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Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

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At least 145 records · Page 8Linked to original sources
PubMed1957

The effects of mecamylamine in the cat as modified by the administration of carbon dioxide.

A series of cats, anaesthetized with chloralose, was given intravenously a sufficient quantity of mecamylamine to produce hypotension and a 50% neuromuscular block. Inhalation of carbon dioxide then produced a further depression of blood pressure and an increase in the neuromuscular blocking effect. It was shown that, following the administration of carbon dioxide, the plasma mecamylamine levels increased coincident with the increased pharmacological effects.

Animals↗
PubMed1959

Supersensitivity due to prolonged administration of ganglion-blocking compounds.

Repeated subcutaneous injections of ganglionic blocking agents in cats were found to cause a supersensitivity towards adrenaline in the submaxillary gland and the nictitating membrane. The supersensitivity resembled that produced by preganglionic denervation, namely section of the chorda tympani in the case of the gland and of the cervical sympathetic trunk in the case of the membrane. The blocking compounds used were chlorisondamine chloride and hexamethonium. With the former, the sensitization could be obtained in the normally innervated structures. When hexamethonium was used, however, the effect on the gland could be produced only if the synapse had been made particularly susceptible to the blocking action of this agent; this was achieved by cross-suture experiments.

Animals↗