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Stability of thrombosis induced by electrocoagulation of rat middle cerebral artery.

BACKGROUND AND PURPOSE: Although it is often assumed in experimental stroke studies that cautery-induced occlusion is permanent, surgeons commonly expect cauterized vessels to recanalize spontaneously. We used the rat middle cerebral artery to determine if electrocoagulation would produce a permanent occlusion in this preparation. METHODS AND RESULTS: A standard bipolar coagulator, calibrated to determine actual power output, was adjusted to induce platelet aggregation in the middle cerebral artery of anesthetized Sprague-Dawley rats without inducing bleeding through the arterial wall. A reliable temporary thrombosis was induced by a Malis Bipolar Coagulator set to deliver 10 bursts of 1.5 seconds each at a rate of 24 min-1 and a power setting of 3 W. This thrombus was responsive to the antithrombotic agent flunarizine. An apparently permanent occlusion was produced by 30 bursts at 3 W followed by 20 bursts at 5 W. To our surprise, seven of seven such occlusions recanalized spontaneously within 4 hours. CONCLUSIONS: The electrocoagulation process commonly used in experimental stroke studies may produce only a temporary occlusion of the rat middle cerebral artery.

Animals↗

Current leakage in bipolar electrocoagulation.

Bipolar electrocoagulation has previously been shown to give a considerable amount of current leakage to ground from either of the two outputs. This might result in unwanted tissue destruction. Thus far, no standard has been proposed for current leakage to ground from the outputs of bipolar equipment. This study was performed to establish safe parameters for such leakage. To determine the limit for damage-no damage, monopolar stimulations were performed on the brain surface of dogs. Blood-brain barrier disturbance was used as an indicator of damage. The limit for acceptable current leakage was found to be about 10 to 15 mA. Most bipolar coagulators were found to exceed this value. The electrical data recorded in this study should be considered in the design of bipolar equipment for electrocoagulation.

Animals↗

Polymerase chain reaction for monitoring human papillomavirus contamination of medical personnel during treatment of genital warts with CO2 laser and electrocoagulation.

Genital warts and intraepithelial neoplasia caused by infection with human papillomavirus are usually treated with CO2 laser or electrocoagulation. In this study, contamination of personnel and operating theatres with human papillomavirus DNA during treatment sessions was investigated. Samples were taken from the nostrils, nasolabial folds and conjunctiva of the operating physician before and after operating sessions and from Petri dishes left open in the operating theatres. Human papillomavirus DNA was demonstrated by the polymerase chain reaction technique. The results show that there is a risk of contamination of the operator by human papillomavirus DNA, detectable with the polymerase chain reaction technique, during both CO2 laser and electrocoagulation treatment.

Aerosols↗

Efficacy of laparoscopic electrocoagulation in infertile patients with minimal or mild endometriosis.

The cumulative pregnancy rates in 17 infertile patients with minimal or mild endometriosis who underwent laparoscopic electrocoagulation were compared with those of 20 similar patients who underwent only diagnostic laparoscopy. A life-table method of analysis was used. No significant differences in pregnancy rates was evident at either 6 months (p greater than 0.5) or 12 months (p greater than 0.5) of follow-up. These results question the use of laparoscopic electrocoagulation for the treatment of infertile patients with minimal or mild endometriosis.

Adult↗

Long-term results of Gasserian ganglion electrocoagulation.

This report is a follow-up study of 315 patients under 46 years old who suffered from trigeminal neuralgia and were treated by electrocoagulation of the Gasserian ganglion. The average foll-up period was 12.7 years, the maximum 33 years. Eighty percent had a return of pain, but 96.7% ultimately attained freedom from pain after repeat electrocoagulation.

Adolescent↗

Treatment of low rectal carcinoma by transanal electrocoagulation.

