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Results for “Condylomata Acuminata”

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PubMed1992

[Condylomata acuminata in childhood--pointing to sexual abuse].

The cause of condylomata acuminata and of other anogenitally located HPV lesions in children often remains undetermined. Sexual abuse is a possible cause of HPV infection in childhood. Non-venereal transmission of HPV, such as autoinoculation and heteroinoculation from extragenital sites to genitalia, however, is much more likely in this age group. Histology and HPV typing of genital warts may provide evidence for non-venereal transmission of HPV in children. Identification of the genital HPV types HPV 6, 11, 16, 18, 31, etc. in a child is no proof of sexual abuse. Behavioural abnormalities and a carefully elicited history aid clinicians in coming to reliable conclusions and in deciding whether an HPV infection in a child is sexually transmitted and due to sexual abuse.

Child↗

PubMed2001

Resolution of recurrent perianal condylomata acuminata by topical cidofovir in patients with HIV infection.

Anogenital condylomata acuminata are the most frequent clinical manifestation of genital human papillomavirus (HPV) infection. Association between human immunodeficiency virus (HIV) and HPV infections is frequent (range: 26-60% in males). Topical cidofovir (a nucleotide analogue antiviral drug active against a broad range of DNA viruses) is a potential treatment for anogenital warts in immunocompromised patients. We treated three HIV-infected patients with HPV perianal condylomas with topical 1% cidofovir in flexible collodion once a day for 2 weeks. The treatment resulted in complete clearance of the HPV lesions. The patients experienced mild transient erythema without any other side-effects. None of the patients relapsed during the 10-14-month follow-up period.

AIDS-Related Opportunistic Infections↗

PubMed1990

Immunological study of condylomata acuminata in men infected with the human immunodeficiency virus.

As condylomata acuminata often persist in individuals infected with the human immunodeficiency virus (HIV), an immunohistological study of warts from infected men was undertaken to further knowledge about human papillomavirus persistence in this group. Using an indirect immunoperoxidase method and a panel of monoclonal antibodies, the phenotypes of cells were studied in cryostat sections of perianal or anal warts removed from 14 HIV-infected men (10 homosexual and 4 heterosexual) and from 16 non-infected men (10 homosexual and 6 heterosexual). Although the median numbers of CD1+, CD3+ and CD4+ cells per unit area were similar in each group of individuals, the number of CD8+ cells was significantly higher in HIV-infected homosexual men when compared with non-infected individuals and HIV-infected heterosexual men. The median CD4+ cell count in the peripheral blood was significantly higher in HIV-infected heterosexual men than in HIV-infected homosexual men (P less than 0.05). These findings may reflect differences in duration of HIV infection between the two groups. There was no significant difference in the proportion of cells expressing interleukin-2 receptors between HIV-infected and non-infected individuals. Natural killer (CD16+) cells were not identified in any of the condylomata.

Adult↗

PubMed1991

Comparative virologic studies of condylomata acuminata reveal a lack of dual infections with human papillomaviruses.

Condylomata acuminata are epithelial proliferations caused by infection of the anogenital squamous epithelium with human papillomavirus (HPV). DNA-DNA hybridization techniques and the extremely sensitive polymerase chain reaction (PCR) were used to analyze biopsies from patients with clinically diagnosed condyloma acuminatum for the presence of HPV DNA. PCR analyses using primers and oligonucleotide probes specific for the E6/E7 region of HPV-6, -11, or -16 showed that 31 (93.9%) of 33 tissue biopsies contained HPV DNA: 22 contained type 6 DNA, 6 contained type 11 DNA, and 3 contained type 16 DNA. Eleven biopsies positive by PCR were Southern hybridization-negative or were considered inadequate for Southern analysis. In all 11, the presence of HPV DNA was corroborated by the observation of histopathologic evidence suggestive of HPV infection or by in situ hybridization. No evidence of multiple infections with HPV-6 or -11 and HPV-16 was seen.

Adult↗

PubMed1986

Condylomata acuminata in the pediatric patient.

