains stable with time.

Adolescent↗

PubMed1979

An experimental study of the correction of gastroesophageal reflux by gastroplasty.

The rationale and efficacy of gastroplasty in controlling gastroesophageal reflux were studied by manometry and cinefluorography in the dog. The pressure in a 7 by 3 centimeter gastric tube, constructed from the lesser curvature of the stomach and interposed between the esophagus and the stomach, was 3.6 +/- 1.0 centimeters higher than in the stomach. When abdominal compression was applied, the pressures were similar in the tube and the adjacent stomach, 19.0 +/- 4.0 and 19.4 +/- 4.0 centimeters, and free reflux was demonstrated between the two. When the gastric fundus was wrapped around the gastroplasty tube, its resting pressure was 13.1 +/- 0.5 centimeters higher than gastric pressure. During abdominal compression, the pressure in the gastric tube increased to 23.0 +/- 0.6 centimeters suggesting a flutter-valve arrangement that produced an effective antireflux barrier. These data suggest that gastroplasty can be an effective antireflux method only when combined with fundic wrap.

Animals↗

PubMedDate not supplied

[Transcatheter closure of atrial septal defect with a prototype clamshell septal umbrella: one year follow-up].

Transcatheter closure of a secundum atrial septal defect was attempted using a prototype clamshell septal umbrella closure system in 11 patients (six males, five females, aged 4.4-15.0 years and weighing 16-51 kg). The balloon stretched atrial septal defects were 10.3 to 20 mm in diameter, and 23 to 40 mm diameter umbrellas were used. All patients improved clinically after the procedure. Fixed splitting of the second heart sound disappeared after closure in 10 patients, systolic murmur disappeared in nine, diastolic rumble in nine, and paradoxical ventricular septal motion in seven. Doppler color flow imaging immediately after implantation showed significant residual shunt in all patients; however, no shunt flow was observed in seven patients and minimal residual shunt was present in four one year after the procedure. Nine of 11 umbrellas demonstrated fracture of the stainless steel arm confirmed by chest radiography and cinefluorography. Arm fracture occurred between 1 week and 12 months after implantation. None of the devices were dislodged and no other complications were noted despite the fractures. Transcatheter closure of atrial septal defect is a feasible and useful procedure but the present device needs further modification.

Cardiac Catheterization↗

PubMed1976

Urethral diverticula in the adult female.

Urethral diverticulum in the adult female is an uncommon lesion which is practically ignored in the radiologic literature. The important symptom is incontinence. Because there is such poor clinical differentiation between stress incontinence, urgency incontinence, and post-void dribbling incontinence, we feel that any patient with incontinence that is not classical stress incontinence or of a neurologic cause should be investigated for urethral diverticulum. Six such patients plus one patient with a false positive panendoscopic examination are presented. Our method of examination with cinefluorography and conventional spot filming is explained. The urethrographic examination was found to be more reliable than the panendoscopic examination. When a discrepancy occurs, further studies are indicated.

Adult↗

PubMed1977

Quantification of wear, hemolysis and coagulation deficits in patients with Beall mitral valves.

Fifty-five patients (35 females and 20 males) were studied by noninvasive means 3.5-8.6 years after isolated mitral valve replacement with Models 103 and 104 Beall prostheses. History and physical exams by three physicians, complete hemograms, SMA 18, iron excretion rates, and coagulation profiles were performed. Additionally, electrocardiograms, echocardiograms, phonocardiograms, cardiac series, and high-speed cinefluorography of the prostheses were obtained. Valve wear was assessed by the disc/cage ratio measured from a "three-legged view" with magnification. At a mean duration of 5.85 years after operation, the entire group had a mean disc/cage ratio of operation, the entire group had a mean disc/cage ratio of 0.906 +/- 0.031 vs a normal value of 0.944 +/- 0.014. The group was mildly anemic and had a urinary iron loss that was 40 times normal. The lactic dehydrogenase (LDH) concentration was more than five times normal. The coagulation profiles were abnormal with respect to the bleeding and stypven times, antiheparin activity, fibrin degradation products, and megathrombocyte index. These abnormalities were unrelated to sex, degree of valve wear, and history of thromboembolism. Males were less anemic and had higher urine iron losses than females. Nine patients with severe valve wear (disc/cage ratio less than or equal to 0.87) were significantly more anemic with large urine iron losses and had elevated total bilirubin, serum glutamic oxaloacetic transaminase, and LDH concentrations (ninefold), when compared to nine patients with minimal wear (disc/cage ratio greater than or equal to 0.925). It is emphasized that the findings of a significant anemia, an LDH concentration greater than 1500 mU/ml, and a disc/cage ratio of less than 0.87 in a patient with an isolated Beall mitral valve prosthesis are indicators for the need to replace the prosthesis in the near future. Re-replacement is urged before significant clinical deterioration.

Adult↗

PubMed1962