This study reports the first 13 cases of biopsy-proven low rectal carcinoma treated by transanal electrocoagulation using a locally manufactured instrument. At the University Hospital of the West Indies, over a 16-year period, 9 patients were treated for cure, six of whom have no clinical evidence of recurrence for one to 12 years. Four cases who were offered this procedure for palliation defaulted after a single treatment. Transanal electrocoagulation provides an additional option for treating patients with small, mobile low rectal cancers, following careful screening for evidence of nodal or distant spread. The procedure can also be used in the local control of disease in patients with distant spread or in whom a major operation is not feasible.

Adenocarcinoma↗

[Results of clomiphene citrate ovarian stimulation vs laparoscopic electrocoagulation of the ovaries in infertile women with PCOS].

OBJECTIVE: To assess the results of clomiphene citrate ovarian stimulation vs laparoscopic electrocoagulation of the ovaries in infertile women with PCOS. DESIGN: 47 women with PCOS were included into the study. 25 of them had ovarian stimulation using clomiphene citrate (100 mg for 5 consecutive days, during 6 cycle) and 22 underwent laparoscopic electrocoagulation of the ovary (6 cycle follow-up) No significant differences were detected between age and body mass index. RESULTS: In the first group ovulatory cycles were confirmed in 68% of women, pregnancy rate was 28%. In the second group ovulations were observed in 90.9% of women and pregnancy rate was 63.6%. There were statistically significant differences. CONCLUSION: In summarising, the results showed lower, statistically significant differences in pregnancy rate in the treatment of infertility associated with PCOS. It seems that the much more successful result of the PCOS therapy may be achieved after laparoscopic ovarian diathermy in comparison with stimulation of the ovaries with CC.

Clomiphene↗

Endoscopic injection therapy vs. multipolar electrocoagulation vs. laser vs. injection + octreotide vs. injection + omeprazole in the treatment of bleeding peptic ulcers. A prospective randomized study.

BACKGROUND/AIMS: A prospective randomized study was performed to assess the effectiveness and safety of 5 different methods of hemostasis in selected patients with high-risk bleeding peptic ulcers. METHODOLOGY: Two hundred and eight patients (n = 208; mean age: 61.6 yrs) with endoscopic stigmata of active hemorrhage, non-bleeding vessel or adherent fresh clot were randomized during emergency endoscopy to receive one of the following modalities of endoscopic therapy (with or without pharmacological therapy): I) injection of absolute alcohol (n = 44); II) multipolar electrocoagulation (BICAP; n = 42); III) Nd-YAG laser (n = 40); IV) injection of absolute ethanol + octreotide (n = 42); V) injection of absolute ethanol + omeprazole (n = 40). RESULTS: The 5 treatment groups were clinically and endoscopically comparable. The initial hemostatic success was > 90% in every group. No significant differences between groups were found in any of the following parameters assessed during hospitalization: incidence of rebleeding (I = 14.8% vs. II = 19.0% vs. III = 16.6% vs. IV = 18.1% vs. V = 20.0%; P > 0.05 mean = 17.7%); incidence of definitive hemostasis (I = 89.3% vs. II = 85.7% vs. III = 86.6% vs. IV = 84.0% vs. V = 86.6%; P > 0.05; mean = 86.5%); incidence of emergency surgery (I = 8.5% vs. II = 11.9% vs. III = 10.0% vs. IV = 6.8% vs. V = 11.1%; P > 0.05; mean = 9.6%); mortality rate (I = 4.2% vs. II = 4.7% vs. III = 3.3% vs. IV = 13.6% vs. V = 4.4%; P > 0.05; mean = 6.2%). Mean age of deceased patients was significantly higher than living patients (71.2 +/- 13.4 vs. 60.9 +/- 14.4; P < 0.05). Approximately 2/3 of the fatal cases were strongly weakened by coexistent medical diseases. The duration of hospital stay was similar for all groups. The BICAP group required less units of blood transfusion (1.9 +/- 1.8 vs. I = 3.0 +/- 2.6; III = 3.5 +/- 3.6; IV = 2.8 +/- 2.3; V = 3.1 +/- 2.5; P < 0.05), perhaps due to the higher mean value of hemoglobin of these patients at hospital admission, compared to all other groups. No significant complications were reported. CONCLUSIONS: This study provides good evidence that injection of absolute ethanol, multipolar electrocoagulation (BICAP) and Nd-YAG laser are equally safe and effective in the endoscopic therapy of acute bleeding peptic ulcers. In contrast, no additional hemostatic benefits arose from the association of pharmacological agents (octreotide or omeprazole) to sclerosis injection.