Condyloma acuminatum has been recognized as venereal disease in adults but it has not always been similarly identified in children. We review our experience with 30 children with condylomata acuminata. Of the 14 children evaluated more than half have been determined to have a sexual etiology for the lesion. Recommendations for evaluation and treatment of children with condylomata acuminata are reviewed.

Adolescent↗

PubMedDate not supplied

Condylomata acuminata and their possible relation to cancer of the uterine cervix. Case report and geographic observations.

A unique case is described of a 21-year-old female with gonorrhea, condylomata acuminata of the vulva and the uterine cervix, a squamous-cell papilloma and precancerous changes in the cervix. In the observed lesion, a very gradual transition was seen from benign areas, displaying marked cytoplasmic vacuolization, to moderately dysplastic areas, with only slight vacuolization. Giant squamous cells with centrally located vesicular or hyperchromatic nuclei were a prominent feature of both the condylomatous and premalignant portions of the lesion. A geographic correlation was observed in the 18 districts of Uganda between the incidence of vulvar and vaginal condylomata acuminata and cervical cancer; the finding may include cervical warts since vulvovaginal changes often extend to the cervix uteri. In addition to the common flat condyloma, the acuminate variant may be a precursor of cervical cancer and progress to malignancy through the stage of a squamous-cell papilloma.

Adult↗

PubMed2005

Application of viable bacille Calmette-Guérin topically as a potential therapeutic modality in condylomata acuminata: a placebo-controlled study.

OBJECTIVES: To evaluate the efficacy of topical application of viable bacille Calmette-Guérin (BCG) as a primary line of treatment in patients with condylomata acuminata. METHODS: We recruited 50 patients from the Department of Andrology and Sexually Transmitted Diseases, Cairo University Hospital complaining of genital warts. Patients were divided into two groups. Group 1 consisted of 25 patients who received BCG as a weekly topical treatment for 6 consecutive weeks. If still resistant, another intensive three-times-a-week course for 3 consecutive weeks was given. Group 2 consisted of 25 patients who received 0.9% saline solution as a placebo solution with the same procedure and follow-up as for group 1. All patients were followed up for 6 consecutive months. During the treatment course, the local response, wart state and size, and any side effects were reported. RESULTS: A complete response with the disappearance of all condylomata acuminata was achieved in 20 (80%) of the 25 patients after a maximum of six BCG applications. Three patients (12%) needed another, more extensive, course, resulting in complete clearance 3 weeks later. Only 2 patients (8%) did not achieve a full response even after application of the intensified BCG course. No response was detected in the placebo group, with no improvement during follow-up. No recurrence developed in any responder. Minimal side effects, such as transient erythema and fever, were recorded during the study. CONCLUSIONS: Topical BCG in the treatment of genital warts attained a high success rate in our study compared with the placebo solution, with insignificant side effects and no recurrence.

Adjuvants, Immunologic↗

PubMed1984

[Condylomata acuminata and other papillomavirus-related diseases of the urogenital and anal region].

In view of the postulated etiological role of specific papillomaviruses in human genital cancer, early detection and treatment of papillomavirus-related lesions are requested. Since so far in the genital region papillomaviruses have been associated clinically only with condylomata acuminata, now they are detectable in a spectrum of morphologically and biologically different lesions of the external genitalia and of deeper mucosal sites such as the uterine cervix, the anal mucosa and the urethra. They consist in true condylomata acuminata, giant condylomas (Buschke-Löwenstein tumors), condylomata plana and the so-called pigmented papular lesions, the histology of the latter frequently exhibiting significant cellular atypia that may progress to carcinoma in situ. In the following brief survey morphological, etiological and therapeutical aspects of these diseases are presented.

Animals↗

PubMed1987

Condylomata acuminata arising in a neovagina.

A case is reported in which condylomata acuminata arose in a McIndoe neovagina. Histopathologic and virologic evidence are provided to support the characterization of these lesions as benign warty processes secondary to human papillomavirus-6. Factors influencing viral site specificity are discussed.