Anti-Ulcer Agents↗

Microlaparoscopic technique for partial salpingectomy using bipolar electrocoagulation.

OBJECTIVE: To describe a technique of performing a partial salpingectomy using a small-diameter (2-mm) laparoscope and bipolar electrocoagulation. STUDY DESIGN: Sixty consecutive women desiring permanent sterilization underwent laparoscopic partial salpingectomy using a 2-mm transumbilical laparoscope and secondary midline sites suprapubically and midway above the pubis. A midportion of the tube was coagulated using Kleppinger forceps, transected with scissors and removed using grasping forceps. RESULTS: Additional time to remove both coagulated tubal segments averaged 4 minutes (range, 3-10). Each segment (mean, 1.5 cm; range, 0.9-2.4 cm) was confirmed in the operating room, then histologically. The transected tubal edges were separated with no thermal injury to nearby structures and with no mesosalpingeal hemorrhage. No cases required conversion from microlaparoscopy to a traditional method, and recovery time was not prolonged. The puncture sites healed well without sutures. CONCLUSION: Successful removal of electrocoagulated tubal segments with histologic confirmation was undertaken microlaparoscopically, with minimal additional operative time.

Adult↗

[Bipolar electrocoagulation in patients with persistent hemorrhage secondary to second degree postradiation proctopathy].

OBJECTIVE: Our objective was to evaluate response to bipolar electrocoagulation (BICAP) in patients with persistent rectorragia (PR) secondary to PRP (post-radiation proctitis) degree II (telangiectasias). MATERIAL AND METHODS: We had 64 cases prospective and conducted study cohort of 257 patients, with cervicouterine cancer, radiated, PRP degree II, and PR. DESIGN: We conducted prospective, cross-sectional and descriptive study. Patients were divided in three groups: (group 1), with hemodynamical instability; (group 2) with chronic anemia, and (group 3), without data of chronic anemia (Table 1). Clinical evaluation was carried out before and after the intervention (BICAP). BICAP of radial way at level of telangiectasias was applied, of sigmoides up to 2 cm of anal margin. Three sessions were average. RESULTS: A total of 55 patients had PR radiation dose average, with 49.85 Gy. Time average of appearance of rectorragia was 9 months. GROUP 1: A total of 21 patients, age 51.2 years average). Previous to BICAP, week by frequency of rectorragia was 2.23 (average). With hemoglobin (Hb) and hematocrit (Ht) of 7.1 g (average) and 24.4%, respectively (average). A total of 18 patients (85.7%) required hemotransfusion. Average hospital stay was 1.3 days. Cardiac frequency, arterial, blood and hemoglobin pressure, and hematocrit obtained later improvement to intervention with BICAP was statistically significant (p > 0.0001). Patients did not require additional blood transfusions. GROUP 2: A total of 18 patients with age average 56 years (average). Previous to BICAP they had weekly rectorragia of 2.16 (average). Hb was 11.4 g and Ht of 35.5% (average). Subsequent to BICAP, 100% patients had controlled hemostasis. The improvement observed with regard to cardiac frequency and blood pressure after application of BICAP did not have statistical significance despite the fact that it was demonstrated to laboratory parameters as well as diminution of weekly episodes of rectorragia if they were statistically significant (p > 0.0001). No blood transfusion was required. GROUP 3: There were 16 patients with average of 57.1 years of age (average). Previous to BICAP they had weekly 1 rectorragia of 2.06, Hb of 13.5 g and Ht of 41.2% (average). Subsequent to BICAP, there was 100% controlled haemostasis. In this group, diminution of weekly episodes of rectorragia, cardiac frequency, and blood pressure did not have statistically significant changes; nevertheless, hemoglobin and hematocrit had a statistically significant increase (p > 0.0001). No blood transfusion was required. CONCLUSIONS: Electrocoagulation (BICAP) is effective in hemostasis of bleeding telangiectasias, stabilizing to the patient, and diminishing recurrence, hospital stay, and blood requirements.

Cross-Sectional Studies↗

Electrocoagulation of pelvic endometriotic lesions with laparoscopic control.

Twenty-eight patients presenting with initial complaints of infertility or chronic pelvic pain were found to have pelvic endometriosis at laparoscopy. Destruction of the endometriotic lesions by means of electrocoagulation was performed via laparoscopy in a group of 19 patients. The remaining nine patients did not undergo such management. In the treatment group, seven of the 11 patients with chronic pain experienced complete relief of their symptoms, and six of the eight patients with infertility became pregnant postoperatively. Patients in the control group had a less favorable outcome. Only one of five patients with chronic pain had relief and one of four patients with infertility became pregnant following laparoscopy without cauterization. Electrocoagulation of pelvic endometriotic lesions under laparoscopic control appears to be satisfactory for the management of selected patients with chronic pelvic pain or infertility.

Adolescent↗

[Electrocoagulation in cancer of the rectum].

Twenty-six patients were treated by electrocoagulation of rectal adenocarcinoma between 1975 and 1985 at Santa Cruz y San Pablo Hospital, out of a total of 410 patients operated on for cancer, that is, 6.34% of the total number of cases. Eight cases were excluded from this review because of insufficient data. Indications for electrocoagulation were as follows: contraindication of radical surgery due to a severe underlying disease or old age, patient refusal to undergo surgery or colostomy, as a palliative measure in extremely advanced neoplastic disease, and lastly, in cases where local excision was contraindicated (because of tumor size, the lesion not being removable or being affixed to the muscular plane). The overall survival rate among patients treated with intent to cure was 54.5%. We also present the indications and contraindications of this surgical technique.

Adenocarcinoma↗

Comparison of histological effect of electrocoagulation and Nd-YAG laser coagulation in intact and tumorous rat tissue.

In our animal experiments we used a chemical agent (dibutylnitrosamine) to induce urinary bladder tumor in rats, then this was implanted under the dorsal skin of rats of the same strain to gain a standard tumor preparation. The histological effects of electrocoagulation and Nd-Yag laser coagulation were compared in rat striated muscle, liver, intact rat urinary bladder and in our standard tumor preparation. The histological changes suggested that laser coagulation has advantages over electrocoagulation for inducing deep and homogenous necrosis in intact and tumorous tissues.

Animals↗

[Ligation and sclerosis technique combined with electrocoagulation resection of internal hemorrhoids].

We review 1331 patients who were treated by sclerosis and rubber band ligation, stepped binding, simultaneous binding and sclerosis with electrocoagulation resection as the main hemorrhoidal bundle treatment, from July 1977 through July 1990, was performed. The benefits on symptoms, complications, and final outcome were analyzed. Binding of only one hemorrhoidal bundle with sclerosis of the other two in the 74.9%, binding of two bundles with sclerosis of the other in the 13.7% and simultaneously binding of the three bundles in the 4.8% was performed. Binding, sclerosis and electrocoagulation resection of three bundles was also performed in the 6.45%.

Adolescent↗

Modified endometrial ablation: electrocoagulation with vasopressin and suction curettage preparation.