Adult↗

PubMed2000

Anal verrucous carcinoma and penile condylomata acuminata.

A 50-year-old man presented with recurrent tumorous lesions on the penis and the anal region. The anal lesion was histologically diagnosed as verrucous carcinoma (VC) and the penile lesions were in line with condylomata acuminata. Samples taken from tumors of both sites were human papillomavirus (HPV) DNA positive. Two of them taken from the penis and the perianal region scored HPV DNA 6 positive by using polymerase chain reaction and the Southern blot method. Treatment of both VC and condylomata acuminata consisted in surgery and adjuvant immune therapy. Neither tumor recurrence nor metastases occurred up until 6 months after therapy.

Anus Neoplasms↗

PubMed1993

Presence of human papillomavirus DNA in condylomata acuminata in children and adolescents.

The presence of human papillomavirus (HPV) DNA of types 6, 11, 16, 18, 31 and 33 was determined by in situ hybridization on archival paraffin-embedded tissue sections in 21 condylomata acuminata observed in patients aged 20 or less. HPV DNA was detected in 17 of 21 cases: all of these contained HPV 6, five also contained HPV 11, and one also contained HPV 16 and 18. HPVs 31 and 33 were not observed. Among 21 cases, 4 cases were in children under 6 yrs one of whom had a history of sexual abuse. The hybridization data indicate that condylomata acuminata in young people are associated with the same HPV types found in anogenital lesions in adults.

Adolescent↗

PubMed1987

[Treatment of condylomata acuminata with systemically administered recombinant gamma interferon].

29 patients suffering from condylomata acuminata were systemically treated with human gamma-interferon obtained by means of gene technology. The daily dose, subcutaneous applied, amounted to 100 or 200 micrograms. 12 patients were completely cleared by surgical excision and additionally treated with gamma-interferon for 7 days. 3 of them developed recurrences. 17 patients were exclusively treated with gamma-interferon 100 or 200 micrograms daily; they underwent 6 courses of therapy, each lasting 7 days, with interruptions of 3-5 weeks of observation. As a result, 5 patients showed complete remission; 2 patients partially responded. The tolerance of the drug depended on the dose. We did not observe any toxic side effects. Our findings suggest that gamma-interferon subcutaneously given may be effective with genital warts.

Adult↗

PubMed1986

Laser treatment of condylomata acuminata.

The laser is an increasingly popular modality for the treatment of condylomata acuminata. We present our results on 45 patients treated with the carbon dioxide or neodymium: YAG laser for penile, meatal or intraurethral condylomata. Of these patients 7 with small lesions on the penis, particularly on the glans, were treated with the carbon dioxide laser, while the remaining 38 were treated with the neodymium: YAG laser because the lesions were large, or because they were meatal, intraurethral or perianal in location. The only persistent lesions in laser-treated areas were those that were metal or urethral in origin and represented 4.4 per cent of the total series. Of the patients 13 per cent had recurrent condylomatous lesions elsewhere, usually 2 to 3 months after the initial therapy. The long-term cosmetic results have been excellent.

Anal Canal↗

PubMed1993

Detection of human papillomavirus L1 protein in condylomata acuminata from adults with defects in cell-mediated immunity.

Immunohistochemical assays for human papillomavirus (HPV) L1 protein, using antiserum directed against the L1 major capsid protein of bovine papillomavirus (anti-BPV serum), were performed on 101 condylomata acuminata biopsy samples from 47 men (40 of whom had intact cell mediated immunity [CMI], and 7 with conditions known to cause CMI defects), and 54 women (48 with normal CMI, and 6 with CMI defects). L1 protein was detected in 28% of all biopsies, including 20.5% of samples from patients with normal CMI and 76.9% of patients with CMI defects (P = .00002). For both males and females, L1 protein was detected significantly more often in samples from patients with CMI defects than those with normal CMI. Immunohistochemical assays of HPV 11-infected human foreskin implants grown in athymic mice were performed to optimize the conditions of the assay. Three dilutions of anti-BPV serum or preimmune rabbit serum were used. A 1:500 dilution provided readily interpretable results, while preimmune serum at this dilution did not stain to any significant degree. However, at 1:10 and 1:100 dilution, both the anti-BPV serum and preimmune serum caused an unacceptable amount of nuclear staining, making results uninterpretable. Defects in CMI may allow active viral particle assembly at an increased rate, as judged by detection of L1 protein in condylomata acuminata from these patients.