Patient preparation and a modified operative technique are described for electrocoagulation ablation of the endometrium using a roller-bar electrode. No preoperative or postoperative endometrial suppression was used. Rather, the endometrial cavity was denuded by suction curettage just before ablation, which was performed in the early proliferative phase of the menstrual cycle. Lidocaine paracervical block containing vasopressin was injected at the start of the procedure to control pain and to minimize bleeding and irrigation fluid absorption. Pulsed irrigation of the uterus was used to improve visibility through uterine debris and the bubbles generated by the electrical current. The first 20 patients who had electrocoagulation ablation of the endometrium with these modifications were compared with the first 18 patients who had laser coagulation ablation using standard technique and preoperative endometrial suppression. Compared with the laser method, the modified coagulation method resulted in a comparable rate of satisfactory bleeding decrease at 6 months (90 versus 94%), but involved a clinically significant reduction in total anesthesia time (66.8 versus 117.3 minutes) and volume of irrigation fluid used (5.7 versus 15.9 L).

Adult↗

[Laparoscopic sterilization of women by electrocoagulation. A 5-year material].

A retrospective questionnaire investigation was undertaken involving 253 women who had been sterilized by electrocoagulation in a small department of general surgery during a five-year period. This revealed a frequency of pregnancy of 1.6% following a total period of observation averaging 42 months. The average age of the women in this material was 35.8 years and these had, on an average, 2.8 children. 4.0% regretted the intervention. The majority of the women (97.0%) would choose laparoscopic sterilization as the method of contraception today, if they should choose again. The per- and postoperative frequency of complications was 4.3%. The operating time was 33.8 minutes on an average and the duration of postoperative hospitalization was 1.5 days on an average. On a average, the patients felt well after 7.9 days and they resumed sexual activities after an average of 16.7 days. The conclusion of this investigation is that laparoscopic sterilization by electrocoagulation carried out by an experienced surgeon in a small department for general surgery is a safe and cheap method of sterilization which is reasonably free from complications for the patients.

Adult↗

[Electrocoagulation of the His bundle node junction in dogs by a high-frequency current delivered by suction catheter].

High-frequency currents constitute an attractive form of energy for transcutaneous myocardial destruction, but their potential for creating lesions varies with the nature of contact between electrode and skin. The adequacy of a suction catheter for electrocoagulation of the AV node-His bundle junction was assessed in 7 dogs. The high-frequency current (1.2 MHz) was delivered as bursts of 6 watts lasting 30 seconds, between the distal electrode of a bipolar catheter containing a central lumen (USCI 8F) and a wide skin electrode. During firing, an 80 kPa depression was applied to the lumen. Electrophysiological testing was performed before and immediately after firing. Continuous 24-hour Holter recording was carried out before, immediately after, then between the 2nd and 20th days post-firing. Following another electrophysiological study, the animals were killed on the 15th or 21st day for anatomical study. Complete atrioventricular block was obtained in all dogs during the first (n = 4) or second (n = 3) firing and persisted in 6 dogs up to the time of anatomical study. The atrial and right ventricular electrophysiological parameters remained unmodified after firing, and no severe ventricular arrhythmia was recorded during the study. The histological lesions were 4.7 +/- 0.7 mm in mean diameter and 3.1 +/- 0.6 mm in mean depth. It is concluded that electrocoagulation of the AV node-His bundle junction performed with high-frequency currents is a safe and selective technique. Using suction catheters makes this technique well reproducible with moderate amounts of energy. The development of preformed catheters should reduce the duration of the procedure.

Animals↗

[Electrocoagulation as radical treatment of anorectal cancer].

During a 17 year period, 19 patients with ano-rectal cancers were treated radically by electrocoagulation. Ten patients (52%) were treated successfully with electrocoagulation as the only treatment. The method is recommended as an alternative to radical surgery in carefully selected patients. The patients should be followed up at regular intervals. No serious complications occurred.

Aged↗