Capsid↗

PubMed1976

Viral "tumorigenesis" in man: cell markers in condylomata acuminata.

Determination of the glucose-6-phosphate dehydrogenase (G-6-PD) phenotype of a neoplasm occurring in a heterozygous female can be used to trace the cellular origin of the tumor. This technique was performed on 834 individual verrucous subunits from four condylomata acuminata (venereal warts) arising in two patients heterozygous for a B and an A gene at the G-6-PD locus. All four specimens contained both A and B types of G-6-PD. Furthermore, even single verrucous subunits from each specimen occasionally contained both enzyme types. These data indicate that condylomata acuminata have a multicellular origin. The initial number of cells which, after viral infection, developed into a condyloma acuminatum was estimated to be about 4,400 cells, on the basis of statistical analysis of the data in one case.

Adolescent↗

PubMed1990

[DNA determination by cytophotometry in bowenoid papules in comparison with condylomata acuminata and Bowen's disease].

The relation between bowenoid papules and Bowen's disease is characterized by largely corresponding histological pictures and diverging clinical-epidemiological features. In bowenoid papules and Bowen's disease, 5 cases each, compared with 5 cases of common condylomata acuminata, we determined the DNA by means of Feulgen's cytophotometry in visible light after Feulgen's staining. The following results were obtained: The average DNA content in bowenoid papules equals that in Bowen's disease, but it is significantly higher than in condylomata acuminata. What is different between the two groups "bowenoid papules" and "Bowen's disease" is the distribution of DNA: In Bowen's disease, DNA spreads into higher ranges of polyploidy. If we take recent molecular biological/virological findings into account, this result can be interpreted as a transition towards carcinoma in situ.

Adult↗

PubMed1999

[Condylomata acuminata. The correlation between affecting sexual partners and the risk of developing preneoplasia of the cervix uteri. The therapeutic potentials of the Nd-Yag laser].

The present study summarized results from 206 patients (120 females and 80 males) with diagnosis condylomata acuminata. The diagnostic and surveillance methods used in the present work were: clinical, colposcopic, histologies and microbiological examination. 114 from all patients--46.5% females, and 62.2% males were sexual partners. In 25 women (43.8%) from that group HPV-lesions were found. In 8 patients with cervical lesions CIN I-III was diagnosed. Our results confirmed the previously announced literary data about an enhanced risk for CIN development in women with HPV infection, whose sexual partners had clinical data of Condylomata acuminata. Our therapeutic protocol with Nd-YAG laser treatment in a determined scheme and number of applications according to the stage of the disease and pathological diagnosis was very successful, as compared to data from the literature.

Condylomata Acuminata↗

PubMed1987

Characterization of human papilloma virus types in condylomata acuminata in children by in situ hybridization.

The presence of human papilloma virus (HPV) DNA sequences of types 6, 11, 16, and 18 was determined by in situ hybridization under stringent conditions on archival paraffin-embedded tissue sections in eight condylomata acuminata observed in children below the age of 12 years. Viral sequences were detected in seven of eight cases: all of them contained HPV 6, four contained also HPV 11, and one contained HPV 16 and 18. Papilloma virus common antigen was detected in only three of eight cases, all of them being positive also by in situ hybridization. We conclude that most condylomata acuminata in children are associated with the same types found in anogenital lesions in adults. Since little is known about the long-term significance of genital condylomas in children the identification of the papilloma virus type may prove to be important as a prognostic tool particularly in patients infected with HPV types 16 and 18, thought to have high oncogenic potential.

Antigens, Viral↗